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Research article:
HbA1C variability and hypoglycemia hospitalization in adults with type 1 and type 2 diabetes: a nested case-control study
Reference:
Victor W. Zhong; Juhaeri Juhaeri; Stephen R. Cole; Christina M. Shay; Penny Gordon-Larsen; Evangelos Kontopantelis; Elizabeth J Mayer-Davis(2017) HbA1C variability and hypoglycemia hospitalization in adults with type 1 and type 2 diabetes: a nested case-control study. Journal of Diabetes and its Complications, doi: http://dx.doi.org/10.1016/j.jdiacomp.2017.10.008
- Link to article
- Abstract
- Aims: To determine association between HbA1C variability and hypoglycemia requiring hospitalization (HH) in adults with type 1 diabetes (T1D) and type 2 diabetes (T2D). Methods: Using nested case-control design in electronic health record data in England, one case with first or recurrent HH was matched to one control who had not experienced HH in incident T1D and T2D adults. HbA1C variability was determined by standard deviation of ≥3 HbA1C results. Conditional logistic models were applied to determine association of HbA1C variability with first and recurrent HH. Results: In T1D, every 1.0% increase in HbA1C variability was associated with 90% higher first HH risk (95% CI, 1.25-2.89) and 392% higher recurrent HH risk (95% CI, 1.17- 20.61). In T2D, a 1.0% increase in HbA1C variability was associated with 556% higher first HH risk (95% CI, 3.88-11.08) and 573% higher recurrent HH risk (95% CI, 1.59-28.51). In T2D for first HH, the association was the strongest in non-insulin non-sulfonylurea users (P<0.0001); for recurrent HH, the association was stronger in insulin users than sulfonylurea users (P=0.07). The HbA1C variability-HH association was stronger in more recent years in T2D (P≤0.004). Conclusions: HbA1C variability is a strong predictor for HH in T1D and T2D.
- Author for correspondence
- Elizabeth J Mayer-Davis
- Email for correspondence
- mayerdav@email.unc.edu
Code list: res50: glinide
17 codes in list
| Code | Coding system | Description | Entity type | List name | drugsubstance | bnfcode | bnfchapter |
|---|---|---|---|---|---|---|---|
| 11316 | CPRD_product_code | NovoNorm 500microgram tablets (Novo Nordisk Ltd) | drug | res50: glinide | Repaglinide | 06010203 | Other Antidiabetic Drugs |
| 11321 | CPRD_product_code | NovoNorm 1mg tablets (Novo Nordisk Ltd) | drug | res50: glinide | Repaglinide | 06010203 | Other Antidiabetic Drugs |
| 11366 | CPRD_product_code | NovoNorm 2mg tablets (Novo Nordisk Ltd) | drug | res50: glinide | Repaglinide | 06010203 | Other Antidiabetic Drugs |
| 11483 | CPRD_product_code | Nateglinide 60mg tablets | drug | res50: glinide | Nateglinide | 06010203 | Other Antidiabetic Drugs |
| 15955 | CPRD_product_code | Starlix 120mg tablets (Novartis Pharmaceuticals UK Ltd) | drug | res50: glinide | Nateglinide | 06010203 | Other Antidiabetic Drugs |
| 23945 | CPRD_product_code | Starlix 60mg tablets (Novartis Pharmaceuticals UK Ltd) | drug | res50: glinide | Nateglinide | 06010203 | Other Antidiabetic Drugs |
| 27125 | CPRD_product_code | Starlix 180mg tablets (Novartis Pharmaceuticals UK Ltd) | drug | res50: glinide | Nateglinide | 06010203 | Other Antidiabetic Drugs |
| 35561 | CPRD_product_code | Prandin 2mg tablets (Novo Nordisk Ltd) | drug | res50: glinide | Repaglinide | 06010203 | Other Antidiabetic Drugs |
| 36774 | CPRD_product_code | Prandin 1mg tablets (Novo Nordisk Ltd) | drug | res50: glinide | Repaglinide | 06010203 | Other Antidiabetic Drugs |
| 36948 | CPRD_product_code | Prandin 0.5mg tablets (Novo Nordisk Ltd) | drug | res50: glinide | Repaglinide | 06010203 | Other Antidiabetic Drugs |
| 52203 | CPRD_product_code | Enyglid 0.5mg tablets (Consilient Health Ltd) | drug | res50: glinide | Repaglinide | 06010203 | Other Antidiabetic Drugs |
| 5678 | CPRD_product_code | Nateglinide 120mg tablets | drug | res50: glinide | Nateglinide | 06010203 | Other Antidiabetic Drugs |
| 5989 | CPRD_product_code | Nateglinide 180mg tablets | drug | res50: glinide | Nateglinide | 06010203 | Other Antidiabetic Drugs |
| 61925 | CPRD_product_code | NovoNorm 500microgram tablets (Waymade Healthcare Plc) | drug | res50: glinide | Repaglinide | 06010203 | Other Antidiabetic Drugs |
| 9707 | CPRD_product_code | Repaglinide 1mg tablets | drug | res50: glinide | Repaglinide | 06010203 | Other Antidiabetic Drugs |
| 9748 | CPRD_product_code | Repaglinide 2mg tablets | drug | res50: glinide | Repaglinide | 06010203 | Other Antidiabetic Drugs |
| 9865 | CPRD_product_code | Repaglinide 500microgram tablets | drug | res50: glinide | Repaglinide | 06010203 | Other Antidiabetic Drugs |
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