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Research article:
Adaptation and validation of the Charlson Index for Read/OXMIS coded databases
Reference:
Nada F Khan, Rafael Perera, Stephen Harper, Peter W Rose(2010) Adaptation and validation of the Charlson Index for Read/OXMIS coded databases. BMC Family Practice, doi: 10.1186/1471-2296-11-1
- Link to fulltext article
- Abstract
- Background The Charlson comorbidity index is widely used in ICD-9 administrative data, however, there is no translation for Read/OXMIS coded data despite increasing use of the General Practice Research Database (GPRD). Our main objective was to translate the Charlson index for use with Read/OXMIS coded data such as the GPRD and test its association with mortality. We also aimed to provide a version of the comorbidity index for other researchers using similar datasets. Methods Two clinicians translated the Charlson index into Read/OXMIS codes. We tested the association between comorbidity score and increased mortality in 146 441 patients from the GPRD using proportional hazards models. Results This Read/OXMIS translation of the Charlson index contains 3156 codes. Our validation showed a strong positive association between Charlson score and age. Cox proportional models show a positive increasing association with mortality and Charlson score. The discrimination of the logistic regression model for mortality was good (AUC = 0.853). Conclusion We have translated a commonly used comorbidity index into Read/OXMIS for use in UK primary care databases. The translated index showed a good discrimination in our study population. This is the first study to develop a co-morbidity index for use with the Read/OXMIS coding system and the GPRD. A copy of the co-morbidity index is provided for other researchers using similar databases.
- Author for correspondence
- Nada F Khan
- Email for correspondence
- nada.khan@dphpc.ox.ac.uk
Code list: res27: Dementia
48 codes in list
| Code | Coding system | Description | Entity type | List name | Charlson score weight | ||
|---|---|---|---|---|---|---|---|
| 1461 | Read/OXMIS | H/O: dementia | diagnostic | res27: Dementia | 1 | ||
| 2900 | Read/OXMIS | SENILE DEMENTIA | diagnostic | res27: Dementia | 1 | ||
| 2901A | Read/OXMIS | PRESENILE DEMENTIA | diagnostic | res27: Dementia | 1 | ||
| 2930 | Read/OXMIS | DEMENTIA ARTERIOSCLEROTIC | diagnostic | res27: Dementia | 1 | ||
| 299 B | Read/OXMIS | DEMENTIA | diagnostic | res27: Dementia | 1 | ||
| 299 G | Read/OXMIS | DEMENTIA AGGRESSIVE | diagnostic | res27: Dementia | 1 | ||
| 794 D | Read/OXMIS | SENILE DETERIORATION | diagnostic | res27: Dementia | 1 | ||
| e000.00 | Read/OXMIS | Uncomplicated senile dementia | diagnostic | res27: Dementia | 1 | ||
| E000.00 | Read/OXMIS | Uncomplicated senile dementia | diagnostic | res27: Dementia | 1 | ||
| E001.00 | Read/OXMIS | Presenile dementia | diagnostic | res27: Dementia | 1 | ||
| E001000 | Read/OXMIS | Uncomplicated presenile dementia | diagnostic | res27: Dementia | 1 | ||
| E00..11 | Read/OXMIS | Senile dementia | diagnostic | res27: Dementia | 1 | ||
| E00..12 | Read/OXMIS | Senile/presenile dementia | diagnostic | res27: Dementia | 1 | ||
| E001z00 | Read/OXMIS | Presenile dementia NOS | diagnostic | res27: Dementia | 1 | ||
| E004.00 | Read/OXMIS | Arteriosclerotic dementia | diagnostic | res27: Dementia | 1 | ||
| E004000 | Read/OXMIS | Uncomplicated arteriosclerotic dementia | diagnostic | res27: Dementia | 1 | ||
| E004100 | Read/OXMIS | Arteriosclerotic dementia with delirium | diagnostic | res27: Dementia | 1 | ||
| E004.11 | Read/OXMIS | Multi infarct dementia | diagnostic | res27: Dementia | 1 | ||
| E004200 | Read/OXMIS | Arteriosclerotic dementia with paranoia | diagnostic | res27: Dementia | 1 | ||
| E004300 | Read/OXMIS | Arteriosclerotic dementia with depression | diagnostic | res27: Dementia | 1 | ||
| E004z00 | Read/OXMIS | Arteriosclerotic dementia NOS | diagnostic | res27: Dementia | 1 | ||
| E041.00 | Read/OXMIS | Dementia in conditions EC | diagnostic | res27: Dementia | 1 | ||
| Eu00.00 | Read/OXMIS | [X]Dementia in Alzheimer's disease | diagnostic | res27: Dementia | 1 | ||
| Eu00000 | Read/OXMIS | [X]Dementia in Alzheimer's disease with early onset | diagnostic | res27: Dementia | 1 | ||
| Eu00011 | Read/OXMIS | [X]Presenile dementia;Alzheimer's type | diagnostic | res27: Dementia | 1 | ||
| Eu00012 | Read/OXMIS | [X]Primary degen dementia; Alzheimer's type; presenile onset | diagnostic | res27: Dementia | 1 | ||
| Eu00100 | Read/OXMIS | [X]Dementia in Alzheimer's disease with late onset | diagnostic | res27: Dementia | 1 | ||
| Eu00112 | Read/OXMIS | [X]Senile dementia;Alzheimer's type | diagnostic | res27: Dementia | 1 | ||
| Eu00113 | Read/OXMIS | [X]Primary degen dementia of Alzheimer's type; senile onset | diagnostic | res27: Dementia | 1 | ||
| Eu00200 | Read/OXMIS | [X]Dementia in Alzheimer's dis; atypical or mixed type | diagnostic | res27: Dementia | 1 | ||
| Eu00z00 | Read/OXMIS | [X]Dementia in Alzheimer's disease; unspecified | diagnostic | res27: Dementia | 1 | ||
| Eu00z11 | Read/OXMIS | [X]Alzheimer's dementia unspec | diagnostic | res27: Dementia | 1 | ||
| Eu01.00 | Read/OXMIS | [X]Vascular dementia | diagnostic | res27: Dementia | 1 | ||
| Eu01000 | Read/OXMIS | [X]Vascular dementia of acute onset | diagnostic | res27: Dementia | 1 | ||
| Eu01100 | Read/OXMIS | [X]Multi-infarct dementia | diagnostic | res27: Dementia | 1 | ||
| Eu01.11 | Read/OXMIS | [X]Arteriosclerotic dementia | diagnostic | res27: Dementia | 1 | ||
| Eu01111 | Read/OXMIS | [X]Predominantly cortical dementia | diagnostic | res27: Dementia | 1 | ||
| Eu01200 | Read/OXMIS | [X]Subcortical vascular dementia | diagnostic | res27: Dementia | 1 | ||
| Eu01300 | Read/OXMIS | [X]Mixed cortical and subcortical vascular dementia | diagnostic | res27: Dementia | 1 | ||
| Eu01y00 | Read/OXMIS | [X]Other vascular dementia | diagnostic | res27: Dementia | 1 | ||
| Eu01z00 | Read/OXMIS | [X]Vascular dementia; unspecified | diagnostic | res27: Dementia | 1 | ||
| Eu02.00 | Read/OXMIS | [X]Dementia in other diseases classified elsewhere | diagnostic | res27: Dementia | 1 | ||
| Eu02500 | Read/OXMIS | [X]Lewy body dementia | diagnostic | res27: Dementia | 1 | ||
| Eu02y00 | Read/OXMIS | [X]Dementia in other specified diseases classif elsewhere | diagnostic | res27: Dementia | 1 | ||
| Eu02z00 | Read/OXMIS | [X] Unspecified dementia | diagnostic | res27: Dementia | 1 | ||
| Eu02z13 | Read/OXMIS | [X] Primary degenerative dementia NOS | diagnostic | res27: Dementia | 1 | ||
| Eu02z14 | Read/OXMIS | [X] Senile dementia NOS | diagnostic | res27: Dementia | 1 | ||
| Eu02z16 | Read/OXMIS | [X] Senile dementia; depressed or paranoid type | diagnostic | res27: Dementia | 1 |
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