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Research article:

HbA1C variability and hypoglycemia hospitalization in adults with type 1 and type 2 diabetes: a nested case-control study

Reference:

Victor W. Zhong; Juhaeri Juhaeri; Stephen R. Cole; Christina M. Shay; Penny Gordon-Larsen; Evangelos Kontopantelis; Elizabeth J Mayer-Davis(2017) HbA1C variability and hypoglycemia hospitalization in adults with type 1 and type 2 diabetes: a nested case-control study. Journal of Diabetes and its Complications, doi: http://dx.doi.org/10.1016/j.jdiacomp.2017.10.008

Link to article
Abstract
Aims: To determine association between HbA1C variability and hypoglycemia requiring hospitalization (HH) in adults with type 1 diabetes (T1D) and type 2 diabetes (T2D). Methods: Using nested case-control design in electronic health record data in England, one case with first or recurrent HH was matched to one control who had not experienced HH in incident T1D and T2D adults. HbA1C variability was determined by standard deviation of ≥3 HbA1C results. Conditional logistic models were applied to determine association of HbA1C variability with first and recurrent HH. Results: In T1D, every 1.0% increase in HbA1C variability was associated with 90% higher first HH risk (95% CI, 1.25-2.89) and 392% higher recurrent HH risk (95% CI, 1.17- 20.61). In T2D, a 1.0% increase in HbA1C variability was associated with 556% higher first HH risk (95% CI, 3.88-11.08) and 573% higher recurrent HH risk (95% CI, 1.59-28.51). In T2D for first HH, the association was the strongest in non-insulin non-sulfonylurea users (P<0.0001); for recurrent HH, the association was stronger in insulin users than sulfonylurea users (P=0.07). The HbA1C variability-HH association was stronger in more recent years in T2D (P≤0.004). Conclusions: HbA1C variability is a strong predictor for HH in T1D and T2D.
Author for correspondence
Elizabeth J Mayer-Davis
Email for correspondence
mayerdav@email.unc.edu

Code list: res50: mild liver disease

73 codes in list

Code Coding system Description Entity type List name
A785200 Read Cytomegaloviral hepatitis diagnostic res50: mild liver disease
A916100 Read Secondary syphilitic hepatitis diagnostic res50: mild liver disease
A98yy11 Read Gonococcal hepatitis diagnostic res50: mild liver disease
A98yy13 Read Gonococcal perihepatitis diagnostic res50: mild liver disease
AD05.00 Read Toxoplasma hepatitis diagnostic res50: mild liver disease
AE23.00 Read Sequelae of viral hepatitis diagnostic res50: mild liver disease
AyuB.00 Read [X]Viral hepatitis diagnostic res50: mild liver disease
AyuB000 Read [X]Other specified acute viral hepatitis diagnostic res50: mild liver disease
AyuB100 Read [X]Other chronic viral hepatitis diagnostic res50: mild liver disease
AyuB200 Read [X]Chronic viral hepatitis, unspecified diagnostic res50: mild liver disease
AyuJ900 Read [X]Sequelae of viral hepatitis diagnostic res50: mild liver disease
C310400 Read Glycogenosis with hepatic cirrhosis diagnostic res50: mild liver disease
C350012 Read Pigmentary cirrhosis of liver diagnostic res50: mild liver disease
C370800 Read Cystic fibrosis related cirrhosis diagnostic res50: mild liver disease
C376100 Read Alpha-1-antitrypsin hepatitis diagnostic res50: mild liver disease
G852200 Read Oesophageal varices in cirrhosis of the liver diagnostic res50: mild liver disease
G852300 Read Oesophageal varices in alcoholic cirrhosis of the liver diagnostic res50: mild liver disease
J61..00 Read Cirrhosis and chronic liver disease diagnostic res50: mild liver disease
J611.00 Read Acute alcoholic hepatitis diagnostic res50: mild liver disease
J612.00 Read Alcoholic cirrhosis of liver diagnostic res50: mild liver disease
J612.11 Read Florid cirrhosis diagnostic res50: mild liver disease
J612.12 Read Laennec's cirrhosis diagnostic res50: mild liver disease
J614.00 Read Chronic hepatitis diagnostic res50: mild liver disease
J614000 Read Chronic persistent hepatitis diagnostic res50: mild liver disease
J614100 Read Chronic active hepatitis diagnostic res50: mild liver disease
J614111 Read Autoimmune chronic active hepatitis diagnostic res50: mild liver disease
J614200 Read Chronic aggressive hepatitis diagnostic res50: mild liver disease
J614300 Read Recurrent hepatitis diagnostic res50: mild liver disease
J614400 Read Chronic lobular hepatitis diagnostic res50: mild liver disease
J614y00 Read Chronic hepatitis unspecified diagnostic res50: mild liver disease
J614z00 Read Chronic hepatitis NOS diagnostic res50: mild liver disease
J615.00 Read Cirrhosis - non alcoholic diagnostic res50: mild liver disease
J615100 Read Multilobular portal cirrhosis diagnostic res50: mild liver disease
J615.11 Read Portal cirrhosis diagnostic res50: mild liver disease
J615300 Read Diffuse nodular cirrhosis diagnostic res50: mild liver disease
J615400 Read Fatty portal cirrhosis diagnostic res50: mild liver disease
J615500 Read Hypertrophic portal cirrhosis diagnostic res50: mild liver disease
J615600 Read Capsular portal cirrhosis diagnostic res50: mild liver disease
J615700 Read Cardiac portal cirrhosis diagnostic res50: mild liver disease
J615711 Read Congestive cirrhosis diagnostic res50: mild liver disease
J615800 Read Juvenile portal cirrhosis diagnostic res50: mild liver disease
J615812 Read Indian childhood cirrhosis diagnostic res50: mild liver disease
J615C00 Read Xanthomatous portal cirrhosis diagnostic res50: mild liver disease
J615D00 Read Bacterial portal cirrhosis diagnostic res50: mild liver disease
J615H00 Read Infectious cirrhosis NOS diagnostic res50: mild liver disease
J615y00 Read Portal cirrhosis unspecified diagnostic res50: mild liver disease
J615z00 Read Non-alcoholic cirrhosis NOS diagnostic res50: mild liver disease
J615z11 Read Macronodular cirrhosis of liver diagnostic res50: mild liver disease
J615z12 Read Cryptogenic cirrhosis of liver diagnostic res50: mild liver disease
J615z13 Read Cirrhosis of liver NOS diagnostic res50: mild liver disease
J616.00 Read Biliary cirrhosis diagnostic res50: mild liver disease
J616000 Read Primary biliary cirrhosis diagnostic res50: mild liver disease
J616100 Read Secondary biliary cirrhosis diagnostic res50: mild liver disease
J616200 Read Biliary cirrhosis of children diagnostic res50: mild liver disease
J616z00 Read Biliary cirrhosis NOS diagnostic res50: mild liver disease
J617.00 Read Alcoholic hepatitis diagnostic res50: mild liver disease
J617000 Read Chronic alcoholic hepatitis diagnostic res50: mild liver disease
J61y.00 Read Other non-alcoholic chronic liver disease diagnostic res50: mild liver disease
J61y300 Read Portal fibrosis without cirrhosis diagnostic res50: mild liver disease
J61y800 Read Nonalcoholic steatohepatitis diagnostic res50: mild liver disease
J61yz00 Read Other non-alcoholic chronic liver disease NOS diagnostic res50: mild liver disease
J61z.00 Read Chronic liver disease NOS diagnostic res50: mild liver disease
J633000 Read Toxic hepatitis diagnostic res50: mild liver disease
J635300 Read Toxic liver disease with chronic persistent hepatitis diagnostic res50: mild liver disease
J635400 Read Toxic liver disease with chronic lobular hepatitis diagnostic res50: mild liver disease
J635500 Read Toxic liver disease with chronic active hepatitis diagnostic res50: mild liver disease
J635600 Read Toxic liver disease with fibrosis and cirrhosis of liver diagnostic res50: mild liver disease
J63B.00 Read Autoimmune hepatitis diagnostic res50: mild liver disease
J63X.00 Read Granulomatous hepatitis, not elsewhere classified diagnostic res50: mild liver disease
J63y100 Read Nonspecific reactive hepatitis diagnostic res50: mild liver disease
Jyu7100 Read [X]Other and unspecified cirrhosis of liver diagnostic res50: mild liver disease
Jyu7700 Read [X]Granulomatous hepatitis, not elsewhere classified diagnostic res50: mild liver disease
L176500 Read Viral hepatitis comp pregnancy, childbirth & the puerperium diagnostic res50: mild liver disease

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