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Research article:

Clinical management following self-harm in a UK-wide primary care cohort

Reference:

Matthew J Carr, Darren M Ashcroft, Evan Kontopantelis, David While, Yvonne Awenat, Jayne Cooper, Carolyn Chew-Graham, Nav Kapur, Roger T Webb(2016) Clinical management following self-harm in a UK-wide primary care cohort. Journal of Affective Disorders, doi:

Link to article
Abstract
Background: Little is known about the clinical management of patients in primary care following self-harm. Methods: A descriptive cohort study using data from 684 UK general practices that contributed to the Clinical Practice Research Datalink (CPRD) during 2001-2013. We identified 49,970 patients with a self-harm episode, 41,500 of whom had one complete year of follow-up. Results: Among those with complete follow-up, 26,065 (62.8%, 62.3-63.3) were prescribed psychotropic medication and 6,318 (15.2%, 14.9-15.6) were referred to mental health services; 4,105 (9.9%, CI 9.6-10.2) were medicated without an antecedent psychiatric diagnosis or referral, and 4,506 (10.9%, CI 10.6-11.2) had a diagnosis but were not subsequently medicated or referred. Patients registered at practices in the most deprived localities were 27.1% (CI 21.5-32.2) less likely to be referred than those in the least deprived. Despite a specifically flagged NICE ‘Do not do’ recommendation in 2011 against prescribing tricyclic antidepressants following self-harm because of their potentially lethal toxicity in overdose, 8.8% (CI 7.8-9.8) of individuals were issued a prescription in the subsequent year. The percentage prescribed Citalopram, an SSRI antidepressant with higher toxicity in overdose, fell sharply during 2012/2013 in the aftermath of a Medicines and Healthcare products Regulatory Agency (MHRA) safety alert issued in 2011. Conclusions: A relatively small percentage of these vulnerable patients are referred to mental health services, and reduced likelihood of referral in more deprived localities reflects a marked health inequality. National clinical guidelines have not yet been effective in reducing rates of tricyclic antidepressant prescribing for this high-risk group.
Author for correspondence
Matthew J Carr
Email for correspondence
matthew.carr@manchester.ac.uk

Code list: res36: Depot APDs

56 codes in list

Code Coding system Description Entity type List name
48900020 Multilex Depixol -conc 100mg/ml Injection (Lundbeck Ltd) drug res36: Depot APDs
50445020 Multilex Modecate 25mg/ml Injection (Sanofi-Synthelabo Ltd) drug res36: Depot APDs
53027020 Multilex Clopixol 200mg/ml Oily injection (Lundbeck Ltd) drug res36: Depot APDs
53030020 Multilex Depixol 20mg/ml Injection (Lundbeck Ltd) drug res36: Depot APDs
53031020 Multilex Depixol 40mg/2ml solution for injection ampoules (Lundbeck Ltd) drug res36: Depot APDs
53053020 Multilex Modecate concentrate 100mg/ml Injection (Sanofi-Synthelabo Ltd) drug res36: Depot APDs
53586020 Multilex Piportil 50mg/ml Depot injection (JHC Healthcare Ltd) drug res36: Depot APDs
57938020 Multilex Depixol Low Volume 200mg/1ml solution for injection ampoules (Lundbeck Ltd) drug res36: Depot APDs
58509020 Multilex Haldol decanoate 50mg/1ml solution for injection ampoules (Janssen-Cilag Ltd) drug res36: Depot APDs
58510020 Multilex Haldol decanoate 100mg/1ml solution for injection ampoules (Janssen-Cilag Ltd) drug res36: Depot APDs
61027020 Multilex Fluphenazine decanoate 25mg/1ml solution for injection ampoules (Hospira UK Ltd) drug res36: Depot APDs
61511020 Multilex Zuclopenthixol decanoate 200mg/ml oily injection drug res36: Depot APDs
61512020 Multilex Zuclopenthixol decanoate 500mg/1ml solution for injection ampoules drug res36: Depot APDs
62032020 Multilex Flupentixol decanoate 20mg/ml Injection drug res36: Depot APDs
62033020 Multilex Flupentixol decanoate 100mg/ml Injection drug res36: Depot APDs
62034020 Multilex Flupentixol 200mg/1ml solution for injection ampoules drug res36: Depot APDs
62048020 Multilex Fluphenazine decanoate 25mg/ml Injection drug res36: Depot APDs
62049020 Multilex Fluphenazine decanoate 100mg/ml Injection drug res36: Depot APDs
62954020 Multilex Fluphenazine decanoate 25mg/ml Injection (Antigen Pharmaceuticals) drug res36: Depot APDs
63123020 Multilex Haloperidol decanoate 50mg/1ml solution for injection ampoules drug res36: Depot APDs
63124020 Multilex Haloperidol decanoate 100mg/1ml solution for injection ampoules drug res36: Depot APDs
65842020 Multilex Pipotiazine palmitate 50mg/ml depot injection drug res36: Depot APDs
67405020 Multilex Clopixol Conc 500mg/1ml solution for injection ampoules (Lundbeck Ltd) drug res36: Depot APDs
68096020 Multilex Flupentixol 40mg/2ml solution for injection ampoules drug res36: Depot APDs
89970020 Multilex Flupentixol 50mg/0.5ml solution for injection ampoules drug res36: Depot APDs
89972020 Multilex Flupentixol 100mg/1ml solution for injection ampoules drug res36: Depot APDs
89974020 Multilex Depixol Conc 50mg/0.5ml solution for injection ampoules (Lundbeck Ltd) drug res36: Depot APDs
89976020 Multilex Depixol Conc 100mg/1ml solution for injection ampoules (Lundbeck Ltd) drug res36: Depot APDs
91582020 Multilex Flupentixol 20mg/1ml solution for injection ampoules drug res36: Depot APDs
91584020 Multilex Depixol 20mg/1ml solution for injection ampoules (Lundbeck Ltd) drug res36: Depot APDs
91592020 Multilex Zuclopenthixol decanoate 200mg/1ml solution for injection ampoules drug res36: Depot APDs
91596020 Multilex Clopixol 200mg/1ml solution for injection ampoules (Lundbeck Ltd) drug res36: Depot APDs
91981020 Multilex Pipotiazine 50mg/1ml solution for injection ampoules drug res36: Depot APDs
91985020 Multilex Pipotiazine 100mg/2ml solution for injection ampoules drug res36: Depot APDs
91987020 Multilex Piportil Depot 50mg/1ml solution for injection ampoules (Sanofi) drug res36: Depot APDs
91989020 Multilex Piportil Depot 100mg/2ml solution for injection ampoules (Sanofi) drug res36: Depot APDs
92200020 Multilex Fluphenazine decanoate 12.5mg/0.5ml solution for injection ampoules drug res36: Depot APDs
92202020 Multilex Fluphenazine decanoate 25mg/1ml solution for injection ampoules drug res36: Depot APDs
92204020 Multilex Fluphenazine decanoate 50mg/2ml solution for injection ampoules drug res36: Depot APDs
92206020 Multilex Modecate 12.5mg/0.5ml solution for injection ampoules (Sanofi) drug res36: Depot APDs
92208020 Multilex Modecate 25mg/1ml solution for injection ampoules (Sanofi) drug res36: Depot APDs
92210020 Multilex Modecate 50mg/2ml solution for injection ampoules (Sanofi) drug res36: Depot APDs
92212020 Multilex Fluphenazine decanoate 50mg/0.5ml solution for injection ampoules drug res36: Depot APDs
92214020 Multilex Fluphenazine decanoate 100mg/1ml solution for injection ampoules drug res36: Depot APDs
92216020 Multilex Modecate Concentrate 50mg/0.5ml solution for injection ampoules (Sanofi) drug res36: Depot APDs
92218020 Multilex Modecate Concentrate 100mg/1ml solution for injection ampoules (Sanofi) drug res36: Depot APDs
98278020 Multilex Olanzapine embonate 210mg powder and solvent for suspension for injection vials drug res36: Depot APDs
98329020 Multilex Olanzapine embonate 300mg powder and solvent for suspension for injection vials drug res36: Depot APDs
99841020 Multilex Paliperidone 50mg/0.5ml suspension for injection pre-filled syringes drug res36: Depot APDs
99843020 Multilex Paliperidone 75mg/0.75ml suspension for injection pre-filled syringes drug res36: Depot APDs
99845020 Multilex Paliperidone 100mg/1ml suspension for injection pre-filled syringes drug res36: Depot APDs
99847020 Multilex Paliperidone 150mg/1.5ml suspension for injection pre-filled syringes drug res36: Depot APDs
99849020 Multilex Xeplion 50mg/0.5ml suspension for injection pre-filled syringes (Janssen-Cilag Ltd) drug res36: Depot APDs
99851020 Multilex Xeplion 75mg/0.75ml suspension for injection pre-filled syringes (Janssen-Cilag Ltd) drug res36: Depot APDs
99853020 Multilex Xeplion 100mg/1ml suspension for injection pre-filled syringes (Janssen-Cilag Ltd) drug res36: Depot APDs
99855020 Multilex Xeplion 150mg/1.5ml suspension for injection pre-filled syringes (Janssen-Cilag Ltd) drug res36: Depot APDs

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