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Research article:

Adaptation and validation of the Charlson Index for Read/OXMIS coded databases

Reference:

Nada F Khan, Rafael Perera, Stephen Harper, Peter W Rose(2010) Adaptation and validation of the Charlson Index for Read/OXMIS coded databases. BMC Family Practice, doi: 10.1186/1471-2296-11-1

Link to fulltext article
Abstract
Background The Charlson comorbidity index is widely used in ICD-9 administrative data, however, there is no translation for Read/OXMIS coded data despite increasing use of the General Practice Research Database (GPRD). Our main objective was to translate the Charlson index for use with Read/OXMIS coded data such as the GPRD and test its association with mortality. We also aimed to provide a version of the comorbidity index for other researchers using similar datasets. Methods Two clinicians translated the Charlson index into Read/OXMIS codes. We tested the association between comorbidity score and increased mortality in 146 441 patients from the GPRD using proportional hazards models. Results This Read/OXMIS translation of the Charlson index contains 3156 codes. Our validation showed a strong positive association between Charlson score and age. Cox proportional models show a positive increasing association with mortality and Charlson score. The discrimination of the logistic regression model for mortality was good (AUC = 0.853). Conclusion We have translated a commonly used comorbidity index into Read/OXMIS for use in UK primary care databases. The translated index showed a good discrimination in our study population. This is the first study to develop a co-morbidity index for use with the Read/OXMIS coding system and the GPRD. A copy of the co-morbidity index is provided for other researchers using similar databases.
Author for correspondence
Nada F Khan
Email for correspondence
nada.khan@dphpc.ox.ac.uk

Code list: res27: Cancer

1769 codes in list

Code Coding system Description Entity type List name Charlson score weight
1409A Read/OXMIS MALIGNANT NEOPLASM LIP diagnostic res27: Cancer 2
1409C Read/OXMIS LIP CARCINOMA diagnostic res27: Cancer 2
1419A Read/OXMIS TONGUE TUMOUR MALIGNANT diagnostic res27: Cancer 2
1419AA Read/OXMIS LINGUAL/TONGUE CANCER diagnostic res27: Cancer 2
1419C Read/OXMIS TONGUE CARCINOMA diagnostic res27: Cancer 2
1420A Read/OXMIS PAROTID MALIGNANT NEOPLASM diagnostic res27: Cancer 2
1429B Read/OXMIS SALIVARY GLAND MALIGNANT NEOPLASM diagnostic res27: Cancer 2
1429C Read/OXMIS CARCINOMA SALIVARY GLAND diagnostic res27: Cancer 2
1439A Read/OXMIS MALIGNANT NEOPLASM GUM diagnostic res27: Cancer 2
144 C Read/OXMIS CARCINOMA MOUTH FLOOR diagnostic res27: Cancer 2
1450A Read/OXMIS MALIGNANT NEOPLASM CHEEK INTERNAL diagnostic res27: Cancer 2
1450C Read/OXMIS CARCINOMA MOUTH CHEEK INTERNAL diagnostic res27: Cancer 2
1459A Read/OXMIS MALIGNANT NEOPLASM MOUTH diagnostic res27: Cancer 2
1459C Read/OXMIS MOUTH CARCINOMA diagnostic res27: Cancer 2
1460A Read/OXMIS MALIGNANT NEOPLASM TONSIL diagnostic res27: Cancer 2
1460C Read/OXMIS CARCINOMA TONSIL diagnostic res27: Cancer 2
1468A Read/OXMIS MALIGNANT NEOPLASM BRANCHIAL CLEFT diagnostic res27: Cancer 2
147 A Read/OXMIS MALIGNANT NEOPLASM ADENOID diagnostic res27: Cancer 2
1480C Read/OXMIS POSTCRICOID CARCINOMA diagnostic res27: Cancer 2
149 A Read/OXMIS MALIGNANT NEOPLASM THROAT diagnostic res27: Cancer 2
149 AT Read/OXMIS MALIGNANT NEOPLASM PHARYNX diagnostic res27: Cancer 2
149 C Read/OXMIS PHARYNX CARCINOMA diagnostic res27: Cancer 2
149 CT Read/OXMIS CARCINOMA THROAT diagnostic res27: Cancer 2
150 A Read/OXMIS MALIGNANT NEOPLASM OESOPHAGUS diagnostic res27: Cancer 2
150 B Read/OXMIS SARCOMA OESOPHAGUS diagnostic res27: Cancer 2
150 C Read/OXMIS OESOPHAGUS CARCINOMA diagnostic res27: Cancer 2
1510A Read/OXMIS MALIGNANT NEOPLASM CARDIA diagnostic res27: Cancer 2
1519A Read/OXMIS MALIGNANT NEOPLASM STOMACH diagnostic res27: Cancer 2
1519AA Read/OXMIS GASTRIC CANCER diagnostic res27: Cancer 2
1519B Read/OXMIS SARCOMA STOMACH diagnostic res27: Cancer 2
1519BL Read/OXMIS MALIGNANT LYMPHOMA STOMACH diagnostic res27: Cancer 2
1519C Read/OXMIS STOMACH CARCINOMA diagnostic res27: Cancer 2
1519CL Read/OXMIS LINITIS PLASTICA diagnostic res27: Cancer 2
1519DA Read/OXMIS ADENOCARCINOMA STOMACH diagnostic res27: Cancer 2
1519L Read/OXMIS STOMACH LEIOMYBLASTOMA diagnostic res27: Cancer 2
1520A Read/OXMIS MALIGNANT NEOPLASM DUODENUM diagnostic res27: Cancer 2
1520B Read/OXMIS SARCOMA DUODENUM diagnostic res27: Cancer 2
1528LA Read/OXMIS MALIGNANT NEOPLASM ILEUM diagnostic res27: Cancer 2
1529A Read/OXMIS MALIGNANT NEOPLASM SMALL INTESTINE diagnostic res27: Cancer 2
1529B Read/OXMIS SARCOMA SMALL INTESTINE diagnostic res27: Cancer 2
1529BL Read/OXMIS LYMPHOSARCOMA SMALL INTESTINE diagnostic res27: Cancer 2
1529C Read/OXMIS CARCINOMA SMALL INTESTINE diagnostic res27: Cancer 2
1530AC Read/OXMIS MALIGNANT NEOPLASM CAECUM diagnostic res27: Cancer 2
1530AD Read/OXMIS ADENOCARCINOMA ASCENDING COLON diagnostic res27: Cancer 2
1530CC Read/OXMIS CARCINOMA CAECUM diagnostic res27: Cancer 2
1533A Read/OXMIS MALIGNANT NEOPLASM SIGMOID diagnostic res27: Cancer 2
1533AD Read/OXMIS ADENOCARCINOMA SIGMOID