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Research article:

HbA1C variability and hypoglycemia hospitalization in adults with type 1 and type 2 diabetes: a nested case-control study

Reference:

Victor W. Zhong; Juhaeri Juhaeri; Stephen R. Cole; Christina M. Shay; Penny Gordon-Larsen; Evangelos Kontopantelis; Elizabeth J Mayer-Davis(2017) HbA1C variability and hypoglycemia hospitalization in adults with type 1 and type 2 diabetes: a nested case-control study. Journal of Diabetes and its Complications, doi: http://dx.doi.org/10.1016/j.jdiacomp.2017.10.008

Link to article
Abstract
Aims: To determine association between HbA1C variability and hypoglycemia requiring hospitalization (HH) in adults with type 1 diabetes (T1D) and type 2 diabetes (T2D). Methods: Using nested case-control design in electronic health record data in England, one case with first or recurrent HH was matched to one control who had not experienced HH in incident T1D and T2D adults. HbA1C variability was determined by standard deviation of ≥3 HbA1C results. Conditional logistic models were applied to determine association of HbA1C variability with first and recurrent HH. Results: In T1D, every 1.0% increase in HbA1C variability was associated with 90% higher first HH risk (95% CI, 1.25-2.89) and 392% higher recurrent HH risk (95% CI, 1.17- 20.61). In T2D, a 1.0% increase in HbA1C variability was associated with 556% higher first HH risk (95% CI, 3.88-11.08) and 573% higher recurrent HH risk (95% CI, 1.59-28.51). In T2D for first HH, the association was the strongest in non-insulin non-sulfonylurea users (P<0.0001); for recurrent HH, the association was stronger in insulin users than sulfonylurea users (P=0.07). The HbA1C variability-HH association was stronger in more recent years in T2D (P≤0.004). Conclusions: HbA1C variability is a strong predictor for HH in T1D and T2D.
Author for correspondence
Elizabeth J Mayer-Davis
Email for correspondence
mayerdav@email.unc.edu

Code list: res50: dementia

115 codes in list

Code Coding system Description Entity type List name
1461 Read H/O: dementia diagnostic res50: dementia
A411.00 Read Jakob-Creutzfeldt disease diagnostic res50: dementia
BBC9.11 Read [M]Pick's tubular adenoma diagnostic res50: dementia
E00..00 Read Senile and presenile organic psychotic conditions diagnostic res50: dementia
E000.00 Read Uncomplicated senile dementia diagnostic res50: dementia
E001.00 Read Presenile dementia diagnostic res50: dementia
E001000 Read Uncomplicated presenile dementia diagnostic res50: dementia
E00..11 Read Senile dementia diagnostic res50: dementia
E001100 Read Presenile dementia with delirium diagnostic res50: dementia
E00..12 Read Senile/presenile dementia diagnostic res50: dementia
E001200 Read Presenile dementia with paranoia diagnostic res50: dementia
E001300 Read Presenile dementia with depression diagnostic res50: dementia
E001z00 Read Presenile dementia NOS diagnostic res50: dementia
E002.00 Read Senile dementia with depressive or paranoid features diagnostic res50: dementia
E002000 Read Senile dementia with paranoia diagnostic res50: dementia
E002100 Read Senile dementia with depression diagnostic res50: dementia
E002z00 Read Senile dementia with depressive or paranoid features NOS diagnostic res50: dementia
E003.00 Read Senile dementia with delirium diagnostic res50: dementia
E004.00 Read Arteriosclerotic dementia diagnostic res50: dementia
E004000 Read Uncomplicated arteriosclerotic dementia diagnostic res50: dementia
E004100 Read Arteriosclerotic dementia with delirium diagnostic res50: dementia
E004.11 Read Multi infarct dementia diagnostic res50: dementia
E004200 Read Arteriosclerotic dementia with paranoia diagnostic res50: dementia
E004300 Read Arteriosclerotic dementia with depression diagnostic res50: dementia
E004z00 Read Arteriosclerotic dementia NOS diagnostic res50: dementia
E00y.00 Read Other senile and presenile organic psychoses diagnostic res50: dementia
E00y.11 Read Presbyophrenic psychosis diagnostic res50: dementia
E00z.00 Read Senile or presenile psychoses NOS diagnostic res50: dementia
E012.00 Read Other alcoholic dementia diagnostic res50: dementia
E012000 Read Chronic alcoholic brain syndrome diagnostic res50: dementia
E012.11 Read Alcoholic dementia NOS diagnostic res50: dementia
E02y100 Read Drug-induced dementia diagnostic res50: dementia
E040.11 Read Korsakoff's non-alcoholic psychosis diagnostic res50: dementia
E041.00 Read Dementia in conditions EC diagnostic res50: dementia
Eu00.00 Read [X]Dementia in Alzheimer's disease diagnostic res50: dementia
Eu00000 Read [X]Dementia in Alzheimer's disease with early onset diagnostic res50: dementia
Eu00011 Read [X]Presenile dementia,Alzheimer's type diagnostic res50: dementia
Eu00012 Read [X]Primary degen dementia, Alzheimer's type, presenile onset diagnostic res50: dementia
Eu00013 Read [X]Alzheimer's disease type 2 diagnostic res50: dementia
Eu00100 Read [X]Dementia in Alzheimer's disease with late onset diagnostic res50: dementia
Eu00111 Read [X]Alzheimer's disease type 1 diagnostic res50: dementia
Eu00112 Read [X]Senile dementia,Alzheimer's type diagnostic res50: dementia
Eu00113 Read [X]Primary degen dementia of Alzheimer's type, senile onset diagnostic res50: dementia
Eu00200 Read [X]Dementia in Alzheimer's dis, atypical or mixed type diagnostic res50: dementia
Eu00z00 Read [X]Dementia in Alzheimer's disease, unspecified diagnostic res50: dementia
Eu00z11 Read [X]Alzheimer's dementia unspec diagnostic res50: dementia
Eu01.00 Read [X]Vascular dementia diagnostic res50: dementia
Eu01000 Read [X]Vascular dementia of acute onset diagnostic res50: dementia
Eu01100 Read [X]Multi-infarct dementia diagnostic res50: dementia
Eu01.11 Read [X]Arteriosclerotic dementia diagnostic res50: dementia
Eu01111 Read [X]Predominantly cortical dementia diagnostic res50: dementia
Eu01200 Read [X]Subcortical vascular dementia diagnostic res50: dementia
Eu01300 Read [X]Mixed cortical and subcortical vascular dementia diagnostic res50: dementia
Eu01y00 Read [X]Other vascular dementia diagnostic res50: dementia
Eu01z00 Read [X]Vascular dementia, unspecified diagnostic res50: dementia
Eu02.00 Read [X]Dementia in other diseases classified elsewhere diagnostic res50: dementia
Eu02000 Read [X]Dementia in Pick's disease diagnostic res50: dementia
Eu02100 Read [X]Dementia in Creutzfeldt-Jakob disease diagnostic res50: dementia
Eu02200 Read [X]Dementia in Huntington's disease diagnostic res50: dementia
Eu02300 Read [X]Dementia in Parkinson's disease diagnostic res50: dementia
Eu02400 Read [X]Dementia in human immunodef virus [HIV] disease diagnostic res50: dementia
Eu02500 Read [X]Lewy body dementia diagnostic res50: dementia
Eu02y00 Read [X]Dementia in other specified diseases classif elsewhere diagnostic res50: dementia
Eu02z00 Read [X] Unspecified dementia diagnostic res50: dementia
Eu02z11 Read [X] Presenile dementia NOS diagnostic res50: dementia
Eu02z12 Read [X] Presenile psychosis NOS diagnostic res50: dementia
Eu02z13 Read [X] Primary degenerative dementia NOS diagnostic res50: dementia
Eu02z14 Read [X] Senile dementia NOS diagnostic res50: dementia
Eu02z15 Read [X] Senile psychosis NOS diagnostic res50: dementia
Eu02z16 Read [X] Senile dementia, depressed or paranoid type diagnostic res50: dementia
Eu04000 Read [X]Delirium not superimposed on dementia, so described diagnostic res50: dementia
Eu04100 Read [X]Delirium superimposed on dementia diagnostic res50: dementia
Eu05700 Read [X]Mild cognitive disorder diagnostic res50: dementia
Eu10711 Read [X]Alcoholic dementia NOS diagnostic res50: dementia
Eu10712 Read [X]Chronic alcoholic brain syndrome diagnostic res50: dementia
Eu84311 Read [X]Dementia infantalis diagnostic res50: dementia
F10..00 Read Cerebral degenerations usually manifest in childhood diagnostic res50: dementia
F102100 Read Cerebral degeneration in Niemann-Pick disease diagnostic res50: dementia
F103.00 Read Cerebral degeneration in diseases EC diagnostic res50: dementia
F103000 Read Cerebral degeneration in Hunter's disease diagnostic res50: dementia
F103100 Read Cerebral degeneration in mucopolysaccharidoses diagnostic res50: dementia
F103z00 Read Cerebral degeneration in disease NOS diagnostic res50: dementia
F10z.00 Read Childhood cerebral degenerations NOS diagnostic res50: dementia
F11..00 Read Other cerebral degenerations diagnostic res50: dementia
F110.00 Read Alzheimer's disease diagnostic res50: dementia
F110000 Read Alzheimer's disease with early onset diagnostic res50: dementia
F110100 Read Alzheimer's disease with late onset diagnostic res50: dementia
F111.00 Read Pick's disease diagnostic res50: dementia
F112.00 Read Senile degeneration of brain diagnostic res50: dementia
F113000 Read Normal pressure hydrocephalus diagnostic res50: dementia
F116.00 Read Lewy body disease diagnostic res50: dementia
F11x.00 Read Cerebral degeneration in other disease EC diagnostic res50: dementia
F11x000 Read Cerebral degeneration due to alcoholism diagnostic res50: dementia
F11x200 Read Cerebral degeneration due to cerebrovascular disease diagnostic res50: dementia
F11x400 Read Cerebral degeneration due to neoplastic disease diagnostic res50: dementia
F11x500 Read Cerebral degeneration due to myxoedema diagnostic res50: dementia
F11x600 Read Cerebral degeneration due to vitamin B12 deficiency diagnostic res50: dementia
F11x700 Read Cerebral degeneration due to Jakob - Creutzfeldt disease diagnostic res50: dementia
F11x800 Read Cerebral degeneration due to multifocal leucoencephalopathy diagnostic res50: dementia
F11x900 Read Cerebral degeneration in Parkinson's disease diagnostic res50: dementia
F11xz00 Read Cerebral degeneration other disease NOS diagnostic res50: dementia
F11y.00 Read Other cerebral degeneration diagnostic res50: dementia
F11y000 Read Reye's syndrome diagnostic res50: dementia
F11y100 Read Cerebral ataxia diagnostic res50: dementia
F11yz00 Read Other cerebral degeneration NOS diagnostic res50: dementia
F11z.00 Read Cerebral degeneration NOS diagnostic res50: dementia
F11z.11 Read Cerebral atrophy diagnostic res50: dementia
F12..00 Read Parkinson's disease diagnostic res50: dementia
F12z.00 Read Parkinson's disease NOS diagnostic res50: dementia
F13..11 Read Extrapyramidal disease excluding Parkinson's disease diagnostic res50: dementia
F134.00 Read Huntington's chorea diagnostic res50: dementia
Fyu3000 Read [X]Other Alzheimer's disease diagnostic res50: dementia
G532100 Read Pick's disease of heart diagnostic res50: dementia
ZR1T.00 Read Arizona battery for communication disorders of dementia diagnostic res50: dementia
ZS7C500 Read Language disorder of dementia diagnostic res50: dementia

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