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Research article:
Adaptation and validation of the Charlson Index for Read/OXMIS coded databases
Reference:
Nada F Khan, Rafael Perera, Stephen Harper, Peter W Rose(2010) Adaptation and validation of the Charlson Index for Read/OXMIS coded databases. BMC Family Practice, doi: 10.1186/1471-2296-11-1
- Link to fulltext article
- Abstract
- Background The Charlson comorbidity index is widely used in ICD-9 administrative data, however, there is no translation for Read/OXMIS coded data despite increasing use of the General Practice Research Database (GPRD). Our main objective was to translate the Charlson index for use with Read/OXMIS coded data such as the GPRD and test its association with mortality. We also aimed to provide a version of the comorbidity index for other researchers using similar datasets. Methods Two clinicians translated the Charlson index into Read/OXMIS codes. We tested the association between comorbidity score and increased mortality in 146 441 patients from the GPRD using proportional hazards models. Results This Read/OXMIS translation of the Charlson index contains 3156 codes. Our validation showed a strong positive association between Charlson score and age. Cox proportional models show a positive increasing association with mortality and Charlson score. The discrimination of the logistic regression model for mortality was good (AUC = 0.853). Conclusion We have translated a commonly used comorbidity index into Read/OXMIS for use in UK primary care databases. The translated index showed a good discrimination in our study population. This is the first study to develop a co-morbidity index for use with the Read/OXMIS coding system and the GPRD. A copy of the co-morbidity index is provided for other researchers using similar databases.
- Author for correspondence
- Nada F Khan
- Email for correspondence
- nada.khan@dphpc.ox.ac.uk
Code list: res27: Mild liver disease
51 codes in list
| Code | Coding system | Description | Entity type | List name | Charlson score weight | ||
|---|---|---|---|---|---|---|---|
| 070 G | Read/OXMIS | HEPATITIS CHRONIC AGGRESSIVE | diagnostic | res27: Mild liver disease | 1 | ||
| 5710CA | Read/OXMIS | CIRRHOSIS ALCOHOLIC | diagnostic | res27: Mild liver disease | 1 | ||
| 5710MC | Read/OXMIS | MICRONODULAR CIRRHOSIS | diagnostic | res27: Mild liver disease | 1 | ||
| 5719CB | Read/OXMIS | SECONDARY BILIARY CIRRHOSIS (LIVER) | diagnostic | res27: Mild liver disease | 1 | ||
| 5719CH | Read/OXMIS | HEPATITIS CHRONIC | diagnostic | res27: Mild liver disease | 1 | ||
| 5719CL | Read/OXMIS | CIRRHOSIS | diagnostic | res27: Mild liver disease | 1 | ||
| 5719HP | Read/OXMIS | LIVER CIRRHOSIS | diagnostic | res27: Mild liver disease | 1 | ||
| 5719MA | Read/OXMIS | MACRONODULAR CIRRHOSIS | diagnostic | res27: Mild liver disease | 1 | ||
| 5719PB | Read/OXMIS | PRIMARY BILIARY CIRRHOSIS (LIVER) | diagnostic | res27: Mild liver disease | 1 | ||
| 5730CA | Read/OXMIS | HEPATITIS CHRONIC ACTIVE | diagnostic | res27: Mild liver disease | 1 | ||
| C310400 | Read/OXMIS | Glycogenosis with hepatic cirrhosis | diagnostic | res27: Mild liver disease | 1 | ||
| C350012 | Read/OXMIS | Pigmentary cirrhosis of liver | diagnostic | res27: Mild liver disease | 1 | ||
| J600200 | Read/OXMIS | Acute yellow atrophy | diagnostic | res27: Mild liver disease | 1 | ||
| J601200 | Read/OXMIS | Subacute yellow atrophy | diagnostic | res27: Mild liver disease | 1 | ||
| J61..00 | Read/OXMIS | Cirrhosis and chronic liver disease | diagnostic | res27: Mild liver disease | 1 | ||
| J612.00 | Read/OXMIS | Alcoholic cirrhosis of liver | diagnostic | res27: Mild liver disease | 1 | ||
| J612.11 | Read/OXMIS | Florid cirrhosis | diagnostic | res27: Mild liver disease | 1 | ||
| J614.00 | Read/OXMIS | Chronic hepatitis | diagnostic | res27: Mild liver disease | 1 | ||
| J614000 | Read/OXMIS | Chronic persistent hepatitis | diagnostic | res27: Mild liver disease | 1 | ||
| J614100 | Read/OXMIS | Chronic active hepatitis | diagnostic | res27: Mild liver disease | 1 | ||
| J614200 | Read/OXMIS | Chronic aggressive hepatitis | diagnostic | res27: Mild liver disease | 1 | ||
| J614300 | Read/OXMIS | Recurrent hepatitis | diagnostic | res27: Mild liver disease | 1 | ||
| J614y00 | Read/OXMIS | Chronic hepatitis unspecified | diagnostic | res27: Mild liver disease | 1 | ||
| J614z00 | Read/OXMIS | Chronic hepatitis NOS | diagnostic | res27: Mild liver disease | 1 | ||
| J615.00 | Read/OXMIS | Cirrhosis - non alcoholic | diagnostic | res27: Mild liver disease | 1 | ||
| J615000 | Read/OXMIS | Unilobular portal cirrhosis | diagnostic | res27: Mild liver disease | 1 | ||
| J615100 | Read/OXMIS | Multilobular portal cirrhosis | diagnostic | res27: Mild liver disease | 1 | ||
| J615.11 | Read/OXMIS | Portal cirrhosis | diagnostic | res27: Mild liver disease | 1 | ||
| J615111 | Read/OXMIS | Postnecrotic cirrhosis of liver | diagnostic | res27: Mild liver disease | 1 | ||
| J615300 | Read/OXMIS | Diffuse nodular cirrhosis | diagnostic | res27: Mild liver disease | 1 | ||
| J615400 | Read/OXMIS | Fatty portal cirrhosis | diagnostic | res27: Mild liver disease | 1 | ||
| J615700 | Read/OXMIS | Cardiac portal cirrhosis | diagnostic | res27: Mild liver disease | 1 | ||
| J615A00 | Read/OXMIS | Pipe-stem portal cirrhosis | diagnostic | res27: Mild liver disease | 1 | ||
| J615B00 | Read/OXMIS | Toxic portal cirrhosis | diagnostic | res27: Mild liver disease | 1 | ||
| J615C00 | Read/OXMIS | Xanthomatous portal cirrhosis | diagnostic | res27: Mild liver disease | 1 | ||
| J615F00 | Read/OXMIS | Syphilitic portal cirrhosis | diagnostic | res27: Mild liver disease | 1 | ||
| J615y00 | Read/OXMIS | Portal cirrhosis unspecified | diagnostic | res27: Mild liver disease | 1 | ||
| J615z00 | Read/OXMIS | Non-alcoholic cirrhosis NOS | diagnostic | res27: Mild liver disease | 1 | ||
| J615z11 | Read/OXMIS | Macronodular cirrhosis of liver | diagnostic | res27: Mild liver disease | 1 | ||
| J615z12 | Read/OXMIS | Cryptogenic cirrhosis of liver | diagnostic | res27: Mild liver disease | 1 | ||
| J615z13 | Read/OXMIS | Cirrhosis of liver NOS | diagnostic | res27: Mild liver disease | 1 | ||
| J615z14 | Read/OXMIS | Laennec's cirrhosis; non-alcoholic | diagnostic | res27: Mild liver disease | 1 | ||
| J616.00 | Read/OXMIS | Biliary cirrhosis | diagnostic | res27: Mild liver disease | 1 | ||
| J616000 | Read/OXMIS | Primary biliary cirrhosis | diagnostic | res27: Mild liver disease | 1 | ||
| J616100 | Read/OXMIS | Secondary biliary cirrhosis | diagnostic | res27: Mild liver disease | 1 | ||
| J616z00 | Read/OXMIS | Biliary cirrhosis NOS | diagnostic | res27: Mild liver disease | 1 | ||
| J617000 | Read/OXMIS | Chronic alcoholic hepatitis | diagnostic | res27: Mild liver disease | 1 | ||
| J61y300 | Read/OXMIS | Portal fibrosis without cirrhosis | diagnostic | res27: Mild liver disease | 1 | ||
| J633.00 | Read/OXMIS | Hepatitis unspecified | diagnostic | res27: Mild liver disease | 1 | ||
| J635600 | Read/OXMIS | Toxic liver disease with fibrosis and cirrhosis of liver | diagnostic | res27: Mild liver disease | 1 | ||
| Jyu7100 | Read/OXMIS | [X]Other and unspecified cirrhosis of liver | diagnostic | res27: Mild liver disease | 1 |
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