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Research article:
HbA1C variability and hypoglycemia hospitalization in adults with type 1 and type 2 diabetes: a nested case-control study
Reference:
Victor W. Zhong; Juhaeri Juhaeri; Stephen R. Cole; Christina M. Shay; Penny Gordon-Larsen; Evangelos Kontopantelis; Elizabeth J Mayer-Davis(2017) HbA1C variability and hypoglycemia hospitalization in adults with type 1 and type 2 diabetes: a nested case-control study. Journal of Diabetes and its Complications, doi: http://dx.doi.org/10.1016/j.jdiacomp.2017.10.008
- Link to article
- Abstract
- Aims: To determine association between HbA1C variability and hypoglycemia requiring hospitalization (HH) in adults with type 1 diabetes (T1D) and type 2 diabetes (T2D). Methods: Using nested case-control design in electronic health record data in England, one case with first or recurrent HH was matched to one control who had not experienced HH in incident T1D and T2D adults. HbA1C variability was determined by standard deviation of ≥3 HbA1C results. Conditional logistic models were applied to determine association of HbA1C variability with first and recurrent HH. Results: In T1D, every 1.0% increase in HbA1C variability was associated with 90% higher first HH risk (95% CI, 1.25-2.89) and 392% higher recurrent HH risk (95% CI, 1.17- 20.61). In T2D, a 1.0% increase in HbA1C variability was associated with 556% higher first HH risk (95% CI, 3.88-11.08) and 573% higher recurrent HH risk (95% CI, 1.59-28.51). In T2D for first HH, the association was the strongest in non-insulin non-sulfonylurea users (P<0.0001); for recurrent HH, the association was stronger in insulin users than sulfonylurea users (P=0.07). The HbA1C variability-HH association was stronger in more recent years in T2D (P≤0.004). Conclusions: HbA1C variability is a strong predictor for HH in T1D and T2D.
- Author for correspondence
- Elizabeth J Mayer-Davis
- Email for correspondence
- mayerdav@email.unc.edu
Code list: res50: diseases causing hypoglycemia
46 codes in list
| Code | Coding system | Description | Entity type | List name | |||
|---|---|---|---|---|---|---|---|
| 14CH.00 | Read | History of chronic pancreatitis | diagnostic | res50: diseases causing hypoglycemia | |||
| 677C100 | Read | Cystic fibrosis gene carrier | diagnostic | res50: diseases causing hypoglycemia | |||
| A176.00 | Read | Tuberculosis of adrenal glands - Addison's disease | diagnostic | res50: diseases causing hypoglycemia | |||
| B7H2.11 | Read | Pituitary adenoma | diagnostic | res50: diseases causing hypoglycemia | |||
| BB5B.00 | Read | [M]Pancreatic adenomas and carcinomas | diagnostic | res50: diseases causing hypoglycemia | |||
| BB5B200 | Read | [M]Insulinoma NOS | diagnostic | res50: diseases causing hypoglycemia | |||
| BB5B300 | Read | [M]Insulinoma, malignant | diagnostic | res50: diseases causing hypoglycemia | |||
| BB5Bz00 | Read | [M]Pancreatic adenoma or carcinoma NOS | diagnostic | res50: diseases causing hypoglycemia | |||
| BB5V.00 | Read | [M]Pituitary adenomas and carcinomas | diagnostic | res50: diseases causing hypoglycemia | |||
| BB5Vz00 | Read | [M]Pituitary adenoma or carcinoma NOS | diagnostic | res50: diseases causing hypoglycemia | |||
| C10N100 | Read | Cystic fibrosis related diabetes mellitus | diagnostic | res50: diseases causing hypoglycemia | |||
| C132.00 | Read | Panhypopituitarism | diagnostic | res50: diseases causing hypoglycemia | |||
| C132000 | Read | Idiopathic panhypopituitarism | diagnostic | res50: diseases causing hypoglycemia | |||
| C132100 | Read | Post-birth injury panhypopituitarism | diagnostic | res50: diseases causing hypoglycemia | |||
| C132.11 | Read | Hypopituitarism NOS | diagnostic | res50: diseases causing hypoglycemia | |||
| C132200 | Read | Postinfarction panhypopituitarism | diagnostic | res50: diseases causing hypoglycemia | |||
| C132300 | Read | Postinfective panhypopituitarism | diagnostic | res50: diseases causing hypoglycemia | |||
| C132y00 | Read | Other specified panhypopituitarism | diagnostic | res50: diseases causing hypoglycemia | |||
| C132z00 | Read | Panhypopituitarism NOS | diagnostic | res50: diseases causing hypoglycemia | |||
| C137000 | Read | Hormone-induced hypopituitarism | diagnostic | res50: diseases causing hypoglycemia | |||
| C137100 | Read | Post-hypophysectomy hypopituitarism | diagnostic | res50: diseases causing hypoglycemia | |||
| C137.11 | Read | Iatrogenic hypopituitarism | diagnostic | res50: diseases causing hypoglycemia | |||
| C137111 | Read | Surgically-induced hypopituitarism | diagnostic | res50: diseases causing hypoglycemia | |||
| C137200 | Read | Post-radiotherapy hypopituitarism | diagnostic | res50: diseases causing hypoglycemia | |||
| C154.00 | Read | Corticoadrenal insufficiency | diagnostic | res50: diseases causing hypoglycemia | |||
| C154000 | Read | Acute adrenal insufficiency | diagnostic | res50: diseases causing hypoglycemia | |||
| C154100 | Read | Addison's disease | diagnostic | res50: diseases causing hypoglycemia | |||
| C154z00 | Read | Corticoadrenal insufficiency NOS | diagnostic | res50: diseases causing hypoglycemia | |||
| C154z12 | Read | Adrenal insufficiency NEC | diagnostic | res50: diseases causing hypoglycemia | |||
| C370.00 | Read | Cystic fibrosis | diagnostic | res50: diseases causing hypoglycemia | |||
| C370000 | Read | Cystic fibrosis with no meconium ileus | diagnostic | res50: diseases causing hypoglycemia | |||
| C370100 | Read | Cystic fibrosis with meconium ileus | diagnostic | res50: diseases causing hypoglycemia | |||
| C370111 | Read | Meconium ileus in cystic fibrosis | diagnostic | res50: diseases causing hypoglycemia | |||
| C370200 | Read | Cystic fibrosis with pulmonary manifestations | diagnostic | res50: diseases causing hypoglycemia | |||
| C370300 | Read | Cystic fibrosis with intestinal manifestations | diagnostic | res50: diseases causing hypoglycemia | |||
| C370400 | Read | Arthropathy in cystic fibrosis | diagnostic | res50: diseases causing hypoglycemia | |||
| C370500 | Read | Cystic fibrosis with distal intestinal obstruction syndrome | diagnostic | res50: diseases causing hypoglycemia | |||
| C370800 | Read | Cystic fibrosis related cirrhosis | diagnostic | res50: diseases causing hypoglycemia | |||
| C370900 | Read | Exacerbation of cystic fibrosis | diagnostic | res50: diseases causing hypoglycemia | |||
| C370y00 | Read | Cystic fibrosis with other manifestations | diagnostic | res50: diseases causing hypoglycemia | |||
| C370z00 | Read | Cystic fibrosis NOS | diagnostic | res50: diseases causing hypoglycemia | |||
| F395000 | Read | Myopathy due to Addison's disease | diagnostic | res50: diseases causing hypoglycemia | |||
| J671.00 | Read | Chronic pancreatitis | diagnostic | res50: diseases causing hypoglycemia | |||
| J671000 | Read | Alcohol-induced chronic pancreatitis | diagnostic | res50: diseases causing hypoglycemia | |||
| J671100 | Read | Gallstone chronic pancreatitis | diagnostic | res50: diseases causing hypoglycemia | |||
| Jyu8400 | Read | [X]Other chronic pancreatitis | diagnostic | res50: diseases causing hypoglycemia |
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