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Research article:

Can analyses of electronic patient records be independently and externally validated? Study 2: the Effect of Beta-Adrenoceptor Blocker Therapy on Cancer Survival; a Retrospective Cohort Study

Reference:

David a Springate, Darren M Ashcroft, Evangelos Kontopantelis, Tim Doran, Ronan Ryan, David Reeves(2015) Can analyses of electronic patient records be independently and externally validated? Study 2: the Effect of Beta-Adrenoceptor Blocker Therapy on Cancer Survival; a Retrospective Cohort Study. BMJ Open, doi: 10.1136/bmjopen-2014-007299

Link to fulltext article
Abstract
Objectives To conduct a fully independent and external validation of a research study based on one electronic health record database, using a different database sampling the same population. Design Retrospective cohort analysis of beta-blocker therapy and all-cause mortality in cancer patients. Setting Two UK national primary care databases (PCDs): the Clinical Practice Research Datalink (CPRD) and Doctors’ Independent Network (DIN). Participants CPRD data for 11302 cancer patients compared to published results from DIN for 3462 patients. Study period January 1997 to December 2006. Primary and secondary outcome measures All-cause mortality: overall; by treatment subgroup (betablockers only, beta-blockers plus other blood pressure lowering medicines (BPLM), other BPLMs only); and by cancer-site. Results Using CPRD, beta-blocker use was not associated with mortality (HR=1.03, 95%CI 0.93-1.14, vs patients prescribed other BPLMs only), but in DIN beta-blocker users had significantly higher mortality (HR=1.18, 95%CI 1.04 to 1.33). However, these hazard ratios were not statistically different (p=0.063), but did differ for patients on beta-blockers alone (CPRD=0.94, 95%CI 0.82-1.07; DIN=1.37, 95%CI 1.16-1.61; p<0.001). Results for nine individual cancer sites differed by study, but only significantly for prostate and pancreas cancers. Results were robust under sensitivity analyses, but we could not be certain that mortality was identically defined in both databases. Conclusions We found a complex pattern of similarities and differences between databases. Our finding that overall treatment effect estimates were not statistically different, adds to a growing body of evidence that different UK PCDs produce effect estimates comparable within statistical tolerance. However, some subgroup effects differed significantly and individually the two studies lead to different conclusions regarding the safety of beta-blockers for cancer patients. Single studies based on internally well-validated databases therefore do not guarantee generalisable results, especially for subgroups. In all cases, confirmatory studies using at least one other independent data source are strongly recommended.
Author for correspondence
David Reeves
Email for correspondence
david.reeves@manchester.ac.uk

Code list: res24: diuretics

271 codes in list

Code Coding system Description Entity type List name bnfcode
1021 CPRD_product_code INNOZIDE tablets [M S D] drug res24: diuretics 02020100/02050501
10316 CPRD_product_code COAPROVEL tablets 150mg + 12.5mg [SANOFI BMS] drug res24: diuretics 02020100/02050502
10323 CPRD_product_code losartan with hydrochlorothiazide tablets 100mg + 25mg drug res24: diuretics 02020100/02050502
10627 CPRD_product_code CO-BETALOC tablets 100mg + 12.5mg [PHARMACIA] drug res24: diuretics 02020100/02040000
10902 CPRD_product_code captopril with hydrochlorothiazide tablets 50mg + 25mg drug res24: diuretics 02020100/02050501
11133 CPRD_product_code hydrochlorothiazide with captopril tablets 25mg + 50mg drug res24: diuretics 02020100/02050501
1124 CPRD_product_code TENORETIC tablets 100mg + 25mg [ASTRAZENEC] drug res24: diuretics 02020100/02040000
1125 CPRD_product_code NAVIDREX -K tablets [NOV/CIBA] drug res24: diuretics 02020100
11338 CPRD_product_code bendroflumethiazide with nadolol tablets 5mg + 40mg drug res24: diuretics 02020100/02040000
11351 CPRD_product_code co-zidocapt (hydrochlorothiazide and captopril) tablets 25mg + 50mg drug res24: diuretics 02020100/02050501
11384 CPRD_product_code co-flumactone (hydroflumethiazide and spironolactone) tablets 50mg+50mg drug res24: diuretics 02020100/02020300/02020400
11448 CPRD_product_code irbesartan with hydrochlorothiazide tablets 150mg + 12.5mg drug res24: diuretics 02020100/02050502
11469 CPRD_product_code irbesartan with hydrochlorothiazide tablets 300mg + 12.5mg drug res24: diuretics 02020100/02050502
11526 CPRD_product_code COAPROVEL tablets 300mg + 12.5mg [SANOFI BMS] drug res24: diuretics 02020100/02050502
11561 CPRD_product_code co-zidocapt (hydrochlorothiazide and captopril) tablets 12.5mg + 25mg drug res24: diuretics 02020100/02050501
11641 CPRD_product_code captopril with hydrochlorothiazide tablets 25mg + 12.5mg drug res24: diuretics 02020100/02050501
1170 CPRD_product_code cyclopenthiazide tablets 0.5mg drug res24: diuretics 02020100
11864 CPRD_product_code valsartan with hydrochlorothiazide tablets 160mg + 12.5mg drug res24: diuretics 02020100/02050502
12054 CPRD_product_code propranolol with bendroflumethiazide capsules 80mg + 2.5mg drug res24: diuretics 02020100/02040000
1209 CPRD_product_code NEO-NACLEX tablets 5mg [GOLDSHIELD] drug res24: diuretics 02020100
12110 CPRD_product_code hydroflumethiazide tablets 50mg drug res24: diuretics 02020100
12360 CPRD_product_code NEPHRIL tablets 1mg [PFIZER] drug res24: diuretics 02020100
12440 CPRD_product_code HYDROSALURIC tablets 25mg [M S D] drug res24: diuretics 02020100
1251 CPRD_product_code MODURET 25 tablets [M S D] drug res24: diuretics 02020100/02020300/02020400
12517 CPRD_product_code timolol maleate with bendroflumethiazide tablets 20mg + 5mg drug res24: diuretics 02020100/02040000
12546 CPRD_product_code KALSPARE tablets [DOMINION] drug res24: diuretics 02020100/02020300/02020400
12547 CPRD_product_code triamterene with chlortalidone tablets 50mg + 50mg drug res24: diuretics 02020100/02020300/02020400
12651 CPRD_product_code timolol maleate with bendroflumethiazide tablets 10mg + 2.5mg drug res24: diuretics 02020100/02040000
1288 CPRD_product_code TENORET tablets 50mg + 12.5mg [ASTRAZENEC] drug res24: diuretics 02020100/02040000
12926 CPRD_product_code polythiazide tablets 1mg drug res24: diuretics 02020100
1297 CPRD_product_code ALDACTIDE film coated tablets 50mg + 50mg [PHARMACIA] drug res24: diuretics 02020100/02020300/02020400
13246 CPRD_product_code chlorothiazide oral suspension 150mg/5ml drug res24: diuretics 02020100
13363 CPRD_product_code ESIDREX tablets 50mg [NOV/CIBA] drug res24: diuretics 02020100
13525 CPRD_product_code HYDRENOX tablets 50mg [KNOLL] drug res24: diuretics 02020100
13526 CPRD_product_code ATENIXCO tablets 100mg + 25mg [ASHBOURNE] drug res24: diuretics 02020100/02040000
13871 CPRD_product_code co-prenozide (oxprenolol and cyclopenthiazide) modified release tablet 160mg + 0.25mg drug res24: diuretics 02020100/02040000
14126 CPRD_product_code acebutolol hydrochloride and hydrochlorothiazide tablets 200mg + 12.5mg drug res24: diuretics 02020100/02040000
14228 CPRD_product_code COVERSYL PLUS tablets [SERVIER] drug res24: diuretics 02020100/02050501
14283 CPRD_product_code valsartan with hydrochlorothiazide tablets 160mg + 25mg drug res24: diuretics 02020100/02050502
14438 CPRD_product_code CORGARETIC 80 tablets [SANOFI S] drug res24: diuretics 02020100/02040000
14738 CPRD_product_code hydrochlorothiazide with losartan tablets 12.5mg + 50mg drug res24: diuretics 02020100/02050502
14870 CPRD_product_code telmisartan with hydrochlorothiazide tablets 40mg + 12.5mg drug res24: diuretics 02020100/02050502
15031 CPRD_product_code ACCURETIC tablets 10mg + 12.5mg [PFIZER] drug res24: diuretics 02020100/02050501
15108 CPRD_product_code quinapril and hydrochlorothiazide tablets 10mg + 12.5mg drug res24: diuretics 02020100/02050501
15127 CPRD_product_code hydrochlorothiazide with triamterene tablets 25mg+50mg drug res24: diuretics 02020100/02020300/02020400
15135 CPRD_product_code hydrochlorothiazide with captopril tablets 12.5mg + 25mg drug res24: diuretics 02020100/02050501
1520 CPRD_product_code CAPOZIDE tablets [SQUIBB] drug res24: diuretics 02020100/02050501
15457 CPRD_product_code BAYCARON tablets 25mg [BAYER] drug res24: diuretics 02020100
15488 CPRD_product_code metoprolol tartrate with chlortalidone tablets drug res24: diuretics 02020100/02040000
15811 CPRD_product_code co-flumactone (hydroflumethiazide and spironolactone) tablets 25mg+25mg drug res24: diuretics 02020100/02020300/02020400
16060 CPRD_product_code valsartan with hydrochlorothiazide tablets 80mg + 12.5mg drug res24: diuretics 02020100/02050502
16161 CPRD_product_code telmisartan with hydrochlorothiazide tablets 80mg + 12.5mg drug res24: diuretics 02020100/02050502
16498 CPRD_product_code KALSPARE tablets [DHP] drug res24: diuretics 02020100/02020300/02020400
16632 CPRD_product_code HYDROSALURIC tablets 50mg [M S D] drug res24: diuretics 02020100
16786 CPRD_product_code chlortalidone with atenolol tablets 25mg+100mg drug res24: diuretics 02020100/02040000
17143 CPRD_product_code mefruside tablets 25mg drug res24: diuretics 02020100
1721 CPRD_product_code DYAZIDE tablets [GOLDSHIELD] drug res24: diuretics 02020100/02020300/02020400
17252 CPRD_product_code ESIDREX tablets 25mg [NOV/CIBA] drug res24: diuretics 02020100
17655 CPRD_product_code CARACE 10 plus tablets [BMS] drug res24: diuretics 02020100/02050501
17689 CPRD_product_code MICARDIS PLUS tablets 80mg + 12.5mg [BOEH INGL] drug res24: diuretics 02020100/02050502
17720 CPRD_product_code SALURIC tablets 500mg [M S D] drug res24: diuretics 02020100
1788 CPRD_product_code atenolol with chlortalidone tablets 100mg+25mg drug res24: diuretics 02020100/02040000
18200 CPRD_product_code olmesartan medoxomil with hydrochlorothiazide tablets 20mg + 12.5mg drug res24: diuretics 02020100/02050502
18202 CPRD_product_code MICARDIS PLUS tablets 40mg + 12.5mg [BOEH INGL] drug res24: diuretics 02020100/02050502
18263 CPRD_product_code ACEZIDE tablets [SQUIBB] drug res24: diuretics 02020100/02050501
18267 CPRD_product_code ENDURON tablets 5mg [ABBOTT] drug res24: diuretics 02020100
18287 CPRD_product_code CO-BETALOC SA tablets 200mg + 25mg [PHARMACIA] drug res24: diuretics 02020100/02040000
18361 CPRD_product_code AMILMAXCO tablets [ASHBOURNE] drug res24: diuretics 02020100/02020300/02020400
18606 CPRD_product_code diltiazem and hydrochlorothiazide modified release capsules 150mg + 12.5mg drug res24: diuretics 02020100/02060200
18726 CPRD_product_code TRIAMAXCO tablets [ASHBOURNE] drug res24: diuretics 02020100/02020300/02020400
18733 CPRD_product_code co-amilozide (amiloride and hydrochlorothiazide) oral solution 5mg + 50mg/5ml drug res24: diuretics 02020100/02020300/02020400
18743 CPRD_product_code TENBEN capsules 25mg + 1.25mg [GALEN] drug res24: diuretics 02020100/02040000
18903 CPRD_product_code olmesartan medoxomil with hydrochlorothiazide tablets 20mg + 25mg drug res24: diuretics 02020100/02050502
18973 CPRD_product_code CENTYL tablets 2.5mg [BURGESS] drug res24: diuretics 02020100
19055 CPRD_product_code chlortalidone with atenolol tablets 12.5mg+50mg drug res24: diuretics 02020100/02040000
19142 CPRD_product_code bendroflumethiazide with timolol maleate tablets 2.5mg + 10mg drug res24: diuretics 02020100/02040000
19352 CPRD_product_code XURET low dose tablets 0.5mg [GALEN] drug res24: diuretics 02020100
19890 CPRD_product_code hydrochlorothiazide with amiloride tablets 25mg+2.5mg drug res24: diuretics 02020100/02020300/02020400
2 CPRD_product_code bendroflumethiazide tablets 2.5mg drug res24: diuretics 02020100
2001 CPRD_product_code ALDACTIDE film coated tablets 25mg + 25mg [PHARMACIA] drug res24: diuretics 02020100/02020300/02020400
2002 CPRD_product_code amiloride hydrochloride with hydrochlorothiazide tablets 5mg + 50mg drug res24: diuretics 02020100/02020300/02020400
20057 CPRD_product_code methyclothiazide tablets 5mg drug res24: diuretics 02020100
20066 CPRD_product_code AMIL-CO tablets 5mg + 50mg [IVAX] drug res24: diuretics 02020100/02020300/02020400
20093 CPRD_product_code metoprolol tartrate with hydrochlorothiazide modified release tablet 200mg + 25mg drug res24: diuretics 02020100/02040000
2046 CPRD_product_code NAVIDREX tablets 0.5mg [GOLDSHIELD] drug res24: diuretics 02020100
21025 CPRD_product_code PRESTIM FORTE tablets [LEO] drug res24: diuretics 02020100/02040000
21182 CPRD_product_code hydrochlorothiazide with timolol and amiloride tablets 25mg + 10mg + 2.5mg drug res24: diuretics 02020100/02020300/02040000
21231 CPRD_product_code CARALPHA tablets 20mg + 12.5mg [ACTAVIS] drug res24: diuretics 02020100/02050501
21423 CPRD_product_code COZAAR-COMP tablets 100mg + 25mg [M S D] drug res24: diuretics 02020100/02050502
21803 CPRD_product_code BERKOZIDE tablets 2.5mg [BERK] drug res24: diuretics 02020100
21867 CPRD_product_code BERKOZIDE tablets 5mg [BERK] drug res24: diuretics 02020100
21873 CPRD_product_code ATENIXCO tablets 50mg+12.5mg [ASHBOURNE] drug res24: diuretics 02020100/02040000
2255 CPRD_product_code NAVISPARE tablets [GOLDSHIELD] drug res24: diuretics 02020100/02020300/02020400
22912 CPRD_product_code bendroflumethiazide with propranolol capsules 2.5mg + 80mg drug res24: diuretics 02020100/02040000
22923 CPRD_product_code hydrochlorothiazide with amiloride tablets 50mg + 5mg drug res24: diuretics 02020100/02020300/02020400
23131 CPRD_product_code bendroflumethiazide with propranolol modified release capsules 5mg + 160mg drug res24: diuretics 02020100/02040000
23134 CPRD_product_code nadolol with bendroflumethiazide tablets 40mg + 5mg drug res24: diuretics 02020100/02040000
23427 CPRD_product_code BENDROFLUMETHIAZIDE tablets 5mg [HILLCROSS] drug res24: diuretics 02020100
23456 CPRD_product_code hydrochlorothiazide with valsartan tablets 25mg + 160mg drug res24: diuretics 02020100/02050502
23505 CPRD_product_code ADIZEM XL PLUS controlled release capsules 150mg + 12.5mg [NAPP] drug res24: diuretics 02020100/02060200
24008 CPRD_product_code VASETIC tablets [SHIRE] drug res24: diuretics 02020100/02020300/02020400
24189 CPRD_product_code NEO-BENDROMAX tablets 2.5mg [ASHBOURNE] drug res24: diuretics 02020100
24190 CPRD_product_code NEO-BENDROMAX tablets 5mg [ASHBOURNE] drug res24: diuretics 02020100
24268 CPRD_product_code hydrochlorothiazide with valsartan tablets 12.5mg + 80mg drug res24: diuretics 02020100/02050502
24280 CPRD_product_code TOTARETIC tablets 100mg+25mg [CP PHARM] drug res24: diuretics 02020100/02040000
24484 CPRD_product_code hydrochlorothiazide with valsartan tablets 12.5mg + 160mg drug res24: diuretics 02020100/02050502
24632 CPRD_product_code hydrochlorothiazide with losartan tablets 25mg + 100mg drug res24: diuretics 02020100/02050502
25363 CPRD_product_code PRESTIM tablets [MEDA] drug res24: diuretics 02020100/02040000
25382 CPRD_product_code CO-DIOVAN tablets 160mg + 25mg [NOVARTIS] drug res24: diuretics 02020100/02050502
25500 CPRD_product_code HYPERTANE 50 tablets [SCHWARZ] drug res24: diuretics 02020100/02020300/02020400
25505 CPRD_product_code SPIRO-CO tablets 50mg+50mg [IVAX] drug res24: diuretics 02020100/02020300/02020400
25730 CPRD_product_code timolol maleate with amiloride and hydrochlorothiazide tablets drug res24: diuretics 02020100/02020300/02040000
2612 CPRD_product_code indapamide tablets 2.5mg drug res24: diuretics 02020100
26219 CPRD_product_code ZIDA-CO tablets 5mg + 50mg [OPUS] drug res24: diuretics 02020100/02020300/02020400
26220 CPRD_product_code DELVAS tablets [BERK] drug res24: diuretics 02020100/02020300/02020400
26248 CPRD_product_code TENCHLOR tablets 100mg + 25mg [BERK] drug res24: diuretics 02020100/02040000
26256 CPRD_product_code OPUMIDE tablets 2.5mg [OPUS] drug res24: diuretics 02020100
26275 CPRD_product_code NINDAXA tablets 2.5mg [ASHBOURNE] drug res24: diuretics 02020100
26741 CPRD_product_code TOTARETIC tablets 50mg+12.5mg [CP PHARM] drug res24: diuretics 02020100/02040000
27256 CPRD_product_code BENDROFLUMETHIAZIDE tablets 2.5mg [WOCKHARDT] drug res24: diuretics 02020100
27520 CPRD_product_code OLMETEC PLUS tablets 20mg + 25mg [DAIIC-SANK] drug res24: diuretics 02020100/02050502
27689 CPRD_product_code BENDROFLUMETHIAZIDE tablets 2.5mg [IVAX] drug res24: diuretics 02020100
27946 CPRD_product_code nadolol with bendroflumethiazide tablets 80mg + 5mg drug res24: diuretics 02020100/02040000
27957 CPRD_product_code NATRAMID tablets 2.5mg [TRINITY] drug res24: diuretics 02020100
28157 CPRD_product_code KALSPARE LS tablets [DOMINION] drug res24: diuretics 02020100/02020300/02020400
28177 CPRD_product_code hydrochlorothiazide with atenolol and amiloride capsules drug res24: diuretics 02020100/02020300/02040000
2833 CPRD_product_code cyclopenthiazide -k tablets drug res24: diuretics 02020100
29427 CPRD_product_code hydrochlorothiazide with metoprolol tartrate tablets 12.5mg + 100mg drug res24: diuretics 02020100/02040000
29529 CPRD_product_code hydroflumethiazide with spironolactone tablets 25mg+25mg drug res24: diuretics 02020100/02020300/02020400
29634 CPRD_product_code OLMETEC PLUS tablets 20mg + 12.5mg [DAIIC-SANK] drug res24: diuretics 02020100/02050502
2982 CPRD_product_code ZESTORETIC 20-tablets 20mg + 12.5mg [ASTRAZENEC] drug res24: diuretics 02020100/02050501
29991 CPRD_product_code CENTYL tablets 5mg [BURGESS] drug res24: diuretics 02020100
30272 CPRD_product_code benzthiazide with triamterene capsules drug res24: diuretics 02020100/02020300/02020400
30519 CPRD_product_code amiloride hydrochloride with timolol and hydrochlorothiazide tablets drug res24: diuretics 02020100/02020300/02040000
3054 CPRD_product_code HYGROTON tablets 100mg [ALLIANCE] drug res24: diuretics 02020100/06050200
3056 CPRD_product_code NATRILIX SR sustained release tablets 1.5mg [SERVIER] drug res24: diuretics 02020100
31131 CPRD_product_code SPIRO-CO tablets 25mg+25mg [IVAX] drug res24: diuretics 02020100/02020300/02020400
31150 CPRD_product_code CO-AMILOZIDE tablets 5mg+50mg [IVAX] drug res24: diuretics 02020100/02020300/02020400
31470 CPRD_product_code TENCHLOR tablets 50mg+12.5mg [BERK] drug res24: diuretics 02020100/02040000
31670 CPRD_product_code BENDROFLUMETHIAZIDE tablets 2.5mg [TEVA] drug res24: diuretics 02020100
31708 CPRD_product_code CO-TENIDONE tablets 50mg+12.5mg [ACTAVIS] drug res24: diuretics 02020100/02040000
31820 CPRD_product_code BENDROFLUMETHIAZIDE tablets 5mg [WOCKHARDT] drug res24: diuretics 02020100
3203 CPRD_product_code CAPOZIDE LS tablets [SQUIBB] drug res24: diuretics 02020100/02050501
32094 CPRD_product_code CO-TENIDONE tablets 50mg+12.5mg [HILLCROSS] drug res24: diuretics 02020100/02040000
32166 CPRD_product_code CAPTO-CO tablets 25mg+50mg [IVAX] drug res24: diuretics 02020100/02050501
3293 CPRD_product_code MODURETIC solution [BMS] drug res24: diuretics 02020100/02020300/02020400
33083 CPRD_product_code INDAPAMIDE tablets 2.5mg [TEVA] drug res24: diuretics 02020100
33353 CPRD_product_code LISINOPRIL AND HYDROCHLOROTHIAZIDE tablets 20mg + 12.5mg [TEVA] drug res24: diuretics 02020100/02050501
33415 CPRD_product_code BENDROFLUMETHIAZIDE tablets 2.5mg [GEN (UK)] drug res24: diuretics 02020100
33651 CPRD_product_code BENDROFLUMETHIAZIDE tablets 2.5mg [HILLCROSS] drug res24: diuretics 02020100
33659 CPRD_product_code hydrochlorothiazide with metoprolol tartrate modified release tablet 25mg + 200mg drug res24: diuretics 02020100/02040000
33724 CPRD_product_code DIURIL oral suspension 250mg/5ml [M S D] drug res24: diuretics 02020100
34012 CPRD_product_code CO-TENIDONE tablets 100mg+25mg [IVAX] drug res24: diuretics 02020100/02040000
34034 CPRD_product_code CO-TENIDONE tablets 50mg+12.5mg [IVAX] drug res24: diuretics 02020100/02040000
34059 CPRD_product_code BENDROFLUMETHIAZIDE tablets 2.5mg [ACTAVIS] drug res24: diuretics 02020100
34124 CPRD_product_code BENDROFLUMETHIAZIDE tablets 5mg [ACTAVIS] drug res24: diuretics 02020100
34367 CPRD_product_code CO-AMILOZIDE tablets 2.5mg+25mg [WOCKHARDT] drug res24: diuretics 02020100/02020300/02020400
34449 CPRD_product_code CO-TENIDONE tablets 50mg+12.5mg [GEN (UK)] drug res24: diuretics 02020100/02040000
34551 CPRD_product_code INDAPAMIDE tablets 2.5mg [GEN (UK)] drug res24: diuretics 02020100
34602 CPRD_product_code BENDROFLUMETHIAZIDE tablets 2.5mg [SOVEREIGN] drug res24: diuretics 02020100
348 CPRD_product_code MODURETIC tablets [BMS] drug res24: diuretics 02020100/02020300/02020400
34803 CPRD_product_code BENDROFLUMETHIAZIDE tablets 2.5mg [REGENT] drug res24: diuretics 02020100
34825 CPRD_product_code CO-TENIDONE tablets 50mg+12.5mg [TEVA] drug res24: diuretics 02020100/02040000
34899 CPRD_product_code CO-TENIDONE tablets 100mg+25mg [HILLCROSS] drug res24: diuretics 02020100/02040000
3517 CPRD_product_code hydrochlorothiazide tablets 50mg drug res24: diuretics 02020100
35196 CPRD_product_code COAPROVEL tablets 300mg + 25mg [SANOFI BMS] drug res24: diuretics 02020100/02050502
3526 CPRD_product_code amiloride hydrochloride with atenolol and hydrochlorothiazide capsules drug res24: diuretics 02020100/02020300/02040000
35380 CPRD_product_code hydrochlorothiazide with olmesartan medoxomil tablets 12.5mg + 20mg drug res24: diuretics 02020100/02050502
3548 CPRD_product_code chlortalidone tablets 100mg drug res24: diuretics 02020100/06050200
35481 CPRD_product_code irbesartan with hydrochlorothiazide tablets 300mg + 25mg drug res24: diuretics 02020100/02050502
3701 CPRD_product_code amiloride hydrochloride with hydrochlorothiazide tablets 2.5mg+25mg drug res24: diuretics 02020100/02020300/02020400
37294 CPRD_product_code triamterene with chlortalidone tablets 50mg + 25mg drug res24: diuretics 02020100/02020300/02020400
37650 CPRD_product_code losartan with hydrochlorothiazide tablets 100mg + 12.5mg drug res24: diuretics 02020100/02050502
37710 CPRD_product_code LISINOPRIL AND HYDROCHLOROTHIAZIDE tablets 10mg + 12.5mg [TEVA] drug res24: diuretics 02020100/02050501
37725 CPRD_product_code CO-TENIDONE tablets 100mg+25mg [GEN (UK)] drug res24: diuretics 02020100/02040000
37747 CPRD_product_code COZAAR-COMP tablets 100mg + 12.5mg [M S D] drug res24: diuretics 02020100/02050502
37908 CPRD_product_code COVERSYL ARGININE PLUS tablets 5mg + 1.25mg [SERVIER] drug res24: diuretics 02020100/02050501
37978 CPRD_product_code perindopril arginine with indapamide tablets 5mg + 1.25mg drug res24: diuretics 02020100/02050501
38367 CPRD_product_code hydrochlorothiazide with losartan tablets 12.5mg + 100mg drug res24: diuretics 02020100/02050502
38459 CPRD_product_code telmisartan with hydrochlorothiazide tablets 80mg + 25mg drug res24: diuretics 02020100/02050502
38889 CPRD_product_code MICARDIS PLUS tablets 80mg + 25mg [BOEH INGL] drug res24: diuretics 02020100/02050502
38995 CPRD_product_code ZESTORETIC 20 tablets [ASTRAZENEC] drug res24: diuretics 02020100/02050501
39021 CPRD_product_code hydrochlorothiazide with olmesartan medoxomil tablets 25mg + 20mg drug res24: diuretics 02020100/02050502
39137 CPRD_product_code ZESTORETIC 10 tablets [ASTRAZENEC] drug res24: diuretics 02020100/02050501
39147 CPRD_product_code CARACE 20 PLUS tablets [M S D] drug res24: diuretics 02020100/02050501
39227 CPRD_product_code CAPOZIDE LS tablets [BMS] drug res24: diuretics 02020100/02050501
39242 CPRD_product_code CARACE 10 PLUS tablets [M S D] drug res24: diuretics 02020100/02050501
39447 CPRD_product_code VARBIM XL prolonged release tablet 1.5mg [TEVA] drug res24: diuretics 02020100
3997 CPRD_product_code HYGROTON tablets 50mg [ALLIANCE] drug res24: diuretics 02020100/06050200
40149 CPRD_product_code BENDROFLUMETHIAZIDE tablets 5mg [IVAX] drug res24: diuretics 02020100
4034 CPRD_product_code amiloride hydrochloride with hydrochlorothiazide solution 5mg + 50mg/5ml drug res24: diuretics 02020100/02020300/02020400
4044 CPRD_product_code DIUREXAN tablets 20mg [MEDA] drug res24: diuretics 02020100
40886 CPRD_product_code BENDROFLUMETHIAZIDE tablets 2.5mg [ALMUS] drug res24: diuretics 02020100
40907 CPRD_product_code INDAPAMIDE tablets 2.5mg [GENUS] drug res24: diuretics 02020100
41517 CPRD_product_code BENDROFLUMETHIAZIDE tablets 5mg [TEVA] drug res24: diuretics 02020100
41556 CPRD_product_code CO-AMILOZIDE tablets 5mg+50mg [TEVA] drug res24: diuretics 02020100/02020300/02020400
41572 CPRD_product_code CO-TENIDONE tablets 100mg+25mg [TEVA] drug res24: diuretics 02020100/02040000
41861 CPRD_product_code TENSAID XL tablets 1.5mg [GEN (UK)] drug res24: diuretics 02020100
41885 CPRD_product_code ETHIBIDE XL prolonged release tablet 1.5mg [GENUS] drug res24: diuretics 02020100
42142 CPRD_product_code MODURETIC tablets [M S D] drug res24: diuretics 02020100/02020300/02020400
42906 CPRD_product_code INDAPAMIDE tablets 2.5mg [NICHE] drug res24: diuretics 02020100
43184 CPRD_product_code MAPEMID XL prolonged release tablet 1.5mg [RATIOPHARM] drug res24: diuretics 02020100
4332 CPRD_product_code metolazone tablets 5mg drug res24: diuretics 02020100
43322 CPRD_product_code olmesartan medoxomil with hydrochlorothiazide tablets 40mg + 12.5mg drug res24: diuretics 02020100/02050502
4334 CPRD_product_code metolazone low dose tablets 500micrograms drug res24: diuretics 02020100
43516 CPRD_product_code INDAPAMIDE tablets 2.5mg [ACTAVIS] drug res24: diuretics 02020100
43915 CPRD_product_code OLMETEC PLUS tablets 40mg + 12.5mg [DAIIC-SANK] drug res24: diuretics 02020100/02050502
44168 CPRD_product_code INDIPAM XL prolonged release tablet 1.5mg [ACTAVIS] drug res24: diuretics 02020100
4429 CPRD_product_code TRASIDREX tablets [GOLDSHIELD] drug res24: diuretics 02020100/02040000
4540 CPRD_product_code COZAAR-COMP tablets 50mg + 12.5mg [M S D] drug res24: diuretics 02020100/02050502
45916 CPRD_product_code hydroflumethiazide with spironolactone tablets 50mg+50mg drug res24: diuretics 02020100/02020300/02020400
4605 CPRD_product_code MODUCREN tablets [M S D] drug res24: diuretics 02020100/02020300/02040000
46302 CPRD_product_code NEO-NACLEX tablets 2.5mg [GOLDSHIELD] drug res24: diuretics 02020100
46355 CPRD_product_code SEVIKAR HCT tablets 20mg + 5mg + 12.5mg [DAIIC-SANK] drug res24: diuretics 02020100/02060200/02050502
46675 CPRD_product_code INDAPAMIDE SR tablets 1.5mg [HILLCROSS] drug res24: diuretics 02020100
46687 CPRD_product_code olmesartan medoxomil with amlodipine and hydrochlorothiazide tablets 20mg + 5mg + 12.5mg drug res24: diuretics 02020100/02060200/02050502
46715 CPRD_product_code olmesartan medoxomil with amlodipine and hydrochlorothiazide tablets 40mg + 10mg + 12.5mg drug res24: diuretics 02020100/02060200/02050502
46792 CPRD_product_code olmesartan medoxomil with amlodipine and hydrochlorothiazide tablets 40mg + 5mg + 12.5mg drug res24: diuretics 02020100/02060200/02050502
46916 CPRD_product_code CO-AMILOZIDE tablets 5mg+50mg [HILLCROSS] drug res24: diuretics 02020100/02020300/02020400
46952 CPRD_product_code CO-TENIDONE tablets 100mg+25mg [ACTAVIS] drug res24: diuretics 02020100/02040000
47467 CPRD_product_code olmesartan medoxomil with amlodipine and hydrochlorothiazide tablets 40mg + 5mg + 25mg drug res24: diuretics 02020100/02060200/02050502
4796 CPRD_product_code INDERETIC capsules [ASTRAZENEC] drug res24: diuretics 02020100/02040000
4983 CPRD_product_code atenolol with amiloride and hydrochlorothiazide capsules drug res24: diuretics 02020100/02020300/02040000
5112 CPRD_product_code indapamide modified release tablet 1.5mg drug res24: diuretics 02020100
5189 CPRD_product_code enalapril with hydrochlorothiazide tablets 20mg + 12.5mg drug res24: diuretics 02020100/02050501
5330 CPRD_product_code CORGARETIC 40 tablets [SANOFI S] drug res24: diuretics 02020100/02040000
5416 CPRD_product_code co-triamterzide (triamterene and hydrochlorothiazide) tablets 50mg+25mg drug res24: diuretics 02020100/02020300/02020400
542 CPRD_product_code hydrochlorothiazide tablets 25mg drug res24: diuretics 02020100
5721 CPRD_product_code co-tenidone (atenolol and chlortalidone) tablets 100mg+25mg drug res24: diuretics 02020100/02040000
5727 CPRD_product_code cyclopenthiazide with amiloride tablets 250micrograms + 2.5mg drug res24: diuretics 02020100/02020300/02020400
58 CPRD_product_code bendroflumethiazide tablets 5mg drug res24: diuretics 02020100
581 CPRD_product_code atenolol with chlortalidone tablets 50mg+12.5mg drug res24: diuretics 02020100/02040000
605 CPRD_product_code chlortalidone tablets 50mg drug res24: diuretics 02020100/06050200
6359 CPRD_product_code ZESTORETIC 10-tablets 10mg + 12.5mg [ASTRAZENEC] drug res24: diuretics 02020100/02050501
6437 CPRD_product_code losartan with hydrochlorothiazide tablets 50mg + 12.5mg drug res24: diuretics 02020100/02050502
6468 CPRD_product_code lisinopril with hydrochlorothiazide tablets 20mg + 12.5mg drug res24: diuretics 02020100/02050501
6786 CPRD_product_code lisinopril with hydrochlorothiazide tablets 10mg + 12.5mg drug res24: diuretics 02020100/02050501
6794 CPRD_product_code perindopril erbumine with indapamide tablets 4mg + 1.25mg drug res24: diuretics 02020100/02050501
6816 CPRD_product_code chlorothiazide oral suspension 250mg/5ml drug res24: diuretics 02020100
6877 CPRD_product_code CO-DIOVAN tablets 160mg + 12.5mg [NOVARTIS] drug res24: diuretics 02020100/02050502
7066 CPRD_product_code metoprolol tartrate with hydrochlorothiazide tablets 100mg + 12.5mg drug res24: diuretics 02020100/02040000
7136 CPRD_product_code DYTIDE capsules 50mg+25mg [GOLDSHIELD] drug res24: diuretics 02020100/02020300/02020400
7351 CPRD_product_code bendroflumethiazide oral suspension 2.5mg/5ml drug res24: diuretics 02020100
7543 CPRD_product_code KALTEN capsules [M&A PHARM] drug res24: diuretics 02020100/02020300/02040000
7618 CPRD_product_code xipamide tablets 20mg drug res24: diuretics 02020100
764 CPRD_product_code CO-DIOVAN tablets 80mg + 12.5mg [NOVARTIS] drug res24: diuretics 02020100/02050502
7641 CPRD_product_code NATRILIX tablets 2.5mg [SERVIER] drug res24: diuretics 02020100
7698 CPRD_product_code APRINOX tablets 5mg [SOVEREIGN] drug res24: diuretics 02020100
7740 CPRD_product_code triamterene with benzthiazide capsules 50mg+25mg drug res24: diuretics 02020100/02020300/02020400
7961 CPRD_product_code spironolactone with hydroflumethiazide tablets 50mg+50mg drug res24: diuretics 02020100/02020300/02020400
8058 CPRD_product_code NORMETIC tablets [ABBOTT] drug res24: diuretics 02020100/02020300/02020400
8147 CPRD_product_code LOPRESORETIC tablets [NOV/GEIGY] drug res24: diuretics 02020100/02040000
8189 CPRD_product_code SECADREX tablets [AVENTIS] drug res24: diuretics 02020100/02040000
8303 CPRD_product_code TENAVOID tablets [BURGESS] drug res24: diuretics 02020100/04010200
8369 CPRD_product_code INDEREX capsules [ASTRAZENEC] drug res24: diuretics 02020100/02040000
8464 CPRD_product_code meprobamate with bendroflumethiazide tablets drug res24: diuretics 02020100/04010200
8521 CPRD_product_code spironolactone with hydroflumethiazide tablets 25mg+25mg drug res24: diuretics 02020100/02020300/02020400
8526 CPRD_product_code APRINOX tablets 2.5mg [SOVEREIGN] drug res24: diuretics 02020100
8602 CPRD_product_code METENIX tablets 5mg [SANOFI/AVE] drug res24: diuretics 02020100
8623 CPRD_product_code PRESTIM tablets [ICN] drug res24: diuretics 02020100/02040000
8673 CPRD_product_code oxprenolol with cyclopenthiazide modified release tablet 160mg+0.25mg drug res24: diuretics 02020100/02040000
8836 CPRD_product_code chlorothiazide tablets 500mg drug res24: diuretics 02020100
8891 CPRD_product_code HYGROTON -K tablets [NOV/GEIGY] drug res24: diuretics 02020100
8897 CPRD_product_code TRIAM-CO tablets 50mg+25mg [IVAX] drug res24: diuretics 02020100/02020300/02020400
8987 CPRD_product_code propranolol with bendroflumethiazide modified release capsules 160mg + 5mg drug res24: diuretics 02020100/02040000
9178 CPRD_product_code atenolol with bendroflumethiazide capsules 25mg + 1.25mg drug res24: diuretics 02020100/02040000
9223 CPRD_product_code triamterene with hydrochlorothiazide tablets 50mg+25mg drug res24: diuretics 02020100/02020300/02020400
923 CPRD_product_code co-amilozide (amiloride and hydrochlorothiazide) tablets 5mg+50mg drug res24: diuretics 02020100/02020300/02020400
924 CPRD_product_code co-amilozide (amiloride and hydrochlorothiazide) tablets 2.5mg+25mg drug res24: diuretics 02020100/02020300/02020400
9764 CPRD_product_code CARACE 20 plus tablets [BMS] drug res24: diuretics 02020100/02050501
9783 CPRD_product_code co-tenidone (atenolol and chlortalidone) tablets 50mg+12.5mg drug res24: diuretics 02020100/02040000

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