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Research article:
Sodium channel-inhibiting drugs and cancer survival: protocol for a cohort study using the CPRD primary care database
Reference:
Caroline Fairhurst, Fabiola Martin, Ian Watt, Tim Doran, Martin Bland, William J. Brackenbury(2016) Sodium channel-inhibiting drugs and cancer survival: protocol for a cohort study using the CPRD primary care database. BMJ Open, doi:
- Link to fulltext article
- Abstract
- Introduction: Voltage-gated sodium channel (VGSC)-inhibiting drugs are commonly used to treat epilepsy and cardiac arrhythmia. VGSCs are also widely expressed in various cancers, including those of the breast, bowel and prostate. A number of VGSC-inhibiting drugs have been shown to inhibit cancer cell proliferation, invasion, tumour growth and metastasis in preclinical models, suggesting that VGSCs may be novel molecular targets for cancer treatment. Surprisingly, we previously found that prior exposure to VGSC-inhibiting drugs may be associated with reduced overall survival in cancer patients, but we were unable to control for cause of death or indication for prescription. The purpose of the present study is to interrogate a different database in order to further investigate the relationship between VGSC-inhibiting drugs and cancer-specific survival. Methods and analysis: A cohort study using primary care data from the Clinical Practice Research Datalink (CPRD) database will include patients with diagnosis of breast, bowel and prostate cancer (approx. n=13,000). The primary outcome will be cancer-specific survival from date of cancer diagnosis. Cox proportional hazards regression will be used to compare survival of patients taking VGSC-inhibiting drugs (including antiepileptic drugs and Class I antiarrhythmic agents) with cancer patients not taking these drugs, adjusting for cancer type, age and sex. Drug exposure will be treated as a time-varying covariate to account for potential immortal time bias. Various sensitivity and secondary analyses will be performed. Ethics and dissemination: The project has been reviewed and approved by the University of York Ethical Review Process. Results will be presented at an international conference and published in open access peer-reviewed journals according to the STROBE and RECORD guidelines.
- Author for correspondence
- William J. Brackenbury
- Email for correspondence
- william.brackenbury@york.ac.uk
Code list: res47: Alcohol intake
36 codes in list
| Code | Coding system | Description | Entity type | List name | |||
|---|---|---|---|---|---|---|---|
| 136..00 | Read | Alcohol consumption | test | res47: Alcohol intake | |||
| 1361.11 | Read | Non drinker alcohol | test | res47: Alcohol intake | |||
| 1361.12 | Read | Non-drinker alcohol | test | res47: Alcohol intake | |||
| 1362.11 | Read | Drinks rarely | test | res47: Alcohol intake | |||
| 1362.12 | Read | Drinks occasionally | test | res47: Alcohol intake | |||
| 136a.00 | Read | Increasing risk drinking | test | res47: Alcohol intake | |||
| 136A.00 | Read | Ex-trivial drinker (<1u/day) | test | res47: Alcohol intake | |||
| 136b.00 | Read | Feels should cut down drinking | test | res47: Alcohol intake | |||
| 136B.00 | Read | Ex-light drinker - (1-2u/day) | test | res47: Alcohol intake | |||
| 136c.00 | Read | Higher risk drinking | test | res47: Alcohol intake | |||
| 136C.00 | Read | Ex-moderate drinker - (3-6u/d) | test | res47: Alcohol intake | |||
| 136d.00 | Read | Lower risk drinking | test | res47: Alcohol intake | |||
| 136D.00 | Read | Ex-heavy drinker - (7-9u/day) | test | res47: Alcohol intake | |||
| 136e.00 | Read | Declines to state current alcohol consumption | test | res47: Alcohol intake | |||
| 136E.00 | Read | Ex-very heavy drinker-(>9u/d) | test | res47: Alcohol intake | |||
| 136F.00 | Read | Spirit drinker | test | res47: Alcohol intake | |||
| 136G.00 | Read | Beer drinker | test | res47: Alcohol intake | |||
| 136H.00 | Read | Drinks beer and spirits | test | res47: Alcohol intake | |||
| 136I.00 | Read | Drinks wine | test | res47: Alcohol intake | |||
| 136J.00 | Read | Social drinker | test | res47: Alcohol intake | |||
| 136K.00 | Read | Alcohol intake above recommended sensible limits | test | res47: Alcohol intake | |||
| 136L.00 | Read | Alcohol intake within recommended sensible limits | test | res47: Alcohol intake | |||
| 136M.00 | Read | Current non drinker | test | res47: Alcohol intake | |||
| 136N.00 | Read | Light drinker | test | res47: Alcohol intake | |||
| 136O.00 | Read | Moderate drinker | test | res47: Alcohol intake | |||
| 136P.00 | Read | Heavy drinker | test | res47: Alcohol intake | |||
| 136Q.00 | Read | Very heavy drinker | test | res47: Alcohol intake | |||
| 136R.00 | Read | Binge drinker | test | res47: Alcohol intake | |||
| 136S.00 | Read | Hazardous alcohol use | test | res47: Alcohol intake | |||
| 136T.00 | Read | Harmful alcohol use | test | res47: Alcohol intake | |||
| 136V.00 | Read | Alcohol units per week | test | res47: Alcohol intake | |||
| 136W.00 | Read | Alcohol misuse | test | res47: Alcohol intake | |||
| 136X.00 | Read | Alcohol units consumed on heaviest drinking day | test | res47: Alcohol intake | |||
| 136Y.00 | Read | Drinks in morning to get rid of hangover | test | res47: Alcohol intake | |||
| 136Z.00 | Read | Alcohol consumption NOS | test | res47: Alcohol intake | |||
| E23..12 | Read | Alcohol problem drinking | test | res47: Alcohol intake |
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