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Research article:
Adaptation and validation of the Charlson Index for Read/OXMIS coded databases
Reference:
Nada F Khan, Rafael Perera, Stephen Harper, Peter W Rose(2010) Adaptation and validation of the Charlson Index for Read/OXMIS coded databases. BMC Family Practice, doi: 10.1186/1471-2296-11-1
- Link to fulltext article
- Abstract
- Background The Charlson comorbidity index is widely used in ICD-9 administrative data, however, there is no translation for Read/OXMIS coded data despite increasing use of the General Practice Research Database (GPRD). Our main objective was to translate the Charlson index for use with Read/OXMIS coded data such as the GPRD and test its association with mortality. We also aimed to provide a version of the comorbidity index for other researchers using similar datasets. Methods Two clinicians translated the Charlson index into Read/OXMIS codes. We tested the association between comorbidity score and increased mortality in 146 441 patients from the GPRD using proportional hazards models. Results This Read/OXMIS translation of the Charlson index contains 3156 codes. Our validation showed a strong positive association between Charlson score and age. Cox proportional models show a positive increasing association with mortality and Charlson score. The discrimination of the logistic regression model for mortality was good (AUC = 0.853). Conclusion We have translated a commonly used comorbidity index into Read/OXMIS for use in UK primary care databases. The translated index showed a good discrimination in our study population. This is the first study to develop a co-morbidity index for use with the Read/OXMIS coding system and the GPRD. A copy of the co-morbidity index is provided for other researchers using similar databases.
- Author for correspondence
- Nada F Khan
- Email for correspondence
- nada.khan@dphpc.ox.ac.uk
Code list: res27: AIDS
42 codes in list
| Code | Coding system | Description | Entity type | List name | Charlson score weight | ||
|---|---|---|---|---|---|---|---|
| 799MD | Read/OXMIS | AIDS | diagnostic | res27: AIDS | 6 | ||
| A788.00 | Read/OXMIS | Acquired immune deficiency syndrome | diagnostic | res27: AIDS | 6 | ||
| A788100 | Read/OXMIS | Asymptomatic human immunodeficiency virus infection | diagnostic | res27: AIDS | 6 | ||
| A788200 | Read/OXMIS | HIV infection with persistent generalised lymphadenopathy | diagnostic | res27: AIDS | 6 | ||
| A788300 | Read/OXMIS | Human immunodeficiency virus with constitutional disease | diagnostic | res27: AIDS | 6 | ||
| A788400 | Read/OXMIS | Human immunodeficiency virus with neurological disease | diagnostic | res27: AIDS | 6 | ||
| A788500 | Read/OXMIS | Human immunodeficiency virus with secondary infection | diagnostic | res27: AIDS | 6 | ||
| A788600 | Read/OXMIS | Human immunodeficiency virus with secondary cancers | diagnostic | res27: AIDS | 6 | ||
| A788U00 | Read/OXMIS | HIV disease result/haematological???? abnorms;NEC | diagnostic | res27: AIDS | 6 | ||
| A788V00 | Read/OXMIS | HIV disease resulting in multiple diseases CE | diagnostic | res27: AIDS | 6 | ||
| A788W00 | Read/OXMIS | HIV disease resulting in unspecified malignant neoplasm | diagnostic | res27: AIDS | 6 | ||
| A788X00 | Read/OXMIS | HIV disease resulting/unspcf infectious disease | diagnostic | res27: AIDS | 6 | ||
| A788y00 | Read/OXMIS | Human immunodeficiency virus with other clinical findings | diagnostic | res27: AIDS | 6 | ||
| A788z00 | Read/OXMIS | Acquired human immunodeficiency virus infection syndrome NOS | diagnostic | res27: AIDS | 6 | ||
| A789.00 | Read/OXMIS | Human immunodef virus resulting in other disease | diagnostic | res27: AIDS | 6 | ||
| A789000 | Read/OXMIS | HIV disease resulting in mycobacterial infection | diagnostic | res27: AIDS | 6 | ||
| A789100 | Read/OXMIS | HIV disease resulting in cytomegaloviral disease | diagnostic | res27: AIDS | 6 | ||
| A789200 | Read/OXMIS | HIV disease resulting in candidiasis | diagnostic | res27: AIDS | 6 | ||
| A789300 | Read/OXMIS | HIV disease resulting in Pneumocystis carinii pneumonia | diagnostic | res27: AIDS | 6 | ||
| A789400 | Read/OXMIS | HIV disease resulting in multiple infections | diagnostic | res27: AIDS | 6 | ||
| A789500 | Read/OXMIS | HIV disease resulting in Kaposi's sarcoma | diagnostic | res27: AIDS | 6 | ||
| A789600 | Read/OXMIS | HIV disease resulting in Burkitt's lymphoma | diagnostic | res27: AIDS | 6 | ||
| A789800 | Read/OXMIS | HIV disease resulting in multiple malignant neoplasms | diagnostic | res27: AIDS | 6 | ||
| A789900 | Read/OXMIS | HIV disease resulting in lymphoid interstitial pneumonitis | diagnostic | res27: AIDS | 6 | ||
| A789A00 | Read/OXMIS | HIV disease resulting in wasting syndrome | diagnostic | res27: AIDS | 6 | ||
| A789X00 | Read/OXMIS | HIV dis reslt/oth mal neopl/lymph;h'matopoetc? tissu | diagnostic | res27: AIDS | 6 | ||
| AyuC.00 | Read/OXMIS | [X]Human immunodeficiency virus disease | diagnostic | res27: AIDS | 6 | ||
| AyuC000 | Read/OXMIS | [X]HIV disease resulting in other bacterial infections | diagnostic | res27: AIDS | 6 | ||
| AyuC100 | Read/OXMIS | [X]HIV disease resulting in other viral infections | diagnostic | res27: AIDS | 6 | ||
| AyuC200 | Read/OXMIS | [X]HIV disease resulting in other mycoses | diagnostic | res27: AIDS | 6 | ||
| AyuC300 | Read/OXMIS | [X]HIV disease resulting in multiple infections | diagnostic | res27: AIDS | 6 | ||
| AyuC400 | Read/OXMIS | [X]HIV disease resulting/other infectious??? diseases | diagnostic | res27: AIDS | 6 | ||
| AyuC500 | Read/OXMIS | [X]HIV disease resulting/unspcf infectious??? disease | diagnostic | res27: AIDS | 6 | ||
| AyuC600 | Read/OXMIS | [X]HIV disease resulting in other non-Hodgkin's lymphoma | diagnostic | res27: AIDS | 6 | ||
| AyuC700 | Read/OXMIS | [X]HIV dis reslt/oth mal neopl/lymph;h'matopoetc? tissu | diagnostic | res27: AIDS | 6 | ||
| AyuC800 | Read/OXMIS | [X]HIV disease resulting in other malignant neoplasms | diagnostic | res27: AIDS | 6 | ||
| AyuC900 | Read/OXMIS | [X]HIV disease resulting in unspecified malignant neoplasm | diagnostic | res27: AIDS | 6 | ||
| AyuCA00 | Read/OXMIS | [X]HIV disease resulting in multiple diseases CE | diagnostic | res27: AIDS | 6 | ||
| AyuCB00 | Read/OXMIS | [X]HIV disease result/haematological???? abnorms;NEC | diagnostic | res27: AIDS | 6 | ||
| AyuCC00 | Read/OXMIS | [X]HIV disease resulting in other specified conditions | diagnostic | res27: AIDS | 6 | ||
| AyuCD00 | Read/OXMIS | [X]Unspecified human immunodeficiency virus [HIV] disease | diagnostic | res27: AIDS | 6 | ||
| L7990A | Read/OXMIS | ACQUIRED IMMUNE DEFICIENCY SYNDROME | diagnostic | res27: AIDS | 6 |
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