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Research article:
Adaptation and validation of the Charlson Index for Read/OXMIS coded databases
Reference:
Nada F Khan, Rafael Perera, Stephen Harper, Peter W Rose(2010) Adaptation and validation of the Charlson Index for Read/OXMIS coded databases. BMC Family Practice, doi: 10.1186/1471-2296-11-1
- Link to fulltext article
- Abstract
- Background The Charlson comorbidity index is widely used in ICD-9 administrative data, however, there is no translation for Read/OXMIS coded data despite increasing use of the General Practice Research Database (GPRD). Our main objective was to translate the Charlson index for use with Read/OXMIS coded data such as the GPRD and test its association with mortality. We also aimed to provide a version of the comorbidity index for other researchers using similar datasets. Methods Two clinicians translated the Charlson index into Read/OXMIS codes. We tested the association between comorbidity score and increased mortality in 146 441 patients from the GPRD using proportional hazards models. Results This Read/OXMIS translation of the Charlson index contains 3156 codes. Our validation showed a strong positive association between Charlson score and age. Cox proportional models show a positive increasing association with mortality and Charlson score. The discrimination of the logistic regression model for mortality was good (AUC = 0.853). Conclusion We have translated a commonly used comorbidity index into Read/OXMIS for use in UK primary care databases. The translated index showed a good discrimination in our study population. This is the first study to develop a co-morbidity index for use with the Read/OXMIS coding system and the GPRD. A copy of the co-morbidity index is provided for other researchers using similar databases.
- Author for correspondence
- Nada F Khan
- Email for correspondence
- nada.khan@dphpc.ox.ac.uk
Code list: res27: Cerebrovascular disease
92 codes in list
| Code | Coding system | Description | Entity type | List name | Charlson score weight | ||
|---|---|---|---|---|---|---|---|
| 1477 | Read/OXMIS | H/O: cerebrovascular disease | diagnostic | res27: Cerebrovascular disease | 1 | ||
| 14A7.00 | Read/OXMIS | H/O: CVA/stroke | diagnostic | res27: Cerebrovascular disease | 1 | ||
| 14A7.12 | Read/OXMIS | H/O: stroke | diagnostic | res27: Cerebrovascular disease | 1 | ||
| 4300 | Read/OXMIS | SUBARACHNOID HAEMORRHAGE WITH HYPERTENSI | diagnostic | res27: Cerebrovascular disease | 1 | ||
| 4309 | Read/OXMIS | SUBARACHNOID HAEMORRHAGE | diagnostic | res27: Cerebrovascular disease | 1 | ||
| 4309M | Read/OXMIS | MENINGEAL HAEMORRHAGE | diagnostic | res27: Cerebrovascular disease | 1 | ||
| 4310 | Read/OXMIS | HAEMORRHAGE INTRACEREBRAL WITH HYPERTENS | diagnostic | res27: Cerebrovascular disease | 1 | ||
| 4319CE | Read/OXMIS | HAEMORRHAGE INTRACEREBRAL | diagnostic | res27: Cerebrovascular disease | 1 | ||
| 4319CR | Read/OXMIS | HAEMORRHAGE INTRACRANIAL | diagnostic | res27: Cerebrovascular disease | 1 | ||
| 4350 | Read/OXMIS | TRANSIENT CEREBRAL ISCHAEMIA WITH HYPERT | diagnostic | res27: Cerebrovascular disease | 1 | ||
| 4369B | Read/OXMIS | STROKE | diagnostic | res27: Cerebrovascular disease | 1 | ||
| 4380 | Read/OXMIS | CEREBROVASCULAR DISEASE WITH HYPERTENSIO | diagnostic | res27: Cerebrovascular disease | 1 | ||
| 4389 | Read/OXMIS | CEREBROVASCULAR DISEASE | diagnostic | res27: Cerebrovascular disease | 1 | ||
| 662M.00 | Read/OXMIS | Stroke monitoring | diagnostic | res27: Cerebrovascular disease | 1 | ||
| 7004300 | Read/OXMIS | Evacuation of intracerebral haematoma NEC | diagnostic | res27: Cerebrovascular disease | 1 | ||
| 8520A | Read/OXMIS | HAEMORRHAGE SUBARACHNOID TRAUMATIC | diagnostic | res27: Cerebrovascular disease | 1 | ||
| 8520M | Read/OXMIS | MENINGEAL HAEMORRHAGE TRAUMATIC | diagnostic | res27: Cerebrovascular disease | 1 | ||
| F11x200 | Read/OXMIS | Cerebral degeneration due to cerebrovascular disease | diagnostic | res27: Cerebrovascular disease | 1 | ||
| G6...00 | Read/OXMIS | Cerebrovascular disease | diagnostic | res27: Cerebrovascular disease | 1 | ||
| G60..00 | Read/OXMIS | Subarachnoid haemorrhage | diagnostic | res27: Cerebrovascular disease | 1 | ||
| G600.00 | Read/OXMIS | Ruptured berry aneurysm | diagnostic | res27: Cerebrovascular disease | 1 | ||
| G601.00 | Read/OXMIS | Subarachnoid haemorrhage from carotid siphon and bifurcation | diagnostic | res27: Cerebrovascular disease | 1 | ||
| G602.00 | Read/OXMIS | Subarachnoid haemorrhage from middle cerebral artery | diagnostic | res27: Cerebrovascular disease | 1 | ||
| G603.00 | Read/OXMIS | Subarachnoid haemorrhage from anterior communicating artery | diagnostic | res27: Cerebrovascular disease | 1 | ||
| G604.00 | Read/OXMIS | Subarachnoid haemorrhage from posterior communicating artery | diagnostic | res27: Cerebrovascular disease | 1 | ||
| G605.00 | Read/OXMIS | Subarachnoid haemorrhage from basilar artery | diagnostic | res27: Cerebrovascular disease | 1 | ||
| G606.00 | Read/OXMIS | Subarachnoid haemorrhage from vertebral artery | diagnostic | res27: Cerebrovascular disease | 1 | ||
| G60X.00 | Read/OXMIS | Subarachnoid haemorrh from intracranial artery; unspecif | diagnostic | res27: Cerebrovascular disease | 1 | ||
| G60z.00 | Read/OXMIS | Subarachnoid haemorrhage NOS | diagnostic | res27: Cerebrovascular disease | 1 | ||
| G61..00 | Read/OXMIS | Intracerebral haemorrhage | diagnostic | res27: Cerebrovascular disease | 1 | ||
| G61..11 | Read/OXMIS | CVA - cerebrovascular accid due to intracerebral haemorrhage | diagnostic | res27: Cerebrovascular disease | 1 | ||
| G61..12 | Read/OXMIS | Stroke due to intracerebral haemorrhage | diagnostic | res27: Cerebrovascular disease | 1 | ||
| G613.00 | Read/OXMIS | Cerebellar haemorrhage | diagnostic | res27: Cerebrovascular disease | 1 | ||
| G617.00 | Read/OXMIS | Intracerebral haemorrhage; intraventricular | diagnostic | res27: Cerebrovascular disease | 1 | ||
| G618.00 | Read/OXMIS | Intracerebral haemorrhage; multiple localized | diagnostic | res27: Cerebrovascular disease | 1 | ||
| G61X.00 | Read/OXMIS | Intracerebral haemorrhage in hemisphere; unspecified | diagnostic | res27: Cerebrovascular disease | 1 | ||
| G61X000 | Read/OXMIS | Left sided intracerebral haemorrhage; unspecified | diagnostic | res27: Cerebrovascular disease | 1 | ||
| G61X100 | Read/OXMIS | Right sided intracerebral haemorrhage; unspecified | diagnostic | res27: Cerebrovascular disease | 1 | ||
| G61z.00 | Read/OXMIS | Intracerebral haemorrhage NOS | diagnostic | res27: Cerebrovascular disease | 1 | ||
| G623.00 | Read/OXMIS | Subdural haemorrhage NOS | diagnostic | res27: Cerebrovascular disease | 1 | ||
| G62z.00 | Read/OXMIS | Intracranial haemorrhage NOS | diagnostic | res27: Cerebrovascular disease | 1 | ||
| G63..00 | Read/OXMIS | Precerebral arterial occlusion | diagnostic | res27: Cerebrovascular disease | 1 | ||
| G63..12 | Read/OXMIS | Stenosis of precerebral arteries | diagnostic | res27: Cerebrovascular disease | 1 | ||
| G633.00 | Read/OXMIS | Multiple and bilateral precerebral arterial occlusion | diagnostic | res27: Cerebrovascular disease | 1 | ||
| G63y.00 | Read/OXMIS | Other precerebral artery occlusion | diagnostic | res27: Cerebrovascular disease | 1 | ||
| G63z.00 | Read/OXMIS | Precerebral artery occlusion NOS | diagnostic | res27: Cerebrovascular disease | 1 | ||
| G641000 | Read/OXMIS | Cerebral infarction due to embolism of cerebral arteries | diagnostic | res27: Cerebrovascular disease | 1 | ||
| G64..13 | Read/OXMIS | Stroke due to cerebral arterial occlusion | diagnostic | res27: Cerebrovascular disease | 1 | ||
| G65..00 | Read/OXMIS | Transient cerebral ischaemia | diagnostic | res27: Cerebrovascular disease | 1 | ||
| G65y.00 | Read/OXMIS | Other transient cerebral ischaemia | diagnostic | res27: Cerebrovascular disease | 1 | ||
| G65z.00 | Read/OXMIS | Transient cerebral ischaemia NOS | diagnostic | res27: Cerebrovascular disease | 1 | ||
| G65zz00 | Read/OXMIS | Transient cerebral ischaemia NOS | diagnostic | res27: Cerebrovascular disease | 1 | ||
| G66..00 | Read/OXMIS | Stroke and cerebrovascular accident unspecified | diagnostic | res27: Cerebrovascular disease | 1 | ||
| G660.00 | Read/OXMIS | Middle cerebral artery syndrome | diagnostic | res27: Cerebrovascular disease | 1 | ||
| G661.00 | Read/OXMIS | Anterior cerebral artery syndrome | diagnostic | res27: Cerebrovascular disease | 1 | ||
| G66..11 | Read/OXMIS | CVA unspecified | diagnostic | res27: Cerebrovascular disease | 1 | ||
| G66..12 | Read/OXMIS | Stroke unspecified | diagnostic | res27: Cerebrovascular disease | 1 | ||
| G66..13 | Read/OXMIS | CVA - Cerebrovascular accident unspecified | diagnostic | res27: Cerebrovascular disease | 1 | ||
| G662.00 | Read/OXMIS | Posterior cerebral artery syndrome | diagnostic | res27: Cerebrovascular disease | 1 | ||
| G663.00 | Read/OXMIS | Brain stem stroke syndrome | diagnostic | res27: Cerebrovascular disease | 1 | ||
| G664.00 | Read/OXMIS | Cerebellar stroke syndrome | diagnostic | res27: Cerebrovascular disease | 1 | ||
| G665.00 | Read/OXMIS | Pure motor lacunar syndrome | diagnostic | res27: Cerebrovascular disease | 1 | ||
| G666.00 | Read/OXMIS | Pure sensory lacunar syndrome | diagnostic | res27: Cerebrovascular disease | 1 | ||
| G667.00 | Read/OXMIS | Left sided CVA | diagnostic | res27: Cerebrovascular disease | 1 | ||
| G668.00 | Read/OXMIS | Right sided CVA | diagnostic | res27: Cerebrovascular disease | 1 | ||
| G669.00 | Read/OXMIS | Cerebral palsy; not congenital or infantile; acute | diagnostic | res27: Cerebrovascular disease | 1 | ||
| G67..00 | Read/OXMIS | Other cerebrovascular disease | diagnostic | res27: Cerebrovascular disease | 1 | ||
| G671.00 | Read/OXMIS | Generalised ischaemic cerebrovascular disease NOS | diagnostic | res27: Cerebrovascular disease | 1 | ||
| G671z00 | Read/OXMIS | Generalised ischaemic cerebrovascular disease NOS | diagnostic | res27: Cerebrovascular disease | 1 | ||
| G677400 | Read/OXMIS | Occlusion??? of multiple and bilat cerebral arteries | diagnostic | res27: Cerebrovascular disease | 1 | ||
| G67y.00 | Read/OXMIS | Other cerebrovascular disease OS | diagnostic | res27: Cerebrovascular disease | 1 | ||
| G67z.00 | Read/OXMIS | Other cerebrovascular disease NOS | diagnostic | res27: Cerebrovascular disease | 1 | ||
| G68..00 | Read/OXMIS | Late effects of cerebrovascular disease | diagnostic | res27: Cerebrovascular disease | 1 | ||
| G680.00 | Read/OXMIS | Sequelae of subarachnoid haemorrhage | diagnostic | res27: Cerebrovascular disease | 1 | ||
| G681.00 | Read/OXMIS | Sequelae of intracerebral haemorrhage | diagnostic | res27: Cerebrovascular disease | 1 | ||
| G68W.00 | Read/OXMIS | Sequelae/other unspecified cerebrovascular diseases | diagnostic | res27: Cerebrovascular disease | 1 | ||
| G6y..00 | Read/OXMIS | Other specified cerebrovascular disease | diagnostic | res27: Cerebrovascular disease | 1 | ||
| G6z..00 | Read/OXMIS | Cerebrovascular disease NOS | diagnostic | res27: Cerebrovascular disease | 1 | ||
| Gyu6.00 | Read/OXMIS | [X]Cerebrovascular diseases | diagnostic | res27: Cerebrovascular disease | 1 | ||
| Gyu6000 | Read/OXMIS | [X]Subarachnoid haemorrhage from other intracranial arteries | diagnostic | res27: Cerebrovascular disease | 1 | ||
| Gyu6100 | Read/OXMIS | [X]Other subarachnoid haemorrhage | diagnostic | res27: Cerebrovascular disease | 1 | ||
| Gyu6200 | Read/OXMIS | [X]Other intracerebral haemorrhage | diagnostic | res27: Cerebrovascular disease | 1 | ||
| Gyu6500 | Read/OXMIS | [X]Occlusion and stenosis of other precerebral arteries | diagnostic | res27: Cerebrovascular disease | 1 | ||
| Gyu6600 | Read/OXMIS | [X]Occlusion and stenosis of other cerebral arteries | diagnostic | res27: Cerebrovascular disease | 1 | ||
| Gyu6700 | Read/OXMIS | [X]Other specified cerebrovascular diseases | diagnostic | res27: Cerebrovascular disease | 1 | ||
| Gyu6D00 | Read/OXMIS | [X]Sequelae/other unspecified cerebrovascular diseases | diagnostic | res27: Cerebrovascular disease | 1 | ||
| Gyu6F00 | Read/OXMIS | [X]Intracerebral haemorrhage in hemisphere; unspecified | diagnostic | res27: Cerebrovascular disease | 1 | ||
| S620.00 | Read/OXMIS | Closed traumatic subarachnoid haemorrhage | diagnostic | res27: Cerebrovascular disease | 1 | ||
| S621.00 | Read/OXMIS | Open traumatic subarachnoid haemorrhage | diagnostic | res27: Cerebrovascular disease | 1 | ||
| S62..12 | Read/OXMIS | Subarachnoid haemorrhage following injury | diagnostic | res27: Cerebrovascular disease | 1 | ||
| S627.00 | Read/OXMIS | Traumatic subarachnoid haemorrhage | diagnostic | res27: Cerebrovascular disease | 1 | ||
| S628.00 | Read/OXMIS | Traumatic subdural haemorrhage | diagnostic | res27: Cerebrovascular disease | 1 |
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