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Research article:
HbA1C variability and hypoglycemia hospitalization in adults with type 1 and type 2 diabetes: a nested case-control study
Reference:
Victor W. Zhong; Juhaeri Juhaeri; Stephen R. Cole; Christina M. Shay; Penny Gordon-Larsen; Evangelos Kontopantelis; Elizabeth J Mayer-Davis(2017) HbA1C variability and hypoglycemia hospitalization in adults with type 1 and type 2 diabetes: a nested case-control study. Journal of Diabetes and its Complications, doi: http://dx.doi.org/10.1016/j.jdiacomp.2017.10.008
- Link to article
- Abstract
- Aims: To determine association between HbA1C variability and hypoglycemia requiring hospitalization (HH) in adults with type 1 diabetes (T1D) and type 2 diabetes (T2D). Methods: Using nested case-control design in electronic health record data in England, one case with first or recurrent HH was matched to one control who had not experienced HH in incident T1D and T2D adults. HbA1C variability was determined by standard deviation of ≥3 HbA1C results. Conditional logistic models were applied to determine association of HbA1C variability with first and recurrent HH. Results: In T1D, every 1.0% increase in HbA1C variability was associated with 90% higher first HH risk (95% CI, 1.25-2.89) and 392% higher recurrent HH risk (95% CI, 1.17- 20.61). In T2D, a 1.0% increase in HbA1C variability was associated with 556% higher first HH risk (95% CI, 3.88-11.08) and 573% higher recurrent HH risk (95% CI, 1.59-28.51). In T2D for first HH, the association was the strongest in non-insulin non-sulfonylurea users (P<0.0001); for recurrent HH, the association was stronger in insulin users than sulfonylurea users (P=0.07). The HbA1C variability-HH association was stronger in more recent years in T2D (P≤0.004). Conclusions: HbA1C variability is a strong predictor for HH in T1D and T2D.
- Author for correspondence
- Elizabeth J Mayer-Davis
- Email for correspondence
- mayerdav@email.unc.edu
Code list: res50: Metastatic tumour
135 codes in list
| Code | Coding system | Description | Entity type | List name | |||
|---|---|---|---|---|---|---|---|
| 142..00 | Read | H/O: malignant neoplasm (*) | diagnostic | res50: Metastatic tumour | |||
| B56..00 | Read | Secondary and unspecified malignant neoplasm of lymph nodes | diagnostic | res50: Metastatic tumour | |||
| B560.00 | Read | Secondary and unspec malig neop lymph nodes head/face/neck | diagnostic | res50: Metastatic tumour | |||
| B560000 | Read | Secondary and unspec malig neop of superficial parotid LN | diagnostic | res50: Metastatic tumour | |||
| B560100 | Read | Secondary and unspec malignant neoplasm mastoid lymph nodes | diagnostic | res50: Metastatic tumour | |||
| B560200 | Read | Secondary and unspec malig neop superficial cervical LN | diagnostic | res50: Metastatic tumour | |||
| B560300 | Read | Secondary and unspec malignant neoplasm occipital lymph node | diagnostic | res50: Metastatic tumour | |||
| B560400 | Read | Secondary and unspec malig neop deep parotid lymph nodes | diagnostic | res50: Metastatic tumour | |||
| B560500 | Read | Secondary and unspec malig neop submandibular lymph nodes | diagnostic | res50: Metastatic tumour | |||
| B560600 | Read | Secondary and unspec malig neop of facial lymph nodes | diagnostic | res50: Metastatic tumour | |||
| B560700 | Read | Secondary and unspec malig neop submental lymph nodes | diagnostic | res50: Metastatic tumour | |||
| B560800 | Read | Secondary and unspec malig neop anterior cervical LN | diagnostic | res50: Metastatic tumour | |||
| B560900 | Read | Secondary and unspec malig neop deep cervical LN | diagnostic | res50: Metastatic tumour | |||
| B560z00 | Read | Secondary unspec malig neop lymph nodes head/face/neck NOS | diagnostic | res50: Metastatic tumour | |||
| B561.00 | Read | Secondary and unspec malig neop intrathoracic lymph nodes | diagnostic | res50: Metastatic tumour | |||
| B561000 | Read | Secondary and unspec malig neop internal mammary lymph nodes | diagnostic | res50: Metastatic tumour | |||
| B56..11 | Read | Lymph node metastases | diagnostic | res50: Metastatic tumour | |||
| B561100 | Read | Secondary and unspec malig neop intercostal lymph nodes | diagnostic | res50: Metastatic tumour | |||
| B561200 | Read | Secondary and unspec malig neop diaphragmatic lymph nodes | diagnostic | res50: Metastatic tumour | |||
| B561300 | Read | Secondary and unspec malig neop ant mediastinal lymph nodes | diagnostic | res50: Metastatic tumour | |||
| B561400 | Read | Secondary and unspec malig neop post mediastinal lymph nodes | diagnostic | res50: Metastatic tumour | |||
| B561500 | Read | Secondary and unspec malig neop paratracheal lymph nodes | diagnostic | res50: Metastatic tumour | |||
| B561600 | Read | Secondary and unspec malig neop superfic tracheobronchial LN | diagnostic | res50: Metastatic tumour | |||
| B561700 | Read | Secondary and unspec malig neop inferior tracheobronchial LN | diagnostic | res50: Metastatic tumour | |||
| B561800 | Read | Secondary and unspec malig neop bronchopulmonary lymph nodes | diagnostic | res50: Metastatic tumour | |||
| B561900 | Read | Secondary and unspec malig neop pulmonary lymph nodes | diagnostic | res50: Metastatic tumour | |||
| B561z00 | Read | Secondary and unspec malig neop intrathoracic LN NOS | diagnostic | res50: Metastatic tumour | |||
| B562.00 | Read | Secondary and unspec malig neop intra-abdominal lymph nodes | diagnostic | res50: Metastatic tumour | |||
| B562000 | Read | Secondary and unspec malig neop coeliac lymph nodes | diagnostic | res50: Metastatic tumour | |||
| B562100 | Read | Secondary and unspec malig neop superficial mesenteric LN | diagnostic | res50: Metastatic tumour | |||
| B562200 | Read | Secondary and unspec malig neop inferior mesenteric LN | diagnostic | res50: Metastatic tumour | |||
| B562300 | Read | Secondary and unspec malig neop common iliac lymph nodes | diagnostic | res50: Metastatic tumour | |||
| B562400 | Read | Secondary and unspec malig neop external iliac lymph nodes | diagnostic | res50: Metastatic tumour | |||
| B562z00 | Read | Secondary and unspec malig neop intra-abdominal LN NOS | diagnostic | res50: Metastatic tumour | |||
| B563.00 | Read | Secondary and unspec malig neop axilla and upper limb LN | diagnostic | res50: Metastatic tumour | |||
| B563000 | Read | Secondary and unspec malig neop axillary lymph nodes | diagnostic | res50: Metastatic tumour | |||
| B563100 | Read | Secondary and unspec malig neop supratrochlear lymph nodes | diagnostic | res50: Metastatic tumour | |||
| B563200 | Read | Secondary and unspec malig neop infraclavicular lymph nodes | diagnostic | res50: Metastatic tumour | |||
| B563300 | Read | Secondary and unspec malig neop pectoral lymph nodes | diagnostic | res50: Metastatic tumour | |||
| B563z00 | Read | Secondary and unspec malig neop axilla and upper limb LN NOS | diagnostic | res50: Metastatic tumour | |||
| B564.00 | Read | Secondary and unspec malig neop inguinal and lower limb LN | diagnostic | res50: Metastatic tumour | |||
| B564000 | Read | Secondary and unspec malig neop superficial inguinal LN | diagnostic | res50: Metastatic tumour | |||
| B564100 | Read | Secondary and unspec malig neop deep inguinal lymph nodes | diagnostic | res50: Metastatic tumour | |||
| B564z00 | Read | Secondary and unspec malig neop of inguinal and leg LN NOS | diagnostic | res50: Metastatic tumour | |||
| B565.00 | Read | Secondary and unspec malig neop intrapelvic lymph nodes | diagnostic | res50: Metastatic tumour | |||
| B565000 | Read | Secondary and unspec malig neop internal iliac lymph nodes | diagnostic | res50: Metastatic tumour | |||
| B565200 | Read | Secondary and unspec malig neop circumflex iliac LN | diagnostic | res50: Metastatic tumour | |||
| B565300 | Read | Secondary and unspec malig neop sacral lymph nodes | diagnostic | res50: Metastatic tumour | |||
| B565z00 | Read | Secondary and unspec malig neop intrapelvic LN NOS | diagnostic | res50: Metastatic tumour | |||
| B56y.00 | Read | Secondary and unspec malig neop lymph nodes multiple sites | diagnostic | res50: Metastatic tumour | |||
| B56z.00 | Read | Secondary and unspec malig neop lymph nodes NOS | diagnostic | res50: Metastatic tumour | |||
| B57..00 | Read | Secondary malig neop of respiratory and digestive systems | diagnostic | res50: Metastatic tumour | |||
| B570.00 | Read | Secondary malignant neoplasm of lung | diagnostic | res50: Metastatic tumour | |||
| B571.00 | Read | Secondary malignant neoplasm of mediastinum | diagnostic | res50: Metastatic tumour | |||
| B57..11 | Read | Metastases of respiratory and/or digestive systems | diagnostic | res50: Metastatic tumour | |||
| B57..12 | Read | Secondary carcinoma of respiratory and/or digestive systems | diagnostic | res50: Metastatic tumour | |||
| B572.00 | Read | Secondary malignant neoplasm of pleura | diagnostic | res50: Metastatic tumour | |||
| B573.00 | Read | Secondary malignant neoplasm of other respiratory organs | diagnostic | res50: Metastatic tumour | |||
| B574.00 | Read | Secondary malignant neoplasm of small intestine and duodenum | diagnostic | res50: Metastatic tumour | |||
| B574000 | Read | Secondary malignant neoplasm of duodenum | diagnostic | res50: Metastatic tumour | |||
| B574200 | Read | Secondary malignant neoplasm of ileum | diagnostic | res50: Metastatic tumour | |||
| B574z00 | Read | Secondary malig neop of small intestine or duodenum NOS | diagnostic | res50: Metastatic tumour | |||
| B575.00 | Read | Secondary malignant neoplasm of large intestine and rectum | diagnostic | res50: Metastatic tumour | |||
| B575000 | Read | Secondary malignant neoplasm of colon | diagnostic | res50: Metastatic tumour | |||
| B575100 | Read | Secondary malignant neoplasm of rectum | diagnostic | res50: Metastatic tumour | |||
| B575z00 | Read | Secondary malig neop of large intestine or rectum NOS | diagnostic | res50: Metastatic tumour | |||
| B576.00 | Read | Secondary malig neop of retroperitoneum and peritoneum | diagnostic | res50: Metastatic tumour | |||
| B576000 | Read | Secondary malignant neoplasm of retroperitoneum | diagnostic | res50: Metastatic tumour | |||
| B576100 | Read | Secondary malignant neoplasm of peritoneum | diagnostic | res50: Metastatic tumour | |||
| B576200 | Read | Malignant ascites | diagnostic | res50: Metastatic tumour | |||
| B576z00 | Read | Secondary malig neop of retroperitoneum or peritoneum NOS | diagnostic | res50: Metastatic tumour | |||
| B577.00 | Read | Secondary malignant neoplasm of liver | diagnostic | res50: Metastatic tumour | |||
| B577.11 | Read | Liver metastases | diagnostic | res50: Metastatic tumour | |||
| B57y.00 | Read | Secondary malignant neoplasm of other digestive organ | diagnostic | res50: Metastatic tumour | |||
| B57z.00 | Read | Secondary malig neop of respiratory or digestive system NOS | diagnostic | res50: Metastatic tumour | |||
| B58..00 | Read | Secondary malignant neoplasm of other specified sites | diagnostic | res50: Metastatic tumour | |||
| B580.00 | Read | Secondary malignant neoplasm of kidney | diagnostic | res50: Metastatic tumour | |||
| B581.00 | Read | Secondary malignant neoplasm of other urinary organs | diagnostic | res50: Metastatic tumour | |||
| B581000 | Read | Secondary malignant neoplasm of ureter | diagnostic | res50: Metastatic tumour | |||
| B58..11 | Read | Secondary carcinoma of other specified sites | diagnostic | res50: Metastatic tumour | |||
| B581100 | Read | Secondary malignant neoplasm of bladder | diagnostic | res50: Metastatic tumour | |||
| B581200 | Read | Secondary malignant neoplasm of urethra | diagnostic | res50: Metastatic tumour | |||
| B581z00 | Read | Secondary malignant neoplasm of other urinary organ NOS | diagnostic | res50: Metastatic tumour | |||
| B582.00 | Read | Secondary malignant neoplasm of skin | diagnostic | res50: Metastatic tumour | |||
| B582000 | Read | Secondary malignant neoplasm of skin of head | diagnostic | res50: Metastatic tumour | |||
| B582100 | Read | Secondary malignant neoplasm of skin of face | diagnostic | res50: Metastatic tumour | |||
| B582200 | Read | Secondary malignant neoplasm of skin of neck | diagnostic | res50: Metastatic tumour | |||
| B582300 | Read | Secondary malignant neoplasm of skin of trunk | diagnostic | res50: Metastatic tumour | |||
| B582400 | Read | Secondary malignant neoplasm of skin of shoulder and arm | diagnostic | res50: Metastatic tumour | |||
| B582500 | Read | Secondary malignant neoplasm of skin of hip and leg | diagnostic | res50: Metastatic tumour | |||
| B582600 | Read | Secondary malignant neoplasm of skin of breast | diagnostic | res50: Metastatic tumour | |||
| B582z00 | Read | Secondary malignant neoplasm of skin NOS | diagnostic | res50: Metastatic tumour | |||
| B583.00 | Read | Secondary malignant neoplasm of brain and spinal cord | diagnostic | res50: Metastatic tumour | |||
| B583000 | Read | Secondary malignant neoplasm of brain | diagnostic | res50: Metastatic tumour | |||
| B583100 | Read | Secondary malignant neoplasm of spinal cord | diagnostic | res50: Metastatic tumour | |||
| B583200 | Read | Cerebral metastasis | diagnostic | res50: Metastatic tumour | |||
| B583z00 | Read | Secondary malignant neoplasm of brain or spinal cord NOS | diagnostic | res50: Metastatic tumour | |||
| B584.00 | Read | Secondary malignant neoplasm of other part of nervous system | diagnostic | res50: Metastatic tumour | |||
| B585.00 | Read | Secondary malignant neoplasm of bone and bone marrow | diagnostic | res50: Metastatic tumour | |||
| B585000 | Read | Pathological fracture due to metastatic bone disease | diagnostic | res50: Metastatic tumour | |||
| B586.00 | Read | Secondary malignant neoplasm of ovary | diagnostic | res50: Metastatic tumour | |||
| B587.00 | Read | Secondary malignant neoplasm of adrenal gland | diagnostic | res50: Metastatic tumour | |||
| B58y.00 | Read | Secondary malignant neoplasm of other specified sites | diagnostic | res50: Metastatic tumour | |||
| B58y000 | Read | Secondary malignant neoplasm of breast | diagnostic | res50: Metastatic tumour | |||
| B58y100 | Read | Secondary malignant neoplasm of uterus | diagnostic | res50: Metastatic tumour | |||
| B58y200 | Read | Secondary malignant neoplasm of cervix uteri | diagnostic | res50: Metastatic tumour | |||
| B58y211 | Read | Secondary cancer of the cervix | diagnostic | res50: Metastatic tumour | |||
| B58y300 | Read | Secondary malignant neoplasm of vagina | diagnostic | res50: Metastatic tumour | |||
| B58y400 | Read | Secondary malignant neoplasm of vulva | diagnostic | res50: Metastatic tumour | |||
| B58y411 | Read | Secondary cancer of the vulva | diagnostic | res50: Metastatic tumour | |||
| B58y500 | Read | Secondary malignant neoplasm of prostate | diagnostic | res50: Metastatic tumour | |||
| B58y600 | Read | Secondary malignant neoplasm of testis | diagnostic | res50: Metastatic tumour | |||
| B58y700 | Read | Secondary malignant neoplasm of penis | diagnostic | res50: Metastatic tumour | |||
| B58y800 | Read | Secondary malignant neoplasm of epididymis and vas deferens | diagnostic | res50: Metastatic tumour | |||
| B58y900 | Read | Secondary malignant neoplasm of tongue | diagnostic | res50: Metastatic tumour | |||
| B58yz00 | Read | Secondary malignant neoplasm of other specified site NOS | diagnostic | res50: Metastatic tumour | |||
| B58z.00 | Read | Secondary malignant neoplasm of other specified site NOS | diagnostic | res50: Metastatic tumour | |||
| B59..00 | Read | Malignant neoplasm of unspecified site | diagnostic | res50: Metastatic tumour | |||
| B591.00 | Read | Other malignant neoplasm NOS | diagnostic | res50: Metastatic tumour | |||
| B592.00 | Read | Malignant neoplasms of independent (primary) multiple sites | diagnostic | res50: Metastatic tumour | |||
| B593.00 | Read | Primary malignant neoplasm of unknown site | diagnostic | res50: Metastatic tumour | |||
| B594.00 | Read | Secondary malignant neoplasm of unknown site | diagnostic | res50: Metastatic tumour | |||
| B59z.00 | Read | Malignant neoplasm of unspecified site NOS | diagnostic | res50: Metastatic tumour | |||
| B5y..00 | Read | Malignant neoplasm of other and unspecified site OS | diagnostic | res50: Metastatic tumour | |||
| B5z..00 | Read | Malignant neoplasm of other and unspecified site NOS | diagnostic | res50: Metastatic tumour | |||
| ByuC.00 | Read | [X]Malignant neoplasm of ill-defined, secondary and unspeci | diagnostic | res50: Metastatic tumour | |||
| ByuC000 | Read | [X]Malignant neoplasm of other specified sites | diagnostic | res50: Metastatic tumour | |||
| ByuC100 | Read | [X]Malignant neoplasm/overlap lesion/other+ill-defined sites | diagnostic | res50: Metastatic tumour | |||
| ByuC200 | Read | [X]2ndry+unspcf malignant neoplasm lymph nodes/multi regions | diagnostic | res50: Metastatic tumour | |||
| ByuC300 | Read | [X]Secondary malignant neoplasm/oth+unspc respiratory organs | diagnostic | res50: Metastatic tumour | |||
| ByuC400 | Read | [X]Secondary malignant neoplasm/oth+unspcfd digestive organs | diagnostic | res50: Metastatic tumour | |||
| ByuC500 | Read | [X]2ndry malignant neoplasm/bladder+oth+unsp urinary organs | diagnostic | res50: Metastatic tumour | |||
| ByuC600 | Read | [X]2ndry malignant neoplasm/oth+unspec parts/nervous system | diagnostic | res50: Metastatic tumour | |||
| ByuC700 | Read | [X]Secondary malignant neoplasm of other specified sites | diagnostic | res50: Metastatic tumour | |||
| ByuC800 | Read | [X]Malignant neoplasm without specification of site | diagnostic | res50: Metastatic tumour |
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