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Research article:
Psoriasis and the Risk of Major Cardiovascular Events: Cohort Study Using the Clinical Practice Research Datalink
Reference:
Parisi R, Rutter MK, Lunt M, Young HS, Symmons DPM, Griffiths CEM, Ashcroft DM; Identification and Management of Psoriasis Associated ComorbidiTy (IMPACT) project team(2015) Psoriasis and the Risk of Major Cardiovascular Events: Cohort Study Using the Clinical Practice Research Datalink. Journal of Investigative Dermatology, doi: https://doi.org/10.1038/jid.2015.87
- Link to article
- Abstract
- The association between psoriasis and risk of major cardiovascular (CV) events (myocardial infarction, acute coronary syndrome, unstable angina, and stroke) is unclear. A cohort study with 48,523 patients with psoriasis and 208,187 controls was conducted. During a median follow-up of 5.2 years, 1,257 patients with psoriasis (2.59%) had a major CV event, compared with 4,784 controls (2.30%). In the multivariable analysis, inflammatory arthritis hazard ratio (HR) 1.36 (1.18-1.58), diabetes HR 1.18 (1.06-1.31), chronic kidney disease HR 1.18 (1.07-1.31), hypertension HR 1.37 (1.29-1.45), transient ischemic attack HR 2.74 (2.41-3.12), atrial fibrillation HR 1.54 (1.36-1.73), valvular heart disease HR 1.23 (1.05-1.44), thromboembolism 1.32 (1.17-1.49), congestive heart failure HR 1.57 (1.39-1.78), depression HR 1.16 (1.01-1.34), current smoker HR 2.18 (2.03-2.33), age (year) HR 1.07 (1.07-1.07), and male gender HR 1.83 (1.69-1.98) were statistically significant for the risk of major CV events. The age- and gender-adjusted HRs of a major CV event for psoriasis were 1.10 (1.04-1.17) and for severe psoriasis 1.40 (1.07-1.84), whereas the fully adjusted HRs were attenuated to 1.02 (0.95-1.08) and 1.28 (0.96-1.69). In conclusion, neither psoriasis nor severe psoriasis were associated with the short-to-medium term (over 3-5 years) risk of major CV events after adjusting for known cardiovascular disease risk factors.
- Author for correspondence
- Darren M Ashcroft
- Email for correspondence
- Darren.Ashcroft@manchester.ac.uk
Code list: res66: psoriasis
24 codes in list
| Code | Coding system | Description | Entity type | List name | |||
|---|---|---|---|---|---|---|---|
| M16..00 | Read | Psoriasis and similar disorders | diagnostic | res66: psoriasis | |||
| M161.00 | Read | Other psoriasis | diagnostic | res66: psoriasis | |||
| M161000 | Read | Psoriasis unspecified | diagnostic | res66: psoriasis | |||
| M161100 | Read | Psoriasis annularis | diagnostic | res66: psoriasis | |||
| M161200 | Read | Psoriasis circinata | diagnostic | res66: psoriasis | |||
| M161300 | Read | Psoriasis diffusa | diagnostic | res66: psoriasis | |||
| M161400 | Read | Psoriasis discoidea | diagnostic | res66: psoriasis | |||
| M161500 | Read | Psoriasis geographica | diagnostic | res66: psoriasis | |||
| M161600 | Read | Guttate psoriasis | diagnostic | res66: psoriasis | |||
| M161700 | Read | Psoriasis gyrata | diagnostic | res66: psoriasis | |||
| M161800 | Read | Psoriasis inveterata | diagnostic | res66: psoriasis | |||
| M161900 | Read | Psoriasis ostracea | diagnostic | res66: psoriasis | |||
| M161A00 | Read | Psoriasis palmaris | diagnostic | res66: psoriasis | |||
| M161B00 | Read | Psoriasis plantaris | diagnostic | res66: psoriasis | |||
| M161C00 | Read | Psoriasis punctata | diagnostic | res66: psoriasis | |||
| M161E00 | Read | Psoriasis universalis | diagnostic | res66: psoriasis | |||
| M161F00 | Read | Psoriasis vulgaris | diagnostic | res66: psoriasis | |||
| M161F11 | Read | Chronic large plaque psoriasis | diagnostic | res66: psoriasis | |||
| M161H00 | Read | Erythrodermic psoriasis | diagnostic | res66: psoriasis | |||
| M161z00 | Read | Psoriasis NOS | diagnostic | res66: psoriasis | |||
| M16y.00 | Read | Other psoriasis and similar disorders | diagnostic | res66: psoriasis | |||
| M16y000 | Read | Scalp psoriasis | diagnostic | res66: psoriasis | |||
| M16z.00 | Read | Psoriasis and similar disorders NOS | diagnostic | res66: psoriasis | |||
| Myu3000 | Read | [X]Other psoriasis | diagnostic | res66: psoriasis |
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