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Research article:
HbA1C variability and hypoglycemia hospitalization in adults with type 1 and type 2 diabetes: a nested case-control study
Reference:
Victor W. Zhong; Juhaeri Juhaeri; Stephen R. Cole; Christina M. Shay; Penny Gordon-Larsen; Evangelos Kontopantelis; Elizabeth J Mayer-Davis(2017) HbA1C variability and hypoglycemia hospitalization in adults with type 1 and type 2 diabetes: a nested case-control study. Journal of Diabetes and its Complications, doi: http://dx.doi.org/10.1016/j.jdiacomp.2017.10.008
- Link to article
- Abstract
- Aims: To determine association between HbA1C variability and hypoglycemia requiring hospitalization (HH) in adults with type 1 diabetes (T1D) and type 2 diabetes (T2D). Methods: Using nested case-control design in electronic health record data in England, one case with first or recurrent HH was matched to one control who had not experienced HH in incident T1D and T2D adults. HbA1C variability was determined by standard deviation of ≥3 HbA1C results. Conditional logistic models were applied to determine association of HbA1C variability with first and recurrent HH. Results: In T1D, every 1.0% increase in HbA1C variability was associated with 90% higher first HH risk (95% CI, 1.25-2.89) and 392% higher recurrent HH risk (95% CI, 1.17- 20.61). In T2D, a 1.0% increase in HbA1C variability was associated with 556% higher first HH risk (95% CI, 3.88-11.08) and 573% higher recurrent HH risk (95% CI, 1.59-28.51). In T2D for first HH, the association was the strongest in non-insulin non-sulfonylurea users (P<0.0001); for recurrent HH, the association was stronger in insulin users than sulfonylurea users (P=0.07). The HbA1C variability-HH association was stronger in more recent years in T2D (P≤0.004). Conclusions: HbA1C variability is a strong predictor for HH in T1D and T2D.
- Author for correspondence
- Elizabeth J Mayer-Davis
- Email for correspondence
- mayerdav@email.unc.edu
Code list: res50: congestive heart disease
47 codes in list
| Code | Coding system | Description | Entity type | List name | |||
|---|---|---|---|---|---|---|---|
| 14A6.00 | Read | H/O: heart failure | diagnostic | res50: congestive heart disease | |||
| 14AM.00 | Read | H/O: Heart failure in last year | diagnostic | res50: congestive heart disease | |||
| 1O1..00 | Read | Heart failure confirmed | diagnostic | res50: congestive heart disease | |||
| 33BA.00 | Read | Impaired left ventricular function | diagnostic | res50: congestive heart disease | |||
| 585f.00 | Read | Echocardiogram shows left ventricular systolic dysfunction | diagnostic | res50: congestive heart disease | |||
| 585g.00 | Read | Echocardiogram shows left ventricular diastolic dysfunction | diagnostic | res50: congestive heart disease | |||
| 585k.00 | Read | Echocardiogram shows normal left ventricular function | diagnostic | res50: congestive heart disease | |||
| 8B29.00 | Read | Cardiac failure therapy | diagnostic | res50: congestive heart disease | |||
| 8CeC.00 | Read | Preferred place of care for next exacerbation heart failure | diagnostic | res50: congestive heart disease | |||
| 8CL3.00 | Read | Heart failure care plan discussed with patient | diagnostic | res50: congestive heart disease | |||
| 8CMK.00 | Read | Has heart failure management plan | diagnostic | res50: congestive heart disease | |||
| 8CMW800 | Read | Heart failure clinical pathway | diagnostic | res50: congestive heart disease | |||
| 8H2S.00 | Read | Admit heart failure emergency | diagnostic | res50: congestive heart disease | |||
| G232.00 | Read | Hypertensive heart&renal dis wth (congestive) heart failure | diagnostic | res50: congestive heart disease | |||
| G234.00 | Read | Hyperten heart&renal dis+both(congestv)heart and renal fail | diagnostic | res50: congestive heart disease | |||
| G575100 | Read | Sudden cardiac death, so described | diagnostic | res50: congestive heart disease | |||
| G575.11 | Read | Cardio-respiratory arrest | diagnostic | res50: congestive heart disease | |||
| G58..00 | Read | Heart failure | diagnostic | res50: congestive heart disease | |||
| G580.00 | Read | Congestive heart failure | diagnostic | res50: congestive heart disease | |||
| G580000 | Read | Acute congestive heart failure | diagnostic | res50: congestive heart disease | |||
| G580100 | Read | Chronic congestive heart failure | diagnostic | res50: congestive heart disease | |||
| G580.11 | Read | Congestive cardiac failure | diagnostic | res50: congestive heart disease | |||
| G580.12 | Read | Right heart failure | diagnostic | res50: congestive heart disease | |||
| G580.13 | Read | Right ventricular failure | diagnostic | res50: congestive heart disease | |||
| G580.14 | Read | Biventricular failure | diagnostic | res50: congestive heart disease | |||
| G580200 | Read | Decompensated cardiac failure | diagnostic | res50: congestive heart disease | |||
| G580300 | Read | Compensated cardiac failure | diagnostic | res50: congestive heart disease | |||
| G580400 | Read | Congestive heart failure due to valvular disease | diagnostic | res50: congestive heart disease | |||
| G581.00 | Read | Left ventricular failure | diagnostic | res50: congestive heart disease | |||
| G581000 | Read | Acute left ventricular failure | diagnostic | res50: congestive heart disease | |||
| G58..11 | Read | Cardiac failure | diagnostic | res50: congestive heart disease | |||
| G581.13 | Read | Impaired left ventricular function | diagnostic | res50: congestive heart disease | |||
| G582.00 | Read | Acute heart failure | diagnostic | res50: congestive heart disease | |||
| G583.00 | Read | Heart failure with normal ejection fraction | diagnostic | res50: congestive heart disease | |||
| G583.11 | Read | HFNEF - heart failure with normal ejection fraction | diagnostic | res50: congestive heart disease | |||
| G583.12 | Read | Heart failure with preserved ejection fraction | diagnostic | res50: congestive heart disease | |||
| G584.00 | Read | Right ventricular failure | diagnostic | res50: congestive heart disease | |||
| G58z.00 | Read | Heart failure NOS | diagnostic | res50: congestive heart disease | |||
| G58z.11 | Read | Weak heart | diagnostic | res50: congestive heart disease | |||
| G58z.12 | Read | Cardiac failure NOS | diagnostic | res50: congestive heart disease | |||
| G5y4z00 | Read | Post cardiac operation heart failure NOS | diagnostic | res50: congestive heart disease | |||
| G5yy900 | Read | Left ventricular systolic dysfunction | diagnostic | res50: congestive heart disease | |||
| G5yyA00 | Read | Left ventricular diastolic dysfunction | diagnostic | res50: congestive heart disease | |||
| Q48y100 | Read | Congenital cardiac failure | diagnostic | res50: congestive heart disease | |||
| Q490.00 | Read | Neonatal cardiac failure | diagnostic | res50: congestive heart disease | |||
| SP11100 | Read | Cardiac insufficiency as a complication of care | diagnostic | res50: congestive heart disease | |||
| SP11111 | Read | Heart failure as a complication of care | diagnostic | res50: congestive heart disease |
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