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Research article:

Antibiotic prescribing for common infections in UK general practice: variability and drivers

Reference:

Victoria Palin, Anna Mölter, Miguel Belmonte, Darren Ashcroft, Andrew White, William Welfare, Tjeerd van Staa(2018) Antibiotic prescribing for common infections in UK general practice: variability and drivers. Journal of Antimicrobial Chemotherapy, doi:

Link to article
Abstract
Objectives: To examine variations across general practices and factors associated with antibiotic prescribing for common infections in UK primary care to identify potential targets for improvement and optimisation of prescribing. Methods: Oral antibiotics prescribing for common infections were analysed using anonymised UK primary care electronic health records between 2000 and 2015 using the Clinical Practice Research Datalink (CPRD). The rate of prescribing for each condition was observed over time and the correlation of prescribing between each condition estimated within a practice. Drivers of prescribing were estimated using logistic regression in a matched patient cohort (1:1 by age, sex and date). Results: Over 8 million patient records were examined in 587 general practices in the UK. Practices varied considerably in their propensity to prescribe antibiotics and this variance increased over time (except in cases of urinary tract infection (UTI)). Change points in prescribing did not reflect updates to national guidelines and prescribing for different infectious conditions varied within practices. A previous history of antibiotic use significantly increased the risk of receiving a subsequent antibiotic (by 22-48% for patients with ≥ 3 antibiotic prescriptions in the past 12 months), as did higher BMI, history of smoking and flu vaccinations. Other drivers for receiving an antibiotic varied considerably for each condition. Conclusions: Large variability in antibiotic prescribing between practices was observed. Prescribing guidelines alone do not positively influence a change in prescribing, suggesting more targeted interventions are required to optimise antibiotic prescribing in the UK.
Author for correspondence
Victoria Palin
Email for correspondence
victoria.palin@manchester.ac.uk

Code list: res70: Otitis media

45 codes in list

Code Coding system Description Entity type List name
A552.00 Read Postmeasles otitis media diagnostic res70: Otitis media
F51..00 Read Nonsuppurative otitis media + eustachian tube disorders diagnostic res70: Otitis media
F510.00 Read Acute non suppurative otitis media diagnostic res70: Otitis media
F510000 Read Acute otitis media with effusion diagnostic res70: Otitis media
F510011 Read Acute secretory otitis media diagnostic res70: Otitis media
F510100 Read Acute serous otitis media diagnostic res70: Otitis media
F510200 Read Acute mucoid otitis media diagnostic res70: Otitis media
F510300 Read Acute sanguinous otitis media diagnostic res70: Otitis media
F510z00 Read Acute nonsuppurative otitis media NOS diagnostic res70: Otitis media
F511.00 Read Chronic otitis media with effusion, serous diagnostic res70: Otitis media
F511.11 Read Chronic secretory otitis media, serous diagnostic res70: Otitis media
F511z00 Read Chronic serous otitis media NOS diagnostic res70: Otitis media
F512.00 Read Chronic otitis media with effusion, mucoid diagnostic res70: Otitis media
F512000 Read Glue ear, unspecified diagnostic res70: Otitis media
F512.11 Read Glue ear diagnostic res70: Otitis media
F512.12 Read Chronic secretory otitis media, mucoid diagnostic res70: Otitis media
F512z00 Read Chronic mucoid otitis media NOS diagnostic res70: Otitis media
F513.00 Read Chronic otitis media with effusion, other diagnostic res70: Otitis media
F513100 Read Chronic otitis media with effusion, purulent diagnostic res70: Otitis media
F513111 Read Chronic secretory otitis media, purulent diagnostic res70: Otitis media
F514.00 Read Unspecified nonsuppurative otitis media diagnostic res70: Otitis media
F514100 Read Serous otitis media NOS diagnostic res70: Otitis media
F514200 Read Catarrhal otitis media NOS diagnostic res70: Otitis media
F514300 Read Mucoid otitis media NOS diagnostic res70: Otitis media
F514z00 Read Nonsuppurative otitis media NOS diagnostic res70: Otitis media
F515.00 Read Eustachian tube salpingitis diagnostic res70: Otitis media
F515.11 Read Catarrh - eustachian diagnostic res70: Otitis media
F52..00 Read Suppurative and unspecified otitis media diagnostic res70: Otitis media
F520.00 Read Acute suppurative otitis media diagnostic res70: Otitis media
F520000 Read Acute suppurative otitis media tympanic membrane intact diagnostic res70: Otitis media
F520100 Read Acute suppurative otitis media tympanic membrane ruptured diagnostic res70: Otitis media
F520300 Read Acute suppurative otitis media due to disease EC diagnostic res70: Otitis media
F520z00 Read Acute suppurative otitis media NOS diagnostic res70: Otitis media
F521.00 Read Chronic suppurative otitis media, tubotympanic diagnostic res70: Otitis media
F522.00 Read Chronic suppurative otitis media, atticoantral diagnostic res70: Otitis media
F523.00 Read Chronic suppurative otitis media NOS diagnostic res70: Otitis media
F524.00 Read Purulent otitis media NOS diagnostic res70: Otitis media
F524000 Read Bilateral suppurative otitis media diagnostic res70: Otitis media
F525.00 Read Recurrent acute otitis media diagnostic res70: Otitis media
F526.00 Read Acute left otitis media diagnostic res70: Otitis media
F527.00 Read Acute right otitis media diagnostic res70: Otitis media
F528.00 Read Acute bilateral otitis media diagnostic res70: Otitis media
F52z.00 Read Otitis media NOS diagnostic res70: Otitis media
F52z.11 Read Infection ear diagnostic res70: Otitis media
SN30.11 Read Aero-otitis media diagnostic res70: Otitis media

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