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Research article:

HbA1C variability and hypoglycemia hospitalization in adults with type 1 and type 2 diabetes: a nested case-control study

Reference:

Victor W. Zhong; Juhaeri Juhaeri; Stephen R. Cole; Christina M. Shay; Penny Gordon-Larsen; Evangelos Kontopantelis; Elizabeth J Mayer-Davis(2017) HbA1C variability and hypoglycemia hospitalization in adults with type 1 and type 2 diabetes: a nested case-control study. Journal of Diabetes and its Complications, doi: http://dx.doi.org/10.1016/j.jdiacomp.2017.10.008

Link to article
Abstract
Aims: To determine association between HbA1C variability and hypoglycemia requiring hospitalization (HH) in adults with type 1 diabetes (T1D) and type 2 diabetes (T2D). Methods: Using nested case-control design in electronic health record data in England, one case with first or recurrent HH was matched to one control who had not experienced HH in incident T1D and T2D adults. HbA1C variability was determined by standard deviation of ≥3 HbA1C results. Conditional logistic models were applied to determine association of HbA1C variability with first and recurrent HH. Results: In T1D, every 1.0% increase in HbA1C variability was associated with 90% higher first HH risk (95% CI, 1.25-2.89) and 392% higher recurrent HH risk (95% CI, 1.17- 20.61). In T2D, a 1.0% increase in HbA1C variability was associated with 556% higher first HH risk (95% CI, 3.88-11.08) and 573% higher recurrent HH risk (95% CI, 1.59-28.51). In T2D for first HH, the association was the strongest in non-insulin non-sulfonylurea users (P<0.0001); for recurrent HH, the association was stronger in insulin users than sulfonylurea users (P=0.07). The HbA1C variability-HH association was stronger in more recent years in T2D (P≤0.004). Conclusions: HbA1C variability is a strong predictor for HH in T1D and T2D.
Author for correspondence
Elizabeth J Mayer-Davis
Email for correspondence
mayerdav@email.unc.edu

Code list: res50: peptic ulcer disease

130 codes in list

Code Coding system Description Entity type List name
14C1.00 Read H/O: peptic ulcer diagnostic res50: peptic ulcer disease
14C1.11 Read H/O: duodenal ulcer diagnostic res50: peptic ulcer disease
14C1.12 Read H/O: gastric ulcer diagnostic res50: peptic ulcer disease
1956 Read Peptic ulcer symptoms diagnostic res50: peptic ulcer disease
7612111 Read Balfour excision of gastric ulcer diagnostic res50: peptic ulcer disease
7612500 Read Resection of gastric ulcer by cautery diagnostic res50: peptic ulcer disease
761D500 Read Endoscopic injection haemostasis of duodenal ulcer diagnostic res50: peptic ulcer disease
761D600 Read Endoscopic injection haemostasis of gastric ulcer diagnostic res50: peptic ulcer disease
761J.00 Read Operations on gastric ulcer diagnostic res50: peptic ulcer disease
761J000 Read Closure of perforated gastric ulcer diagnostic res50: peptic ulcer disease
761J100 Read Closure of gastric ulcer NEC diagnostic res50: peptic ulcer disease
761J.11 Read Stomach ulcer operations diagnostic res50: peptic ulcer disease
761J111 Read Suture of ulcer of stomach NEC diagnostic res50: peptic ulcer disease
761Jy00 Read Other specified operation on gastric ulcer diagnostic res50: peptic ulcer disease
761Jz00 Read Operation on gastric ulcer NOS diagnostic res50: peptic ulcer disease
7627 Read Operations on duodenal ulcer diagnostic res50: peptic ulcer disease
7627000 Read Closure of perforated duodenal ulcer diagnostic res50: peptic ulcer disease
7627100 Read Suture of duodenal ulcer not elsewhere classified diagnostic res50: peptic ulcer disease
7627200 Read Oversew of blood vessel of duodenal ulcer diagnostic res50: peptic ulcer disease
7627y00 Read Other specified operation on duodenal ulcer diagnostic res50: peptic ulcer disease
7627z00 Read Operation on duodenal ulcer NOS diagnostic res50: peptic ulcer disease
J102000 Read Peptic ulcer of oesophagus diagnostic res50: peptic ulcer disease
J11..00 Read Gastric ulcer - (GU) diagnostic res50: peptic ulcer disease
J110.00 Read Acute gastric ulcer diagnostic res50: peptic ulcer disease
J110000 Read Acute gastric ulcer without mention of complication diagnostic res50: peptic ulcer disease
J110100 Read Acute gastric ulcer with haemorrhage diagnostic res50: peptic ulcer disease
J110111 Read Bleeding acute gastric ulcer diagnostic res50: peptic ulcer disease
J110200 Read Acute gastric ulcer with perforation diagnostic res50: peptic ulcer disease
J110300 Read Acute gastric ulcer with haemorrhage and perforation diagnostic res50: peptic ulcer disease
J110y00 Read Acute gastric ulcer unspecified diagnostic res50: peptic ulcer disease
J110z00 Read Acute gastric ulcer NOS diagnostic res50: peptic ulcer disease
J111.00 Read Chronic gastric ulcer diagnostic res50: peptic ulcer disease
J111000 Read Chronic gastric ulcer without mention of complication diagnostic res50: peptic ulcer disease
J11..11 Read Prepyloric ulcer diagnostic res50: peptic ulcer disease
J111100 Read Chronic gastric ulcer with haemorrhage diagnostic res50: peptic ulcer disease
J111111 Read Bleeding chronic gastric ulcer diagnostic res50: peptic ulcer disease
J11..12 Read Pyloric ulcer diagnostic res50: peptic ulcer disease
J111200 Read Chronic gastric ulcer with perforation diagnostic res50: peptic ulcer disease
J111211 Read Perforated chronic gastric ulcer diagnostic res50: peptic ulcer disease
J111300 Read Chronic gastric ulcer with haemorrhage and perforation diagnostic res50: peptic ulcer disease
J111400 Read Chronic gastric ulcer with obstruction diagnostic res50: peptic ulcer disease
J111y00 Read Chronic gastric ulcer unspecified diagnostic res50: peptic ulcer disease
J111z00 Read Chronic gastric ulcer NOS diagnostic res50: peptic ulcer disease
J112.00 Read Anti-platelet induced gastric ulcer diagnostic res50: peptic ulcer disease
J112z00 Read Anti-platelet induced gastric ulcer NOS diagnostic res50: peptic ulcer disease
J113.00 Read Non steroidal anti inflammatory drug induced gastric ulcer diagnostic res50: peptic ulcer disease
J11y.00 Read Unspecified gastric ulcer diagnostic res50: peptic ulcer disease
J11y000 Read Unspecified gastric ulcer without mention of complication diagnostic res50: peptic ulcer disease
J11y100 Read Unspecified gastric ulcer with haemorrhage diagnostic res50: peptic ulcer disease
J11y200 Read Unspecified gastric ulcer with perforation diagnostic res50: peptic ulcer disease
J11y400 Read Unspecified gastric ulcer with obstruction diagnostic res50: peptic ulcer disease
J11yy00 Read Unspec gastric ulcer; unspec haemorrhage and/or perforation diagnostic res50: peptic ulcer disease
J11yz00 Read Unspecified gastric ulcer NOS diagnostic res50: peptic ulcer disease
J11z.00 Read Gastric ulcer NOS diagnostic res50: peptic ulcer disease
J11z.12 Read Multiple gastric ulcers diagnostic res50: peptic ulcer disease
J12..00 Read Duodenal ulcer - (DU) diagnostic res50: peptic ulcer disease
J120.00 Read Acute duodenal ulcer diagnostic res50: peptic ulcer disease
J120000 Read Acute duodenal ulcer without mention of complication diagnostic res50: peptic ulcer disease
J120100 Read Acute duodenal ulcer with haemorrhage diagnostic res50: peptic ulcer disease
J120200 Read Acute duodenal ulcer with perforation diagnostic res50: peptic ulcer disease
J120300 Read Acute duodenal ulcer with haemorrhage and perforation diagnostic res50: peptic ulcer disease
J120400 Read Acute duodenal ulcer with obstruction diagnostic res50: peptic ulcer disease
J120y00 Read Acute duodenal ulcer unspecified diagnostic res50: peptic ulcer disease
J120z00 Read Acute duodenal ulcer NOS diagnostic res50: peptic ulcer disease
J121.00 Read Chronic duodenal ulcer diagnostic res50: peptic ulcer disease
J121000 Read Chronic duodenal ulcer without mention of complication diagnostic res50: peptic ulcer disease
J121100 Read Chronic duodenal ulcer with haemorrhage diagnostic res50: peptic ulcer disease
J121111 Read Bleeding chronic duodenal ulcer diagnostic res50: peptic ulcer disease
J121200 Read Chronic duodenal ulcer with perforation diagnostic res50: peptic ulcer disease
J121211 Read Perforated chronic duodenal ulcer diagnostic res50: peptic ulcer disease
J121300 Read Chronic duodenal ulcer with haemorrhage and perforation diagnostic res50: peptic ulcer disease
J121400 Read Chronic duodenal ulcer with obstruction diagnostic res50: peptic ulcer disease
J121y00 Read Chronic duodenal ulcer unspecified diagnostic res50: peptic ulcer disease
J121z00 Read Chronic duodenal ulcer NOS diagnostic res50: peptic ulcer disease
J122.00 Read Duodenal ulcer disease diagnostic res50: peptic ulcer disease
J123.00 Read Duodenal erosion diagnostic res50: peptic ulcer disease
J124.00 Read Recurrent duodenal ulcer diagnostic res50: peptic ulcer disease
J125.00 Read Anti-platelet induced duodenal ulcer diagnostic res50: peptic ulcer disease
J126.00 Read Non steroidal anti inflammatory drug induced duodenal ulcer diagnostic res50: peptic ulcer disease
J12y.00 Read Unspecified duodenal ulcer diagnostic res50: peptic ulcer disease
J12y000 Read Unspecified duodenal ulcer without mention of complication diagnostic res50: peptic ulcer disease
J12y100 Read Unspecified duodenal ulcer with haemorrhage diagnostic res50: peptic ulcer disease
J12y200 Read Unspecified duodenal ulcer with perforation diagnostic res50: peptic ulcer disease
J12y300 Read Unspecified duodenal ulcer with haemorrhage and perforation diagnostic res50: peptic ulcer disease
J12y400 Read Unspecified duodenal ulcer with obstruction diagnostic res50: peptic ulcer disease
J12yy00 Read Unspec duodenal ulcer; unspec haemorrhage and/or perforation diagnostic res50: peptic ulcer disease
J12yz00 Read Unspecified duodenal ulcer NOS diagnostic res50: peptic ulcer disease
J12z.00 Read Duodenal ulcer NOS diagnostic res50: peptic ulcer disease
J13..00 Read Peptic ulcer - (PU) site unspecified diagnostic res50: peptic ulcer disease
J130.00 Read Acute peptic ulcer diagnostic res50: peptic ulcer disease
J130000 Read Acute peptic ulcer without mention of complication diagnostic res50: peptic ulcer disease
J130100 Read Acute peptic ulcer with haemorrhage diagnostic res50: peptic ulcer disease
J130200 Read Acute peptic ulcer with perforation diagnostic res50: peptic ulcer disease
J130300 Read Acute peptic ulcer with haemorrhage and perforation diagnostic res50: peptic ulcer disease
J130y00 Read Acute peptic ulcer unspecified diagnostic res50: peptic ulcer disease
J130z00 Read Acute peptic ulcer NOS diagnostic res50: peptic ulcer disease
J131.00 Read Chronic peptic ulcer diagnostic res50: peptic ulcer disease
J131000 Read Chronic peptic ulcer without mention of complication diagnostic res50: peptic ulcer disease
J13..11 Read Stress ulcer NOS diagnostic res50: peptic ulcer disease
J131100 Read Chronic peptic ulcer with haemorrhage diagnostic res50: peptic ulcer disease
J131200 Read Chronic peptic ulcer with perforation diagnostic res50: peptic ulcer disease
J131400 Read Chronic peptic ulcer with obstruction diagnostic res50: peptic ulcer disease
J131y00 Read Chronic peptic ulcer unspecified diagnostic res50: peptic ulcer disease
J131z00 Read Chronic peptic ulcer NOS diagnostic res50: peptic ulcer disease
J13y.00 Read Unspecified peptic ulcer diagnostic res50: peptic ulcer disease
J13y000 Read Unspecified peptic ulcer without mention of complication diagnostic res50: peptic ulcer disease
J13y100 Read Unspecified peptic ulcer with haemorrhage diagnostic res50: peptic ulcer disease
J13y200 Read Unspecified peptic ulcer with perforation diagnostic res50: peptic ulcer disease
J13y300 Read Unspecified peptic ulcer with haemorrhage and perforation diagnostic res50: peptic ulcer disease
J13y400 Read Unspecified peptic ulcer with obstruction diagnostic res50: peptic ulcer disease
J13yz00 Read Unspecified peptic ulcer NOS diagnostic res50: peptic ulcer disease
J13z.00 Read Peptic ulcer NOS diagnostic res50: peptic ulcer disease
J14..00 Read Gastrojejunal ulcer (GJU) diagnostic res50: peptic ulcer disease
J140.00 Read Acute gastrojejunal ulcer diagnostic res50: peptic ulcer disease
J140100 Read Acute gastrojejunal ulcer with haemorrhage diagnostic res50: peptic ulcer disease
J140200 Read Acute gastrojejunal ulcer with perforation diagnostic res50: peptic ulcer disease
J140300 Read Acute gastrojejunal ulcer with haemorrhage and perforation diagnostic res50: peptic ulcer disease
J140z00 Read Acute gastrojejunal ulcer NOS diagnostic res50: peptic ulcer disease
J141.00 Read Chronic gastrojejunal ulcer diagnostic res50: peptic ulcer disease
J14..12 Read Gastrocolic ulcer diagnostic res50: peptic ulcer disease
J14..15 Read Stomal ulcer diagnostic res50: peptic ulcer disease
J14y.00 Read Unspecified gastrojejunal ulcer diagnostic res50: peptic ulcer disease
J14y100 Read Unspecified gastrojejunal ulcer with haemorrhage diagnostic res50: peptic ulcer disease
J14y200 Read Unspecified gastrojejunal ulcer with perforation diagnostic res50: peptic ulcer disease
J14yz00 Read Unspecified gastrojejunal ulcer NOS diagnostic res50: peptic ulcer disease
J14z.00 Read Gastrojejunal ulcer NOS diagnostic res50: peptic ulcer disease
J17y800 Read Healed gastric ulcer leaving a scar diagnostic res50: peptic ulcer disease
ZV12711 Read [V]Personal history of peptic ulcer diagnostic res50: peptic ulcer disease
ZV12712 Read [V]Personal history of duodenal ulcer diagnostic res50: peptic ulcer disease
ZV12C00 Read [V] Personal history of gastric ulcer diagnostic res50: peptic ulcer disease

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