ClinicalCodes.org
An online clinical codes repository to improve validity and reproducibility of medical database research
Research article:
HbA1C variability and hypoglycemia hospitalization in adults with type 1 and type 2 diabetes: a nested case-control study
Reference:
Victor W. Zhong; Juhaeri Juhaeri; Stephen R. Cole; Christina M. Shay; Penny Gordon-Larsen; Evangelos Kontopantelis; Elizabeth J Mayer-Davis(2017) HbA1C variability and hypoglycemia hospitalization in adults with type 1 and type 2 diabetes: a nested case-control study. Journal of Diabetes and its Complications, doi: http://dx.doi.org/10.1016/j.jdiacomp.2017.10.008
- Link to article
- Abstract
- Aims: To determine association between HbA1C variability and hypoglycemia requiring hospitalization (HH) in adults with type 1 diabetes (T1D) and type 2 diabetes (T2D). Methods: Using nested case-control design in electronic health record data in England, one case with first or recurrent HH was matched to one control who had not experienced HH in incident T1D and T2D adults. HbA1C variability was determined by standard deviation of ≥3 HbA1C results. Conditional logistic models were applied to determine association of HbA1C variability with first and recurrent HH. Results: In T1D, every 1.0% increase in HbA1C variability was associated with 90% higher first HH risk (95% CI, 1.25-2.89) and 392% higher recurrent HH risk (95% CI, 1.17- 20.61). In T2D, a 1.0% increase in HbA1C variability was associated with 556% higher first HH risk (95% CI, 3.88-11.08) and 573% higher recurrent HH risk (95% CI, 1.59-28.51). In T2D for first HH, the association was the strongest in non-insulin non-sulfonylurea users (P<0.0001); for recurrent HH, the association was stronger in insulin users than sulfonylurea users (P=0.07). The HbA1C variability-HH association was stronger in more recent years in T2D (P≤0.004). Conclusions: HbA1C variability is a strong predictor for HH in T1D and T2D.
- Author for correspondence
- Elizabeth J Mayer-Davis
- Email for correspondence
- mayerdav@email.unc.edu
Code list: res50: thiazolidinediones
27 codes in list
| Code | Coding system | Description | Entity type | List name | drugsubstance | bnfcode | bnfchapter |
|---|---|---|---|---|---|---|---|
| 10051 | CPRD_product_code | Pioglitazone 45mg tablets | drug | res50: thiazolidinediones | Pioglitazone hydrochloride | 06010203 | Other Antidiabetic Drugs |
| 11601 | CPRD_product_code | Rosiglitazone 2mg / Metformin 500mg tablets | drug | res50: thiazolidinediones | Rosiglitazone maleate/Metformin hydrochloride | 00000000 | Unknown |
| 11604 | CPRD_product_code | Rosiglitazone 1mg / Metformin 500mg tablets | drug | res50: thiazolidinediones | Rosiglitazone maleate/Metformin hydrochloride | 00000000 | Unknown |
| 11717 | CPRD_product_code | Rosiglitazone 2mg / Metformin 1g tablets | drug | res50: thiazolidinediones | Metformin hydrochloride/Rosiglitazone maleate | 00000000 | Unknown |
| 13628 | CPRD_product_code | Romozin 400mg Tablet (Glaxo Wellcome UK Ltd) | drug | res50: thiazolidinediones | Troglitazone | 06010203 | Other Antidiabetic Drugs |
| 14164 | CPRD_product_code | Avandamet 2mg/1000mg tablets (GlaxoSmithKline UK Ltd) | drug | res50: thiazolidinediones | Metformin hydrochloride/Rosiglitazone maleate | 00000000 | Unknown |
| 15232 | CPRD_product_code | Avandia 8mg tablets (GlaxoSmithKline UK Ltd) | drug | res50: thiazolidinediones | Rosiglitazone maleate | 00000000 | Unknown |
| 17580 | CPRD_product_code | Avandamet 1mg/500mg tablets (GlaxoSmithKline UK Ltd) | drug | res50: thiazolidinediones | Rosiglitazone maleate/Metformin hydrochloride | 00000000 | Unknown |
| 18220 | CPRD_product_code | Pioglitazone 15mg / Metformin 850mg tablets | drug | res50: thiazolidinediones | Metformin hydrochloride/Pioglitazone hydrochloride | 06010203 | Other Antidiabetic Drugs |
| 19472 | CPRD_product_code | Actos 45mg tablets (Takeda UK Ltd) | drug | res50: thiazolidinediones | Pioglitazone hydrochloride | 06010203 | Other Antidiabetic Drugs |
| 20287 | CPRD_product_code | Actos 15mg tablets (Takeda UK Ltd) | drug | res50: thiazolidinediones | Pioglitazone hydrochloride | 06010203 | Other Antidiabetic Drugs |
| 20889 | CPRD_product_code | Actos 30mg tablets (Takeda UK Ltd) | drug | res50: thiazolidinediones | Pioglitazone hydrochloride | 06010203 | Other Antidiabetic Drugs |
| 31077 | CPRD_product_code | Competact 15mg/850mg tablets (Takeda UK Ltd) | drug | res50: thiazolidinediones | Metformin hydrochloride/Pioglitazone hydrochloride | 06010203 | Other Antidiabetic Drugs |
| 37617 | CPRD_product_code | Rosiglitazone 2mg tablet | drug | res50: thiazolidinediones | Rosiglitazone Maleate | 06010203 | Other Antidiabetic Drugs |
| 469 | CPRD_product_code | Rosiglitazone 4mg tablets | drug | res50: thiazolidinediones | Rosiglitazone maleate | 00000000 | Unknown |
| 48120 | CPRD_product_code | Avandia 2mg Tablet (GlaxoSmithKline UK Ltd) | drug | res50: thiazolidinediones | Rosiglitazone Maleate | 06010203 | Other Antidiabetic Drugs |
| 48139 | CPRD_product_code | Pioglitazone 30mg tablets (A A H Pharmaceuticals Ltd) | drug | res50: thiazolidinediones | Pioglitazone hydrochloride | 06010203 | Other Antidiabetic Drugs |
| 5227 | CPRD_product_code | Rosiglitazone 8mg tablets | drug | res50: thiazolidinediones | Rosiglitazone maleate | 00000000 | Unknown |
| 548 | CPRD_product_code | Pioglitazone 15mg tablets | drug | res50: thiazolidinediones | Pioglitazone hydrochloride | 06010203 | Other Antidiabetic Drugs |
| 56208 | CPRD_product_code | Pioglitazone 15mg tablets (A A H Pharmaceuticals Ltd) | drug | res50: thiazolidinediones | Pioglitazone hydrochloride | 06010203 | Other Antidiabetic Drugs |
| 56376 | CPRD_product_code | Rosiglitazone 4mg with glimepiride 4mg tablet | drug | res50: thiazolidinediones | Rosiglitazone Maleate | 06010201/06010203 | Sulphonylureas/Other Antidiabetic Drugs |
| 57659 | CPRD_product_code | Pioglitazone 30mg tablets (Actavis UK Ltd) | drug | res50: thiazolidinediones | Pioglitazone hydrochloride | 06010203 | Other Antidiabetic Drugs |
| 6855 | CPRD_product_code | Avandamet 2mg/500mg tablets (GlaxoSmithKline UK Ltd) | drug | res50: thiazolidinediones | Rosiglitazone maleate/Metformin hydrochloride | 00000000 | Unknown |
| 7325 | CPRD_product_code | Avandamet 4mg/1000mg tablets (GlaxoSmithKline UK Ltd) | drug | res50: thiazolidinediones | Metformin hydrochloride/Rosiglitazone maleate | 00000000 | Unknown |
| 7375 | CPRD_product_code | Rosiglitazone 4mg / Metformin 1g tablets | drug | res50: thiazolidinediones | Metformin hydrochloride/Rosiglitazone maleate | 00000000 | Unknown |
| 9662 | CPRD_product_code | Avandia 4mg tablets (GlaxoSmithKline UK Ltd) | drug | res50: thiazolidinediones | Rosiglitazone maleate | 00000000 | Unknown |
| 9699 | CPRD_product_code | Pioglitazone 30mg tablets | drug | res50: thiazolidinediones | Pioglitazone hydrochloride | 06010203 | Other Antidiabetic Drugs |
Please log in to leave a comment.
Code list links:
ClinicalCodes is a project at the University of Manchester Institute of Population Health
The ClinicalCodes project is funded by the National Institute for Health Research (NIHR) School for Primary Care Research (SPCR)