ClinicalCodes.org
An online clinical codes repository to improve validity and reproducibility of medical database research
Research article:
Alcohol-related mortality in patients with psoriasis: a population-based cohort study
Reference:
Parisi R; Webb RT; Carr MJ; Moriarty KJ; C Kleyn E; Griffiths CEM; Ashcroft DM(2017) Alcohol-related mortality in patients with psoriasis: a population-based cohort study. JAMA Dermatology, doi: 10.1001/jamadermatol.2017.3225
- Link to article
- Abstract
- Importance: People diagnosed with psoriasis have an increased risk of premature mortality, but the underlying reasons for this mortality gap are unclear. Objective: To investigate whether patients with psoriasis have an elevated risk of alcohol-related mortality. Design, Setting, and Participants: An incident cohort of patients with psoriasis aged 18 years and older was delineated for 1998 through 2014 using the Clinical Practice Research Datalink (CPRD) and linked to Hospital Episode Statistics (HES) and Office for National Statistics (ONS) mortality records. Patients with psoriasis were matched with up to 20 comparison patients without psoriasis on age, sex, and general practice. Main Outcomes and Measures: Alcohol-related deaths were ascertained via the Office for National Statistics mortality records. A stratified Cox proportional hazard model was used to estimate the cause-specific hazard ratio for alcohol-related death, with adjustment for socioeconomic status. Results: The cohort included 55 537 with psoriasis and 854 314 patients without psoriasis. Median (interquartile) age at index date was 47 (27) years; 408 230 of total patients (44.9%) were men. During a median (IQR) of 4.4 (6.2) years of follow-up, the alcohol-related mortality rate was 4.8 per 10 000 person-years (95% CI, 4.1-5.6; n = 152) for the psoriasis cohort, vs 2.5 per 10 000 (95% CI, 2.4- 2.7; n = 1118) for the comparison cohort. The hazard ratio for alcohol-related death in patients with psoriasis was 1.58 (95% CI, 1.31-1.91), and the predominant causes of alcohol-related deaths were alcoholic liver disease (65.1%), fibrosis and cirrhosis of the liver (23.7%), and mental and behavioral disorders due to alcohol (7.9%). Conclusions and Relevance: People with psoriasis have approximately a 60% greater risk of dying due to alcohol-related causes compared with peers of the same age and sex in the general population. This appears to be a key contributor to the premature mortality gap. These findings call for routine screening, identification and treatment, using the Alcohol Use Disorders Identification Test (AUDIT-C) in both primary and secondary care to detect alcohol consumption and misuse among people diagnosed with psoriasis.
- Author for correspondence
- Darren Ashcroft
- Email for correspondence
- Darren.Ashcroft@manchester.ac.uk
Code list: res61: Alcohol-related mortality
18 codes in list
| Code | Coding system | Description | Entity type | List name | |||
|---|---|---|---|---|---|---|---|
| F10 | ICD-10 | Mental and behavioural disorders due to use of alcohol | diagnostic | res61: Alcohol-related mortality | |||
| G31.2 | ICD-10 | Degeneration of nervous system due to alcohol | diagnostic | res61: Alcohol-related mortality | |||
| G62.1 | ICD-10 | Alcoholic polyneuropathy | diagnostic | res61: Alcohol-related mortality | |||
| I42.6 | ICD-10 | Alcoholic cardiomyopathy | diagnostic | res61: Alcohol-related mortality | |||
| K29.2 | ICD-10 | Alcoholic gastritis | diagnostic | res61: Alcohol-related mortality | |||
| K70 | ICD-10 | Alcoholic liver disease | diagnostic | res61: Alcohol-related mortality | |||
| K73 | ICD-10 | Chronic hepatitis, not elsewhere classified | diagnostic | res61: Alcohol-related mortality | |||
| K74 | ICD-10 | Fibrosis and cirrhosis of liver (Excluding K74.3?K74.5 - Biliary cirrhosis) | diagnostic | res61: Alcohol-related mortality | |||
| K86.0 | ICD-10 | Alcohol induced chronic pancreatitis | diagnostic | res61: Alcohol-related mortality | |||
| X45 | ICD-10 | Accidental poisoning by and exposure to alcohol | diagnostic | res61: Alcohol-related mortality | |||
| X65 | ICD-10 | Intentional self-poisoning by and exposure to alcohol | diagnostic | res61: Alcohol-related mortality | |||
| Y15 | ICD-10 | Poisoning by and exposure to alcohol, undetermined intent | diagnostic | res61: Alcohol-related mortality | |||
| 291 | ICD-9 | Alcoholic psychoses | diagnostic | res61: Alcohol-related mortality | |||
| 303 | ICD-9 | Alcohol dependence syndrome | diagnostic | res61: Alcohol-related mortality | |||
| 305 | ICD-9 | Non-dependent abuse of alcohol | diagnostic | res61: Alcohol-related mortality | |||
| 425.5 | ICD-9 | Alcoholic cardiomyopathy | diagnostic | res61: Alcohol-related mortality | |||
| 571 | ICD-9 | Chronic liver disease and cirrhosis (Excluding 571.6 - Biliary cirrhosis) | diagnostic | res61: Alcohol-related mortality | |||
| E860 | ICD-9 | Accidental poisoning by alcohol | diagnostic | res61: Alcohol-related mortality |
Please log in to leave a comment.
Code list links:
ClinicalCodes is a project at the University of Manchester Institute of Population Health
The ClinicalCodes project is funded by the National Institute for Health Research (NIHR) School for Primary Care Research (SPCR)