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Research article:

Clinical management following self-harm in a UK-wide primary care cohort

Reference:

Matthew J Carr, Darren M Ashcroft, Evan Kontopantelis, David While, Yvonne Awenat, Jayne Cooper, Carolyn Chew-Graham, Nav Kapur, Roger T Webb(2016) Clinical management following self-harm in a UK-wide primary care cohort. Journal of Affective Disorders, doi:

Link to article
Abstract
Background: Little is known about the clinical management of patients in primary care following self-harm. Methods: A descriptive cohort study using data from 684 UK general practices that contributed to the Clinical Practice Research Datalink (CPRD) during 2001-2013. We identified 49,970 patients with a self-harm episode, 41,500 of whom had one complete year of follow-up. Results: Among those with complete follow-up, 26,065 (62.8%, 62.3-63.3) were prescribed psychotropic medication and 6,318 (15.2%, 14.9-15.6) were referred to mental health services; 4,105 (9.9%, CI 9.6-10.2) were medicated without an antecedent psychiatric diagnosis or referral, and 4,506 (10.9%, CI 10.6-11.2) had a diagnosis but were not subsequently medicated or referred. Patients registered at practices in the most deprived localities were 27.1% (CI 21.5-32.2) less likely to be referred than those in the least deprived. Despite a specifically flagged NICE ‘Do not do’ recommendation in 2011 against prescribing tricyclic antidepressants following self-harm because of their potentially lethal toxicity in overdose, 8.8% (CI 7.8-9.8) of individuals were issued a prescription in the subsequent year. The percentage prescribed Citalopram, an SSRI antidepressant with higher toxicity in overdose, fell sharply during 2012/2013 in the aftermath of a Medicines and Healthcare products Regulatory Agency (MHRA) safety alert issued in 2011. Conclusions: A relatively small percentage of these vulnerable patients are referred to mental health services, and reduced likelihood of referral in more deprived localities reflects a marked health inequality. National clinical guidelines have not yet been effective in reducing rates of tricyclic antidepressant prescribing for this high-risk group.
Author for correspondence
Matthew J Carr
Email for correspondence
matthew.carr@manchester.ac.uk

Code list: res36: Atypical APDs

173 codes in list

Code Coding system Description Entity type List name
00209021 Multilex Quetiapine 12.5mg/5ml oral solution drug res36: Atypical APDs
00337021 Multilex Asenapine 5mg sublingual tablets sugar free drug res36: Atypical APDs
00341021 Multilex Asenapine 10mg sublingual tablets sugar free drug res36: Atypical APDs
00411021 Multilex Amisulpride 25mg/5ml oral solution drug res36: Atypical APDs
00447021 Multilex Quetiapine 12.5mg/5ml oral suspension drug res36: Atypical APDs
00589021 Multilex Zalasta 5mg orodispersible tablets (Consilient Health Ltd) drug res36: Atypical APDs
00709021 Multilex Olanzapine 5mg orodispersible tablets sugar free drug res36: Atypical APDs
00711021 Multilex Olanzapine 5mg orodispersible tablets drug res36: Atypical APDs
00713021 Multilex Olanzapine 5mg oral lyophilisates sugar free drug res36: Atypical APDs
00715021 Multilex Olanzapine 10mg orodispersible tablets sugar free drug res36: Atypical APDs
00717021 Multilex Olanzapine 10mg orodispersible tablets drug res36: Atypical APDs
00719021 Multilex Olanzapine 10mg oral lyophilisates sugar free drug res36: Atypical APDs
00723021 Multilex Olanzapine 15mg orodispersible tablets sugar free drug res36: Atypical APDs
00725021 Multilex Olanzapine 15mg orodispersible tablets drug res36: Atypical APDs
00727021 Multilex Olanzapine 15mg oral lyophilisates sugar free drug res36: Atypical APDs
00729021 Multilex Olanzapine 20mg orodispersible tablets sugar free drug res36: Atypical APDs
00731021 Multilex Olanzapine 20mg orodispersible tablets drug res36: Atypical APDs
00733021 Multilex Olanzapine 20mg oral lyophilisates sugar free drug res36: Atypical APDs
03580020 Multilex Olanzapine 2.5mg tablets (Aspire Pharma Ltd) drug res36: Atypical APDs
10469020 Multilex Abilify 5mg tablets (Sigma Pharmaceuticals Plc) drug res36: Atypical APDs
13768020 Multilex Risperdal Consta 50mg powder and solvent for suspension for injection vials (Waymade Healthcare Plc) drug res36: Atypical APDs
33610020 Multilex Quetiapine 25mg/5ml oral solution drug res36: Atypical APDs
35008020 Multilex Amisulpride 12.5mg/5ml oral solution drug res36: Atypical APDs
35010020 Multilex Amisulpride 12.5mg/5ml oral suspension drug res36: Atypical APDs
36328020 Multilex Quetiapine 50mg/5ml oral suspension drug res36: Atypical APDs
36905020 Multilex Risperidone 125micrograms/5ml oral solution drug res36: Atypical APDs
42176020 Multilex Quetiapine 25mg tablets (Zentiva) drug res36: Atypical APDs
49437020 Multilex Risperdal 1mg tablets (Janssen-Cilag Ltd) drug res36: Atypical APDs
49438020 Multilex Risperdal 2mg tablets (Janssen-Cilag Ltd) drug res36: Atypical APDs
49439020 Multilex Risperdal 3mg tablets (Janssen-Cilag Ltd) drug res36: Atypical APDs
49489020 Multilex Risperidone 4mg tablets drug res36: Atypical APDs
49490020 Multilex Risperidone 1mg/ml oral solution sugar free drug res36: Atypical APDs
49491020 Multilex Risperidone 6mg tablets drug res36: Atypical APDs
50780020 Multilex Zotepine 25mg tablets drug res36: Atypical APDs
50781020 Multilex Zotepine 50mg tablets drug res36: Atypical APDs
50782020 Multilex Zotepine 100mg tablets drug res36: Atypical APDs
53727020 Multilex Risperidone 1mg tablets drug res36: Atypical APDs
53728020 Multilex Risperidone 2mg tablets drug res36: Atypical APDs
53729020 Multilex Risperidone 3mg tablets drug res36: Atypical APDs
55209020 Multilex Zoleptil 25 tablets (Movianto UK Ltd) drug res36: Atypical APDs
55210020 Multilex Zoleptil 50 tablets (Movianto UK Ltd) drug res36: Atypical APDs
55972020 Multilex Olanzapine 15mg Orodispersible tablet drug res36: Atypical APDs
58203020 Multilex Zyprexa 15mg tablets (Eli Lilly and Company Ltd) drug res36: Atypical APDs
59434020 Multilex Olanzapine 15mg tablets drug res36: Atypical APDs
65788020 Multilex Risperidone 50mg powder and solvent for suspension for injection vials drug res36: Atypical APDs
68217020 Multilex Amisulpride 50mg tablets (Zentiva) drug res36: Atypical APDs
68222020 Multilex Amisulpride 100mg tablets (Zentiva) drug res36: Atypical APDs
68224020 Multilex Amisulpride 200mg tablets (Zentiva) drug res36: Atypical APDs
69302020 Multilex Amisulpride 200mg tablets (A A H Pharmaceuticals Ltd) drug res36: Atypical APDs
72576020 Multilex Clozaril 25mg tablets (Novartis Pharmaceuticals UK Ltd) drug res36: Atypical APDs
72577020 Multilex Clozaril 100mg tablets (Novartis Pharmaceuticals UK Ltd) drug res36: Atypical APDs
72580020 Multilex Clozapine 25mg tablets drug res36: Atypical APDs
72581020 Multilex Clozapine 100mg tablets drug res36: Atypical APDs
73439020 Multilex Remoxipride 150mg capsule drug res36: Atypical APDs
73440020 Multilex Remoxipride 300mg capsule drug res36: Atypical APDs
73441020 Multilex Remoxipride 75mg capsule drug res36: Atypical APDs
73474020 Multilex Roxiam 150mg Capsule (AstraZeneca UK Ltd) drug res36: Atypical APDs
73475020 Multilex Roxiam 300mg Capsule (AstraZeneca UK Ltd) drug res36: Atypical APDs
73798020 Multilex Risperdal 4mg tablets (Janssen-Cilag Ltd) drug res36: Atypical APDs
73799020 Multilex Risperdal 1mg/ml liquid (Janssen-Cilag Ltd) drug res36: Atypical APDs
73800020 Multilex Risperdal 6mg tablets (Janssen-Cilag Ltd) drug res36: Atypical APDs
74786020 Multilex Risperidone 500microgram tablets (Actavis UK Ltd) drug res36: Atypical APDs
74841020 Multilex Risperidone 1mg tablets (Teva UK Ltd) drug res36: Atypical APDs
74927020 Multilex Risperidone 500microgram tablets (A A H Pharmaceuticals Ltd) drug res36: Atypical APDs
77501020 Multilex Risperdal Quicklet 2mg orodispersible tablets (Janssen-Cilag Ltd) drug res36: Atypical APDs
77550020 Multilex Risperdal Consta 37.5mg powder and solvent for suspension for injection vials (Janssen-Cilag Ltd) drug res36: Atypical APDs
77749020 Multilex Risperdal 500microgram tablets (Janssen-Cilag Ltd) drug res36: Atypical APDs
77912020 Multilex Risperidone 500microgram tablets drug res36: Atypical APDs
78753020 Multilex Risperdal Consta 25mg powder and solvent for suspension for injection vials (Janssen-Cilag Ltd) drug res36: Atypical APDs
78912020 Multilex Zyprexa 5mg Velotabs (Eli Lilly and Company Ltd) drug res36: Atypical APDs
78913020 Multilex Zyprexa 10mg Velotabs (Eli Lilly and Company Ltd) drug res36: Atypical APDs
79348020 Multilex Solian 100mg/ml oral solution (Sanofi) drug res36: Atypical APDs
79476020 Multilex Risperidone 1mg orodispersible tablets sugar free drug res36: Atypical APDs
79499020 Multilex Zyprexa 15mg Velotabs (Eli Lilly and Company Ltd) drug res36: Atypical APDs
80139020 Multilex Amisulpride 100mg tablets drug res36: Atypical APDs
80154020 Multilex Solian 100 tablets (Sanofi) drug res36: Atypical APDs
81008020 Multilex Zyprexa 2.5mg tablets (Eli Lilly and Company Ltd) drug res36: Atypical APDs
81014020 Multilex Olanzapine 2.5mg tablets drug res36: Atypical APDs
81015020 Multilex Olanzapine 5mg Orodispersible tablet drug res36: Atypical APDs
81016020 Multilex Olanzapine 10mg Orodispersible tablet drug res36: Atypical APDs
81543020 Multilex Risperidone 2mg orodispersible tablets sugar free drug res36: Atypical APDs
81545020 Multilex Risperdal Quicklet 1mg orodispersible tablets (Janssen-Cilag Ltd) drug res36: Atypical APDs
81945020 Multilex Amisulpride 100mg/ml oral solution sugar free drug res36: Atypical APDs
82616020 Multilex Risperdal Consta 50mg powder and solvent for suspension for injection vials (Janssen-Cilag Ltd) drug res36: Atypical APDs
82827020 Multilex Sertindole 4mg tablets drug res36: Atypical APDs
82828020 Multilex Sertindole 12mg tablets drug res36: Atypical APDs
82829020 Multilex Sertindole 16mg tablets drug res36: Atypical APDs
82831020 Multilex Sertindole 20mg tablets drug res36: Atypical APDs
82835020 Multilex Serdolect 4mg tablets (Lundbeck Ltd) drug res36: Atypical APDs
82836020 Multilex Serdolect 12mg tablets (Lundbeck Ltd) drug res36: Atypical APDs
82837020 Multilex Serdolect 16mg tablets (Lundbeck Ltd) drug res36: Atypical APDs
83397020 Multilex Zyprexa 5mg tablets (Eli Lilly and Company Ltd) drug res36: Atypical APDs
83398020 Multilex Zyprexa 7.5mg tablets (Eli Lilly and Company Ltd) drug res36: Atypical APDs
83399020 Multilex Zyprexa 10mg tablets (Eli Lilly and Company Ltd) drug res36: Atypical APDs
83403020 Multilex Olanzapine 5mg tablets drug res36: Atypical APDs
83404020 Multilex Olanzapine 7.5mg tablets drug res36: Atypical APDs
83405020 Multilex Olanzapine 10mg tablets drug res36: Atypical APDs
84528020 Multilex Roxiam ir 75mg Capsule (AstraZeneca UK Ltd) drug res36: Atypical APDs
85202020 Multilex Quetiapine Starter Pack drug res36: Atypical APDs
85203020 Multilex Quetiapine 25mg tablets drug res36: Atypical APDs
85204020 Multilex Quetiapine 100mg tablets drug res36: Atypical APDs
85206020 Multilex Quetiapine 200mg tablets drug res36: Atypical APDs
85207020 Multilex Quetiapine 150mg tablets drug res36: Atypical APDs
85212020 Multilex Seroquel 25mg tablets (AstraZeneca UK Ltd) drug res36: Atypical APDs
85213020 Multilex Seroquel 100mg tablets (AstraZeneca UK Ltd) drug res36: Atypical APDs
85215020 Multilex Seroquel 200mg tablets (AstraZeneca UK Ltd) drug res36: Atypical APDs
85216020 Multilex Seroquel 150mg tablets (AstraZeneca UK Ltd) drug res36: Atypical APDs
85992020 Multilex Amisulpride 50mg tablets drug res36: Atypical APDs
85993020 Multilex Amisulpride 200mg tablets drug res36: Atypical APDs
85994020 Multilex Amisulpride 400mg tablets drug res36: Atypical APDs
85999020 Multilex Solian 50 tablets (Sanofi) drug res36: Atypical APDs
86000020 Multilex Solian 200 tablets (Sanofi) drug res36: Atypical APDs
86001020 Multilex Solian 400 tablets (Sanofi) drug res36: Atypical APDs
86494020 Multilex Risperidone 25mg powder and solvent for suspension for injection vials drug res36: Atypical APDs
86496020 Multilex Risperidone 37.5mg powder and solvent for suspension for injection vials drug res36: Atypical APDs
87045020 Multilex Quetiapine 300mg tablets drug res36: Atypical APDs
87047020 Multilex Seroquel 300mg tablets (AstraZeneca UK Ltd) drug res36: Atypical APDs
87556020 Multilex Olanzapine 10mg powder for solution for injection vials drug res36: Atypical APDs
87558020 Multilex Zyprexa 10mg powder for solution for injection vials (Eli Lilly and Company Ltd) drug res36: Atypical APDs
87944020 Multilex Aripiprazole 10mg tablets drug res36: Atypical APDs
87946020 Multilex Aripiprazole 15mg tablets drug res36: Atypical APDs
87948020 Multilex Aripiprazole 30mg tablets drug res36: Atypical APDs
87950020 Multilex Abilify 10mg tablets (Otsuka Pharmaceuticals (U.K.) Ltd) drug res36: Atypical APDs
87952020 Multilex Abilify 15mg tablets (Otsuka Pharmaceuticals (U.K.) Ltd) drug res36: Atypical APDs
87954020 Multilex Abilify 30mg tablets (Otsuka Pharmaceuticals (U.K.) Ltd) drug res36: Atypical APDs
88167020 Multilex Denzapine 25mg tablets (Britannia Pharmaceuticals Ltd) drug res36: Atypical APDs
88169020 Multilex Denzapine 100mg tablets (Britannia Pharmaceuticals Ltd) drug res36: Atypical APDs
88666020 Multilex Aripiprazole 5mg tablets drug res36: Atypical APDs
88668020 Multilex Abilify 5mg tablets (Otsuka Pharmaceuticals (U.K.) Ltd) drug res36: Atypical APDs
88804020 Multilex Zaponex 25mg tablets (Teva UK Ltd) drug res36: Atypical APDs
88806020 Multilex Zaponex 100mg tablets (Teva UK Ltd) drug res36: Atypical APDs
88875020 Multilex Risperidone 500microgram orodispersible tablets sugar free drug res36: Atypical APDs
88877020 Multilex Risperdal Quicklet 500microgram orodispersible tablets (Janssen-Cilag Ltd) drug res36: Atypical APDs
89950020 Multilex Amisulpride 25mg/5ml oral suspension drug res36: Atypical APDs
90165020 Multilex Olanzapine 20mg Orodispersible tablet drug res36: Atypical APDs
90167020 Multilex Zyprexa 20mg Velotabs (Eli Lilly and Company Ltd) drug res36: Atypical APDs
91139020 Multilex Aripiprazole 10mg orodispersible tablets sugar free drug res36: Atypical APDs
91141020 Multilex Aripiprazole 15mg orodispersible tablets sugar free drug res36: Atypical APDs
91143020 Multilex Aripiprazole 1mg/ml oral solution drug res36: Atypical APDs
91145020 Multilex Abilify 10mg orodispersible tablets (Otsuka Pharmaceuticals (U.K.) Ltd) drug res36: Atypical APDs
91147020 Multilex Abilify 15mg orodispersible tablets (Otsuka Pharmaceuticals (U.K.) Ltd) drug res36: Atypical APDs
91149020 Multilex Abilify 1mg/ml oral solution (Otsuka Pharmaceuticals (U.K.) Ltd) drug res36: Atypical APDs
92053020 Multilex Olanzapine 20mg tablets drug res36: Atypical APDs
92055020 Multilex Zyprexa 20mg tablets (Eli Lilly and Company Ltd) drug res36: Atypical APDs
92717020 Multilex Risperidone 3mg orodispersible tablets sugar free drug res36: Atypical APDs
92721020 Multilex Risperidone 4mg orodispersible tablets sugar free drug res36: Atypical APDs
92723020 Multilex Risperdal Quicklet 3mg orodispersible tablets (Janssen-Cilag Ltd) drug res36: Atypical APDs
92725020 Multilex Risperdal Quicklet 4mg orodispersible tablets (Janssen-Cilag Ltd) drug res36: Atypical APDs
93739020 Multilex Paliperidone 3mg modified-release tablets drug res36: Atypical APDs
93741020 Multilex Paliperidone 6mg modified-release tablets drug res36: Atypical APDs
93743020 Multilex Paliperidone 9mg modified-release tablets drug res36: Atypical APDs
93747020 Multilex Invega 6mg modified-release tablets (Janssen-Cilag Ltd) drug res36: Atypical APDs
94787020 Multilex Quetiapine 50mg modified-release tablets drug res36: Atypical APDs
94789020 Multilex Quetiapine 200mg modified-release tablets drug res36: Atypical APDs
94791020 Multilex Quetiapine 300mg modified-release tablets drug res36: Atypical APDs
94793020 Multilex Quetiapine 400mg modified-release tablets drug res36: Atypical APDs
94971020 Multilex Aripiprazole 9.75mg/1.3ml solution for injection vials drug res36: Atypical APDs
94973020 Multilex Abilify 9.75mg/1.3ml solution for injection vials (Otsuka Pharmaceuticals (U.K.) Ltd) drug res36: Atypical APDs
95787020 Multilex Seroquel XL 50mg tablets (AstraZeneca UK Ltd) drug res36: Atypical APDs
95789020 Multilex Seroquel XL 200mg tablets (AstraZeneca UK Ltd) drug res36: Atypical APDs
95791020 Multilex Seroquel XL 300mg tablets (AstraZeneca UK Ltd) drug res36: Atypical APDs
95793020 Multilex Seroquel XL 400mg tablets (AstraZeneca UK Ltd) drug res36: Atypical APDs
97145020 Multilex Clozapine 50mg tablets drug res36: Atypical APDs
97147020 Multilex Denzapine 50mg tablets (Britannia Pharmaceuticals Ltd) drug res36: Atypical APDs
97149020 Multilex Clozapine 200mg tablets drug res36: Atypical APDs
97151020 Multilex Denzapine 200mg tablets (Britannia Pharmaceuticals Ltd) drug res36: Atypical APDs
97153020 Multilex Clozapine 50mg/ml oral suspension sugar free drug res36: Atypical APDs
97155020 Multilex Denzapine 50mg/ml oral suspension (Britannia Pharmaceuticals Ltd) drug res36: Atypical APDs
97203020 Multilex Quetiapine 100mg/5ml oral solution drug res36: Atypical APDs
97205020 Multilex Quetiapine 100mg/5ml oral suspension drug res36: Atypical APDs
98873020 Multilex Quetiapine 150mg modified-release tablets drug res36: Atypical APDs
98875020 Multilex Seroquel XL 150mg tablets (AstraZeneca UK Ltd) drug res36: Atypical APDs
99745020 Multilex Quetiapine 25mg/5ml oral suspension drug res36: Atypical APDs

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