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Research article:

Life Expectancy and Cause-Specific Mortality in Type 2 Diabetes: A Population-Based Cohort Study Quantifying Relationships in Ethnic Subgroups

Reference:

Alison K. Wright, Evangelos Kontopantelis, Richard Emsley, Iain Buchan, Naveed Sattar, Martin K. Rutter, Darren M. Ashcroft(2017) Life Expectancy and Cause-Specific Mortality in Type 2 Diabetes: A Population-Based Cohort Study Quantifying Relationships in Ethnic Subgroups. Diabetes Care, doi: 10.2337/dc16-1616

Link to article
Abstract
OBJECTIVES This study 1) investigated life expectancy and cause-specific mortality rates associated with type 2 diabetes and 2) quantified these relationships in ethnic subgroups. RESEARCH DESIGN AND METHODS This was a cohort study using Clinical Practice Research Datalink data from 383 general practices in England with linked hospitalization and mortality records. A total of 187,968 patients with incident type 2 diabetes from 1998 to 2015 were matched to 908,016 control subjects. Abridged life tables estimated years of life lost, and a competing risk survival model quantified cause-specific hazard ratios (HRs). RESULTS A total of 40,286 deaths occurred in patients with type 2 diabetes. At age 40, white men with diabetes lost 5 years of life and white women lost 6 years compared with those without diabetes. A loss of between 1 and 2 years was observed for South Asians and blacks with diabetes. At age older than 65 years, South Asians with diabetes had up to 1.1 years’ longer life expectancy than South Asians without diabetes. Compared with whites with diabetes, South Asians with diabetes had lower adjusted risks for mortality from cardiovascular (HR 0.82; 95% CI 0.75, 0.89), cancer (HR 0.43; 95% CI 0.36, 0.51), and respiratory diseases (HR 0.60; 95% CI 0.48, 0.76). A similar pattern was observed in blacks with diabetes compared with whites with diabetes. CONCLUSIONS Type 2 diabetes was associated with more years of life lost among whites than among South Asians or blacks, with older South Asians experiencing longer life expectancy compared with South Asians without diabetes. The findings support optimized cardiovascular disease risk factor management, especially in whites with type 2 diabetes.
Author for correspondence
Darren M. Ashcroft
Email for correspondence
darren.ashcroft@manchester.ac.uk.

Code list: res56: Antiplatelet agents

109 codes in list

Code Coding system Description Entity type List name drug type
16 CPRD_product_code aspirin tablets 75mg drug res56: Antiplatelet agents Aspirin
18329 CPRD_product_code ENPRIN enteric coated tablets 75mg [GALPHARM] drug res56: Antiplatelet agents Aspirin
19189 CPRD_product_code MICROPIRIN enteric coated tablets 75mg [RATIOPHARM] drug res56: Antiplatelet agents Aspirin
22618 CPRD_product_code SOLPRIN tablets 75mg [RECKITT B] drug res56: Antiplatelet agents Aspirin
23593 CPRD_product_code POSTMI dispersible tablet 75mg [ASHBOURNE] drug res56: Antiplatelet agents Aspirin
23878 CPRD_product_code NU-SEALS CARDIO EC tablets 75mg [GENUS] drug res56: Antiplatelet agents Aspirin
25335 CPRD_product_code POSTMI EC tablets 75mg [ASHBOURNE] drug res56: Antiplatelet agents Aspirin
25718 CPRD_product_code ANGETTES tablets 75mg [BRISTOL] drug res56: Antiplatelet agents Aspirin
2607 CPRD_product_code PAYNOCIL tablets [BEECHAM] drug res56: Antiplatelet agents Aspirin
2628 CPRD_product_code NU-SEALS ASPIRIN EC tablets 75mg [LILLY] drug res56: Antiplatelet agents Aspirin
3 CPRD_product_code aspirin dispersible tablet 75mg drug res56: Antiplatelet agents Aspirin
31211 CPRD_product_code ASPIRIN dispersible tablet 75mg [AAH(VANT)] drug res56: Antiplatelet agents Aspirin
31938 CPRD_product_code ASPIRIN EC tablets 75mg [SANDOZ] drug res56: Antiplatelet agents Aspirin
31953 CPRD_product_code ASPIRIN dispersible tablet 75mg [IVAX] drug res56: Antiplatelet agents Aspirin
31954 CPRD_product_code ASPIRIN dispersible tablet 75mg [TEVA] drug res56: Antiplatelet agents Aspirin
31956 CPRD_product_code ASPIRIN enteric coated tablets 75mg [KENT] drug res56: Antiplatelet agents Aspirin
32036 CPRD_product_code ASPIRIN dispersible tablet 75mg [ACTAVIS] drug res56: Antiplatelet agents Aspirin
32992 CPRD_product_code ASPIRIN enteric coated tablets 75mg [GEN (UK)] drug res56: Antiplatelet agents Aspirin
33293 CPRD_product_code ASPIRIN enteric coated tablets 75mg [STERWIN] drug res56: Antiplatelet agents Aspirin
33320 CPRD_product_code ASPIRIN dispersible tablet 75mg [SOVEREIGN] drug res56: Antiplatelet agents Aspirin
33656 CPRD_product_code ASPIRIN dispersible tablet 75mg [HILLCROSS] drug res56: Antiplatelet agents Aspirin
33676 CPRD_product_code ASPIRIN dispersible tablet 75mg [KENT] drug res56: Antiplatelet agents Aspirin
34 CPRD_product_code aspirin gastro-resistant tablets 75mg drug res56: Antiplatelet agents Aspirin
34385 CPRD_product_code ASPIRIN soluble tablet 75mg [CO-OPERATI] drug res56: Antiplatelet agents Aspirin
34434 CPRD_product_code ASPIRIN dispersible tablet 75mg [T & R] drug res56: Antiplatelet agents Aspirin
34485 CPRD_product_code ASPIRIN enteric coated tablets 75mg [IVAX] drug res56: Antiplatelet agents Aspirin
34611 CPRD_product_code ASPIRIN enteric coated tablets 75mg [CP PHARM] drug res56: Antiplatelet agents Aspirin
34796 CPRD_product_code ASPIRIN enteric coated tablets 75mg [GALEN] drug res56: Antiplatelet agents Aspirin
34797 CPRD_product_code ASPIRIN enteric coated tablets 75mg [ACTAVIS] drug res56: Antiplatelet agents Aspirin
34942 CPRD_product_code ASPIRIN dispersible tablet 75mg [NUCARE] drug res56: Antiplatelet agents Aspirin
40381 CPRD_product_code ASPIRIN soluble tablet 75mg [CP PHARM] drug res56: Antiplatelet agents Aspirin
40913 CPRD_product_code GREPID film coated tablets 75mg [BEACON] drug res56: Antiplatelet agents Clopidogrel
41512 CPRD_product_code ASPIRIN enteric coated tablets 75mg [TEVA] drug res56: Antiplatelet agents Aspirin
42750 CPRD_product_code CLOPIDOGREL film coated tablets 75mg [ACTAVIS] drug res56: Antiplatelet agents Clopidogrel
43709 CPRD_product_code ASPIRIN enteric coated tablets 75mg [ALMUS] drug res56: Antiplatelet agents Aspirin
45643 CPRD_product_code ASPIRIN soluble tablet 75mg [CELLTECH] drug res56: Antiplatelet agents Aspirin
46891 CPRD_product_code clopidogrel oral suspension 75mg/5ml drug res56: Antiplatelet agents Clopidogrel
47937 CPRD_product_code ASPIRIN dispersible tablet 75mg [WOCKHARDT] drug res56: Antiplatelet agents Aspirin
47992 CPRD_product_code ASPIRIN enteric coated tablets 75mg [HILLCROSS] drug res56: Antiplatelet agents Aspirin
48021 CPRD_product_code ASPIRIN tablets 75mg [HILLCROSS] drug res56: Antiplatelet agents Aspirin
48165 CPRD_product_code Aspirin 300mg tablets (Aspar Pharmaceuticals Ltd) drug res56: Antiplatelet agents Aspirin
489 CPRD_product_code clopidogrel film coated tablets 75mg drug res56: Antiplatelet agents Clopidogrel
48974 CPRD_product_code Aspirin 75mg tablets (Phoenix Healthcare Distribution Ltd) drug res56: Antiplatelet agents Aspirin
49060 CPRD_product_code Aspirin 75mg dispersible tablets (Alliance Healthcare (Distribution) Ltd) drug res56: Antiplatelet agents Aspirin
49220 CPRD_product_code Aspirin 300mg tablets (Kent Pharmaceuticals Ltd) drug res56: Antiplatelet agents Aspirin
49685 CPRD_product_code Aspirin 75mg dispersible tablets (Sigma Pharmaceuticals Plc) drug res56: Antiplatelet agents Aspirin
49799 CPRD_product_code Aspirin 150mg suppositories (A A H Pharmaceuticals Ltd) drug res56: Antiplatelet agents Aspirin
50555 CPRD_product_code Aspirin 300mg dispersible tablets (DE Pharmaceuticals) drug res56: Antiplatelet agents Aspirin
50926 CPRD_product_code Aspirin 75mg dispersible tablets (The Boots Company Plc) drug res56: Antiplatelet agents Aspirin
50949 CPRD_product_code Aspirin 75mg tablets (A A H Pharmaceuticals Ltd) drug res56: Antiplatelet agents Aspirin
51474 CPRD_product_code Aspirin 150mg suppositories (Martindale Pharmaceuticals Ltd) drug res56: Antiplatelet agents Aspirin
51561 CPRD_product_code Aspirin 75mg gastro-resistant tablets (Zanza Laboratories Ltd) drug res56: Antiplatelet agents Aspirin
52044 CPRD_product_code Aspirin 300mg caplets (The Boots Company Plc) drug res56: Antiplatelet agents Aspirin
52280 CPRD_product_code Aspirin 300mg Tablet (Wockhardt UK Ltd) drug res56: Antiplatelet agents Aspirin
52618 CPRD_product_code Aspirin 75mg dispersible tablets (Bristol Laboratories Ltd) drug res56: Antiplatelet agents Aspirin
52761 CPRD_product_code Clopidogrel 75mg tablets (Dr Reddy's Laboratories (UK) Ltd) drug res56: Antiplatelet agents Clopidogrel
52905 CPRD_product_code Aspirin 300mg tablets (Lloyds Pharmacy Ltd) drug res56: Antiplatelet agents Aspirin
53178 CPRD_product_code Aspirin 75mg gastro-resistant tablets (Wockhardt UK Ltd) drug res56: Antiplatelet agents Aspirin
53622 CPRD_product_code Aspirin 300mg Tablet (M & A Pharmachem Ltd) drug res56: Antiplatelet agents Aspirin
53711 CPRD_product_code Aspirin 300mg Tablet (Nucare Plc) drug res56: Antiplatelet agents Aspirin
53751 CPRD_product_code Clopidogrel 75mg tablets (Phoenix Healthcare Distribution Ltd) drug res56: Antiplatelet agents Clopidogrel
53791 CPRD_product_code Aspirin 150mg suppositories (Alliance Healthcare (Distribution) Ltd) drug res56: Antiplatelet agents Aspirin
53804 CPRD_product_code Aspirin 300mg gastro-resistant tablets (Alliance Healthcare (Distribution) Ltd) drug res56: Antiplatelet agents Aspirin
53816 CPRD_product_code Aspirin 300mg dispersible tablets (Alliance Healthcare (Distribution) Ltd) drug res56: Antiplatelet agents Aspirin
54284 CPRD_product_code Aspirin 75mg dispersible tablets (Almus Pharmaceuticals Ltd) drug res56: Antiplatelet agents Aspirin
54430 CPRD_product_code Aspirin 75mg tablets (Alliance Healthcare (Distribution) Ltd) drug res56: Antiplatelet agents Aspirin
54526 CPRD_product_code Aspirin 300mg tablets (Alliance Healthcare (Distribution) Ltd) drug res56: Antiplatelet agents Aspirin
54565 CPRD_product_code Aspirin 75mg dispersible tablets (Lloyds Pharmacy Ltd) drug res56: Antiplatelet agents Aspirin
54700 CPRD_product_code Clopidogrel 75mg tablets (A A H Pharmaceuticals Ltd) drug res56: Antiplatelet agents Clopidogrel
54734 CPRD_product_code Aspirin 300mg tablets (Wockhardt UK Ltd) drug res56: Antiplatelet agents Aspirin
54997 CPRD_product_code Aspirin 75mg dispersible tablets (Dowelhurst Ltd) drug res56: Antiplatelet agents Aspirin
55161 CPRD_product_code Clopidogrel 75mg tablets (Wockhardt UK Ltd) drug res56: Antiplatelet agents Clopidogrel
56007 CPRD_product_code Aspirin 300mg dispersible tablets (Sigma Pharmaceuticals Plc) drug res56: Antiplatelet agents Aspirin
56503 CPRD_product_code Asasantin Retard capsules (Mawdsley-Brooks & Company Ltd) drug res56: Antiplatelet agents Aspirin
56736 CPRD_product_code Aspirin 300mg tablets (Waymade Healthcare Plc) drug res56: Antiplatelet agents Aspirin
56807 CPRD_product_code Clopidogrel 75mg tablets (Teva UK Ltd) drug res56: Antiplatelet agents Clopidogrel
56883 CPRD_product_code Aspirin 75mg tablets (Waymade Healthcare Plc) drug res56: Antiplatelet agents Aspirin
56995 CPRD_product_code Aspirin 75mg dispersible tablets (Phoenix Healthcare Distribution Ltd) drug res56: Antiplatelet agents Aspirin
56996 CPRD_product_code Aspirin 75mg dispersible tablets (Waymade Healthcare Plc) drug res56: Antiplatelet agents Aspirin
57036 CPRD_product_code Clopidogrel 75mg tablets (Mylan Ltd) drug res56: Antiplatelet agents Clopidogrel
57057 CPRD_product_code Aspirin 75mg dispersible tablets (Wockhardt UK Ltd) drug res56: Antiplatelet agents Aspirin
58331 CPRD_product_code Aspirin 300mg gastro-resistant tablets (Mylan Ltd) drug res56: Antiplatelet agents Aspirin
58347 CPRD_product_code Clopidogrel 75mg tablets (DE Pharmaceuticals) drug res56: Antiplatelet agents Clopidogrel
58448 CPRD_product_code Clopidogrel 75mg tablets (Aspire Pharma Ltd) drug res56: Antiplatelet agents Clopidogrel
59021 CPRD_product_code Aspirin 75mg gastro-resistant tablets (Bristol Laboratories Ltd) drug res56: Antiplatelet agents Aspirin
59253 CPRD_product_code Aspirin 75mg gastro-resistant tablets (Waymade Healthcare Plc) drug res56: Antiplatelet agents Aspirin
59728 CPRD_product_code Aspirin 75mg tablets (Alissa Healthcare Research Ltd) drug res56: Antiplatelet agents Aspirin
59791 CPRD_product_code Aspirin 75mg dispersible tablets (Aspar Pharmaceuticals Ltd) drug res56: Antiplatelet agents Aspirin
59904 CPRD_product_code Clopidogrel 75mg/5ml oral solution drug res56: Antiplatelet agents Clopidogrel
6006 CPRD_product_code NU-SEALS ASPIRIN EC tablets 75mg [ALLIANCE] drug res56: Antiplatelet agents Aspirin
60127 CPRD_product_code Aspirin 75mg tablets (DE Pharmaceuticals) drug res56: Antiplatelet agents Aspirin
60278 CPRD_product_code Aspirin 300mg tablets (DE Pharmaceuticals) drug res56: Antiplatelet agents Aspirin
60694 CPRD_product_code Aspirin 25mg/5ml oral solution drug res56: Antiplatelet agents Aspirin
60777 CPRD_product_code Aspirin 75mg gastro-resistant tablets (DE Pharmaceuticals) drug res56: Antiplatelet agents Aspirin
62334 CPRD_product_code Aspirin 300mg caplets (Wockhardt UK Ltd) drug res56: Antiplatelet agents Aspirin
62430 CPRD_product_code Aspirin 300mg suppositories (A A H Pharmaceuticals Ltd) drug res56: Antiplatelet agents Aspirin
62855 CPRD_product_code Clopidogrel 75mg tablets (Alliance Healthcare (Distribution) Ltd) drug res56: Antiplatelet agents Clopidogrel
62978 CPRD_product_code Clopidogrel 75mg tablets (Sandoz Ltd) drug res56: Antiplatelet agents Clopidogrel
63450 CPRD_product_code Clopidogrel 75mg tablets (Almus Pharmaceuticals Ltd) drug res56: Antiplatelet agents Clopidogrel
63603 CPRD_product_code Laboprin Tablet (Laboratories For Applied Biology Ltd) drug res56: Antiplatelet agents Aspirin
64071 CPRD_product_code Aspirin powder (J M Loveridge Ltd) drug res56: Antiplatelet agents Aspirin
65909 CPRD_product_code Clopidogrel 75mg tablets (Milpharm Ltd) drug res56: Antiplatelet agents Clopidogrel
66345 CPRD_product_code Aspirin 75mg dispersible tablets (DE Pharmaceuticals) drug res56: Antiplatelet agents Aspirin
66546 CPRD_product_code Aspirin 75mg dispersible tablets (Numark Management Ltd) drug res56: Antiplatelet agents Aspirin
66563 CPRD_product_code Aspirin 75mg gastro-resistant tablets (Phoenix Healthcare Distribution Ltd) drug res56: Antiplatelet agents Aspirin
66861 CPRD_product_code Aspirin 75mg effervescent tablets drug res56: Antiplatelet agents Aspirin
6696 CPRD_product_code MICROPIRIN enteric coated tablets 75mg [DEXCEL] drug res56: Antiplatelet agents Aspirin
836 CPRD_product_code PLAVIX film coated tablets 75mg [SANOFI BMS] drug res56: Antiplatelet agents Clopidogrel
9144 CPRD_product_code CAPRIN EC tablets 75mg [WOCKHARDT] drug res56: Antiplatelet agents Aspirin

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