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Research article:
Can analyses of electronic patient records be independently and externally validated? Study 2: the Effect of Beta-Adrenoceptor Blocker Therapy on Cancer Survival; a Retrospective Cohort Study
Reference:
David a Springate, Darren M Ashcroft, Evangelos Kontopantelis, Tim Doran, Ronan Ryan, David Reeves(2015) Can analyses of electronic patient records be independently and externally validated? Study 2: the Effect of Beta-Adrenoceptor Blocker Therapy on Cancer Survival; a Retrospective Cohort Study. BMJ Open, doi: 10.1136/bmjopen-2014-007299
- Link to fulltext article
- Abstract
- Objectives To conduct a fully independent and external validation of a research study based on one electronic health record database, using a different database sampling the same population. Design Retrospective cohort analysis of beta-blocker therapy and all-cause mortality in cancer patients. Setting Two UK national primary care databases (PCDs): the Clinical Practice Research Datalink (CPRD) and Doctors’ Independent Network (DIN). Participants CPRD data for 11302 cancer patients compared to published results from DIN for 3462 patients. Study period January 1997 to December 2006. Primary and secondary outcome measures All-cause mortality: overall; by treatment subgroup (betablockers only, beta-blockers plus other blood pressure lowering medicines (BPLM), other BPLMs only); and by cancer-site. Results Using CPRD, beta-blocker use was not associated with mortality (HR=1.03, 95%CI 0.93-1.14, vs patients prescribed other BPLMs only), but in DIN beta-blocker users had significantly higher mortality (HR=1.18, 95%CI 1.04 to 1.33). However, these hazard ratios were not statistically different (p=0.063), but did differ for patients on beta-blockers alone (CPRD=0.94, 95%CI 0.82-1.07; DIN=1.37, 95%CI 1.16-1.61; p<0.001). Results for nine individual cancer sites differed by study, but only significantly for prostate and pancreas cancers. Results were robust under sensitivity analyses, but we could not be certain that mortality was identically defined in both databases. Conclusions We found a complex pattern of similarities and differences between databases. Our finding that overall treatment effect estimates were not statistically different, adds to a growing body of evidence that different UK PCDs produce effect estimates comparable within statistical tolerance. However, some subgroup effects differed significantly and individually the two studies lead to different conclusions regarding the safety of beta-blockers for cancer patients. Single studies based on internally well-validated databases therefore do not guarantee generalisable results, especially for subgroups. In all cases, confirmatory studies using at least one other independent data source are strongly recommended.
- Author for correspondence
- David Reeves
- Email for correspondence
- david.reeves@manchester.ac.uk
Code list: res24: comorbidities
234 codes in list
| Code | Coding system | Description | Entity type | List name | |||
|---|---|---|---|---|---|---|---|
| 14A3.00 | Read | H/O: myocardial infarct <60 | diagnostic | res24: comorbidities | |||
| 14A4.00 | Read | H/O: myocardial infarct >60 | diagnostic | res24: comorbidities | |||
| 14A5.00 | Read | H/O: angina pectoris | diagnostic | res24: comorbidities | |||
| 14A6.00 | Read | H/O: heart failure | diagnostic | res24: comorbidities | |||
| 14A7.00 | Read | H/O: CVA/stroke | diagnostic | res24: comorbidities | |||
| 14AB.00 | Read | H/O: TIA | diagnostic | res24: comorbidities | |||
| 14AH.00 | Read | H/O: Myocardial infarction in last year | diagnostic | res24: comorbidities | |||
| 14AJ.00 | Read | H/O: Angina in last year | diagnostic | res24: comorbidities | |||
| 14AK.00 | Read | H/O: Stroke in last year | diagnostic | res24: comorbidities | |||
| 14AL.00 | Read | H/O: Treatment for ischaemic heart disease | diagnostic | res24: comorbidities | |||
| 14AM.00 | Read | H/O: Heart failure in last year | diagnostic | res24: comorbidities | |||
| 14AN.00 | Read | H/O: atrial fibrillation | diagnostic | res24: comorbidities | |||
| 14B3.00 | Read | H/O: chr.obstr. airway disease | diagnostic | res24: comorbidities | |||
| 14B4.00 | Read | H/O: asthma | diagnostic | res24: comorbidities | |||
| 14V2.00 | Read | H/O: renal dialysis | diagnostic | res24: comorbidities | |||
| 173A.00 | Read | Exercise induced asthma | diagnostic | res24: comorbidities | |||
| 1O2..00 | Read | Asthma confirmed | diagnostic | res24: comorbidities | |||
| 322..00 | Read | ECG: myocardial ischaemia | diagnostic | res24: comorbidities | |||
| 3222 | Read | ECG:shows myocardial ischaemia | diagnostic | res24: comorbidities | |||
| 322Z.00 | Read | ECG: myocardial ischaemia NOS | diagnostic | res24: comorbidities | |||
| 323..00 | Read | ECG: myocardial infarction | diagnostic | res24: comorbidities | |||
| 3232 | Read | ECG: old myocardial infarction | diagnostic | res24: comorbidities | |||
| 3233 | Read | ECG: antero-septal infarct. | diagnostic | res24: comorbidities | |||
| 3234 | Read | ECG:posterior/inferior infarct | diagnostic | res24: comorbidities | |||
| 3235 | Read | ECG: subendocardial infarct | diagnostic | res24: comorbidities | |||
| 3236 | Read | ECG: lateral infarction | diagnostic | res24: comorbidities | |||
| 323Z.00 | Read | ECG: myocardial infarct NOS | diagnostic | res24: comorbidities | |||
| 662K.00 | Read | Angina control | diagnostic | res24: comorbidities | |||
| 7920 | Read | Saphenous vein graft replacement of coronary artery | diagnostic | res24: comorbidities | |||
| 792..00 | Read | Coronary artery operations | diagnostic | res24: comorbidities | |||
| 7920000 | Read | Saphenous vein graft replacement of one coronary artery | diagnostic | res24: comorbidities | |||
| 7920100 | Read | Saphenous vein graft replacement of two coronary arteries | diagnostic | res24: comorbidities | |||
| 7920200 | Read | Saphenous vein graft replacement of three coronary arteries | diagnostic | res24: comorbidities | |||
| 7920300 | Read | Saphenous vein graft replacement of four+ coronary arteries | diagnostic | res24: comorbidities | |||
| 7920y00 | Read | Saphenous vein graft replacement of coronary artery OS | diagnostic | res24: comorbidities | |||
| 7920z00 | Read | Saphenous vein graft replacement coronary artery NOS | diagnostic | res24: comorbidities | |||
| 7921 | Read | Other autograft replacement of coronary artery | diagnostic | res24: comorbidities | |||
| 7921000 | Read | Autograft replacement of one coronary artery NEC | diagnostic | res24: comorbidities | |||
| 7921100 | Read | Autograft replacement of two coronary arteries NEC | diagnostic | res24: comorbidities | |||
| 7921200 | Read | Autograft replacement of three coronary arteries NEC | diagnostic | res24: comorbidities | |||
| 7921300 | Read | Autograft replacement of four of more coronary arteries NEC | diagnostic | res24: comorbidities | |||
| 7921y00 | Read | Other autograft replacement of coronary artery OS | diagnostic | res24: comorbidities | |||
| 7921z00 | Read | Other autograft replacement of coronary artery NOS | diagnostic | res24: comorbidities | |||
| 7922 | Read | Allograft replacement of coronary artery | diagnostic | res24: comorbidities | |||
| 7922000 | Read | Allograft replacement of one coronary artery | diagnostic | res24: comorbidities | |||
| 7922100 | Read | Allograft replacement of two coronary arteries | diagnostic | res24: comorbidities | |||
| 7922200 | Read | Allograft replacement of three coronary arteries | diagnostic | res24: comorbidities | |||
| 7922300 | Read | Allograft replacement of four or more coronary arteries | diagnostic | res24: comorbidities | |||
| 7922y00 | Read | Other specified allograft replacement of coronary artery | diagnostic | res24: comorbidities | |||
| 7922z00 | Read | Allograft replacement of coronary artery NOS | diagnostic | res24: comorbidities | |||
| 7923 | Read | Prosthetic replacement of coronary artery | diagnostic | res24: comorbidities | |||
| 7923000 | Read | Prosthetic replacement of one coronary artery | diagnostic | res24: comorbidities | |||
| 7923100 | Read | Prosthetic replacement of two coronary arteries | diagnostic | res24: comorbidities | |||
| 7923200 | Read | Prosthetic replacement of three coronary arteries | diagnostic | res24: comorbidities | |||
| 7923300 | Read | Prosthetic replacement of four or more coronary arteries | diagnostic | res24: comorbidities | |||
| 7923z00 | Read | Prosthetic replacement of coronary artery NOS | diagnostic | res24: comorbidities | |||
| 7924 | Read | Revision of bypass for coronary artery | diagnostic | res24: comorbidities | |||
| 7924000 | Read | Revision of bypass for one coronary artery | diagnostic | res24: comorbidities | |||
| 7924100 | Read | Revision of bypass for two coronary arteries | diagnostic | res24: comorbidities | |||
| 7924200 | Read | Revision of bypass for three coronary arteries | diagnostic | res24: comorbidities | |||
| 7924300 | Read | Revision of bypass for four or more coronary arteries | diagnostic | res24: comorbidities | |||
| 7924500 | Read | Revision of implantation of thoracic artery into heart | diagnostic | res24: comorbidities | |||
| 7924y00 | Read | Other specified revision of bypass for coronary artery | diagnostic | res24: comorbidities | |||
| 7924z00 | Read | Revision of bypass for coronary artery NOS | diagnostic | res24: comorbidities | |||
| 7925 | Read | Connection of mammary artery to coronary artery | diagnostic | res24: comorbidities | |||
| 7925000 | Read | Double anastomosis of mammary arteries to coronary arteries | diagnostic | res24: comorbidities | |||
| 7925100 | Read | Double implant of mammary arteries into coronary arteries | diagnostic | res24: comorbidities | |||
| 7925200 | Read | Single anast mammary art to left ant descend coronary art | diagnostic | res24: comorbidities | |||
| 7925300 | Read | Single anastomosis of mammary artery to coronary artery NEC | diagnostic | res24: comorbidities | |||
| 7925400 | Read | Single implantation of mammary artery into coronary artery | diagnostic | res24: comorbidities | |||
| 7925y00 | Read | Connection of mammary artery to coronary artery OS | diagnostic | res24: comorbidities | |||
| 7925z00 | Read | Connection of mammary artery to coronary artery NOS | diagnostic | res24: comorbidities | |||
| 7926 | Read | Connection of other thoracic artery to coronary artery | diagnostic | res24: comorbidities | |||
| 7926000 | Read | Double anastom thoracic arteries to coronary arteries NEC | diagnostic | res24: comorbidities | |||
| 7926200 | Read | Single anastomosis of thoracic artery to coronary artery NEC | diagnostic | res24: comorbidities | |||
| 7926300 | Read | Single implantation thoracic artery into coronary artery NEC | diagnostic | res24: comorbidities | |||
| 7926z00 | Read | Connection of other thoracic artery to coronary artery NOS | diagnostic | res24: comorbidities | |||
| 7927 | Read | Other open operations on coronary artery | diagnostic | res24: comorbidities | |||
| 7927500 | Read | Open angioplasty of coronary artery | diagnostic | res24: comorbidities | |||
| 7927y00 | Read | Other specified other open operation on coronary artery | diagnostic | res24: comorbidities | |||
| 7927z00 | Read | Other open operation on coronary artery NOS | diagnostic | res24: comorbidities | |||
| 7928 | Read | Transluminal balloon angioplasty of coronary artery | diagnostic | res24: comorbidities | |||
| 7928000 | Read | Percut transluminal balloon angioplasty one coronary artery | diagnostic | res24: comorbidities | |||
| 7928100 | Read | Percut translum balloon angioplasty mult coronary arteries | diagnostic | res24: comorbidities | |||
| 7928200 | Read | Percut translum balloon angioplasty bypass graft coronary a | diagnostic | res24: comorbidities | |||
| 7928y00 | Read | Transluminal balloon angioplasty of coronary artery OS | diagnostic | res24: comorbidities | |||
| 7928z00 | Read | Transluminal balloon angioplasty of coronary artery NOS | diagnostic | res24: comorbidities | |||
| 7929 | Read | Other therapeutic transluminal operations on coronary artery | diagnostic | res24: comorbidities | |||
| 7929000 | Read | Percutaneous transluminal laser coronary angioplasty | diagnostic | res24: comorbidities | |||
| 7929100 | Read | Percut transluminal coronary thrombolysis with streptokinase | diagnostic | res24: comorbidities | |||
| 7929200 | Read | Percut translum inject therap subst to coronary artery NEC | diagnostic | res24: comorbidities | |||
| 7929300 | Read | Rotary blade coronary angioplasty | diagnostic | res24: comorbidities | |||
| 7929400 | Read | Insertion of coronary artery stent | diagnostic | res24: comorbidities | |||
| 7929500 | Read | Insertion of drug-eluting coronary artery stent | diagnostic | res24: comorbidities | |||
| 7929600 | Read | Percutaneous transluminal atherectomy of coronary artery | diagnostic | res24: comorbidities | |||
| 7929y00 | Read | Other therapeutic transluminal op on coronary artery OS | diagnostic | res24: comorbidities | |||
| 7929z00 | Read | Other therapeutic transluminal op on coronary artery NOS | diagnostic | res24: comorbidities | |||
| 792A.00 | Read | Diagnostic transluminal operations on coronary artery | diagnostic | res24: comorbidities | |||
| 792A000 | Read | Percutaneous transluminal angioscopy | diagnostic | res24: comorbidities | |||
| 792A100 | Read | Intravascular ultrasound of coronary artery | diagnostic | res24: comorbidities | |||
| 792Ay00 | Read | Diagnostic transluminal operation on coronary artery OS | diagnostic | res24: comorbidities | |||
| 792Az00 | Read | Diagnostic transluminal operation on coronary artery NOS | diagnostic | res24: comorbidities | |||
| 792B.00 | Read | Repair of coronary artery NEC | diagnostic | res24: comorbidities | |||
| 792B000 | Read | Endarterectomy of coronary artery NEC | diagnostic | res24: comorbidities | |||
| 792By00 | Read | Other specified repair of coronary artery | diagnostic | res24: comorbidities | |||
| 792Bz00 | Read | Repair of coronary artery NOS | diagnostic | res24: comorbidities | |||
| 792C.00 | Read | Other replacement of coronary artery | diagnostic | res24: comorbidities | |||
| 792C000 | Read | Replacement of coronary arteries using multiple methods | diagnostic | res24: comorbidities | |||
| 792Cy00 | Read | Other specified replacement of coronary artery | diagnostic | res24: comorbidities | |||
| 792Cz00 | Read | Replacement of coronary artery NOS | diagnostic | res24: comorbidities | |||
| 792D.00 | Read | Other bypass of coronary artery | diagnostic | res24: comorbidities | |||
| 792Dy00 | Read | Other specified other bypass of coronary artery | diagnostic | res24: comorbidities | |||
| 792Dz00 | Read | Other bypass of coronary artery NOS | diagnostic | res24: comorbidities | |||
| 792y.00 | Read | Other specified operations on coronary artery | diagnostic | res24: comorbidities | |||
| 792z.00 | Read | Coronary artery operations NOS | diagnostic | res24: comorbidities | |||
| F423600 | Read | Amaurosis fugax | diagnostic | res24: comorbidities | |||
| G3...00 | Read | Ischaemic heart disease | diagnostic | res24: comorbidities | |||
| G30..00 | Read | Acute myocardial infarction | diagnostic | res24: comorbidities | |||
| G300.00 | Read | Acute anterolateral infarction | diagnostic | res24: comorbidities | |||
| G301.00 | Read | Other specified anterior myocardial infarction | diagnostic | res24: comorbidities | |||
| G301000 | Read | Acute anteroapical infarction | diagnostic | res24: comorbidities | |||
| G301100 | Read | Acute anteroseptal infarction | diagnostic | res24: comorbidities | |||
| G301z00 | Read | Anterior myocardial infarction NOS | diagnostic | res24: comorbidities | |||
| G302.00 | Read | Acute inferolateral infarction | diagnostic | res24: comorbidities | |||
| G303.00 | Read | Acute inferoposterior infarction | diagnostic | res24: comorbidities | |||
| G304.00 | Read | Posterior myocardial infarction NOS | diagnostic | res24: comorbidities | |||
| G305.00 | Read | Lateral myocardial infarction NOS | diagnostic | res24: comorbidities | |||
| G306.00 | Read | True posterior myocardial infarction | diagnostic | res24: comorbidities | |||
| G307.00 | Read | Acute subendocardial infarction | diagnostic | res24: comorbidities | |||
| G307000 | Read | Acute non-Q wave infarction | diagnostic | res24: comorbidities | |||
| G307100 | Read | Acute non-ST segment elevation myocardial infarction | diagnostic | res24: comorbidities | |||
| G308.00 | Read | Inferior myocardial infarction NOS | diagnostic | res24: comorbidities | |||
| G309.00 | Read | Acute Q-wave infarct | diagnostic | res24: comorbidities | |||
| G30A.00 | Read | Mural thrombosis | diagnostic | res24: comorbidities | |||
| G30B.00 | Read | Acute posterolateral myocardial infarction | diagnostic | res24: comorbidities | |||
| G30X.00 | Read | Acute transmural myocardial infarction of unspecif site | diagnostic | res24: comorbidities | |||
| G30X000 | Read | Acute ST segment elevation myocardial infarction | diagnostic | res24: comorbidities | |||
| G30y.00 | Read | Other acute myocardial infarction | diagnostic | res24: comorbidities | |||
| G30y000 | Read | Acute atrial infarction | diagnostic | res24: comorbidities | |||
| G30y100 | Read | Acute papillary muscle infarction | diagnostic | res24: comorbidities | |||
| G30y200 | Read | Acute septal infarction | diagnostic | res24: comorbidities | |||
| G30yz00 | Read | Other acute myocardial infarction NOS | diagnostic | res24: comorbidities | |||
| G30z.00 | Read | Acute myocardial infarction NOS | diagnostic | res24: comorbidities | |||
| G31..00 | Read | Other acute and subacute ischaemic heart disease | diagnostic | res24: comorbidities | |||
| G310.00 | Read | Postmyocardial infarction syndrome | diagnostic | res24: comorbidities | |||
| G311.00 | Read | Preinfarction syndrome | diagnostic | res24: comorbidities | |||
| G311000 | Read | Myocardial infarction aborted | diagnostic | res24: comorbidities | |||
| G311100 | Read | Unstable angina | diagnostic | res24: comorbidities | |||
| G311200 | Read | Angina at rest | diagnostic | res24: comorbidities | |||
| G311300 | Read | Refractory angina | diagnostic | res24: comorbidities | |||
| G311400 | Read | Worsening angina | diagnostic | res24: comorbidities | |||
| G311500 | Read | Acute coronary syndrome | diagnostic | res24: comorbidities | |||
| G311z00 | Read | Preinfarction syndrome NOS | diagnostic | res24: comorbidities | |||
| G312.00 | Read | Coronary thrombosis not resulting in myocardial infarction | diagnostic | res24: comorbidities | |||
| G31y.00 | Read | Other acute and subacute ischaemic heart disease | diagnostic | res24: comorbidities | |||
| G31y000 | Read | Acute coronary insufficiency | diagnostic | res24: comorbidities | |||
| G31y100 | Read | Microinfarction of heart | diagnostic | res24: comorbidities | |||
| G31y200 | Read | Subendocardial ischaemia | diagnostic | res24: comorbidities | |||
| G31y300 | Read | Transient myocardial ischaemia | diagnostic | res24: comorbidities | |||
| G31yz00 | Read | Other acute and subacute ischaemic heart disease NOS | diagnostic | res24: comorbidities | |||
| G32..00 | Read | Old myocardial infarction | diagnostic | res24: comorbidities | |||
| G33..00 | Read | Angina pectoris | diagnostic | res24: comorbidities | |||
| G330.00 | Read | Angina decubitus | diagnostic | res24: comorbidities | |||
| G330000 | Read | Nocturnal angina | diagnostic | res24: comorbidities | |||
| G330z00 | Read | Angina decubitus NOS | diagnostic | res24: comorbidities | |||
| G331.00 | Read | Prinzmetal's angina | diagnostic | res24: comorbidities | |||
| G332.00 | Read | Coronary artery spasm | diagnostic | res24: comorbidities | |||
| G33z.00 | Read | Angina pectoris NOS | diagnostic | res24: comorbidities | |||
| G33z000 | Read | Status anginosus | diagnostic | res24: comorbidities | |||
| G33z100 | Read | Stenocardia | diagnostic | res24: comorbidities | |||
| G33z200 | Read | Syncope anginosa | diagnostic | res24: comorbidities | |||
| G33z300 | Read | Angina on effort | diagnostic | res24: comorbidities | |||
| G33z400 | Read | Ischaemic chest pain | diagnostic | res24: comorbidities | |||
| G33z500 | Read | Post infarct angina | diagnostic | res24: comorbidities | |||
| G33z600 | Read | New onset angina | diagnostic | res24: comorbidities | |||
| G33z700 | Read | Stable angina | diagnostic | res24: comorbidities | |||
| G33zz00 | Read | Angina pectoris NOS | diagnostic | res24: comorbidities | |||
| G34..00 | Read | Other chronic ischaemic heart disease | diagnostic | res24: comorbidities | |||
| G340.00 | Read | Coronary atherosclerosis | diagnostic | res24: comorbidities | |||
| G340000 | Read | Single coronary vessel disease | diagnostic | res24: comorbidities | |||
| G340100 | Read | Double coronary vessel disease | diagnostic | res24: comorbidities | |||
| G342.00 | Read | Atherosclerotic cardiovascular disease | diagnostic | res24: comorbidities | |||
| G343.00 | Read | Ischaemic cardiomyopathy | diagnostic | res24: comorbidities | |||
| G344.00 | Read | Silent myocardial ischaemia | diagnostic | res24: comorbidities | |||
| G34y.00 | Read | Other specified chronic ischaemic heart disease | diagnostic | res24: comorbidities | |||
| G34y000 | Read | Chronic coronary insufficiency | diagnostic | res24: comorbidities | |||
| G34y100 | Read | Chronic myocardial ischaemia | diagnostic | res24: comorbidities | |||
| G34yz00 | Read | Other specified chronic ischaemic heart disease NOS | diagnostic | res24: comorbidities | |||
| G34z.00 | Read | Other chronic ischaemic heart disease NOS | diagnostic | res24: comorbidities | |||
| G34z000 | Read | Asymptomatic coronary heart disease | diagnostic | res24: comorbidities | |||
| G35..00 | Read | Subsequent myocardial infarction | diagnostic | res24: comorbidities | |||
| G350.00 | Read | Subsequent myocardial infarction of anterior wall | diagnostic | res24: comorbidities | |||
| G351.00 | Read | Subsequent myocardial infarction of inferior wall | diagnostic | res24: comorbidities | |||
| G353.00 | Read | Subsequent myocardial infarction of other sites | diagnostic | res24: comorbidities | |||
| G35X.00 | Read | Subsequent myocardial infarction of unspecified site | diagnostic | res24: comorbidities | |||
| G36..00 | Read | Certain current complication follow acute myocardial infarct | diagnostic | res24: comorbidities | |||
| G360.00 | Read | Haemopericardium/current comp folow acut myocard infarct | diagnostic | res24: comorbidities | |||
| G361.00 | Read | Atrial septal defect/curr comp folow acut myocardal infarct | diagnostic | res24: comorbidities | |||
| G362.00 | Read | Ventric septal defect/curr comp fol acut myocardal infarctn | diagnostic | res24: comorbidities | |||
| G363.00 | Read | Ruptur cardiac wall w'out haemopericard/cur comp fol ac MI | diagnostic | res24: comorbidities | |||
| G364.00 | Read | Ruptur chordae tendinae/curr comp fol acute myocard infarct | diagnostic | res24: comorbidities | |||
| G365.00 | Read | Rupture papillary muscle/curr comp fol acute myocard infarct | diagnostic | res24: comorbidities | |||
| G366.00 | Read | Thrombosis atrium; auric append&vent/curr comp foll acute MI | diagnostic | res24: comorbidities | |||
| G38..00 | Read | Postoperative myocardial infarction | diagnostic | res24: comorbidities | |||
| G380.00 | Read | Postoperative transmural myocardial infarction anterior wall | diagnostic | res24: comorbidities | |||
| G381.00 | Read | Postoperative transmural myocardial infarction inferior wall | diagnostic | res24: comorbidities | |||
| G384.00 | Read | Postoperative subendocardial myocardial infarction | diagnostic | res24: comorbidities | |||
| G38z.00 | Read | Postoperative myocardial infarction; unspecified | diagnostic | res24: comorbidities | |||
| G3y..00 | Read | Other specified ischaemic heart disease | diagnostic | res24: comorbidities | |||
| G3z..00 | Read | Ischaemic heart disease NOS | diagnostic | res24: comorbidities | |||
| G63y000 | Read | Cerebral infarct due to thrombosis of precerebral arteries | diagnostic | res24: comorbidities | |||
| G63y100 | Read | Cerebral infarction due to embolism of precerebral arteries | diagnostic | res24: comorbidities | |||
| G676000 | Read | Cereb infarct due cerebral venous thrombosis; nonpyogenic | diagnostic | res24: comorbidities | |||
| G6W..00 | Read | Cereb infarct due unsp occlus/stenos precerebr arteries | diagnostic | res24: comorbidities | |||
| G6X..00 | Read | Cerebrl infarctn due/unspcf occlusn or sten/cerebrl artrs | diagnostic | res24: comorbidities | |||
| Gyu3.00 | Read | [X]Ischaemic heart diseases | diagnostic | res24: comorbidities | |||
| Gyu3000 | Read | [X]Other forms of angina pectoris | diagnostic | res24: comorbidities | |||
| Gyu3200 | Read | [X]Other forms of acute ischaemic heart disease | diagnostic | res24: comorbidities | |||
| Gyu3300 | Read | [X]Other forms of chronic ischaemic heart disease | diagnostic | res24: comorbidities | |||
| Gyu3400 | Read | [X]Acute transmural myocardial infarction of unspecif site | diagnostic | res24: comorbidities | |||
| Gyu3600 | Read | [X]Subsequent myocardial infarction of unspecified site | diagnostic | res24: comorbidities | |||
| Gyu6200 | Read | [X]Other intracerebral haemorrhage | diagnostic | res24: comorbidities | |||
| Gyu6300 | Read | [X]Cerebrl infarctn due/unspcf occlusn or sten/cerebrl artrs | diagnostic | res24: comorbidities | |||
| Gyu6400 | Read | [X]Other cerebral infarction | diagnostic | res24: comorbidities | |||
| Gyu6500 | Read | [X]Occlusion and stenosis of other precerebral arteries | diagnostic | res24: comorbidities | |||
| Gyu6600 | Read | [X]Occlusion and stenosis of other cerebral arteries | diagnostic | res24: comorbidities | |||
| Gyu6F00 | Read | [X]Intracerebral haemorrhage in hemisphere; unspecified | diagnostic | res24: comorbidities | |||
| Gyu6G00 | Read | [X]Cereb infarct due unsp occlus/stenos precerebr arteries | diagnostic | res24: comorbidities | |||
| K0C0.00 | Read | Analgesic nephropathy | diagnostic | res24: comorbidities | |||
| K0z..00 | Read | Nephritis; nephrosis and nephrotic syndrome NOS | diagnostic | res24: comorbidities | |||
| ZV45700 | Read | [V]Presence of aortocoronary bypass graft | diagnostic | res24: comorbidities | |||
| ZV45800 | Read | [V]Presence of coronary angioplasty implant and graft | diagnostic | res24: comorbidities | |||
| ZV45K00 | Read | [V]Presence of coronary artery bypass graft | diagnostic | res24: comorbidities | |||
| ZV45L00 | Read | [V]Status following coronary angioplasty NOS | diagnostic | res24: comorbidities |
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