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Research article:
Sodium channel-inhibiting drugs and cancer survival: protocol for a cohort study using the CPRD primary care database
Reference:
Caroline Fairhurst, Fabiola Martin, Ian Watt, Tim Doran, Martin Bland, William J. Brackenbury(2016) Sodium channel-inhibiting drugs and cancer survival: protocol for a cohort study using the CPRD primary care database. BMJ Open, doi:
- Link to fulltext article
- Abstract
- Introduction: Voltage-gated sodium channel (VGSC)-inhibiting drugs are commonly used to treat epilepsy and cardiac arrhythmia. VGSCs are also widely expressed in various cancers, including those of the breast, bowel and prostate. A number of VGSC-inhibiting drugs have been shown to inhibit cancer cell proliferation, invasion, tumour growth and metastasis in preclinical models, suggesting that VGSCs may be novel molecular targets for cancer treatment. Surprisingly, we previously found that prior exposure to VGSC-inhibiting drugs may be associated with reduced overall survival in cancer patients, but we were unable to control for cause of death or indication for prescription. The purpose of the present study is to interrogate a different database in order to further investigate the relationship between VGSC-inhibiting drugs and cancer-specific survival. Methods and analysis: A cohort study using primary care data from the Clinical Practice Research Datalink (CPRD) database will include patients with diagnosis of breast, bowel and prostate cancer (approx. n=13,000). The primary outcome will be cancer-specific survival from date of cancer diagnosis. Cox proportional hazards regression will be used to compare survival of patients taking VGSC-inhibiting drugs (including antiepileptic drugs and Class I antiarrhythmic agents) with cancer patients not taking these drugs, adjusting for cancer type, age and sex. Drug exposure will be treated as a time-varying covariate to account for potential immortal time bias. Various sensitivity and secondary analyses will be performed. Ethics and dissemination: The project has been reviewed and approved by the University of York Ethical Review Process. Results will be presented at an international conference and published in open access peer-reviewed journals according to the STROBE and RECORD guidelines.
- Author for correspondence
- William J. Brackenbury
- Email for correspondence
- william.brackenbury@york.ac.uk
Code list: res47: Comorbidities
289 codes in list
| Code | Coding system | Description | Entity type | List name | Comorbidity | ||
|---|---|---|---|---|---|---|---|
| 14AD.00 | Read | H/O ventricular fibrillation | diagnostic | res47: Comorbidities | Cardiac arrhythmias | ||
| 14AN.00 | Read | H/O: atrial fibrillation | diagnostic | res47: Comorbidities | Cardiac arrhythmias | ||
| 14AP.00 | Read | History of ventricular tachycardia | diagnostic | res47: Comorbidities | Cardiac arrhythmias | ||
| 14AQ.00 | Read | History of supraventricular tachycardia | diagnostic | res47: Comorbidities | Cardiac arrhythmias | ||
| 14AR.00 | Read | History of atrial flutter | diagnostic | res47: Comorbidities | Cardiac arrhythmias | ||
| 14S4.00 | Read | H/O: heart valve recipient | diagnostic | res47: Comorbidities | Cardiac arrhythmias | ||
| 212R.00 | Read | Atrial fibrillation resolved | diagnostic | res47: Comorbidities | Cardiac arrhythmias | ||
| 29B2.00 | Read | O/E - anaesthesia present | diagnostic | res47: Comorbidities | Neuropathic pain/painful neuropathy | ||
| 29B2000 | Read | O/E - anaesthesia in legs | diagnostic | res47: Comorbidities | Neuropathic pain/painful neuropathy | ||
| 29B2100 | Read | O/E - anaesthesia of extremities | diagnostic | res47: Comorbidities | Neuropathic pain/painful neuropathy | ||
| 29B2.11 | Read | O/E - loss of touch sensation | diagnostic | res47: Comorbidities | Neuropathic pain/painful neuropathy | ||
| 29B3.00 | Read | O/E - hypoaesthesia present | diagnostic | res47: Comorbidities | Neuropathic pain/painful neuropathy | ||
| 29B4.00 | Read | O/E - hyperaesthesia present | diagnostic | res47: Comorbidities | Neuropathic pain/painful neuropathy | ||
| 29B8.00 | Read | 10g monofilament sensation absent | diagnostic | res47: Comorbidities | Neuropathic pain/painful neuropathy | ||
| 29B9.00 | Read | 10g monofilament sensation R foot abnormal | diagnostic | res47: Comorbidities | Neuropathic pain/painful neuropathy | ||
| 29BA.00 | Read | 10g monofilament sensation L foot abnormal | diagnostic | res47: Comorbidities | Neuropathic pain/painful neuropathy | ||
| 29H2.00 | Read | O/E - vibration sense reduced | diagnostic | res47: Comorbidities | Neuropathic pain/painful neuropathy | ||
| 29H3.00 | Read | O/E - vibration sense absent | diagnostic | res47: Comorbidities | Neuropathic pain/painful neuropathy | ||
| 29H4.00 | Read | O/E - Vibration sense of right foot abnormal | diagnostic | res47: Comorbidities | Neuropathic pain/painful neuropathy | ||
| 29H6.00 | Read | O/E - Vibration sense of left foot abnormal | diagnostic | res47: Comorbidities | Neuropathic pain/painful neuropathy | ||
| 29H7.00 | Read | O/E - Vibration sense of left foot normal | diagnostic | res47: Comorbidities | Neuropathic pain/painful neuropathy | ||
| 29H8.00 | Read | O/E - vibration sense left foot reduced | diagnostic | res47: Comorbidities | Neuropathic pain/painful neuropathy | ||
| 29H9.00 | Read | O/E - vibration sense right foot reduced | diagnostic | res47: Comorbidities | Neuropathic pain/painful neuropathy | ||
| 29HA.00 | Read | O/E - Vibration sense of right foot absent | diagnostic | res47: Comorbidities | Neuropathic pain/painful neuropathy | ||
| 29HB.00 | Read | O/E - Vibration sense of left foot absent | diagnostic | res47: Comorbidities | Neuropathic pain/painful neuropathy | ||
| 2G51000 | Read | Foot abnormality - diabetes related | diagnostic | res47: Comorbidities | Neuropathic pain/painful neuropathy | ||
| 327..00 | Read | ECG: supraventricular arrhythmia | diagnostic | res47: Comorbidities | Cardiac arrhythmias | ||
| 3272.00 | Read | ECG: atrial fibrillation | diagnostic | res47: Comorbidities | Cardiac arrhythmias | ||
| 3273.00 | Read | ECG: atrial flutter | diagnostic | res47: Comorbidities | Cardiac arrhythmias | ||
| 3274.00 | Read | ECG: paroxysmal atrial tachy. | diagnostic | res47: Comorbidities | Cardiac arrhythmias | ||
| 327Z.00 | Read | ECG: supraventric. arryth. NOS | diagnostic | res47: Comorbidities | Cardiac arrhythmias | ||
| 328..00 | Read | ECG: ventricular arrhythmia | diagnostic | res47: Comorbidities | Cardiac arrhythmias | ||
| 3282.00 | Read | ECG: ventricular tachycardia | diagnostic | res47: Comorbidities | Cardiac arrhythmias | ||
| 3283.00 | Read | ECG: ventricular fibrillation | diagnostic | res47: Comorbidities | Cardiac arrhythmias | ||
| 328Z.00 | Read | ECG: ventricular arrhythmia NOS | diagnostic | res47: Comorbidities | Cardiac arrhythmias | ||
| 329..00 | Read | ECG: heart block | diagnostic | res47: Comorbidities | Cardiac arrhythmias | ||
| 3293.00 | Read | ECG:complete sinu-atrial block | diagnostic | res47: Comorbidities | Cardiac arrhythmias | ||
| 3295.00 | Read | ECG: partial A-V block - 2:1 | diagnostic | res47: Comorbidities | Cardiac arrhythmias | ||
| 3296.00 | Read | ECG: partial A-V block - 3:1 | diagnostic | res47: Comorbidities | Cardiac arrhythmias | ||
| 3298.00 | Read | ECG: complete A-V block | diagnostic | res47: Comorbidities | Cardiac arrhythmias | ||
| 329Z.00 | Read | ECG: heart block NOS | diagnostic | res47: Comorbidities | Cardiac arrhythmias | ||
| 662D.11 | Read | Digitalised | diagnostic | res47: Comorbidities | Cardiac arrhythmias | ||
| 662J000 | Read | Digoxin monitoring | diagnostic | res47: Comorbidities | Cardiac arrhythmias | ||
| 662S.00 | Read | Atrial fibrillation monitoring | diagnostic | res47: Comorbidities | Cardiac arrhythmias | ||
| 6A9..00 | Read | Atrial fibrillation annual review | diagnostic | res47: Comorbidities | Cardiac arrhythmias | ||
| 7936.00 | Read | Introduction of cardiac pacemaker system via vein | diagnostic | res47: Comorbidities | Cardiac arrhythmias | ||
| 7936000 | Read | Implantation of intravenous cardiac pacemaker system | diagnostic | res47: Comorbidities | Cardiac arrhythmias | ||
| 7936100 | Read | Resiting of lead of intravenous pacemaker system | diagnostic | res47: Comorbidities | Cardiac arrhythmias | ||
| 7936.11 | Read | Introduction of intravenous cardiac pacemaker system | diagnostic | res47: Comorbidities | Cardiac arrhythmias | ||
| 7936200 | Read | Maintenance of battery of intravenous cardiac pacemaker syst | diagnostic | res47: Comorbidities | Cardiac arrhythmias | ||
| 7936300 | Read | Maintenance of intravenous cardiac pacemaker system NEC | diagnostic | res47: Comorbidities | Cardiac arrhythmias | ||
| 7936400 | Read | Removal of intravenous cardiac pacemaker system | diagnostic | res47: Comorbidities | Cardiac arrhythmias | ||
| 7936500 | Read | Implantation of emergency intravenous cardiac pacemaker | diagnostic | res47: Comorbidities | Cardiac arrhythmias | ||
| 7936511 | Read | Implantation of temporary intravenous cardiac pacemaker | diagnostic | res47: Comorbidities | Cardiac arrhythmias | ||
| 7936600 | Read | Implantation of permanent intravenous cardiac pacemaker | diagnostic | res47: Comorbidities | Cardiac arrhythmias | ||
| 7936700 | Read | Implantation of intravenous fixed-rate cardiac pacemaker | diagnostic | res47: Comorbidities | Cardiac arrhythmias | ||
| 7936800 | Read | Implantation of intravenous triggered cardiac pacemaker | diagnostic | res47: Comorbidities | Cardiac arrhythmias | ||
| 7936900 | Read | Implantation of intravenous atrial overdrive pacemaker | diagnostic | res47: Comorbidities | Cardiac arrhythmias | ||
| 7936A00 | Read | Implant intravenous pacemaker for atrial fibrillation | diagnostic | res47: Comorbidities | Cardiac arrhythmias | ||
| 7936B00 | Read | Implantation simple one wire intravenous cardiac pacemaker | diagnostic | res47: Comorbidities | Cardiac arrhythmias | ||
| 7936C00 | Read | Implantation of complex 1 wire intravenous cardiac pacemaker | diagnostic | res47: Comorbidities | Cardiac arrhythmias | ||
| 7936D00 | Read | Implantation complex two wire intravenous cardiac pacemaker | diagnostic | res47: Comorbidities | Cardiac arrhythmias | ||
| 7936E00 | Read | Implantation of intravenous dual chamber permanent pacemaker | diagnostic | res47: Comorbidities | Cardiac arrhythmias | ||
| 7936F00 | Read | Renewal of intravenous cardiac pacemaker system | diagnostic | res47: Comorbidities | Cardiac arrhythmias | ||
| 7936G00 | Read | Implantat intraven single chamber cardiac pacemaker system | diagnostic | res47: Comorbidities | Cardiac arrhythmias | ||
| 7936H00 | Read | Implantat intravenous dual chamber cardiac pacemaker system | diagnostic | res47: Comorbidities | Cardiac arrhythmias | ||
| 7936J00 | Read | Implantat intravenous biventricular cardiac pacemaker system | diagnostic | res47: Comorbidities | Cardiac arrhythmias | ||
| 7936K00 | Read | Implantation of intravenous cardiac pacemaker system NEC | diagnostic | res47: Comorbidities | Cardiac arrhythmias | ||
| 7936y00 | Read | Other specified cardiac pacemaker system introduced via vein | diagnostic | res47: Comorbidities | Cardiac arrhythmias | ||
| 7936z00 | Read | Cardiac pacemaker system introduced via vein NOS | diagnostic | res47: Comorbidities | Cardiac arrhythmias | ||
| 7L1H000 | Read | Direct current cardioversion | diagnostic | res47: Comorbidities | Cardiac arrhythmias | ||
| 7L1H100 | Read | External cardioversion NEC | diagnostic | res47: Comorbidities | Cardiac arrhythmias | ||
| 7L1H.11 | Read | Cardioversion and stimulation | diagnostic | res47: Comorbidities | Cardiac arrhythmias | ||
| 7L1H111 | Read | External electrode cardioversion | diagnostic | res47: Comorbidities | Cardiac arrhythmias | ||
| 7L1H.12 | Read | Direct current cardiac shock | diagnostic | res47: Comorbidities | Cardiac arrhythmias | ||
| 7L1H.13 | Read | Defibrillation | diagnostic | res47: Comorbidities | Cardiac arrhythmias | ||
| 7L1H200 | Read | Internal electrode cardioversion | diagnostic | res47: Comorbidities | Cardiac arrhythmias | ||
| 7L1H300 | Read | Electrical sinus rhythm conversion | diagnostic | res47: Comorbidities | Cardiac arrhythmias | ||
| 7L1H700 | Read | External ventricular defibrillation | diagnostic | res47: Comorbidities | Cardiac arrhythmias | ||
| 7L1H800 | Read | Chemical cardioversion | diagnostic | res47: Comorbidities | Cardiac arrhythmias | ||
| 9hF..00 | Read | Exception reporting: atrial fibrillation quality indicators | diagnostic | res47: Comorbidities | Cardiac arrhythmias | ||
| 9hF0.00 | Read | Except from atr fib quality indicators: Patient unsuitable | diagnostic | res47: Comorbidities | Cardiac arrhythmias | ||
| 9hF1.00 | Read | Excepted from atrial fibrillation qual indic: Inform dissent | diagnostic | res47: Comorbidities | Cardiac arrhythmias | ||
| 9Os..00 | Read | Atrial fibrillation monitoring administration | diagnostic | res47: Comorbidities | Cardiac arrhythmias | ||
| 9Os0.00 | Read | Atrial fibrillation monitoring first letter | diagnostic | res47: Comorbidities | Cardiac arrhythmias | ||
| 9Os1.00 | Read | Atrial fibrillation monitoring second letter | diagnostic | res47: Comorbidities | Cardiac arrhythmias | ||
| 9Os2.00 | Read | Atrial fibrillation monitoring third letter | diagnostic | res47: Comorbidities | Cardiac arrhythmias | ||
| 9Os3.00 | Read | Atrial fibrillation monitoring verbal invite | diagnostic | res47: Comorbidities | Cardiac arrhythmias | ||
| 9Os4.00 | Read | Atrial fibrillation monitoring telephone invite | diagnostic | res47: Comorbidities | Cardiac arrhythmias | ||
| A531200 | Read | Postherpetic trigeminal neuralgia | diagnostic | res47: Comorbidities | Neuropathic pain/painful neuropathy | ||
| C106.00 | Read | Diabetes mellitus with neurological manifestation | diagnostic | res47: Comorbidities | Neuropathic pain/painful neuropathy | ||
| C106.12 | Read | Diabetes mellitus with neuropathy | diagnostic | res47: Comorbidities | Neuropathic pain/painful neuropathy | ||
| C106.13 | Read | Diabetes mellitus with polyneuropathy | diagnostic | res47: Comorbidities | Neuropathic pain/painful neuropathy | ||
| C106z00 | Read | Diabetes mellitus NOS with neurological manifestation | diagnostic | res47: Comorbidities | Neuropathic pain/painful neuropathy | ||
| C108211 | Read | Type I diabetes mellitus with neurological complications | diagnostic | res47: Comorbidities | Neuropathic pain/painful neuropathy | ||
| C108B00 | Read | Insulin dependent diabetes mellitus with mononeuropathy | diagnostic | res47: Comorbidities | Neuropathic pain/painful neuropathy | ||
| C108B11 | Read | Type I diabetes mellitus with mononeuropathy | diagnostic | res47: Comorbidities | Neuropathic pain/painful neuropathy | ||
| C108C00 | Read | Insulin dependent diabetes mellitus with polyneuropathy | diagnostic | res47: Comorbidities | Neuropathic pain/painful neuropathy | ||
| C108J00 | Read | Insulin dependent diab mell with neuropathic arthropathy | diagnostic | res47: Comorbidities | Neuropathic pain/painful neuropathy | ||
| C108J11 | Read | Type I diabetes mellitus with neuropathic arthropathy | diagnostic | res47: Comorbidities | Neuropathic pain/painful neuropathy | ||
| C109211 | Read | Type II diabetes mellitus with neurological complications | diagnostic | res47: Comorbidities | Neuropathic pain/painful neuropathy | ||
| C109212 | Read | Type 2 diabetes mellitus with neurological complications | diagnostic | res47: Comorbidities | Neuropathic pain/painful neuropathy | ||
| C109A00 | Read | Non-insulin dependent diabetes mellitus with mononeuropathy | diagnostic | res47: Comorbidities | Neuropathic pain/painful neuropathy | ||
| C109A11 | Read | Type II diabetes mellitus with mononeuropathy | diagnostic | res47: Comorbidities | Neuropathic pain/painful neuropathy | ||
| C109B00 | Read | Non-insulin dependent diabetes mellitus with polyneuropathy | diagnostic | res47: Comorbidities | Neuropathic pain/painful neuropathy | ||
| C109B11 | Read | Type II diabetes mellitus with polyneuropathy | diagnostic | res47: Comorbidities | Neuropathic pain/painful neuropathy | ||
| C109F00 | Read | Non-insulin-dependent d m with peripheral angiopath | diagnostic | res47: Comorbidities | Neuropathic pain/painful neuropathy | ||
| C109F11 | Read | Type II diabetes mellitus with peripheral angiopathy | diagnostic | res47: Comorbidities | Neuropathic pain/painful neuropathy | ||
| C109F12 | Read | Type 2 diabetes mellitus with peripheral angiopathy | diagnostic | res47: Comorbidities | Neuropathic pain/painful neuropathy | ||
| C10E200 | Read | Type 1 diabetes mellitus with neurological complications | diagnostic | res47: Comorbidities | Neuropathic pain/painful neuropathy | ||
| C10E212 | Read | Insulin-dependent diabetes mellitus with neurological comps | diagnostic | res47: Comorbidities | Neuropathic pain/painful neuropathy | ||
| C10E300 | Read | Type 1 diabetes mellitus with multiple complications | diagnostic | res47: Comorbidities | Neuropathic pain/painful neuropathy | ||
| C10E312 | Read | Insulin dependent diabetes mellitus with multiple complicat | diagnostic | res47: Comorbidities | Neuropathic pain/painful neuropathy | ||
| C10EB00 | Read | Type 1 diabetes mellitus with mononeuropathy | diagnostic | res47: Comorbidities | Neuropathic pain/painful neuropathy | ||
| C10EC00 | Read | Type 1 diabetes mellitus with polyneuropathy | diagnostic | res47: Comorbidities | Neuropathic pain/painful neuropathy | ||
| C10EC11 | Read | Type I diabetes mellitus with polyneuropathy | diagnostic | res47: Comorbidities | Neuropathic pain/painful neuropathy | ||
| C10EC12 | Read | Insulin dependent diabetes mellitus with polyneuropathy | diagnostic | res47: Comorbidities | Neuropathic pain/painful neuropathy | ||
| C10F200 | Read | Type 2 diabetes mellitus with neurological complications | diagnostic | res47: Comorbidities | Neuropathic pain/painful neuropathy | ||
| C10F211 | Read | Type II diabetes mellitus with neurological complications | diagnostic | res47: Comorbidities | Neuropathic pain/painful neuropathy | ||
| C10F300 | Read | Type 2 diabetes mellitus with multiple complications | diagnostic | res47: Comorbidities | Neuropathic pain/painful neuropathy | ||
| C10F311 | Read | Type II diabetes mellitus with multiple complications | diagnostic | res47: Comorbidities | Neuropathic pain/painful neuropathy | ||
| C10FA00 | Read | Type 2 diabetes mellitus with mononeuropathy | diagnostic | res47: Comorbidities | Neuropathic pain/painful neuropathy | ||
| C10FA11 | Read | Type II diabetes mellitus with mononeuropathy | diagnostic | res47: Comorbidities | Neuropathic pain/painful neuropathy | ||
| C10FB00 | Read | Type 2 diabetes mellitus with polyneuropathy | diagnostic | res47: Comorbidities | Neuropathic pain/painful neuropathy | ||
| C10FB11 | Read | Type II diabetes mellitus with polyneuropathy | diagnostic | res47: Comorbidities | Neuropathic pain/painful neuropathy | ||
| C10FH00 | Read | Type 2 diabetes mellitus with neuropathic arthropathy | diagnostic | res47: Comorbidities | Neuropathic pain/painful neuropathy | ||
| F132100 | Read | Progressive myoclonic epilepsy | diagnostic | res47: Comorbidities | Epilepsy | ||
| F152.00 | Read | Motor neurone disease | diagnostic | res47: Comorbidities | ALS | ||
| F152000 | Read | Amyotrophic lateral sclerosis | diagnostic | res47: Comorbidities | ALS | ||
| F152z00 | Read | Motor neurone disease NOS | diagnostic | res47: Comorbidities | ALS | ||
| F25..00 | Read | Epilepsy | diagnostic | res47: Comorbidities | Epilepsy | ||
| F250.00 | Read | Generalised nonconvulsive epilepsy | diagnostic | res47: Comorbidities | Epilepsy | ||
| F250000 | Read | Petit mal (minor) epilepsy | diagnostic | res47: Comorbidities | Epilepsy | ||
| F250011 | Read | Epileptic absences | diagnostic | res47: Comorbidities | Epilepsy | ||
| F250100 | Read | Pykno-epilepsy | diagnostic | res47: Comorbidities | Epilepsy | ||
| F250200 | Read | Epileptic seizures - atonic | diagnostic | res47: Comorbidities | Epilepsy | ||
| F250300 | Read | Epileptic seizures - akinetic | diagnostic | res47: Comorbidities | Epilepsy | ||
| F250400 | Read | Juvenile absence epilepsy | diagnostic | res47: Comorbidities | Epilepsy | ||
| F250500 | Read | Lennox-Gastaut syndrome | diagnostic | res47: Comorbidities | Epilepsy | ||
| F250 A | Read | diagnostic | res47: Comorbidities | Epilepsy | |||
| F250y00 | Read | Other specified generalised nonconvulsive epilepsy | diagnostic | res47: Comorbidities | Epilepsy | ||
| F250z00 | Read | Generalised nonconvulsive epilepsy NOS | diagnostic | res47: Comorbidities | Epilepsy | ||
| F2510 | Read | diagnostic | res47: Comorbidities | Epilepsy | |||
| F251.00 | Read | Generalised convulsive epilepsy | diagnostic | res47: Comorbidities | Epilepsy | ||
| F251000 | Read | Grand mal (major) epilepsy | diagnostic | res47: Comorbidities | Epilepsy | ||
| F251011 | Read | Tonic-clonic epilepsy | diagnostic | res47: Comorbidities | Epilepsy | ||
| F251100 | Read | Neonatal myoclonic epilepsy | diagnostic | res47: Comorbidities | Epilepsy | ||
| F251111 | Read | Otohara syndrome | diagnostic | res47: Comorbidities | Epilepsy | ||
| F251200 | Read | Epileptic seizures - clonic | diagnostic | res47: Comorbidities | Epilepsy | ||
| F251300 | Read | Epileptic seizures - myoclonic | diagnostic | res47: Comorbidities | Epilepsy | ||
| F251400 | Read | Epileptic seizures - tonic | diagnostic | res47: Comorbidities | Epilepsy | ||
| F251500 | Read | Tonic-clonic epilepsy | diagnostic | res47: Comorbidities | Epilepsy | ||
| F251600 | Read | Grand mal seizure | diagnostic | res47: Comorbidities | Epilepsy | ||
| F251y00 | Read | Other specified generalised convulsive epilepsy | diagnostic | res47: Comorbidities | Epilepsy | ||
| F251z00 | Read | Generalised convulsive epilepsy NOS | diagnostic | res47: Comorbidities | Epilepsy | ||
| F252.00 | Read | Petit mal status | diagnostic | res47: Comorbidities | Epilepsy | ||
| F253.00 | Read | Grand mal status | diagnostic | res47: Comorbidities | Epilepsy | ||
| F253.11 | Read | Status epilepticus | diagnostic | res47: Comorbidities | Epilepsy | ||
| F254.00 | Read | Partial epilepsy with impairment of consciousness | diagnostic | res47: Comorbidities | Epilepsy | ||
| F254000 | Read | Temporal lobe epilepsy | diagnostic | res47: Comorbidities | Epilepsy | ||
| F254100 | Read | Psychomotor epilepsy | diagnostic | res47: Comorbidities | Epilepsy | ||
| F254200 | Read | Psychosensory epilepsy | diagnostic | res47: Comorbidities | Epilepsy | ||
| F254300 | Read | Limbic system epilepsy | diagnostic | res47: Comorbidities | Epilepsy | ||
| F254400 | Read | Epileptic automatism | diagnostic | res47: Comorbidities | Epilepsy | ||
| F254500 | Read | Complex partial epileptic seizure | diagnostic | res47: Comorbidities | Epilepsy | ||
| F254z00 | Read | Partial epilepsy with impairment of consciousness NOS | diagnostic | res47: Comorbidities | Epilepsy | ||
| F255.00 | Read | Partial epilepsy without impairment of consciousness | diagnostic | res47: Comorbidities | Epilepsy | ||
| F255000 | Read | Jacksonian, focal or motor epilepsy | diagnostic | res47: Comorbidities | Epilepsy | ||
| F255011 | Read | Focal epilepsy | diagnostic | res47: Comorbidities | Epilepsy | ||
| F255012 | Read | Motor epilepsy | diagnostic | res47: Comorbidities | Epilepsy | ||
| F255100 | Read | Sensory induced epilepsy | diagnostic | res47: Comorbidities | Epilepsy | ||
| F255200 | Read | Somatosensory epilepsy | diagnostic | res47: Comorbidities | Epilepsy | ||
| F255300 | Read | Visceral reflex epilepsy | diagnostic | res47: Comorbidities | Epilepsy | ||
| F255311 | Read | Partial epilepsy with autonomic symptoms | diagnostic | res47: Comorbidities | Epilepsy | ||
| F255400 | Read | Visual reflex epilepsy | diagnostic | res47: Comorbidities | Epilepsy | ||
| F255500 | Read | Unilateral epilepsy | diagnostic | res47: Comorbidities | Epilepsy | ||
| F255600 | Read | Simple partial epileptic seizure | diagnostic | res47: Comorbidities | Epilepsy | ||
| F255y00 | Read | Partial epilepsy without impairment of consciousness OS | diagnostic | res47: Comorbidities | Epilepsy | ||
| F255z00 | Read | Partial epilepsy without impairment of consciousness NOS | diagnostic | res47: Comorbidities | Epilepsy | ||
| F256.00 | Read | Infantile spasms | diagnostic | res47: Comorbidities | Epilepsy | ||
| F256000 | Read | Hypsarrhythmia | diagnostic | res47: Comorbidities | Epilepsy | ||
| F256100 | Read | Salaam attacks | diagnostic | res47: Comorbidities | Epilepsy | ||
| F256.11 | Read | Lightning spasms | diagnostic | res47: Comorbidities | Epilepsy | ||
| F256.12 | Read | West syndrome | diagnostic | res47: Comorbidities | Epilepsy | ||
| F256z00 | Read | Infantile spasms NOS | diagnostic | res47: Comorbidities | Epilepsy | ||
| F257.00 | Read | Kojevnikov's epilepsy | diagnostic | res47: Comorbidities | Epilepsy | ||
| F258.00 | Read | Post-ictal state | diagnostic | res47: Comorbidities | Epilepsy | ||
| F259.00 | Read | Early infant epileptic encephalopathy wth suppression bursts | diagnostic | res47: Comorbidities | Epilepsy | ||
| F259.11 | Read | Ohtahara syndrome | diagnostic | res47: Comorbidities | Epilepsy | ||
| F25A.00 | Read | Juvenile myoclonic epilepsy | diagnostic | res47: Comorbidities | Epilepsy | ||
| F25B.00 | Read | Alcohol-induced epilepsy | diagnostic | res47: Comorbidities | Epilepsy | ||
| F25C.00 | Read | Drug-induced epilepsy | diagnostic | res47: Comorbidities | Epilepsy | ||
| F25D.00 | Read | Menstrual epilepsy | diagnostic | res47: Comorbidities | Epilepsy | ||
| F25E.00 | Read | Stress-induced epilepsy | diagnostic | res47: Comorbidities | Epilepsy | ||
| F25F.00 | Read | Photosensitive epilepsy | diagnostic | res47: Comorbidities | Epilepsy | ||
| F25X.00 | Read | Status epilepticus, unspecified | diagnostic | res47: Comorbidities | Epilepsy | ||
| F25y.00 | Read | Other forms of epilepsy | diagnostic | res47: Comorbidities | Epilepsy | ||
| F25y000 | Read | Cursive (running) epilepsy | diagnostic | res47: Comorbidities | Epilepsy | ||
| F25y100 | Read | Gelastic epilepsy | diagnostic | res47: Comorbidities | Epilepsy | ||
| F25y200 | Read | Locl-rlt(foc)(part)idiop epilep&epilptic syn seiz locl onset | diagnostic | res47: Comorbidities | Epilepsy | ||
| F25y300 | Read | Complex partial status epilepticus | diagnostic | res47: Comorbidities | Epilepsy | ||
| F25y400 | Read | Benign Rolandic epilepsy | diagnostic | res47: Comorbidities | Epilepsy | ||
| F25y500 | Read | Panayiotopoulos syndrome | diagnostic | res47: Comorbidities | Epilepsy | ||
| F25yz00 | Read | Other forms of epilepsy NOS | diagnostic | res47: Comorbidities | Epilepsy | ||
| F25z.00 | Read | Epilepsy NOS | diagnostic | res47: Comorbidities | Epilepsy | ||
| F25z.11 | Read | Fit (in known epileptic) NOS | diagnostic | res47: Comorbidities | Epilepsy | ||
| F300.00 | Read | Post-herpetic trigeminal neuralgia | diagnostic | res47: Comorbidities | Neuropathic pain/painful neuropathy | ||
| F301.00 | Read | Other specified trigeminal neuralgia | diagnostic | res47: Comorbidities | Neuropathic pain/painful neuropathy | ||
| F301000 | Read | Tic douloureux | diagnostic | res47: Comorbidities | Neuropathic pain/painful neuropathy | ||
| F301z00 | Read | Trigeminal neuralgia NOS | diagnostic | res47: Comorbidities | Neuropathic pain/painful neuropathy | ||
| F345000 | Read | Diabetic mononeuritis multiplex | diagnostic | res47: Comorbidities | Neuropathic pain/painful neuropathy | ||
| F35z000 | Read | Diabetic mononeuritis NOS | diagnostic | res47: Comorbidities | Neuropathic pain/painful neuropathy | ||
| F366.00 | Read | Polyneuropathy | diagnostic | res47: Comorbidities | Neuropathic pain/painful neuropathy | ||
| F367.00 | Read | Peripheral neuropathy | diagnostic | res47: Comorbidities | Neuropathic pain/painful neuropathy | ||
| F370100 | Read | Postinfectious polyneuritis | diagnostic | res47: Comorbidities | Neuropathic pain/painful neuropathy | ||
| F371200 | Read | Polyneuropathy in rheumatoid arthritis | diagnostic | res47: Comorbidities | Neuropathic pain/painful neuropathy | ||
| F372.00 | Read | Polyneuropathy in diabetes | diagnostic | res47: Comorbidities | Neuropathic pain/painful neuropathy | ||
| F372000 | Read | Acute painful diabetic neuropathy | diagnostic | res47: Comorbidities | Neuropathic pain/painful neuropathy | ||
| F372100 | Read | Chronic painful diabetic neuropathy | diagnostic | res47: Comorbidities | Neuropathic pain/painful neuropathy | ||
| F372.11 | Read | Diabetic polyneuropathy | diagnostic | res47: Comorbidities | Neuropathic pain/painful neuropathy | ||
| F372.12 | Read | Diabetic neuropathy | diagnostic | res47: Comorbidities | Neuropathic pain/painful neuropathy | ||
| F372200 | Read | Asymptomatic diabetic neuropathy | diagnostic | res47: Comorbidities | Neuropathic pain/painful neuropathy | ||
| F373.00 | Read | Polyneuropathy in malignant disease | diagnostic | res47: Comorbidities | Neuropathic pain/painful neuropathy | ||
| F374.00 | Read | Polyneuropathy in disease EC | diagnostic | res47: Comorbidities | Neuropathic pain/painful neuropathy | ||
| F374z00 | Read | Polyneuropathy in disease NOS | diagnostic | res47: Comorbidities | Neuropathic pain/painful neuropathy | ||
| F375.00 | Read | Alcoholic polyneuropathy | diagnostic | res47: Comorbidities | Neuropathic pain/painful neuropathy | ||
| F37z.11 | Read | Polyneuropathy unspecified | diagnostic | res47: Comorbidities | Neuropathic pain/painful neuropathy | ||
| F3y0.00 | Read | Diabetic mononeuropathy | diagnostic | res47: Comorbidities | Neuropathic pain/painful neuropathy | ||
| Fyu6A00 | Read | [X]Other mononeuropathies of upper limb | diagnostic | res47: Comorbidities | Neuropathic pain/painful neuropathy | ||
| Fyu6B00 | Read | [X]Other mononeuropathies of lower limb | diagnostic | res47: Comorbidities | Neuropathic pain/painful neuropathy | ||
| Fyu6C00 | Read | [X]Other specified mononeuropathies | diagnostic | res47: Comorbidities | Neuropathic pain/painful neuropathy | ||
| Fyu6D00 | Read | [X]Other mononeuropathies in diseases classified elsewhere | diagnostic | res47: Comorbidities | Neuropathic pain/painful neuropathy | ||
| Fyu7.00 | Read | [X]Polyneuropathies & other disord of peripheral nerv syst | diagnostic | res47: Comorbidities | Neuropathic pain/painful neuropathy | ||
| Fyu7200 | Read | [X]Other specified polyneuropathies | diagnostic | res47: Comorbidities | Neuropathic pain/painful neuropathy | ||
| Fyu7C00 | Read | [X] Polyneuropathy, unspecified | diagnostic | res47: Comorbidities | Neuropathic pain/painful neuropathy | ||
| G559.00 | Read | Arrhythmogenic right ventricular cardiomyopathy | diagnostic | res47: Comorbidities | Cardiac arrhythmias | ||
| G57..00 | Read | Cardiac dysrhythmias | diagnostic | res47: Comorbidities | Cardiac arrhythmias | ||
| G570.00 | Read | Paroxysmal supraventricular tachycardia | diagnostic | res47: Comorbidities | Cardiac arrhythmias | ||
| G570000 | Read | Paroxysmal atrial tachycardia | diagnostic | res47: Comorbidities | Cardiac arrhythmias | ||
| G570100 | Read | Paroxysmal atrioventricular tachycardia | diagnostic | res47: Comorbidities | Cardiac arrhythmias | ||
| G570200 | Read | Paroxysmal junctional tachycardia | diagnostic | res47: Comorbidities | Cardiac arrhythmias | ||
| G570300 | Read | Paroxysmal nodal tachycardia | diagnostic | res47: Comorbidities | Cardiac arrhythmias | ||
| G570z00 | Read | Paroxysmal supraventricular tachycardia NOS | diagnostic | res47: Comorbidities | Cardiac arrhythmias | ||
| G571.00 | Read | Paroxysmal ventricular tachycardia | diagnostic | res47: Comorbidities | Cardiac arrhythmias | ||
| G57..11 | Read | Cardiac arrhythmias | diagnostic | res47: Comorbidities | Cardiac arrhythmias | ||
| G571.11 | Read | Ventricular tachycardia | diagnostic | res47: Comorbidities | Cardiac arrhythmias | ||
| G572.00 | Read | Paroxysmal tachycardia unspecified | diagnostic | res47: Comorbidities | Cardiac arrhythmias | ||
| G572000 | Read | Essential paroxysmal tachycardia | diagnostic | res47: Comorbidities | Cardiac arrhythmias | ||
| G572100 | Read | Bouveret-Hoffmann syndrome | diagnostic | res47: Comorbidities | Cardiac arrhythmias | ||
| G572z00 | Read | Paroxysmal tachycardia NOS | diagnostic | res47: Comorbidities | Cardiac arrhythmias | ||
| G573.00 | Read | Atrial fibrillation and flutter | diagnostic | res47: Comorbidities | Cardiac arrhythmias | ||
| G573000 | Read | Atrial fibrillation | diagnostic | res47: Comorbidities | Cardiac arrhythmias | ||
| G573100 | Read | Atrial flutter | diagnostic | res47: Comorbidities | Cardiac arrhythmias | ||
| G573200 | Read | Paroxysmal atrial fibrillation | diagnostic | res47: Comorbidities | Cardiac arrhythmias | ||
| G573300 | Read | Non-rheumatic atrial fibrillation | diagnostic | res47: Comorbidities | Cardiac arrhythmias | ||
| G573400 | Read | Permanent atrial fibrillation | diagnostic | res47: Comorbidities | Cardiac arrhythmias | ||
| G573500 | Read | Persistent atrial fibrillation | diagnostic | res47: Comorbidities | Cardiac arrhythmias | ||
| G573z00 | Read | Atrial fibrillation and flutter NOS | diagnostic | res47: Comorbidities | Cardiac arrhythmias | ||
| G574.00 | Read | Ventricular fibrillation and flutter | diagnostic | res47: Comorbidities | Cardiac arrhythmias | ||
| G574000 | Read | Ventricular fibrillation | diagnostic | res47: Comorbidities | Cardiac arrhythmias | ||
| G574011 | Read | Cardiac arrest-ventricular fibrillation | diagnostic | res47: Comorbidities | Cardiac arrhythmias | ||
| G574100 | Read | Ventricular flutter | diagnostic | res47: Comorbidities | Cardiac arrhythmias | ||
| G574z00 | Read | Ventricular fibrillation and flutter NOS | diagnostic | res47: Comorbidities | Cardiac arrhythmias | ||
| G575200 | Read | Electromechanical dissociation with successful resuscitation | diagnostic | res47: Comorbidities | Cardiac arrhythmias | ||
| G575300 | Read | Electromechanical dissociation | diagnostic | res47: Comorbidities | Cardiac arrhythmias | ||
| G57y.00 | Read | Other cardiac dysrhythmias | diagnostic | res47: Comorbidities | Cardiac arrhythmias | ||
| G57y000 | Read | Persistent sinus bradycardia | diagnostic | res47: Comorbidities | Cardiac arrhythmias | ||
| G57y100 | Read | Severe sinus bradycardia | diagnostic | res47: Comorbidities | Cardiac arrhythmias | ||
| G57y.14 | Read | Heart beats irregular | diagnostic | res47: Comorbidities | Cardiac arrhythmias | ||
| G57y200 | Read | Brugada syndrome | diagnostic | res47: Comorbidities | Cardiac arrhythmias | ||
| G57y300 | Read | Sick sinus syndrome | diagnostic | res47: Comorbidities | Cardiac arrhythmias | ||
| G57y400 | Read | Sinoatrial node dysfunction NOS | diagnostic | res47: Comorbidities | Cardiac arrhythmias | ||
| G57y600 | Read | Nodal rhythm disorder | diagnostic | res47: Comorbidities | Cardiac arrhythmias | ||
| G57y900 | Read | Supraventricular tachycardia NOS | diagnostic | res47: Comorbidities | Cardiac arrhythmias | ||
| G57yA00 | Read | Re-entry ventricular arrhythmia | diagnostic | res47: Comorbidities | Cardiac arrhythmias | ||
| G57yz00 | Read | Other cardiac dysrhythmia NOS | diagnostic | res47: Comorbidities | Cardiac arrhythmias | ||
| G57z.00 | Read | Cardiac dysrhythmia NOS | diagnostic | res47: Comorbidities | Cardiac arrhythmias | ||
| G73y000 | Read | Diabetic peripheral angiopathy | diagnostic | res47: Comorbidities | Neuropathic pain/painful neuropathy | ||
| Gyu5a00 | Read | [X]Other specified cardiac arrhythmias | diagnostic | res47: Comorbidities | Cardiac arrhythmias | ||
| M271100 | Read | Neuropathic diabetic ulcer - foot | diagnostic | res47: Comorbidities | Neuropathic pain/painful neuropathy | ||
| N035.00 | Read | Neuropathic arthropathy | diagnostic | res47: Comorbidities | Neuropathic pain/painful neuropathy | ||
| N035.11 | Read | Charcot's arthropathy | diagnostic | res47: Comorbidities | Neuropathic pain/painful neuropathy | ||
| N035.12 | Read | Neuropathic arthritis | diagnostic | res47: Comorbidities | Neuropathic pain/painful neuropathy | ||
| N242.00 | Read | Neuralgia, neuritis and radiculitis unspecified | diagnostic | res47: Comorbidities | Neuropathic pain/painful neuropathy | ||
| N242000 | Read | Neuralgia unspecified | diagnostic | res47: Comorbidities | Neuropathic pain/painful neuropathy | ||
| N242300 | Read | Neuropathic pain | diagnostic | res47: Comorbidities | Neuropathic pain/painful neuropathy | ||
| N242z00 | Read | Neuralgia, neuritis or radiculitis NOS | diagnostic | res47: Comorbidities | Neuropathic pain/painful neuropathy | ||
| N242z11 | Read | Policeman's disease | diagnostic | res47: Comorbidities | Neuropathic pain/painful neuropathy | ||
| SC20000 | Read | Traumatic epilepsy | diagnostic | res47: Comorbidities | Epilepsy |
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ClinicalCodes is a project at the University of Manchester Institute of Population Health
The ClinicalCodes project is funded by the National Institute for Health Research (NIHR) School for Primary Care Research (SPCR)