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Research article:

Clinical management following self-harm in a UK-wide primary care cohort

Reference:

Matthew J Carr, Darren M Ashcroft, Evan Kontopantelis, David While, Yvonne Awenat, Jayne Cooper, Carolyn Chew-Graham, Nav Kapur, Roger T Webb(2016) Clinical management following self-harm in a UK-wide primary care cohort. Journal of Affective Disorders, doi:

Link to article
Abstract
Background: Little is known about the clinical management of patients in primary care following self-harm. Methods: A descriptive cohort study using data from 684 UK general practices that contributed to the Clinical Practice Research Datalink (CPRD) during 2001-2013. We identified 49,970 patients with a self-harm episode, 41,500 of whom had one complete year of follow-up. Results: Among those with complete follow-up, 26,065 (62.8%, 62.3-63.3) were prescribed psychotropic medication and 6,318 (15.2%, 14.9-15.6) were referred to mental health services; 4,105 (9.9%, CI 9.6-10.2) were medicated without an antecedent psychiatric diagnosis or referral, and 4,506 (10.9%, CI 10.6-11.2) had a diagnosis but were not subsequently medicated or referred. Patients registered at practices in the most deprived localities were 27.1% (CI 21.5-32.2) less likely to be referred than those in the least deprived. Despite a specifically flagged NICE ‘Do not do’ recommendation in 2011 against prescribing tricyclic antidepressants following self-harm because of their potentially lethal toxicity in overdose, 8.8% (CI 7.8-9.8) of individuals were issued a prescription in the subsequent year. The percentage prescribed Citalopram, an SSRI antidepressant with higher toxicity in overdose, fell sharply during 2012/2013 in the aftermath of a Medicines and Healthcare products Regulatory Agency (MHRA) safety alert issued in 2011. Conclusions: A relatively small percentage of these vulnerable patients are referred to mental health services, and reduced likelihood of referral in more deprived localities reflects a marked health inequality. National clinical guidelines have not yet been effective in reducing rates of tricyclic antidepressant prescribing for this high-risk group.
Author for correspondence
Matthew J Carr
Email for correspondence
matthew.carr@manchester.ac.uk

Code list: res36: SSRI ADDs

120 codes in list

Code Coding system Description Entity type List name
03837020 Multilex Prozac 20mg capsules (Lexon (UK) Ltd) drug res36: SSRI ADDs
03985020 Multilex Citalopram 20mg tablets (Alliance Healthcare (Distribution) Ltd) drug res36: SSRI ADDs
03997020 Multilex Citalopram 20mg tablets (Bristol Laboratories Ltd) drug res36: SSRI ADDs
04003020 Multilex Citalopram 10mg tablets (Kent Pharmaceuticals Ltd) drug res36: SSRI ADDs
04004020 Multilex Citalopram 10mg tablets (Alliance Healthcare (Distribution) Ltd) drug res36: SSRI ADDs
04007020 Multilex Citalopram 10mg tablets (Arrow Generics Ltd) drug res36: SSRI ADDs
04011020 Multilex Citalopram 10mg tablets (Bristol Laboratories Ltd) drug res36: SSRI ADDs
20738020 Multilex Sertraline 100mg/5ml oral suspension drug res36: SSRI ADDs
33816020 Multilex Sertraline 25mg/5ml oral suspension drug res36: SSRI ADDs
38526020 Multilex Citalopram 20mg tablets (DE Pharmaceuticals) drug res36: SSRI ADDs
49680020 Multilex Felicium 20mg capsules (Opus Pharmaceuticals Ltd) drug res36: SSRI ADDs
53823020 Multilex Escitalopram 20mg tablets drug res36: SSRI ADDs
55602020 Multilex Cipralex 20mg tablets (Lundbeck Ltd) drug res36: SSRI ADDs
60735020 Multilex Fluvoxamine 100mg tablets (IVAX Pharmaceuticals UK Ltd) drug res36: SSRI ADDs
61084020 Multilex Fluoxetine 20mg capsules (A A H Pharmaceuticals Ltd) drug res36: SSRI ADDs
61167020 Multilex Fluoxetine 20mg capsules (IVAX Pharmaceuticals UK Ltd) drug res36: SSRI ADDs
61319020 Multilex Fluoxetine 20mg capsules (Teva UK Ltd) drug res36: SSRI ADDs
61387020 Multilex Fluoxetine 20mg capsules (Sandoz Ltd) drug res36: SSRI ADDs
61409020 Multilex Fluoxetine 20mg capsules (Generics (UK) Ltd) drug res36: SSRI ADDs
61420020 Multilex Fluoxetine 20mg capsules (Niche Generics Ltd) drug res36: SSRI ADDs
61439020 Multilex Fluoxetine 20mg capsules (Wockhardt UK Ltd) drug res36: SSRI ADDs
61452020 Multilex Fluoxetine 20mg capsules (Actavis UK Ltd) drug res36: SSRI ADDs
61455020 Multilex Fluoxetine 20mg capsules (Genus Pharmaceuticals Ltd) drug res36: SSRI ADDs
61616020 Multilex Fluoxetine 20mg capsules (Zentiva) drug res36: SSRI ADDs
62069020 Multilex Fluvoxamine 50mg tablets drug res36: SSRI ADDs
62070020 Multilex Fluvoxamine 100mg tablets drug res36: SSRI ADDs
62073020 Multilex Faverin 50mg tablets (Abbott Healthcare Products Ltd) drug res36: SSRI ADDs
62074020 Multilex Faverin 100mg tablets (Abbott Healthcare Products Ltd) drug res36: SSRI ADDs
62693020 Multilex Fluvoxamine 100mg tablets (Actavis UK Ltd) drug res36: SSRI ADDs
62975020 Multilex Fluoxetine 20mg capsules (Fannin UK Ltd) drug res36: SSRI ADDs
63016020 Multilex Fluoxetine 20mg capsules (Ranbaxy (UK) Ltd) drug res36: SSRI ADDs
63703020 Multilex Paroxetine 20mg tablets (IVAX Pharmaceuticals UK Ltd) drug res36: SSRI ADDs
64692020 Multilex Fluoxetine 20mg/5ml oral solution (Teva UK Ltd) drug res36: SSRI ADDs
64717020 Multilex Fluoxetine 20mg/5ml oral solution (A A H Pharmaceuticals Ltd) drug res36: SSRI ADDs
65125020 Multilex Citalopram 10mg tablets (Sandoz Ltd) drug res36: SSRI ADDs
65128020 Multilex Citalopram 20mg tablets (Sandoz Ltd) drug res36: SSRI ADDs
65131020 Multilex Citalopram 40mg tablets (Sandoz Ltd) drug res36: SSRI ADDs
65254020 Multilex Citalopram 10mg Tablet (Neo Laboratories Ltd) drug res36: SSRI ADDs
65257020 Multilex Citalopram 20mg Tablet (Neo Laboratories Ltd) drug res36: SSRI ADDs
65262020 Multilex Citalopram 40mg Tablet (Neo Laboratories Ltd) drug res36: SSRI ADDs
65376020 Multilex Citalopram 10mg tablets (A A H Pharmaceuticals Ltd) drug res36: SSRI ADDs
65381020 Multilex Citalopram 20mg tablets (A A H Pharmaceuticals Ltd) drug res36: SSRI ADDs
65386020 Multilex Citalopram 40mg tablets (A A H Pharmaceuticals Ltd) drug res36: SSRI ADDs
65464020 Multilex Fluoxetine 60mg capsules (Generics (UK) Ltd) drug res36: SSRI ADDs
65578020 Multilex Paroxetine 20mg tablets (Actavis UK Ltd) drug res36: SSRI ADDs
66129020 Multilex Fluoxetine 20mg/5ml oral solution (IVAX Pharmaceuticals UK Ltd) drug res36: SSRI ADDs
66149020 Multilex Citalopram 10mg tablets (Zentiva) drug res36: SSRI ADDs
66152020 Multilex Citalopram 20mg tablets (Zentiva) drug res36: SSRI ADDs
66160020 Multilex Citalopram 40mg tablets (Zentiva) drug res36: SSRI ADDs
66244020 Multilex Fluvoxamine 100mg tablets (A A H Pharmaceuticals Ltd) drug res36: SSRI ADDs
66273020 Multilex Fluoxetine 20mg capsules (Tillomed Laboratories Ltd) drug res36: SSRI ADDs
66399020 Multilex Paroxetine 20mg tablets (Generics (UK) Ltd) drug res36: SSRI ADDs
66451020 Multilex Citalopram 10mg tablets (Generics (UK) Ltd) drug res36: SSRI ADDs
66454020 Multilex Citalopram 20mg tablets (Generics (UK) Ltd) drug res36: SSRI ADDs
66459020 Multilex Citalopram 40mg tablets (Generics (UK) Ltd) drug res36: SSRI ADDs
66464020 Multilex Paroxetine 20mg tablets (A A H Pharmaceuticals Ltd) drug res36: SSRI ADDs
66680020 Multilex Citalopram 10mg tablets (Niche Generics Ltd) drug res36: SSRI ADDs
66685020 Multilex Citalopram 20mg tablets (Niche Generics Ltd) drug res36: SSRI ADDs
66688020 Multilex Citalopram 40mg tablets (Niche Generics Ltd) drug res36: SSRI ADDs
67575020 Multilex Paroxetine 30mg tablets (Actavis UK Ltd) drug res36: SSRI ADDs
67650020 Multilex Paroxetine 30mg tablets (A A H Pharmaceuticals Ltd) drug res36: SSRI ADDs
67890020 Multilex Citalopram 10mg tablets (Actavis UK Ltd) drug res36: SSRI ADDs
67893020 Multilex Citalopram 20mg tablets (Actavis UK Ltd) drug res36: SSRI ADDs
67898020 Multilex Citalopram 40mg tablets (Actavis UK Ltd) drug res36: SSRI ADDs
68042020 Multilex Citalopram 10mg tablets (Teva UK Ltd) drug res36: SSRI ADDs
68045020 Multilex Citalopram 20mg tablets (Teva UK Ltd) drug res36: SSRI ADDs
68049020 Multilex Citalopram 40mg tablets (Teva UK Ltd) drug res36: SSRI ADDs
69506020 Multilex Prozac 20mg capsules (Eli Lilly and Company Ltd) drug res36: SSRI ADDs
69507020 Multilex Prozac 20mg/5ml liquid (Eli Lilly and Company Ltd) drug res36: SSRI ADDs
69508020 Multilex Prozac 60mg capsules (Eli Lilly and Company Ltd) drug res36: SSRI ADDs
69654020 Multilex Fluoxetine 20mg capsules drug res36: SSRI ADDs
69655020 Multilex Fluoxetine 20mg/5ml oral solution drug res36: SSRI ADDs
69656020 Multilex Fluoxetine 60mg capsules drug res36: SSRI ADDs
69754020 Multilex Paroxetine 20mg tablets (Genus Pharmaceuticals Ltd) drug res36: SSRI ADDs
71214020 Multilex Citalopram 10mg tablets (PLIVA Pharma Ltd) drug res36: SSRI ADDs
71225020 Multilex Citalopram 10mg tablets (IVAX Pharmaceuticals UK Ltd) drug res36: SSRI ADDs
71373020 Multilex Citalopram 10mg tablets (Almus Pharmaceuticals Ltd) drug res36: SSRI ADDs
71376020 Multilex Citalopram 20mg tablets (Almus Pharmaceuticals Ltd) drug res36: SSRI ADDs
71725020 Multilex Sertraline 50mg tablets (A A H Pharmaceuticals Ltd) drug res36: SSRI ADDs
72034020 Multilex Sertraline 50mg tablets (Actavis UK Ltd) drug res36: SSRI ADDs
72095020 Multilex Sertraline 100mg tablets (Teva UK Ltd) drug res36: SSRI ADDs
72932020 Multilex Paroxetine 20mg tablets drug res36: SSRI ADDs
72933020 Multilex Paroxetine 30mg tablets drug res36: SSRI ADDs
72934020 Multilex Paroxetine 10mg/5ml oral suspension sugar free drug res36: SSRI ADDs
72937020 Multilex Seroxat 20mg tablets (GlaxoSmithKline UK Ltd) drug res36: SSRI ADDs
72938020 Multilex Seroxat 30mg tablets (GlaxoSmithKline UK Ltd) drug res36: SSRI ADDs
72939020 Multilex Seroxat 20mg/10ml liquid (GlaxoSmithKline UK Ltd) drug res36: SSRI ADDs
74046020 Multilex Lustral 50mg tablets (Pfizer Ltd) drug res36: SSRI ADDs
74047020 Multilex Lustral 100mg tablets (Pfizer Ltd) drug res36: SSRI ADDs
74050020 Multilex Sertraline 50mg tablets drug res36: SSRI ADDs
74051020 Multilex Sertraline 100mg tablets drug res36: SSRI ADDs
74425020 Multilex Fluoxetine 20mg Capsule (Milpharm Ltd) drug res36: SSRI ADDs
75620020 Multilex Sertraline 50mg tablets (Almus Pharmaceuticals Ltd) drug res36: SSRI ADDs
77306020 Multilex Citalopram 40mg/ml oral drops sugar free drug res36: SSRI ADDs
77312020 Multilex Cipramil 40mg/ml drops (Lundbeck Ltd) drug res36: SSRI ADDs
78768020 Multilex Escitalopram 10mg tablets drug res36: SSRI ADDs
79420020 Multilex Cipramil 20mg tablets (Lundbeck Ltd) drug res36: SSRI ADDs
79421020 Multilex Cipramil 10mg tablets (Lundbeck Ltd) drug res36: SSRI ADDs
79422020 Multilex Cipramil 40mg tablets (Lundbeck Ltd) drug res36: SSRI ADDs
79462020 Multilex Citalopram 20mg tablets drug res36: SSRI ADDs
79463020 Multilex Citalopram 10mg tablets drug res36: SSRI ADDs
79464020 Multilex Citalopram 40mg tablets drug res36: SSRI ADDs
80679020 Multilex Oxactin 20mg capsules (Discovery Pharmaceuticals Ltd) drug res36: SSRI ADDs
80777020 Multilex Prozit 20mg/5ml oral solution (Pinewood Healthcare) drug res36: SSRI ADDs
82055020 Multilex Ranflutin 20mg capsules (Ranbaxy (UK) Ltd) drug res36: SSRI ADDs
86222020 Multilex Cipralex 10mg tablets (Lundbeck Ltd) drug res36: SSRI ADDs
87524020 Multilex Escitalopram 5mg tablets drug res36: SSRI ADDs
87526020 Multilex Cipralex 5mg tablets (Lundbeck Ltd) drug res36: SSRI ADDs
88346020 Multilex Paxoran 10mg Tablet (Ranbaxy (UK) Ltd) drug res36: SSRI ADDs
88348020 Multilex Paxoran 20mg Tablet (Ranbaxy (UK) Ltd) drug res36: SSRI ADDs
90497020 Multilex Sertraline 50mg/5ml oral suspension drug res36: SSRI ADDs
90871020 Multilex Escitalopram 10mg/ml oral drops sugar free drug res36: SSRI ADDs
90873020 Multilex Cipralex 10mg/ml oral drops (Lundbeck Ltd) drug res36: SSRI ADDs
92043020 Multilex Paroxetine 10mg tablets drug res36: SSRI ADDs
93187020 Multilex Seroxat 10mg tablets (GlaxoSmithKline UK Ltd) drug res36: SSRI ADDs
93918020 Multilex Prozep 20mg/5ml oral solution (Chemidex Pharma Ltd) drug res36: SSRI ADDs
93984020 Multilex Fluoxetine 20mg/5ml oral solution sugar free drug res36: SSRI ADDs
97169020 Multilex Escitalopram 20mg/ml oral drops sugar free drug res36: SSRI ADDs
97171020 Multilex Cipralex 20mg/ml oral drops (Lundbeck Ltd) drug res36: SSRI ADDs
98001020 Multilex Fluoxetine 10mg tablets drug res36: SSRI ADDs

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