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Research article:
Can analyses of electronic patient records be independently and externally validated? Study 2: the Effect of Beta-Adrenoceptor Blocker Therapy on Cancer Survival; a Retrospective Cohort Study
Reference:
David a Springate, Darren M Ashcroft, Evangelos Kontopantelis, Tim Doran, Ronan Ryan, David Reeves(2015) Can analyses of electronic patient records be independently and externally validated? Study 2: the Effect of Beta-Adrenoceptor Blocker Therapy on Cancer Survival; a Retrospective Cohort Study. BMJ Open, doi: 10.1136/bmjopen-2014-007299
- Link to fulltext article
- Abstract
- Objectives To conduct a fully independent and external validation of a research study based on one electronic health record database, using a different database sampling the same population. Design Retrospective cohort analysis of beta-blocker therapy and all-cause mortality in cancer patients. Setting Two UK national primary care databases (PCDs): the Clinical Practice Research Datalink (CPRD) and Doctors’ Independent Network (DIN). Participants CPRD data for 11302 cancer patients compared to published results from DIN for 3462 patients. Study period January 1997 to December 2006. Primary and secondary outcome measures All-cause mortality: overall; by treatment subgroup (betablockers only, beta-blockers plus other blood pressure lowering medicines (BPLM), other BPLMs only); and by cancer-site. Results Using CPRD, beta-blocker use was not associated with mortality (HR=1.03, 95%CI 0.93-1.14, vs patients prescribed other BPLMs only), but in DIN beta-blocker users had significantly higher mortality (HR=1.18, 95%CI 1.04 to 1.33). However, these hazard ratios were not statistically different (p=0.063), but did differ for patients on beta-blockers alone (CPRD=0.94, 95%CI 0.82-1.07; DIN=1.37, 95%CI 1.16-1.61; p<0.001). Results for nine individual cancer sites differed by study, but only significantly for prostate and pancreas cancers. Results were robust under sensitivity analyses, but we could not be certain that mortality was identically defined in both databases. Conclusions We found a complex pattern of similarities and differences between databases. Our finding that overall treatment effect estimates were not statistically different, adds to a growing body of evidence that different UK PCDs produce effect estimates comparable within statistical tolerance. However, some subgroup effects differed significantly and individually the two studies lead to different conclusions regarding the safety of beta-blockers for cancer patients. Single studies based on internally well-validated databases therefore do not guarantee generalisable results, especially for subgroups. In all cases, confirmatory studies using at least one other independent data source are strongly recommended.
- Author for correspondence
- David Reeves
- Email for correspondence
- david.reeves@manchester.ac.uk
Code list: res24: other_antihypertensives
176 codes in list
| Code | Coding system | Description | Entity type | List name | bnfcode | ||
|---|---|---|---|---|---|---|---|
| 10088 | CPRD_product_code | DOXADURA tablets 4mg [DISCOVERY] | drug | res24: other_antihypertensives | 02050400/07040101 | ||
| 10134 | CPRD_product_code | FLOMAXTRA XL modified release tablet 400micrograms [ASTELLAS] | drug | res24: other_antihypertensives | 02050400/07040101 | ||
| 10253 | CPRD_product_code | moxonidine tablets 300micrograms | drug | res24: other_antihypertensives | 02050200 | ||
| 10713 | CPRD_product_code | DECASERPYL tablets 5mg [ROUSSEL] | drug | res24: other_antihypertensives | 02050200 | ||
| 10714 | CPRD_product_code | methoserpidine tablets 5mg | drug | res24: other_antihypertensives | 02050200 | ||
| 11177 | CPRD_product_code | PHYSIOTENS tablets 200micrograms [ABBOTT] | drug | res24: other_antihypertensives | 02050200 | ||
| 11394 | CPRD_product_code | BARATOL tablets 25mg [SHIRE] | drug | res24: other_antihypertensives | 02050400/07040101 | ||
| 119 | CPRD_product_code | doxazosin tablets 1mg | drug | res24: other_antihypertensives | 02050400/07040101 | ||
| 12518 | CPRD_product_code | HYPOVASE BD starter pack [PFIZER] | drug | res24: other_antihypertensives | 02050400/07040101 | ||
| 12545 | CPRD_product_code | phentolamine mesilate injection 10mg/ml | drug | res24: other_antihypertensives | 02050400 | ||
| 1292 | CPRD_product_code | HYPOVASE tablets 1mg [PFIZER] | drug | res24: other_antihypertensives | 02050400/07040101 | ||
| 1294 | CPRD_product_code | doxazosin tablets 4mg | drug | res24: other_antihypertensives | 02050400/07040101 | ||
| 13610 | CPRD_product_code | ALPHAVASE tablets 2mg [ASHBOURNE] | drug | res24: other_antihypertensives | 02050400/07040101 | ||
| 14390 | CPRD_product_code | ALDOMET suspension 250mg/5ml [M S D] | drug | res24: other_antihypertensives | 02050200 | ||
| 1455 | CPRD_product_code | prazosin tablets 500 micrograms | drug | res24: other_antihypertensives | 02050400/07040101 | ||
| 14932 | CPRD_product_code | TABPHYN MR capsules 400micrograms [PROSTRAKAN] | drug | res24: other_antihypertensives | 02050400/07040101 | ||
| 15493 | CPRD_product_code | reserpine with hydrochlorothiazide tablets | drug | res24: other_antihypertensives | 02050200 | ||
| 16198 | CPRD_product_code | BARATOL tablets 50mg [SHIRE] | drug | res24: other_antihypertensives | 02050400/07040101 | ||
| 16201 | CPRD_product_code | HYTRIN BPH tablets 2mg [AMDIPHARM] | drug | res24: other_antihypertensives | 02050400/07040101 | ||
| 16248 | CPRD_product_code | clonidine injection 150micrograms/ml | drug | res24: other_antihypertensives | 02050200 | ||
| 1707 | CPRD_product_code | methyldopa tablets 250mg | drug | res24: other_antihypertensives | 02050200 | ||
| 18252 | CPRD_product_code | METALPHA tablets 250mg [ASHBOURNE] | drug | res24: other_antihypertensives | 02050200 | ||
| 19193 | CPRD_product_code | DOXAZOSIN tablets 2mg [TEVA] | drug | res24: other_antihypertensives | 02050400/07040101 | ||
| 19216 | CPRD_product_code | DOXAZOSIN tablets 4mg [IVAX] | drug | res24: other_antihypertensives | 02050400/07040101 | ||
| 19823 | CPRD_product_code | ALPHAVASE tablets 5mg [ASHBOURNE] | drug | res24: other_antihypertensives | 02050400/07040101 | ||
| 19892 | CPRD_product_code | SERPASIL -ESIDREX tablets [NOV/CIBA] | drug | res24: other_antihypertensives | 02050200 | ||
| 20369 | CPRD_product_code | doxazosin oral suspension 1mg/5ml | drug | res24: other_antihypertensives | 02050400/07040101 | ||
| 20656 | CPRD_product_code | SERPASIL tablets 250micrograms [NOV/CIBA] | drug | res24: other_antihypertensives | 02050200 | ||
| 20690 | CPRD_product_code | reserpine tablets 250micrograms | drug | res24: other_antihypertensives | 02050200 | ||
| 2104 | CPRD_product_code | RAUWILOID tablets 2mg [3M] | drug | res24: other_antihypertensives | 02050200 | ||
| 2117 | CPRD_product_code | DORALESE TILTAB tablets 20mg [CHEMIDEX] | drug | res24: other_antihypertensives | 02050400/07040101 | ||
| 21346 | CPRD_product_code | HYDROMET tablets [MSD MORSON] | drug | res24: other_antihypertensives | 02050200 | ||
| 21502 | CPRD_product_code | SERPASIL tablets 100micrograms [NOV/CIBA] | drug | res24: other_antihypertensives | 02050200 | ||
| 22454 | CPRD_product_code | DEMSER capsules 250mg [M S D] | drug | res24: other_antihypertensives | 02050400 | ||
| 22853 | CPRD_product_code | reserpine tablets 100micrograms | drug | res24: other_antihypertensives | 02050200 | ||
| 23010 | CPRD_product_code | ROGITINE injection 10mg/ml [ALLIANCE] | drug | res24: other_antihypertensives | 02050400 | ||
| 23345 | CPRD_product_code | HYPERCAL tablets 2mg [CARLTON] | drug | res24: other_antihypertensives | 02050200 | ||
| 23380 | CPRD_product_code | CATAPRES tablets 300micrograms [BOEH INGL] | drug | res24: other_antihypertensives | 02050200 | ||
| 2345 | CPRD_product_code | HYTRIN BPH starter pack [AMDIPHARM] | drug | res24: other_antihypertensives | 02050400/07040101 | ||
| 23459 | CPRD_product_code | HYPOVASE BENIGN PROSTATIC HYPERPLASIA tablets 2mg [PFIZER] | drug | res24: other_antihypertensives | 02050400/07040101 | ||
| 2346 | CPRD_product_code | HYTRIN tablets 5mg [ABBOTT] | drug | res24: other_antihypertensives | 02050400/07040101 | ||
| 2347 | CPRD_product_code | HYTRIN tablets 10mg [ABBOTT] | drug | res24: other_antihypertensives | 02050400/07040101 | ||
| 2348 | CPRD_product_code | HYTRIN BPH tablets 10mg [AMDIPHARM] | drug | res24: other_antihypertensives | 02050400/07040101 | ||
| 23761 | CPRD_product_code | methyldopa suspension 250mg/5ml | drug | res24: other_antihypertensives | 02050200 | ||
| 24196 | CPRD_product_code | DOPAMET tablets 250mg [BERK] | drug | res24: other_antihypertensives | 02050200 | ||
| 24369 | CPRD_product_code | PETYME MR capsules 400micrograms [TEVA] | drug | res24: other_antihypertensives | 02050400/07040101 | ||
| 25047 | CPRD_product_code | HYPOVASE BENIGN PROSTATIC HYPERPLASIA tablets 500 micrograms [PFIZER] | drug | res24: other_antihypertensives | 02050400/07040101 | ||
| 25275 | CPRD_product_code | METALPHA tablets 500mg [ASHBOURNE] | drug | res24: other_antihypertensives | 02050200 | ||
| 25289 | CPRD_product_code | DOPAMET tablets 500mg [BERK] | drug | res24: other_antihypertensives | 02050200 | ||
| 25393 | CPRD_product_code | DECASERPYL tablets 10mg [ROUSSEL] | drug | res24: other_antihypertensives | 02050200 | ||
| 25487 | CPRD_product_code | CASCOR tablets 2mg [RANBAXY] | drug | res24: other_antihypertensives | 02050400/07040101 | ||
| 25551 | CPRD_product_code | CASCOR tablets 4mg [RANBAXY] | drug | res24: other_antihypertensives | 02050400/07040101 | ||
| 25645 | CPRD_product_code | SEOMINAL tablets [STERLING] | drug | res24: other_antihypertensives | 02050200 | ||
| 26237 | CPRD_product_code | ALPHAVASE tablets 500 micrograms [ASHBOURNE] | drug | res24: other_antihypertensives | 02050400/07040101 | ||
| 26238 | CPRD_product_code | ALPHAVASE tablets 1mg [ASHBOURNE] | drug | res24: other_antihypertensives | 02050400/07040101 | ||
| 2630 | CPRD_product_code | DIXARIT tablets 25micrograms [BOEH INGL] | drug | res24: other_antihypertensives | 02050200/04070405 | ||
| 26693 | CPRD_product_code | HYPOVASE BENIGN PROSTATIC HYPERPLASIA BD starter pack [PFIZER] | drug | res24: other_antihypertensives | 02050400/07040101 | ||
| 26919 | CPRD_product_code | methyldopa injection 50mg/ml | drug | res24: other_antihypertensives | 02050200 | ||
| 27403 | CPRD_product_code | OMNIC MR capsules 400micrograms [ASTELLAS] | drug | res24: other_antihypertensives | 02050400/07040101 | ||
| 2816 | CPRD_product_code | indoramin tablets 20mg | drug | res24: other_antihypertensives | 02050400/07040101 | ||
| 28441 | CPRD_product_code | PAMSVAX XL capsules 400micrograms [ARROW] | drug | res24: other_antihypertensives | 02050400/07040101 | ||
| 28738 | CPRD_product_code | methyldopa with hydrochlorothiazide tablets | drug | res24: other_antihypertensives | 02050200 | ||
| 2878 | CPRD_product_code | clonidine tablets 100micrograms | drug | res24: other_antihypertensives | 02050200 | ||
| 29187 | CPRD_product_code | methoserpidine tablets 10mg | drug | res24: other_antihypertensives | 02050200 | ||
| 29570 | CPRD_product_code | DOPAMET tablets 125mg [BERK] | drug | res24: other_antihypertensives | 02050200 | ||
| 29696 | CPRD_product_code | methoserpidine with benzthiazide tablets | drug | res24: other_antihypertensives | 02050200 | ||
| 30129 | CPRD_product_code | ABICOL tablets [KNOLL] | drug | res24: other_antihypertensives | 02050200 | ||
| 30293 | CPRD_product_code | CATAPRES injection 150micrograms/ml [BOEH INGL] | drug | res24: other_antihypertensives | 02050200 | ||
| 3049 | CPRD_product_code | methyldopa tablets 125mg | drug | res24: other_antihypertensives | 02050200 | ||
| 30691 | CPRD_product_code | HYPERCAL B tablets [CARLTON] | drug | res24: other_antihypertensives | 02050200 | ||
| 3070 | CPRD_product_code | methyldopa tablets 500mg | drug | res24: other_antihypertensives | 02050200 | ||
| 31109 | CPRD_product_code | PROSURIN XL capsules 400micrograms [GEN (UK)] | drug | res24: other_antihypertensives | 02050400/07040101 | ||
| 32913 | CPRD_product_code | METHYLDOPA tablets 250mg [ACTAVIS] | drug | res24: other_antihypertensives | 02050200 | ||
| 33093 | CPRD_product_code | CLONIDINE tablets 25micrograms [SANDOZ] | drug | res24: other_antihypertensives | 02050200/04070405 | ||
| 33094 | CPRD_product_code | DOXAZOSIN tablets 2mg [GEN (UK)] | drug | res24: other_antihypertensives | 02050400/07040101 | ||
| 33322 | CPRD_product_code | MOXONIDINE tablets 200micrograms [SANDOZ] | drug | res24: other_antihypertensives | 02050200 | ||
| 33788 | CPRD_product_code | metirosine capsules 250mg | drug | res24: other_antihypertensives | 02050400 | ||
| 338 | CPRD_product_code | clonidine tablets 25micrograms | drug | res24: other_antihypertensives | 02050200/04070405 | ||
| 34080 | CPRD_product_code | STRONAZON MR capsules 400micrograms [ACTAVIS] | drug | res24: other_antihypertensives | 02050400/07040101 | ||
| 34342 | CPRD_product_code | DOXAZOSIN tablets 1mg [TEVA] | drug | res24: other_antihypertensives | 02050400/07040101 | ||
| 34553 | CPRD_product_code | DOXAZOSIN tablets 4mg [GEN (UK)] | drug | res24: other_antihypertensives | 02050400/07040101 | ||
| 34601 | CPRD_product_code | DOXAZOSIN tablets 1mg [GEN (UK)] | drug | res24: other_antihypertensives | 02050400/07040101 | ||
| 34625 | CPRD_product_code | DOXAZOSIN tablets 2mg [HILLCROSS] | drug | res24: other_antihypertensives | 02050400/07040101 | ||
| 3470 | CPRD_product_code | terazosin tablets 1mg | drug | res24: other_antihypertensives | 02050400/07040101 | ||
| 34715 | CPRD_product_code | DOXAZOSIN tablets 1mg [HILLCROSS] | drug | res24: other_antihypertensives | 02050400/07040101 | ||
| 35058 | CPRD_product_code | DIFFUNDOX XL capsules 400micrograms [ZENTIVA] | drug | res24: other_antihypertensives | 02050400/07040101 | ||
| 35272 | CPRD_product_code | DOXADURA XL tablets 4mg [GENUS] | drug | res24: other_antihypertensives | 02050400/07040101 | ||
| 35312 | CPRD_product_code | BAZETHAM MR capsules 400micrograms [PLIVA] | drug | res24: other_antihypertensives | 02050400/07040101 | ||
| 35466 | CPRD_product_code | ALPHACARD MR capsules 400micrograms [RATIOPHARM] | drug | res24: other_antihypertensives | 02050400/07040101 | ||
| 35603 | CPRD_product_code | doxazosin oral suspension 4mg/5ml | drug | res24: other_antihypertensives | 02050400/07040101 | ||
| 35925 | CPRD_product_code | CONTIFLO XL capsules 400micrograms [RANBAXY] | drug | res24: other_antihypertensives | 02050400/07040101 | ||
| 36023 | CPRD_product_code | CARDOZIN XL tablets 4mg [HILLCROSS] | drug | res24: other_antihypertensives | 02050400/07040101 | ||
| 36282 | CPRD_product_code | MORVESIN XL capsules 400micrograms [SANDOZ] | drug | res24: other_antihypertensives | 02050400/07040101 | ||
| 36649 | CPRD_product_code | HYTRIN tablets 2mg [AMDIPHARM] | drug | res24: other_antihypertensives | 02050400/07040101 | ||
| 36740 | CPRD_product_code | SLOCINX XL tablets 4mg [WINTHROP] | drug | res24: other_antihypertensives | 02050400/07040101 | ||
| 36780 | CPRD_product_code | HYTRIN tablets 5mg [AMDIPHARM] | drug | res24: other_antihypertensives | 02050400/07040101 | ||
| 3715 | CPRD_product_code | prazosin tablets 5mg | drug | res24: other_antihypertensives | 02050400/07040101 | ||
| 37243 | CPRD_product_code | CARDOZIN XL tablets 4mg [TEVA] | drug | res24: other_antihypertensives | 02050400/07040101 | ||
| 37428 | CPRD_product_code | HYTRIN tablets 10mg [AMDIPHARM] | drug | res24: other_antihypertensives | 02050400/07040101 | ||
| 38461 | CPRD_product_code | CARDOZIN XL tablets 4mg [ARROW] | drug | res24: other_antihypertensives | 02050400/07040101 | ||
| 3923 | CPRD_product_code | terazosin bph starter pack 7 x 1mg + 14 x 2mg + 7 x 5mg | drug | res24: other_antihypertensives | 02050400/07040101 | ||
| 3924 | CPRD_product_code | terazosin tablets 5mg | drug | res24: other_antihypertensives | 02050400/07040101 | ||
| 40256 | CPRD_product_code | BARATOL tablets 25mg [AMDIPHARM] | drug | res24: other_antihypertensives | 02050400/07040101 | ||
| 40310 | CPRD_product_code | MOXONIDINE tablets 200micrograms [TEVA] | drug | res24: other_antihypertensives | 02050200 | ||
| 40678 | CPRD_product_code | DOXAZOSIN tablets 4mg [TEVA] | drug | res24: other_antihypertensives | 02050400/07040101 | ||
| 40810 | CPRD_product_code | phenoxybenzamine oral suspension 10mg/5ml | drug | res24: other_antihypertensives | 02050400 | ||
| 40891 | CPRD_product_code | DOXAZOSIN tablets 2mg [IVAX] | drug | res24: other_antihypertensives | 02050400/07040101 | ||
| 4111 | CPRD_product_code | HYPOVASE tablets 500 micrograms [PFIZER] | drug | res24: other_antihypertensives | 02050400/07040101 | ||
| 41543 | CPRD_product_code | DOXAZOSIN tablets 1mg [IVAX] | drug | res24: other_antihypertensives | 02050400/07040101 | ||
| 41651 | CPRD_product_code | PRAZOSIN tablets 500 micrograms [APS] | drug | res24: other_antihypertensives | 02050400/07040101 | ||
| 41652 | CPRD_product_code | PRAZOSIN tablets 500 micrograms [HILLCROSS] | drug | res24: other_antihypertensives | 02050400/07040101 | ||
| 41661 | CPRD_product_code | METHYLDOPA tablets 250mg [CP PHARM] | drug | res24: other_antihypertensives | 02050200 | ||
| 41721 | CPRD_product_code | PRAZOSIN tablets 1mg [HILLCROSS] | drug | res24: other_antihypertensives | 02050400/07040101 | ||
| 4215 | CPRD_product_code | CATAPRES tablets 100micrograms [BOEH INGL] | drug | res24: other_antihypertensives | 02050200 | ||
| 42462 | CPRD_product_code | KIRTACAP MR capsules 400micrograms [CONSILIENT] | drug | res24: other_antihypertensives | 02050400/07040101 | ||
| 42936 | CPRD_product_code | FLOMAX RELIEF MR modified release capsules 400micrograms [BOEH INGL] | drug | res24: other_antihypertensives | 02050400/07040101 | ||
| 43531 | CPRD_product_code | MOXONIDINE tablets 400micrograms [SANDOZ] | drug | res24: other_antihypertensives | 02050200 | ||
| 43547 | CPRD_product_code | PRAZOSIN tablets 500 micrograms [IVAX] | drug | res24: other_antihypertensives | 02050400/07040101 | ||
| 43695 | CPRD_product_code | COLIXIL XL tablets 4mg [SANDOZ] | drug | res24: other_antihypertensives | 02050400/07040101 | ||
| 43988 | CPRD_product_code | ALDOMET tablets 250mg [SIGMA] | drug | res24: other_antihypertensives | 02050200 | ||
| 43989 | CPRD_product_code | ALDOMET tablets 500mg [SIGMA] | drug | res24: other_antihypertensives | 02050200 | ||
| 4406 | CPRD_product_code | DECASERPYL PLUS tablets [ROUSSEL] | drug | res24: other_antihypertensives | 02050200 | ||
| 4449 | CPRD_product_code | CARDURA tablets 1mg [PFIZER] | drug | res24: other_antihypertensives | 02050400/07040101 | ||
| 445 | CPRD_product_code | prazosin titration pack 8x500micrograms + 32x1mg | drug | res24: other_antihypertensives | 02050400/07040101 | ||
| 44553 | CPRD_product_code | PINEXEL PR capsules 400micrograms [WOCKHARDT] | drug | res24: other_antihypertensives | 02050400/07040101 | ||
| 45040 | CPRD_product_code | LARBEX XL prolonged release tablet 4mg [TEVA] | drug | res24: other_antihypertensives | 02050400/07040101 | ||
| 45265 | CPRD_product_code | DOXAZOSIN SR tablets 4mg [GEN (UK)] | drug | res24: other_antihypertensives | 02050400/07040101 | ||
| 45328 | CPRD_product_code | DOXAZOSIN tablets 1mg [SANDOZ] | drug | res24: other_antihypertensives | 02050400/07040101 | ||
| 45342 | CPRD_product_code | DOXAZOSIN tablets 4mg [SANDOZ] | drug | res24: other_antihypertensives | 02050400/07040101 | ||
| 45578 | CPRD_product_code | CLONIDINE tablets 25micrograms [HILLCROSS] | drug | res24: other_antihypertensives | 02050200/04070405 | ||
| 45583 | CPRD_product_code | DOXAZOSIN tablets 2mg [DEXCEL] | drug | res24: other_antihypertensives | 02050400/07040101 | ||
| 45584 | CPRD_product_code | phenoxybenzamine concentrate for solution for infusion 100mg/2ml | drug | res24: other_antihypertensives | 02050400 | ||
| 460 | CPRD_product_code | FLOMAX MR modified release capsules 400micrograms [YAMANOUCHI] | drug | res24: other_antihypertensives | 02050400/07040101 | ||
| 46066 | CPRD_product_code | CARDOZIN XL tablets 4mg [ALMUS] | drug | res24: other_antihypertensives | 02050400/07040101 | ||
| 46206 | CPRD_product_code | PAMSVAX XL capsules 400micrograms [ALMUS] | drug | res24: other_antihypertensives | 02050400/07040101 | ||
| 4637 | CPRD_product_code | terazosin tablets 2mg | drug | res24: other_antihypertensives | 02050400/07040101 | ||
| 46526 | CPRD_product_code | RAPORSIN XL prolonged release tablet 4mg [ACTAVIS] | drug | res24: other_antihypertensives | 02050400/07040101 | ||
| 46922 | CPRD_product_code | PRAZOSIN tablets 1mg [IVAX] | drug | res24: other_antihypertensives | 02050400/07040101 | ||
| 4694 | CPRD_product_code | terazosin starter pack 7 x 1mg + 21 x 2mg | drug | res24: other_antihypertensives | 02050400/07040101 | ||
| 4802 | CPRD_product_code | CARDURA tablets 2mg [PFIZER] | drug | res24: other_antihypertensives | 02050400/07040101 | ||
| 4875 | CPRD_product_code | terazosin tablets 10mg | drug | res24: other_antihypertensives | 02050400/07040101 | ||
| 493 | CPRD_product_code | doxazosin tablets 2mg | drug | res24: other_antihypertensives | 02050400/07040101 | ||
| 4993 | CPRD_product_code | moxonidine tablets 200micrograms | drug | res24: other_antihypertensives | 02050200 | ||
| 5183 | CPRD_product_code | HYPOVASE tablets 2mg [PFIZER] | drug | res24: other_antihypertensives | 02050400/07040101 | ||
| 5289 | CPRD_product_code | clonidine modified release capsules 0.25mg | drug | res24: other_antihypertensives | 02050200 | ||
| 5337 | CPRD_product_code | HYTRIN BPH tablets 5mg [AMDIPHARM] | drug | res24: other_antihypertensives | 02050400/07040101 | ||
| 5496 | CPRD_product_code | doxazosin modified release tablet 8mg | drug | res24: other_antihypertensives | 02050400/07040101 | ||
| 5618 | CPRD_product_code | CARDURA XL modified release tablet 8mg [PFIZER] | drug | res24: other_antihypertensives | 02050400/07040101 | ||
| 5815 | CPRD_product_code | indoramin tablets 25mg | drug | res24: other_antihypertensives | 02050400/07040101 | ||
| 582 | CPRD_product_code | doxazosin modified release tablet 4mg | drug | res24: other_antihypertensives | 02050400/07040101 | ||
| 591 | CPRD_product_code | prazosin tablets 1mg | drug | res24: other_antihypertensives | 02050400/07040101 | ||
| 6008 | CPRD_product_code | OMNIC MR capsules 400micrograms [P & B] | drug | res24: other_antihypertensives | 02050400/07040101 | ||
| 634 | CPRD_product_code | tamsulosin hydrochloride modified release capsules 400micrograms | drug | res24: other_antihypertensives | 02050400/07040101 | ||
| 6694 | CPRD_product_code | clonidine tablets 300micrograms | drug | res24: other_antihypertensives | 02050200 | ||
| 7056 | CPRD_product_code | tamsulosin hydrochloride modified release tablet 400micrograms | drug | res24: other_antihypertensives | 02050400/07040101 | ||
| 7174 | CPRD_product_code | moxonidine tablets 400micrograms | drug | res24: other_antihypertensives | 02050200 | ||
| 726 | CPRD_product_code | prazosin tablets 2mg | drug | res24: other_antihypertensives | 02050400/07040101 | ||
| 7416 | CPRD_product_code | ALDOMET injection 50mg/ml [M S D] | drug | res24: other_antihypertensives | 02050200 | ||
| 7547 | CPRD_product_code | DOXADURA tablets 2mg [DISCOVERY] | drug | res24: other_antihypertensives | 02050400/07040101 | ||
| 7549 | CPRD_product_code | DOXADURA tablets 1mg [DISCOVERY] | drug | res24: other_antihypertensives | 02050400/07040101 | ||
| 755 | CPRD_product_code | CARDURA XL modified release tablet 4mg [PFIZER] | drug | res24: other_antihypertensives | 02050400/07040101 | ||
| 7626 | CPRD_product_code | ALDOMET tablets 250mg [M S D] | drug | res24: other_antihypertensives | 02050200 | ||
| 7642 | CPRD_product_code | ALDOMET tablets 500mg [M S D] | drug | res24: other_antihypertensives | 02050200 | ||
| 7759 | CPRD_product_code | phenoxybenzamine capsules 10mg | drug | res24: other_antihypertensives | 02050400 | ||
| 8033 | CPRD_product_code | ALDOMET tablets 125mg [M S D] | drug | res24: other_antihypertensives | 02050200 | ||
| 8076 | CPRD_product_code | HYTRIN starter pack [AMDIPHARM] | drug | res24: other_antihypertensives | 02050400/07040101 | ||
| 8077 | CPRD_product_code | HYTRIN tablets 2mg [ABBOTT] | drug | res24: other_antihypertensives | 02050400/07040101 | ||
| 8086 | CPRD_product_code | CARDURA tablets 4mg [PFIZER] | drug | res24: other_antihypertensives | 02050400/07040101 | ||
| 8198 | CPRD_product_code | HYPOVASE tablets 5mg [PFIZER] | drug | res24: other_antihypertensives | 02050400/07040101 | ||
| 8296 | CPRD_product_code | CATAPRES PL PERLONGETS 0.25mg [BOEH INGL] | drug | res24: other_antihypertensives | 02050200 | ||
| 8863 | CPRD_product_code | HYPOVASE BENIGN PROSTATIC HYPERPLASIA tablets 1mg [PFIZER] | drug | res24: other_antihypertensives | 02050400/07040101 | ||
| 8942 | CPRD_product_code | DIBENYLINE capsules 10mg [GOLDSHIELD] | drug | res24: other_antihypertensives | 02050400 | ||
| 9019 | CPRD_product_code | indoramin tablets 50mg | drug | res24: other_antihypertensives | 02050400/07040101 | ||
| 9225 | CPRD_product_code | methyldopa capsules 250mg | drug | res24: other_antihypertensives | 02050200 | ||
| 9749 | CPRD_product_code | PHYSIOTENS tablets 400micrograms [ABBOTT] | drug | res24: other_antihypertensives | 02050200 | ||
| 9876 | CPRD_product_code | PHYSIOTENS tablets 300micrograms [ABBOTT] | drug | res24: other_antihypertensives | 02050200 |
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Code list links:
ClinicalCodes is a project at the University of Manchester Institute of Population Health
The ClinicalCodes project is funded by the National Institute for Health Research (NIHR) School for Primary Care Research (SPCR)