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Research article:
Adaptation and validation of the Charlson Index for Read/OXMIS coded databases
Reference:
Nada F Khan, Rafael Perera, Stephen Harper, Peter W Rose(2010) Adaptation and validation of the Charlson Index for Read/OXMIS coded databases. BMC Family Practice, doi: 10.1186/1471-2296-11-1
- Link to fulltext article
- Abstract
- Background The Charlson comorbidity index is widely used in ICD-9 administrative data, however, there is no translation for Read/OXMIS coded data despite increasing use of the General Practice Research Database (GPRD). Our main objective was to translate the Charlson index for use with Read/OXMIS coded data such as the GPRD and test its association with mortality. We also aimed to provide a version of the comorbidity index for other researchers using similar datasets. Methods Two clinicians translated the Charlson index into Read/OXMIS codes. We tested the association between comorbidity score and increased mortality in 146 441 patients from the GPRD using proportional hazards models. Results This Read/OXMIS translation of the Charlson index contains 3156 codes. Our validation showed a strong positive association between Charlson score and age. Cox proportional models show a positive increasing association with mortality and Charlson score. The discrimination of the logistic regression model for mortality was good (AUC = 0.853). Conclusion We have translated a commonly used comorbidity index into Read/OXMIS for use in UK primary care databases. The translated index showed a good discrimination in our study population. This is the first study to develop a co-morbidity index for use with the Read/OXMIS coding system and the GPRD. A copy of the co-morbidity index is provided for other researchers using similar databases.
- Author for correspondence
- Nada F Khan
- Email for correspondence
- nada.khan@dphpc.ox.ac.uk
Code list: res27: Diabetes
166 codes in list
| Code | Coding system | Description | Entity type | List name | Charlson score weight | ||
|---|---|---|---|---|---|---|---|
| 1434 | Read/OXMIS | H/O: diabetes mellitus | diagnostic | res27: Diabetes | 1 | ||
| 2500AH | Read/OXMIS | LATENT DIABETES | diagnostic | res27: Diabetes | 1 | ||
| 250 A | Read/OXMIS | SUGAR DIABETES | diagnostic | res27: Diabetes | 1 | ||
| 250 AB | Read/OXMIS | ABSCESS DIABETIC | diagnostic | res27: Diabetes | 1 | ||
| 250 AD | Read/OXMIS | DIABETES MELLITUS INSULIN DEPENDANT | diagnostic | res27: Diabetes | 1 | ||
| 250 AK | Read/OXMIS | MATURITY ONSET DIABETES MELLITUS INSULIN | diagnostic | res27: Diabetes | 1 | ||
| 250 AN | Read/OXMIS | DIABETES | diagnostic | res27: Diabetes | 1 | ||
| 250 AT | Read/OXMIS | DIABETIC AMYOTROPHY | diagnostic | res27: Diabetes | 1 | ||
| 250 CT | Read/OXMIS | DIABETIC CATARACT | diagnostic | res27: Diabetes | 1 | ||
| 250 DC | Read/OXMIS | DIETARY CONTROL DIABETES | diagnostic | res27: Diabetes | 1 | ||
| 250 DR | Read/OXMIS | DIABETIC DIARRHOEA | diagnostic | res27: Diabetes | 1 | ||
| 250 E | Read/OXMIS | HYPOGLYCAEMIA IN DIABETES MELLITUS | diagnostic | res27: Diabetes | 1 | ||
| 250 G | Read/OXMIS | ULCER DIABETIC | diagnostic | res27: Diabetes | 1 | ||
| 250 GA | Read/OXMIS | GANGRENE DIABETIC | diagnostic | res27: Diabetes | 1 | ||
| 250 H | Read/OXMIS | COMA DIABETIC | diagnostic | res27: Diabetes | 1 | ||
| 250 HC | Read/OXMIS | HYPOGLYCAEMIC COMA DIABETIC | diagnostic | res27: Diabetes | 1 | ||
| 250 HP | Read/OXMIS | PRECOMA DIABETIC | diagnostic | res27: Diabetes | 1 | ||
| 250 JA | Read/OXMIS | DIABETIC ACIDOSIS | diagnostic | res27: Diabetes | 1 | ||
| 250 JK | Read/OXMIS | KETOACIDOSIS DIABETIC | diagnostic | res27: Diabetes | 1 | ||
| 250 JL | Read/OXMIS | KETOSIS DIABETIC | diagnostic | res27: Diabetes | 1 | ||
| 250 NH | Read/OXMIS | HYPEROSMOLAR DIABETIC STATE | diagnostic | res27: Diabetes | 1 | ||
| 250 NT | Read/OXMIS | UNSTABLE DIABETIC | diagnostic | res27: Diabetes | 1 | ||
| 250 PR | Read/OXMIS | PRURITUS DIABETIC | diagnostic | res27: Diabetes | 1 | ||
| 66A5.00 | Read/OXMIS | Diabetic on insulin | diagnostic | res27: Diabetes | 1 | ||
| 66AI.00 | Read/OXMIS | Diabetic - good control | diagnostic | res27: Diabetes | 1 | ||
| 66AJ.00 | Read/OXMIS | Diabetic - poor control | diagnostic | res27: Diabetes | 1 | ||
| 66AJ.11 | Read/OXMIS | Unstable diabetes | diagnostic | res27: Diabetes | 1 | ||
| 66AJz00 | Read/OXMIS | Diabetic - poor control NOS | diagnostic | res27: Diabetes | 1 | ||
| 66AK.00 | Read/OXMIS | Diabetic - cooperative patient | diagnostic | res27: Diabetes | 1 | ||
| 66AS.00 | Read/OXMIS | Diabetic annual review | diagnostic | res27: Diabetes | 1 | ||
| 66AV.00 | Read/OXMIS | Diabetic on insulin and oral treatment | diagnostic | res27: Diabetes | 1 | ||
| 8A13.00 | Read/OXMIS | Diabetic stabilisation | diagnostic | res27: Diabetes | 1 | ||
| 8BL2.00 | Read/OXMIS | Patient on maximal tolerated therapy for diabetes | diagnostic | res27: Diabetes | 1 | ||
| 8H2J.00 | Read/OXMIS | Admit diabetic emergency | diagnostic | res27: Diabetes | 1 | ||
| C10..00 | Read/OXMIS | Diabetes mellitus | diagnostic | res27: Diabetes | 1 | ||
| C100.00 | Read/OXMIS | Diabetes mellitus with no mention of complication | diagnostic | res27: Diabetes | 1 | ||
| C100000 | Read/OXMIS | Diabetes mellitus; juvenile type; no mention of complication | diagnostic | res27: Diabetes | 1 | ||
| C100011 | Read/OXMIS | Insulin dependent diabetes mellitus | diagnostic | res27: Diabetes | 1 | ||
| C100100 | Read/OXMIS | Diabetes mellitus; adult onset; no mention of complication | diagnostic | res27: Diabetes | 1 | ||
| C100111 | Read/OXMIS | Maturity onset diabetes | diagnostic | res27: Diabetes | 1 | ||
| C100112 | Read/OXMIS | Non-insulin dependent diabetes mellitus | diagnostic | res27: Diabetes | 1 | ||
| C100z00 | Read/OXMIS | Diabetes mellitus NOS with no mention of complication | diagnostic | res27: Diabetes | 1 | ||
| C101.00 | Read/OXMIS | Diabetes mellitus with ketoacidosis | diagnostic | res27: Diabetes | 1 | ||
| C101000 | Read/OXMIS | Diabetes mellitus; juvenile type; with ketoacidosis | diagnostic | res27: Diabetes | 1 | ||
| C101100 | Read/OXMIS | Diabetes mellitus; adult onset; with ketoacidosis | diagnostic | res27: Diabetes | 1 | ||
| C101y00 | Read/OXMIS | Other specified diabetes mellitus with ketoacidosis | diagnostic | res27: Diabetes | 1 | ||
| C101z00 | Read/OXMIS | Diabetes mellitus NOS with ketoacidosis | diagnostic | res27: Diabetes | 1 | ||
| C102.00 | Read/OXMIS | Diabetes mellitus with hyperosmolar coma | diagnostic | res27: Diabetes | 1 | ||
| C102000 | Read/OXMIS | Diabetes mellitus; juvenile type; with hyperosmolar coma | diagnostic | res27: Diabetes | 1 | ||
| C102100 | Read/OXMIS | Diabetes mellitus; adult onset; with hyperosmolar coma | diagnostic | res27: Diabetes | 1 | ||
| C102z00 | Read/OXMIS | Diabetes mellitus NOS with hyperosmolar coma | diagnostic | res27: Diabetes | 1 | ||
| C103.00 | Read/OXMIS | Diabetes mellitus with ketoacidotic coma | diagnostic | res27: Diabetes | 1 | ||
| C103000 | Read/OXMIS | Diabetes mellitus; juvenile type; with ketoacidotic coma | diagnostic | res27: Diabetes | 1 | ||
| C103y00 | Read/OXMIS | Other specified diabetes mellitus with coma | diagnostic | res27: Diabetes | 1 | ||
| C103z00 | Read/OXMIS | Diabetes mellitus NOS with ketoacidotic coma | diagnostic | res27: Diabetes | 1 | ||
| C107.00 | Read/OXMIS | Diabetes mellitus with peripheral circulatory disorder | diagnostic | res27: Diabetes | 1 | ||
| C107000 | Read/OXMIS | Diabetes mellitus; juvenile ??? circulatory disorder | diagnostic | res27: Diabetes | 1 | ||
| C107100 | Read/OXMIS | Diabetes mellitus; adult; peripheral circulatory disorder | diagnostic | res27: Diabetes | 1 | ||
| C107.11 | Read/OXMIS | Diabetes mellitus with gangrene | diagnostic | res27: Diabetes | 1 | ||
| C107200 | Read/OXMIS | Diabetes mellitus; adult with gangrene | diagnostic | res27: Diabetes | 1 | ||
| C107300 | Read/OXMIS | IDDM with peripheral circulatory disorder | diagnostic | res27: Diabetes | 1 | ||
| C107400 | Read/OXMIS | NIDDM with peripheral circulatory disorder | diagnostic | res27: Diabetes | 1 | ||
| C107z00 | Read/OXMIS | Diabetes mellitus NOS with peripheral circulatory disorder | diagnostic | res27: Diabetes | 1 | ||
| C108.00 | Read/OXMIS | Insulin dependent diabetes mellitus | diagnostic | res27: Diabetes | 1 | ||
| C108.11 | Read/OXMIS | IDDM-Insulin dependent diabetes mellitus | diagnostic | res27: Diabetes | 1 | ||
| C108.12 | Read/OXMIS | Type 1 diabetes mellitus | diagnostic | res27: Diabetes | 1 | ||
| C108.13 | Read/OXMIS | Type I diabetes mellitus | diagnostic | res27: Diabetes | 1 | ||
| C108400 | Read/OXMIS | Unstable insulin dependent diabetes mellitus | diagnostic | res27: Diabetes | 1 | ||
| C108411 | Read/OXMIS | Unstable type I diabetes mellitus | diagnostic | res27: Diabetes | 1 | ||
| C108500 | Read/OXMIS | Insulin dependent diabetes mellitus with ulcer | diagnostic | res27: Diabetes | 1 | ||
| C108511 | Read/OXMIS | Type I diabetes mellitus with ulcer | diagnostic | res27: Diabetes | 1 | ||
| C108600 | Read/OXMIS | Insulin dependent diabetes mellitus with gangrene | diagnostic | res27: Diabetes | 1 | ||
| C108800 | Read/OXMIS | Insulin dependent diabetes mellitus - poor control | diagnostic | res27: Diabetes | 1 | ||
| C108811 | Read/OXMIS | Type I diabetes mellitus - poor control | diagnostic | res27: Diabetes | 1 | ||
| C108812 | Read/OXMIS | Type 1 diabetes mellitus - poor control | diagnostic | res27: Diabetes | 1 | ||
| C108911 | Read/OXMIS | Type I diabetes mellitus maturity onset | diagnostic | res27: Diabetes | 1 | ||
| C108E00 | Read/OXMIS | Insulin dependent diabetes mellitus with hypoglycaemic coma | diagnostic | res27: Diabetes | 1 | ||
| C108E11 | Read/OXMIS | Type I diabetes mellitus with hypoglycaemic coma | diagnostic | res27: Diabetes | 1 | ||
| C108E12 | Read/OXMIS | Type 1 diabetes mellitus with hypoglycaemic coma | diagnostic | res27: Diabetes | 1 | ||
| C108G00 | Read/OXMIS | Insulin dependent diab mell with peripheral angiopathy | diagnostic | res27: Diabetes | 1 | ||
| C109.00 | Read/OXMIS | Non-insulin-dependent diabetes mellitus | diagnostic | res27: Diabetes | 1 | ||
| C109.11 | Read/OXMIS | NIDDM - Non-insulin dependent diabetes mellitus | diagnostic | res27: Diabetes | 1 | ||
| C109.12 | Read/OXMIS | Type 2 diabetes mellitus | diagnostic | res27: Diabetes | 1 | ||
| C109.13 | Read/OXMIS | Type II diabetes mellitus | diagnostic | res27: Diabetes | 1 | ||
| C109300 | Read/OXMIS | Non-insulin-dependent diabetes mellitus with multiple comps | diagnostic | res27: Diabetes | 1 | ||
| C109400 | Read/OXMIS | Non-insulin dependent diabetes mellitus with ulcer | diagnostic | res27: Diabetes | 1 | ||
| C109411 | Read/OXMIS | Type II diabetes mellitus with ulcer | diagnostic | res27: Diabetes | 1 | ||
| C109412 | Read/OXMIS | Type 2 diabetes mellitus with ulcer | diagnostic | res27: Diabetes | 1 | ||
| C109500 | Read/OXMIS | Non-insulin dependent diabetes mellitus with gangrene | diagnostic | res27: Diabetes | 1 | ||
| C109511 | Read/OXMIS | Type II diabetes mellitus with gangrene | diagnostic | res27: Diabetes | 1 | ||
| C109700 | Read/OXMIS | Non-insulin dependant diabetes mellitus - poor control | diagnostic | res27: Diabetes | 1 | ||
| C109711 | Read/OXMIS | Type II diabetes mellitus - poor control | diagnostic | res27: Diabetes | 1 | ||
| C109712 | Read/OXMIS | Type 2 diabetes mellitus - poor control | diagnostic | res27: Diabetes | 1 | ||
| C109900 | Read/OXMIS | Non-insulin-dependent diabetes mellitus without complication | diagnostic | res27: Diabetes | 1 | ||
| C109D00 | Read/OXMIS | Non-insulin dependent diabetes mellitus with hypoglyca coma | diagnostic | res27: Diabetes | 1 | ||
| C109D11 | Read/OXMIS | Type II diabetes mellitus with hypoglycaemic coma | diagnostic | res27: Diabetes | 1 | ||
| C109D12 | Read/OXMIS | Type 2 diabetes mellitus with hypoglycaemic coma | diagnostic | res27: Diabetes | 1 | ||
| C109F11 | Read/OXMIS | Type II diabetes mellitus with peripheral angiopathy | diagnostic | res27: Diabetes | 1 | ||
| C109F12 | Read/OXMIS | Type 2 diabetes mellitus with peripheral angiopathy | diagnostic | res27: Diabetes | 1 | ||
| C109G00 | Read/OXMIS | Non-insulin dependent diabetes mellitus with arthropathy | diagnostic | res27: Diabetes | 1 | ||
| C109G11 | Read/OXMIS | Type II diabetes mellitus with arthropathy | diagnostic | res27: Diabetes | 1 | ||
| C109G12 | Read/OXMIS | Type 2 diabetes mellitus with arthropathy | diagnostic | res27: Diabetes | 1 | ||
| C109J00 | Read/OXMIS | Insulin treated Type 2 diabetes mellitus | diagnostic | res27: Diabetes | 1 | ||
| C109J11 | Read/OXMIS | Insulin treated non-insulin dependent diabetes mellitus | diagnostic | res27: Diabetes | 1 | ||
| C109J12 | Read/OXMIS | Insulin treated Type II diabetes mellitus | diagnostic | res27: Diabetes | 1 | ||
| C109K00 | Read/OXMIS | Hyperosmolar non-ketotic state in type 2 diabetes mellitus | diagnostic | res27: Diabetes | 1 | ||
| C10A.00 | Read/OXMIS | Malnutrition-related diabetes mellitus | diagnostic | res27: Diabetes | 1 | ||
| C10A000 | Read/OXMIS | Malnutrition-related diabetes mellitus with coma | diagnostic | res27: Diabetes | 1 | ||
| C10A100 | Read/OXMIS | Malnutrition-related diabetes mellitus with ketoacidosis | diagnostic | res27: Diabetes | 1 | ||
| C10B000 | Read/OXMIS | Steroid induced diabetes mellitus without complication | diagnostic | res27: Diabetes | 1 | ||
| C10D.00 | Read/OXMIS | Diabetes mellitus autosomal dominant type 2 | diagnostic | res27: Diabetes | 1 | ||
| C10D.11 | Read/OXMIS | Maturity onset diabetes in youth type 2 | diagnostic | res27: Diabetes | 1 | ||
| C10E.00 | Read/OXMIS | Type 1 diabetes mellitus | diagnostic | res27: Diabetes | 1 | ||
| C10E.11 | Read/OXMIS | Type I diabetes mellitus | diagnostic | res27: Diabetes | 1 | ||
| C10E.12 | Read/OXMIS | Insulin dependent diabetes mellitus | diagnostic | res27: Diabetes | 1 | ||
| C10E400 | Read/OXMIS | Unstable type 1 diabetes mellitus | diagnostic | res27: Diabetes | 1 | ||
| C10E412 | Read/OXMIS | Unstable insulin dependent diabetes mellitus | diagnostic | res27: Diabetes | 1 | ||
| C10E500 | Read/OXMIS | Type 1 diabetes mellitus with ulcer | diagnostic | res27: Diabetes | 1 | ||
| C10E600 | Read/OXMIS | Type 1 diabetes mellitus with gangrene | diagnostic | res27: Diabetes | 1 | ||
| C10E800 | Read/OXMIS | Type 1 diabetes mellitus - poor control | diagnostic | res27: Diabetes | 1 | ||
| C10E812 | Read/OXMIS | Insulin dependent diabetes mellitus - poor control | diagnostic | res27: Diabetes | 1 | ||
| C10E900 | Read/OXMIS | Type 1 diabetes mellitus maturity onset | diagnostic | res27: Diabetes | 1 | ||
| C10EA00 | Read/OXMIS | Type 1 diabetes mellitus without complication | diagnostic | res27: Diabetes | 1 | ||
| C10EE00 | Read/OXMIS | Type 1 diabetes mellitus with hypoglycaemic coma | diagnostic | res27: Diabetes | 1 | ||
| C10EG00 | Read/OXMIS | Type 1 diabetes mellitus with peripheral angiopathy | diagnostic | res27: Diabetes | 1 | ||
| C10EK00 | Read/OXMIS | Type 1 diabetes mellitus with persistent proteinuria | diagnostic | res27: Diabetes | 1 | ||
| C10EL00 | Read/OXMIS | Type 1 diabetes mellitus with persistent microalbuminuria | diagnostic | res27: Diabetes | 1 | ||
| C10EM00 | Read/OXMIS | Type 1 diabetes mellitus with ketoacidosis | diagnostic | res27: Diabetes | 1 | ||
| C10EM11 | Read/OXMIS | Type I diabetes mellitus with ketoacidosis | diagnostic | res27: Diabetes | 1 | ||
| C10EN00 | Read/OXMIS | Type 1 diabetes mellitus with ketoacidotic coma | diagnostic | res27: Diabetes | 1 | ||
| C10EN11 | Read/OXMIS | Type I diabetes mellitus with ketoacidotic coma | diagnostic | res27: Diabetes | 1 | ||
| C10F.00 | Read/OXMIS | Type 2 diabetes mellitus | diagnostic | res27: Diabetes | 1 | ||
| C10F.11 | Read/OXMIS | Type II diabetes mellitus | diagnostic | res27: Diabetes | 1 | ||
| C10F400 | Read/OXMIS | Type 2 diabetes mellitus with ulcer | diagnostic | res27: Diabetes | 1 | ||
| C10F500 | Read/OXMIS | Type 2 diabetes mellitus with gangrene | diagnostic | res27: Diabetes | 1 | ||
| C10F700 | Read/OXMIS | Type 2 diabetes mellitus - poor control | diagnostic | res27: Diabetes | 1 | ||
| C10F711 | Read/OXMIS | Type II diabetes mellitus - poor control | diagnostic | res27: Diabetes | 1 | ||
| C10F900 | Read/OXMIS | Type 2 diabetes mellitus without complication | diagnostic | res27: Diabetes | 1 | ||
| C10FD00 | Read/OXMIS | Type 2 diabetes mellitus with hypoglycaemic coma | diagnostic | res27: Diabetes | 1 | ||
| C10FF00 | Read/OXMIS | Type 2 diabetes mellitus with peripheral angiopathy | diagnostic | res27: Diabetes | 1 | ||
| C10FG00 | Read/OXMIS | Type 2 diabetes mellitus with arthropathy | diagnostic | res27: Diabetes | 1 | ||
| C10FJ00 | Read/OXMIS | Insulin treated Type 2 diabetes mellitus | diagnostic | res27: Diabetes | 1 | ||
| C10FJ11 | Read/OXMIS | Insulin treated Type II diabetes mellitus | diagnostic | res27: Diabetes | 1 | ||
| C10FL00 | Read/OXMIS | Type 2 diabetes mellitus with persistent proteinuria | diagnostic | res27: Diabetes | 1 | ||
| C10FL11 | Read/OXMIS | Type II diabetes mellitus with persistent proteinuria | diagnostic | res27: Diabetes | 1 | ||
| C10FM00 | Read/OXMIS | Type 2 diabetes mellitus with persistent microalbuminuria | diagnostic | res27: Diabetes | 1 | ||
| C10FN00 | Read/OXMIS | Type 2 diabetes mellitus with ketoacidosis | diagnostic | res27: Diabetes | 1 | ||
| C10FP00 | Read/OXMIS | Type 2 diabetes mellitus with ketoacidotic coma | diagnostic | res27: Diabetes | 1 | ||
| C10G.00 | Read/OXMIS | Secondary pancreatic diabetes mellitus | diagnostic | res27: Diabetes | 1 | ||
| C10H.00 | Read/OXMIS | Diabetes mellitus induced by non-steroid drugs | diagnostic | res27: Diabetes | 1 | ||
| C10M.00 | Read/OXMIS | Lipoatrophic diabetes mellitus | diagnostic | res27: Diabetes | 1 | ||
| C10N.00 | Read/OXMIS | Secondary diabetes mellitus | diagnostic | res27: Diabetes | 1 | ||
| C10y.00 | Read/OXMIS | Diabetes mellitus with other specified manifestation | diagnostic | res27: Diabetes | 1 | ||
| C10y100 | Read/OXMIS | Diabetes mellitus; adult; other specified manifestation | diagnostic | res27: Diabetes | 1 | ||
| C10yy00 | Read/OXMIS | Other specified diabetes mellitus with other spec comps | diagnostic | res27: Diabetes | 1 | ||
| C10yz00 | Read/OXMIS | Diabetes mellitus NOS with other specified manifestation | diagnostic | res27: Diabetes | 1 | ||
| C10z.00 | Read/OXMIS | Diabetes mellitus with unspecified complication | diagnostic | res27: Diabetes | 1 | ||
| C10z100 | Read/OXMIS | Diabetes mellitus; adult onset; unspecified complication | diagnostic | res27: Diabetes | 1 | ||
| C10zy00 | Read/OXMIS | Other specified diabetes mellitus with unspecified comps | diagnostic | res27: Diabetes | 1 | ||
| C10zz00 | Read/OXMIS | Diabetes mellitus NOS with unspecified complication | diagnostic | res27: Diabetes | 1 | ||
| Cyu2.00 | Read/OXMIS | [X]Diabetes mellitus | diagnostic | res27: Diabetes | 1 | ||
| Cyu2000 | Read/OXMIS | [X]Other specified diabetes mellitus | diagnostic | res27: Diabetes | 1 | ||
| G73y000 | Read/OXMIS | Diabetic peripheral angiopathy | diagnostic | res27: Diabetes | 1 | ||
| L180500 | Read/OXMIS | Pre-existing diabetes mellitus; insulin-dependent | diagnostic | res27: Diabetes | 1 | ||
| L180600 | Read/OXMIS | Pre-existing diabetes mellitus; non-insulin-dependent | diagnostic | res27: Diabetes | 1 | ||
| L180X00 | Read/OXMIS | Pre-existing diabetes mellitus; unspecified | diagnostic | res27: Diabetes | 1 |
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