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Research article:

HbA1C variability and hypoglycemia hospitalization in adults with type 1 and type 2 diabetes: a nested case-control study

Reference:

Victor W. Zhong; Juhaeri Juhaeri; Stephen R. Cole; Christina M. Shay; Penny Gordon-Larsen; Evangelos Kontopantelis; Elizabeth J Mayer-Davis(2017) HbA1C variability and hypoglycemia hospitalization in adults with type 1 and type 2 diabetes: a nested case-control study. Journal of Diabetes and its Complications, doi: http://dx.doi.org/10.1016/j.jdiacomp.2017.10.008

Link to article
Abstract
Aims: To determine association between HbA1C variability and hypoglycemia requiring hospitalization (HH) in adults with type 1 diabetes (T1D) and type 2 diabetes (T2D). Methods: Using nested case-control design in electronic health record data in England, one case with first or recurrent HH was matched to one control who had not experienced HH in incident T1D and T2D adults. HbA1C variability was determined by standard deviation of ≥3 HbA1C results. Conditional logistic models were applied to determine association of HbA1C variability with first and recurrent HH. Results: In T1D, every 1.0% increase in HbA1C variability was associated with 90% higher first HH risk (95% CI, 1.25-2.89) and 392% higher recurrent HH risk (95% CI, 1.17- 20.61). In T2D, a 1.0% increase in HbA1C variability was associated with 556% higher first HH risk (95% CI, 3.88-11.08) and 573% higher recurrent HH risk (95% CI, 1.59-28.51). In T2D for first HH, the association was the strongest in non-insulin non-sulfonylurea users (P<0.0001); for recurrent HH, the association was stronger in insulin users than sulfonylurea users (P=0.07). The HbA1C variability-HH association was stronger in more recent years in T2D (P≤0.004). Conclusions: HbA1C variability is a strong predictor for HH in T1D and T2D.
Author for correspondence
Elizabeth J Mayer-Davis
Email for correspondence
mayerdav@email.unc.edu

Code list: res50: AIDS

36 codes in list

Code Coding system Description Entity type List name
A788.00 Read Acquired immune deficiency syndrome diagnostic res50: AIDS
A788000 Read Acute human immunodeficiency virus infection diagnostic res50: AIDS
A788100 Read Asymptomatic human immunodeficiency virus infection diagnostic res50: AIDS
A788.11 Read Human immunodeficiency virus infection diagnostic res50: AIDS
A788200 Read HIV infection with persistent generalised lymphadenopathy diagnostic res50: AIDS
A788300 Read Human immunodeficiency virus with constitutional disease diagnostic res50: AIDS
A788400 Read Human immunodeficiency virus with neurological disease diagnostic res50: AIDS
A788500 Read Human immunodeficiency virus with secondary infection diagnostic res50: AIDS
A788600 Read Human immunodeficiency virus with secondary cancers diagnostic res50: AIDS
A788W00 Read HIV disease resulting in unspecified malignant neoplasm diagnostic res50: AIDS
A788X00 Read HIV disease resulting/unspcf infectious+parasitic disease diagnostic res50: AIDS
A788y00 Read Human immunodeficiency virus with other clinical findings diagnostic res50: AIDS
A788z00 Read Acquired human immunodeficiency virus infection syndrome NOS diagnostic res50: AIDS
A789000 Read HIV disease resulting in mycobacterial infection diagnostic res50: AIDS
A789100 Read HIV disease resulting in cytomegaloviral disease diagnostic res50: AIDS
A789200 Read HIV disease resulting in candidiasis diagnostic res50: AIDS
A789300 Read HIV disease resulting in Pneumocystis carinii pneumonia diagnostic res50: AIDS
A789311 Read HIV disease resulting in Pneumocystis jirovecii pneumonia diagnostic res50: AIDS
A789400 Read HIV disease resulting in multiple infections diagnostic res50: AIDS
A789500 Read HIV disease resulting in Kaposi's sarcoma diagnostic res50: AIDS
A789511 Read HIV disease resulting in Kaposi sarcoma diagnostic res50: AIDS
A789600 Read HIV disease resulting in Burkitt's lymphoma diagnostic res50: AIDS
A789700 Read HIV dis resulting oth types of non-Hodgkin's lymphoma diagnostic res50: AIDS
A789800 Read HIV disease resulting in multiple malignant neoplasms diagnostic res50: AIDS
A789900 Read HIV disease resulting in lymphoid interstitial pneumonitis diagnostic res50: AIDS
A789A00 Read HIV disease resulting in wasting syndrome diagnostic res50: AIDS
A789X00 Read HIV dis reslt/oth mal neopl/lymph,h'matopoetc+reltd tissu diagnostic res50: AIDS
AyuC.00 Read [X]Human immunodeficiency virus disease diagnostic res50: AIDS
AyuC100 Read [X]HIV disease resulting in other viral infections diagnostic res50: AIDS
AyuC300 Read [X]HIV disease resulting in multiple infections diagnostic res50: AIDS
AyuC400 Read [X]HIV disease resulting/other infectious+parasitic diseases diagnostic res50: AIDS
AyuC600 Read [X]HIV disease resulting in other non-Hodgkin's lymphoma diagnostic res50: AIDS
AyuCC00 Read [X]HIV disease resulting in other specified conditions diagnostic res50: AIDS
AyuCD00 Read [X]Unspecified human immunodeficiency virus [HIV] disease diagnostic res50: AIDS
Eu02400 Read [X]Dementia in human immunodef virus [HIV] disease diagnostic res50: AIDS
L179.00 Read HIV disease complicating pregnancy childbirth puerperium diagnostic res50: AIDS

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