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Research article:

Adaptation and validation of the Charlson Index for Read/OXMIS coded databases

Reference:

Nada F Khan, Rafael Perera, Stephen Harper, Peter W Rose(2010) Adaptation and validation of the Charlson Index for Read/OXMIS coded databases. BMC Family Practice, doi: 10.1186/1471-2296-11-1

Link to fulltext article
Abstract
Background The Charlson comorbidity index is widely used in ICD-9 administrative data, however, there is no translation for Read/OXMIS coded data despite increasing use of the General Practice Research Database (GPRD). Our main objective was to translate the Charlson index for use with Read/OXMIS coded data such as the GPRD and test its association with mortality. We also aimed to provide a version of the comorbidity index for other researchers using similar datasets. Methods Two clinicians translated the Charlson index into Read/OXMIS codes. We tested the association between comorbidity score and increased mortality in 146 441 patients from the GPRD using proportional hazards models. Results This Read/OXMIS translation of the Charlson index contains 3156 codes. Our validation showed a strong positive association between Charlson score and age. Cox proportional models show a positive increasing association with mortality and Charlson score. The discrimination of the logistic regression model for mortality was good (AUC = 0.853). Conclusion We have translated a commonly used comorbidity index into Read/OXMIS for use in UK primary care databases. The translated index showed a good discrimination in our study population. This is the first study to develop a co-morbidity index for use with the Read/OXMIS coding system and the GPRD. A copy of the co-morbidity index is provided for other researchers using similar databases.
Author for correspondence
Nada F Khan
Email for correspondence
nada.khan@dphpc.ox.ac.uk

Code list: res27: Renal disease

77 codes in list

Code Coding system Description Entity type List name Charlson score weight
14D1.00 Read/OXMIS H/O: nephritis diagnostic res27: Renal disease 2
1Z10.00 Read/OXMIS Chronic kidney disease stage 1 diagnostic res27: Renal disease 2
1Z11.00 Read/OXMIS Chronic kidney disease stage 2 diagnostic res27: Renal disease 2
1Z12.00 Read/OXMIS Chronic kidney disease stage 3 diagnostic res27: Renal disease 2
1Z13.00 Read/OXMIS Chronic kidney disease stage 4 diagnostic res27: Renal disease 2
1Z14.00 Read/OXMIS Chronic kidney disease stage 5 diagnostic res27: Renal disease 2
582 N Read/OXMIS CHRONIC NEPHRITIS diagnostic res27: Renal disease 2
583 A Read/OXMIS NEPHRITIS diagnostic res27: Renal disease 2
583 GC Read/OXMIS GLOMERULONEPHRITIS CHRONIC diagnostic res27: Renal disease 2
583 MA Read/OXMIS MESANGIOCAPILLARY GLOMERULONEPHRITIS diagnostic res27: Renal disease 2
583 MN Read/OXMIS NEPHROPATHY MEMBRANOUS diagnostic res27: Renal disease 2
583 MP Read/OXMIS MEMBRANOPROLIFERATIVE GLOMERULONEPHRITIS diagnostic res27: Renal disease 2
5930A Read/OXMIS OSTEODYSTROPHY AZOTAEMIC diagnostic res27: Renal disease 2
5930AR Read/OXMIS OSTEODYSTROPHY URAEMIC diagnostic res27: Renal disease 2
5930R Read/OXMIS OSTEODYSTROPHY RENAL diagnostic res27: Renal disease 2
5932A Read/OXMIS RENAL DISEASE diagnostic res27: Renal disease 2
5932E Read/OXMIS RENAL FAILURE diagnostic res27: Renal disease 2
5932EC Read/OXMIS CHRONIC RENAL FAILURE diagnostic res27: Renal disease 2
5932KH Read/OXMIS NEPHROPATHY HYPOKALAEMIC diagnostic res27: Renal disease 2
5932MN Read/OXMIS RENAL MEDULLARY NECROSIS diagnostic res27: Renal disease 2
7598A Read/OXMIS NEPHRITIS HEREDITARY diagnostic res27: Renal disease 2
K0...00 Read/OXMIS Nephritis; nephrosis and nephrotic syndrome diagnostic res27: Renal disease 2
K001.00 Read/OXMIS Acute nephritis with lesions of necrotising glomerulitis diagnostic res27: Renal disease 2
K012.00 Read/OXMIS Nephrotic syndrome??????? glomerulonephritis diagnostic res27: Renal disease 2
K019.00 Read/OXMIS Nephrotic syn;diffuse mesangiocapillary glomerulonephritis diagnostic res27: Renal disease 2
K02..00 Read/OXMIS Chronic glomerulonephritis diagnostic res27: Renal disease 2
K021.00 Read/OXMIS Chronic membranous glomerulonephritis diagnostic res27: Renal disease 2
K02..11 Read/OXMIS Nephritis - chronic diagnostic res27: Renal disease 2
K02..12 Read/OXMIS Nephropathy - chronic diagnostic res27: Renal disease 2
K022.00 Read/OXMIS Chronic membranoproliferative glomerulonephritis diagnostic res27: Renal disease 2
K023.00 Read/OXMIS Chronic rapidly progressive glomerulonephritis diagnostic res27: Renal disease 2
K02y000 Read/OXMIS Chronic glomerulonephritis diseases EC diagnostic res27: Renal disease 2
K02y200 Read/OXMIS Chronic focal glomerulonephritis diagnostic res27: Renal disease 2
K02y300 Read/OXMIS Chronic diffuse glomerulonephritis diagnostic res27: Renal disease 2
K02yz00 Read/OXMIS Other chronic glomerulonephritis NOS diagnostic res27: Renal disease 2
K02z.00 Read/OXMIS Chronic glomerulonephritis NOS diagnostic res27: Renal disease 2
K03..00 Read/OXMIS Nephritis and nephropathy unspecified diagnostic res27: Renal disease 2
K03..11 Read/OXMIS Nephritis and nephropathy unspecified diagnostic res27: Renal disease 2
K032.00 Read/OXMIS Membranoproliferative nephritis unspecified diagnostic res27: Renal disease 2
K032000 Read/OXMIS Focal membranoproliferative glomerulonephritis diagnostic res27: Renal disease 2
K032y00 Read/OXMIS Nephritis unsp membranoprolif glomerulonephritis lesion diagnostic res27: Renal disease 2
K032y13 Read/OXMIS Mesangioproliferative glomerulonephritis NEC diagnostic res27: Renal disease 2
K032y14 Read/OXMIS Mesangiocapillary glomerulonephritis NEC diagnostic res27: Renal disease 2
K032z00 Read/OXMIS Nephritis unsp????? glomerulonephritis lesion NOS diagnostic res27: Renal disease 2
K034.00 Read/OXMIS Renal cortical necrosis unspecified diagnostic res27: Renal disease 2
K035.00 Read/OXMIS Renal medullary necrosis unspecified diagnostic res27: Renal disease 2
K041.00 Read/OXMIS Acute renal cortical necrosis diagnostic res27: Renal disease 2
K042.00 Read/OXMIS Acute renal medullary necrosis diagnostic res27: Renal disease 2
K04y.00 Read/OXMIS Other acute renal failure diagnostic res27: Renal disease 2
K04z.00 Read/OXMIS Acute renal failure NOS diagnostic res27: Renal disease 2
K05..00 Read/OXMIS Chronic renal failure diagnostic res27: Renal disease 2
K050.00 Read/OXMIS End stage renal failure diagnostic res27: Renal disease 2
K06..00 Read/OXMIS Renal failure unspecified diagnostic res27: Renal disease 2
K060.11 Read/OXMIS Impaired renal function diagnostic res27: Renal disease 2
K080.00 Read/OXMIS Renal osteodystrophy diagnostic res27: Renal disease 2
K080000 Read/OXMIS Phosphate-losing tubular disorders diagnostic res27: Renal disease 2
K080100 Read/OXMIS Renal dwarfism diagnostic res27: Renal disease 2
K080200 Read/OXMIS Renal infantilism diagnostic res27: Renal disease 2
K080300 Read/OXMIS Renal rickets diagnostic res27: Renal disease 2
K080z00 Read/OXMIS Renal osteodystrophy NOS diagnostic res27: Renal disease 2
K081.00 Read/OXMIS Nephrogenic diabetes insipidus diagnostic res27: Renal disease 2
K08y000 Read/OXMIS Hypokalaemic nephropathy diagnostic res27: Renal disease 2
K08yz00 Read/OXMIS Other impaired renal function disorder NOS diagnostic res27: Renal disease 2
K08z.00 Read/OXMIS Impaired renal function disorder NOS diagnostic res27: Renal disease 2
K0A3200 Read/OXMIS Chron nephritic syndrom difuse membranous glomerulonephritis diagnostic res27: Renal disease 2
K0A3300 Read/OXMIS Chron neph syn difus mesangial prolifrtiv glomerulonephritis diagnostic res27: Renal disease 2
K0A3400 Read/OXMIS Chron neph syn difuse endocap prolifrativ glomerulonephritis diagnostic res27: Renal disease 2
K0A3500 Read/OXMIS Chronic neph syn difus mesangiocapillary glomerulonephritis diagnostic res27: Renal disease 2
K0A3700 Read/OXMIS Chronic nephritic syn diffuse crescentic glomerulonephritis diagnostic res27: Renal disease 2
K0A5500 Read/OXMIS [X]Heredtry nephrpthy NEC difus mesangiocapilry glomneph diagnostic res27: Renal disease 2
K100000 Read/OXMIS Chronic pyelonephritis without medullary necrosis diagnostic res27: Renal disease 2
K100100 Read/OXMIS Chronic pyelonephritis with medullary necrosis diagnostic res27: Renal disease 2
K101000 Read/OXMIS Acute pyelonephritis without medullary necrosis diagnostic res27: Renal disease 2
K101100 Read/OXMIS Acute pyelonephritis with medullary necrosis diagnostic res27: Renal disease 2
Kyu2.00 Read/OXMIS [X]Renal failure diagnostic res27: Renal disease 2
Kyu2000 Read/OXMIS [X]Other acute renal failure diagnostic res27: Renal disease 2
Kyu2100 Read/OXMIS [X]Other chronic renal failure diagnostic res27: Renal disease 2

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