ClinicalCodes.org
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Research article:
HbA1C variability and hypoglycemia hospitalization in adults with type 1 and type 2 diabetes: a nested case-control study
Reference:
Victor W. Zhong; Juhaeri Juhaeri; Stephen R. Cole; Christina M. Shay; Penny Gordon-Larsen; Evangelos Kontopantelis; Elizabeth J Mayer-Davis(2017) HbA1C variability and hypoglycemia hospitalization in adults with type 1 and type 2 diabetes: a nested case-control study. Journal of Diabetes and its Complications, doi: http://dx.doi.org/10.1016/j.jdiacomp.2017.10.008
- Link to article
- Abstract
- Aims: To determine association between HbA1C variability and hypoglycemia requiring hospitalization (HH) in adults with type 1 diabetes (T1D) and type 2 diabetes (T2D). Methods: Using nested case-control design in electronic health record data in England, one case with first or recurrent HH was matched to one control who had not experienced HH in incident T1D and T2D adults. HbA1C variability was determined by standard deviation of ≥3 HbA1C results. Conditional logistic models were applied to determine association of HbA1C variability with first and recurrent HH. Results: In T1D, every 1.0% increase in HbA1C variability was associated with 90% higher first HH risk (95% CI, 1.25-2.89) and 392% higher recurrent HH risk (95% CI, 1.17- 20.61). In T2D, a 1.0% increase in HbA1C variability was associated with 556% higher first HH risk (95% CI, 3.88-11.08) and 573% higher recurrent HH risk (95% CI, 1.59-28.51). In T2D for first HH, the association was the strongest in non-insulin non-sulfonylurea users (P<0.0001); for recurrent HH, the association was stronger in insulin users than sulfonylurea users (P=0.07). The HbA1C variability-HH association was stronger in more recent years in T2D (P≤0.004). Conclusions: HbA1C variability is a strong predictor for HH in T1D and T2D.
- Author for correspondence
- Elizabeth J Mayer-Davis
- Email for correspondence
- mayerdav@email.unc.edu
Code list: res50: type 2 diabetes
117 codes in list
| Code | Coding system | Description | Entity type | List name | |||
|---|---|---|---|---|---|---|---|
| 66A3.00 | Read | Diabetic on diet only | diagnostic | res50: type 2 diabetes | |||
| 66A4.00 | Read | Diabetic on oral treatment | diagnostic | res50: type 2 diabetes | |||
| 66Ao.00 | Read | Diabetes type 2 review | diagnostic | res50: type 2 diabetes | |||
| 66At100 | Read | Type II diabetic dietary review | diagnostic | res50: type 2 diabetes | |||
| 66At111 | Read | Type 2 diabetic dietary review | diagnostic | res50: type 2 diabetes | |||
| 66AV.00 | Read | Diabetic on insulin and oral treatment | diagnostic | res50: type 2 diabetes | |||
| C100112 | Read | Non-insulin dependent diabetes mellitus | diagnostic | res50: type 2 diabetes | |||
| C107400 | Read | NIDDM with peripheral circulatory disorder | diagnostic | res50: type 2 diabetes | |||
| C109.00 | Read | Non-insulin dependent diabetes mellitus | diagnostic | res50: type 2 diabetes | |||
| C109000 | Read | Non-insulin-dependent diabetes mellitus with renal comps | diagnostic | res50: type 2 diabetes | |||
| C109011 | Read | Type II diabetes mellitus with renal complications | diagnostic | res50: type 2 diabetes | |||
| C109012 | Read | Type 2 diabetes mellitus with renal complications | diagnostic | res50: type 2 diabetes | |||
| C109100 | Read | Non-insulin-dependent diabetes mellitus with ophthalm comps | diagnostic | res50: type 2 diabetes | |||
| C109.11 | Read | NIDDM - Non-insulin dependent diabetes mellitus | diagnostic | res50: type 2 diabetes | |||
| C109111 | Read | Type II diabetes mellitus with ophthalmic complications | diagnostic | res50: type 2 diabetes | |||
| C109112 | Read | Type 2 diabetes mellitus with ophthalmic complications | diagnostic | res50: type 2 diabetes | |||
| C109.12 | Read | Type 2 diabetes mellitus | diagnostic | res50: type 2 diabetes | |||
| C109.13 | Read | Type II diabetes mellitus | diagnostic | res50: type 2 diabetes | |||
| C109200 | Read | Non-insulin-dependent diabetes mellitus with neuro comps | diagnostic | res50: type 2 diabetes | |||
| C109211 | Read | Type II diabetes mellitus with neurological complications | diagnostic | res50: type 2 diabetes | |||
| C109212 | Read | Type 2 diabetes mellitus with neurological complications | diagnostic | res50: type 2 diabetes | |||
| C109300 | Read | Non-insulin-dependent diabetes mellitus with multiple comps | diagnostic | res50: type 2 diabetes | |||
| C109312 | Read | Type 2 diabetes mellitus with multiple complications | diagnostic | res50: type 2 diabetes | |||
| C109400 | Read | Non-insulin dependent diabetes mellitus with ulcer | diagnostic | res50: type 2 diabetes | |||
| C109411 | Read | Type II diabetes mellitus with ulcer | diagnostic | res50: type 2 diabetes | |||
| C109412 | Read | Type 2 diabetes mellitus with ulcer | diagnostic | res50: type 2 diabetes | |||
| C109500 | Read | Non-insulin dependent diabetes mellitus with gangrene | diagnostic | res50: type 2 diabetes | |||
| C109511 | Read | Type II diabetes mellitus with gangrene | diagnostic | res50: type 2 diabetes | |||
| C109512 | Read | Type 2 diabetes mellitus with gangrene | diagnostic | res50: type 2 diabetes | |||
| C109600 | Read | Non-insulin-dependent diabetes mellitus with retinopathy | diagnostic | res50: type 2 diabetes | |||
| C109611 | Read | Type II diabetes mellitus with retinopathy | diagnostic | res50: type 2 diabetes | |||
| C109612 | Read | Type 2 diabetes mellitus with retinopathy | diagnostic | res50: type 2 diabetes | |||
| C109700 | Read | Non-insulin dependent diabetes mellitus - poor control | diagnostic | res50: type 2 diabetes | |||
| C109711 | Read | Type II diabetes mellitus - poor control | diagnostic | res50: type 2 diabetes | |||
| C109712 | Read | Type 2 diabetes mellitus - poor control | diagnostic | res50: type 2 diabetes | |||
| C109900 | Read | Non-insulin-dependent diabetes mellitus without complication | diagnostic | res50: type 2 diabetes | |||
| C109911 | Read | Type II diabetes mellitus without complication | diagnostic | res50: type 2 diabetes | |||
| C109912 | Read | Type 2 diabetes mellitus without complication | diagnostic | res50: type 2 diabetes | |||
| C109A00 | Read | Non-insulin dependent diabetes mellitus with mononeuropathy | diagnostic | res50: type 2 diabetes | |||
| C109A11 | Read | Type II diabetes mellitus with mononeuropathy | diagnostic | res50: type 2 diabetes | |||
| C109B00 | Read | Non-insulin dependent diabetes mellitus with polyneuropathy | diagnostic | res50: type 2 diabetes | |||
| C109B11 | Read | Type II diabetes mellitus with polyneuropathy | diagnostic | res50: type 2 diabetes | |||
| C109C00 | Read | Non-insulin dependent diabetes mellitus with nephropathy | diagnostic | res50: type 2 diabetes | |||
| C109C11 | Read | Type II diabetes mellitus with nephropathy | diagnostic | res50: type 2 diabetes | |||
| C109C12 | Read | Type 2 diabetes mellitus with nephropathy | diagnostic | res50: type 2 diabetes | |||
| C109D00 | Read | Non-insulin dependent diabetes mellitus with hypoglyca coma | diagnostic | res50: type 2 diabetes | |||
| C109D11 | Read | Type II diabetes mellitus with hypoglycaemic coma | diagnostic | res50: type 2 diabetes | |||
| C109D12 | Read | Type 2 diabetes mellitus with hypoglycaemic coma | diagnostic | res50: type 2 diabetes | |||
| C109E00 | Read | Non-insulin depend diabetes mellitus with diabetic cataract | diagnostic | res50: type 2 diabetes | |||
| C109E11 | Read | Type II diabetes mellitus with diabetic cataract | diagnostic | res50: type 2 diabetes | |||
| C109E12 | Read | Type 2 diabetes mellitus with diabetic cataract | diagnostic | res50: type 2 diabetes | |||
| C109F00 | Read | Non-insulin-dependent d m with peripheral angiopath | diagnostic | res50: type 2 diabetes | |||
| C109F11 | Read | Type II diabetes mellitus with peripheral angiopathy | diagnostic | res50: type 2 diabetes | |||
| C109F12 | Read | Type 2 diabetes mellitus with peripheral angiopathy | diagnostic | res50: type 2 diabetes | |||
| C109G00 | Read | Non-insulin dependent diabetes mellitus with arthropathy | diagnostic | res50: type 2 diabetes | |||
| C109G11 | Read | Type II diabetes mellitus with arthropathy | diagnostic | res50: type 2 diabetes | |||
| C109G12 | Read | Type 2 diabetes mellitus with arthropathy | diagnostic | res50: type 2 diabetes | |||
| C109H00 | Read | Non-insulin dependent d m with neuropathic arthropathy | diagnostic | res50: type 2 diabetes | |||
| C109H11 | Read | Type II diabetes mellitus with neuropathic arthropathy | diagnostic | res50: type 2 diabetes | |||
| C109H12 | Read | Type 2 diabetes mellitus with neuropathic arthropathy | diagnostic | res50: type 2 diabetes | |||
| C109J00 | Read | Insulin treated Type 2 diabetes mellitus | diagnostic | res50: type 2 diabetes | |||
| C109J11 | Read | Insulin treated non-insulin dependent diabetes mellitus | diagnostic | res50: type 2 diabetes | |||
| C109J12 | Read | Insulin treated Type II diabetes mellitus | diagnostic | res50: type 2 diabetes | |||
| C109K00 | Read | Hyperosmolar non-ketotic state in type 2 diabetes mellitus | diagnostic | res50: type 2 diabetes | |||
| C10F.00 | Read | Type 2 diabetes mellitus | diagnostic | res50: type 2 diabetes | |||
| C10F000 | Read | Type 2 diabetes mellitus with renal complications | diagnostic | res50: type 2 diabetes | |||
| C10F011 | Read | Type II diabetes mellitus with renal complications | diagnostic | res50: type 2 diabetes | |||
| C10F100 | Read | Type 2 diabetes mellitus with ophthalmic complications | diagnostic | res50: type 2 diabetes | |||
| C10F.11 | Read | Type II diabetes mellitus | diagnostic | res50: type 2 diabetes | |||
| C10F111 | Read | Type II diabetes mellitus with ophthalmic complications | diagnostic | res50: type 2 diabetes | |||
| C10F200 | Read | Type 2 diabetes mellitus with neurological complications | diagnostic | res50: type 2 diabetes | |||
| C10F211 | Read | Type II diabetes mellitus with neurological complications | diagnostic | res50: type 2 diabetes | |||
| C10F300 | Read | Type 2 diabetes mellitus with multiple complications | diagnostic | res50: type 2 diabetes | |||
| C10F311 | Read | Type II diabetes mellitus with multiple complications | diagnostic | res50: type 2 diabetes | |||
| C10F400 | Read | Type 2 diabetes mellitus with ulcer | diagnostic | res50: type 2 diabetes | |||
| C10F411 | Read | Type II diabetes mellitus with ulcer | diagnostic | res50: type 2 diabetes | |||
| C10F500 | Read | Type 2 diabetes mellitus with gangrene | diagnostic | res50: type 2 diabetes | |||
| C10F511 | Read | Type II diabetes mellitus with gangrene | diagnostic | res50: type 2 diabetes | |||
| C10F600 | Read | Type 2 diabetes mellitus with retinopathy | diagnostic | res50: type 2 diabetes | |||
| C10F611 | Read | Type II diabetes mellitus with retinopathy | diagnostic | res50: type 2 diabetes | |||
| C10F700 | Read | Type 2 diabetes mellitus - poor control | diagnostic | res50: type 2 diabetes | |||
| C10F711 | Read | Type II diabetes mellitus - poor control | diagnostic | res50: type 2 diabetes | |||
| C10F900 | Read | Type 2 diabetes mellitus without complication | diagnostic | res50: type 2 diabetes | |||
| C10F911 | Read | Type II diabetes mellitus without complication | diagnostic | res50: type 2 diabetes | |||
| C10FA00 | Read | Type 2 diabetes mellitus with mononeuropathy | diagnostic | res50: type 2 diabetes | |||
| C10FA11 | Read | Type II diabetes mellitus with mononeuropathy | diagnostic | res50: type 2 diabetes | |||
| C10FB00 | Read | Type 2 diabetes mellitus with polyneuropathy | diagnostic | res50: type 2 diabetes | |||
| C10FB11 | Read | Type II diabetes mellitus with polyneuropathy | diagnostic | res50: type 2 diabetes | |||
| C10FC00 | Read | Type 2 diabetes mellitus with nephropathy | diagnostic | res50: type 2 diabetes | |||
| C10FC11 | Read | Type II diabetes mellitus with nephropathy | diagnostic | res50: type 2 diabetes | |||
| C10FD00 | Read | Type 2 diabetes mellitus with hypoglycaemic coma | diagnostic | res50: type 2 diabetes | |||
| C10FD11 | Read | Type II diabetes mellitus with hypoglycaemic coma | diagnostic | res50: type 2 diabetes | |||
| C10FE00 | Read | Type 2 diabetes mellitus with diabetic cataract | diagnostic | res50: type 2 diabetes | |||
| C10FE11 | Read | Type II diabetes mellitus with diabetic cataract | diagnostic | res50: type 2 diabetes | |||
| C10FF00 | Read | Type 2 diabetes mellitus with peripheral angiopathy | diagnostic | res50: type 2 diabetes | |||
| C10FF11 | Read | Type II diabetes mellitus with peripheral angiopathy | diagnostic | res50: type 2 diabetes | |||
| C10FG00 | Read | Type 2 diabetes mellitus with arthropathy | diagnostic | res50: type 2 diabetes | |||
| C10FG11 | Read | Type II diabetes mellitus with arthropathy | diagnostic | res50: type 2 diabetes | |||
| C10FH00 | Read | Type 2 diabetes mellitus with neuropathic arthropathy | diagnostic | res50: type 2 diabetes | |||
| C10FH11 | Read | Type II diabetes mellitus with neuropathic arthropathy | diagnostic | res50: type 2 diabetes | |||
| C10FJ00 | Read | Insulin treated Type 2 diabetes mellitus | diagnostic | res50: type 2 diabetes | |||
| C10FJ11 | Read | Insulin treated Type II diabetes mellitus | diagnostic | res50: type 2 diabetes | |||
| C10FK00 | Read | Hyperosmolar non-ketotic state in type 2 diabetes mellitus | diagnostic | res50: type 2 diabetes | |||
| C10FK11 | Read | Hyperosmolar non-ketotic state in type II diabetes mellitus | diagnostic | res50: type 2 diabetes | |||
| C10FL00 | Read | Type 2 diabetes mellitus with persistent proteinuria | diagnostic | res50: type 2 diabetes | |||
| C10FL11 | Read | Type II diabetes mellitus with persistent proteinuria | diagnostic | res50: type 2 diabetes | |||
| C10FM00 | Read | Type 2 diabetes mellitus with persistent microalbuminuria | diagnostic | res50: type 2 diabetes | |||
| C10FM11 | Read | Type II diabetes mellitus with persistent microalbuminuria | diagnostic | res50: type 2 diabetes | |||
| C10FN00 | Read | Type 2 diabetes mellitus with ketoacidosis | diagnostic | res50: type 2 diabetes | |||
| C10FN11 | Read | Type II diabetes mellitus with ketoacidosis | diagnostic | res50: type 2 diabetes | |||
| C10FP00 | Read | Type 2 diabetes mellitus with ketoacidotic coma | diagnostic | res50: type 2 diabetes | |||
| C10FP11 | Read | Type II diabetes mellitus with ketoacidotic coma | diagnostic | res50: type 2 diabetes | |||
| C10FQ00 | Read | Type 2 diabetes mellitus with exudative maculopathy | diagnostic | res50: type 2 diabetes | |||
| C10FR00 | Read | Type 2 diabetes mellitus with gastroparesis | diagnostic | res50: type 2 diabetes | |||
| C10P100 | Read | Type II diabetes mellitus in remission | diagnostic | res50: type 2 diabetes | |||
| L180600 | Read | Pre-existing diabetes mellitus, non-insulin-dependent | diagnostic | res50: type 2 diabetes | |||
| ZC2CA00 | Read | Dietary advice for type II diabetes | diagnostic | res50: type 2 diabetes |
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