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Research article:

Are symptoms of insomnia in primary care associated with subsequent onset of dementia? A matched retrospective case-control study

Reference:

Richard Hoile, Naji Tabet, Helen Smith, Stephen Bremner, Jackie Cassell, Elizabeth Ford(2019) Are symptoms of insomnia in primary care associated with subsequent onset of dementia? A matched retrospective case-control study. , doi:

Link to article
Abstract
Objective There is evidence from neuroimaging studies of an association between insomnia and early dementia biomarkers, but observational studies have so far failed to show a clear association between insomnia and the later development of dementia. We investigated the association between dementia diagnosis and recording of insomnia symptoms 5-10 years earlier in primary care. Method A case-control study using data from the Clinical Practice Research Datalink. 15,209 cases with dementia (either Alzheimer’s, vascular, mixed or non-specific subtypes) at least 65 years old at time of diagnosis, were matched with the same number of controls on year of birth and gender. We ascertained the presence of insomnia symptoms during a five-year period starting 10 years before the index date. Odds ratios for developing dementia were estimated using logistic regression after controlling for hypnotic exposure and physical and mental health comorbidities. Results The adjusted odds ratio for dementia in those with previous insomnia was 1.34 (95% CI = 1.20 to 1.50). Conclusion There is an association between dementia and previous insomnia. It may be possible to incorporate insomnia into predictive tools for dementia.
Author for correspondence
Richard Hoile
Email for correspondence
richard.hoile@sussexpartnership.nhs.uk

Code list: res38: Bipolar disorder

111 codes in list

Code Coding system Description Entity type List name
146D.00 Read H/O: manic depressive disorder diagnostic res38: Bipolar disorder
1S42.00 Read Manic mood diagnostic res38: Bipolar disorder
6657.00 Read On lithium diagnostic res38: Bipolar disorder
6657.11 Read Lithium monitoring diagnostic res38: Bipolar disorder
6657.12 Read Started lithium diagnostic res38: Bipolar disorder
E11..00 Read Affective psychoses diagnostic res38: Bipolar disorder
E110.00 Read Manic disorder, single episode diagnostic res38: Bipolar disorder
E110000 Read Single manic episode, unspecified diagnostic res38: Bipolar disorder
E110100 Read Single manic episode, mild diagnostic res38: Bipolar disorder
E110.11 Read Hypomanic psychoses diagnostic res38: Bipolar disorder
E110200 Read Single manic episode, moderate diagnostic res38: Bipolar disorder
E110300 Read Single manic episode, severe without mention of psychosis diagnostic res38: Bipolar disorder
E110400 Read Single manic episode, severe, with psychosis diagnostic res38: Bipolar disorder
E110600 Read Single manic episode in full remission diagnostic res38: Bipolar disorder
E110z00 Read Manic disorder, single episode NOS diagnostic res38: Bipolar disorder
E111.00 Read Recurrent manic episodes diagnostic res38: Bipolar disorder
E111000 Read Recurrent manic episodes, unspecified diagnostic res38: Bipolar disorder
E11..11 Read Bipolar psychoses diagnostic res38: Bipolar disorder
E111100 Read Recurrent manic episodes, mild diagnostic res38: Bipolar disorder
E111200 Read Recurrent manic episodes, moderate diagnostic res38: Bipolar disorder
E11..13 Read Manic psychoses diagnostic res38: Bipolar disorder
E111300 Read Recurrent manic episodes, severe without mention psychosis diagnostic res38: Bipolar disorder
E111400 Read Recurrent manic episodes, severe, with psychosis diagnostic res38: Bipolar disorder
E111500 Read Recurrent manic episodes, partial or unspecified remission diagnostic res38: Bipolar disorder
E111600 Read Recurrent manic episodes, in full remission diagnostic res38: Bipolar disorder
E111z00 Read Recurrent manic episode NOS diagnostic res38: Bipolar disorder
E114.00 Read Bipolar affective disorder, currently manic diagnostic res38: Bipolar disorder
E114000 Read Bipolar affective disorder, currently manic, unspecified diagnostic res38: Bipolar disorder
E114100 Read Bipolar affective disorder, currently manic, mild diagnostic res38: Bipolar disorder
E114.11 Read Manic-depressive - now manic diagnostic res38: Bipolar disorder
E114200 Read Bipolar affective disorder, currently manic, moderate diagnostic res38: Bipolar disorder
E114300 Read Bipolar affect disord, currently manic, severe, no psychosis diagnostic res38: Bipolar disorder
E114400 Read Bipolar affect disord, currently manic,severe with psychosis diagnostic res38: Bipolar disorder
E114500 Read Bipolar affect disord,currently manic, part/unspec remission diagnostic res38: Bipolar disorder
E114600 Read Bipolar affective disorder, currently manic, full remission diagnostic res38: Bipolar disorder
E114z00 Read Bipolar affective disorder, currently manic, NOS diagnostic res38: Bipolar disorder
E115.00 Read Bipolar affective disorder, currently depressed diagnostic res38: Bipolar disorder
E115000 Read Bipolar affective disorder, currently depressed, unspecified diagnostic res38: Bipolar disorder
E115100 Read Bipolar affective disorder, currently depressed, mild diagnostic res38: Bipolar disorder
E115.11 Read Manic-depressive - now depressed diagnostic res38: Bipolar disorder
E115200 Read Bipolar affective disorder, currently depressed, moderate diagnostic res38: Bipolar disorder
E115300 Read Bipolar affect disord, now depressed, severe, no psychosis diagnostic res38: Bipolar disorder
E115400 Read Bipolar affect disord, now depressed, severe with psychosis diagnostic res38: Bipolar disorder
E115500 Read Bipolar affect disord, now depressed, part/unspec remission diagnostic res38: Bipolar disorder
E115600 Read Bipolar affective disorder, now depressed, in full remission diagnostic res38: Bipolar disorder
E115z00 Read Bipolar affective disorder, currently depressed, NOS diagnostic res38: Bipolar disorder
E116.00 Read Mixed bipolar affective disorder diagnostic res38: Bipolar disorder
E116000 Read Mixed bipolar affective disorder, unspecified diagnostic res38: Bipolar disorder
E116100 Read Mixed bipolar affective disorder, mild diagnostic res38: Bipolar disorder
E116200 Read Mixed bipolar affective disorder, moderate diagnostic res38: Bipolar disorder
E116300 Read Mixed bipolar affective disorder, severe, without psychosis diagnostic res38: Bipolar disorder
E116400 Read Mixed bipolar affective disorder, severe, with psychosis diagnostic res38: Bipolar disorder
E116500 Read Mixed bipolar affective disorder, partial/unspec remission diagnostic res38: Bipolar disorder
E116600 Read Mixed bipolar affective disorder, in full remission diagnostic res38: Bipolar disorder
E116z00 Read Mixed bipolar affective disorder, NOS diagnostic res38: Bipolar disorder
E117.00 Read Unspecified bipolar affective disorder diagnostic res38: Bipolar disorder
E117000 Read Unspecified bipolar affective disorder, unspecified diagnostic res38: Bipolar disorder
E117100 Read Unspecified bipolar affective disorder, mild diagnostic res38: Bipolar disorder
E117200 Read Unspecified bipolar affective disorder, moderate diagnostic res38: Bipolar disorder
E117300 Read Unspecified bipolar affective disorder, severe, no psychosis diagnostic res38: Bipolar disorder
E117400 Read Unspecified bipolar affective disorder,severe with psychosis diagnostic res38: Bipolar disorder
E117500 Read Unspecified bipolar affect disord, partial/unspec remission diagnostic res38: Bipolar disorder
E117600 Read Unspecified bipolar affective disorder, in full remission diagnostic res38: Bipolar disorder
E117z00 Read Unspecified bipolar affective disorder, NOS diagnostic res38: Bipolar disorder
E11y.00 Read Other and unspecified manic-depressive psychoses diagnostic res38: Bipolar disorder
E11y000 Read Unspecified manic-depressive psychoses diagnostic res38: Bipolar disorder
E11y100 Read Atypical manic disorder diagnostic res38: Bipolar disorder
E11y300 Read Other mixed manic-depressive psychoses diagnostic res38: Bipolar disorder
E11yz00 Read Other and unspecified manic-depressive psychoses NOS diagnostic res38: Bipolar disorder
Eu3..00 Read [X]Mood - affective disorders diagnostic res38: Bipolar disorder
Eu30.00 Read [X]Manic episode diagnostic res38: Bipolar disorder
Eu30000 Read [X]Hypomania diagnostic res38: Bipolar disorder
Eu30100 Read [X]Mania without psychotic symptoms diagnostic res38: Bipolar disorder
Eu30.11 Read [X]Bipolar disorder, single manic episode diagnostic res38: Bipolar disorder
Eu30200 Read [X]Mania with psychotic symptoms diagnostic res38: Bipolar disorder
Eu30211 Read [X]Mania with mood-congruent psychotic symptoms diagnostic res38: Bipolar disorder
Eu30212 Read [X]Mania with mood-incongruent psychotic symptoms diagnostic res38: Bipolar disorder
Eu30y00 Read [X]Other manic episodes diagnostic res38: Bipolar disorder
Eu30z00 Read [X]Manic episode, unspecified diagnostic res38: Bipolar disorder
Eu30z11 Read [X]Mania NOS diagnostic res38: Bipolar disorder
Eu31.00 Read [X]Bipolar affective disorder diagnostic res38: Bipolar disorder
Eu31000 Read [X]Bipolar affective disorder, current episode hypomanic diagnostic res38: Bipolar disorder
Eu31100 Read [X]Bipolar affect disorder cur epi manic wout psychotic symp diagnostic res38: Bipolar disorder
Eu31.11 Read [X]Manic-depressive illness diagnostic res38: Bipolar disorder
Eu31.12 Read [X]Manic-depressive psychosis diagnostic res38: Bipolar disorder
Eu31.13 Read [X]Manic-depressive reaction diagnostic res38: Bipolar disorder
Eu31200 Read [X]Bipolar affect disorder cur epi manic with psychotic symp diagnostic res38: Bipolar disorder
Eu31300 Read [X]Bipolar affect disorder cur epi mild or moderate depressn diagnostic res38: Bipolar disorder
Eu31400 Read [X]Bipol aff disord, curr epis sev depress, no psychot symp diagnostic res38: Bipolar disorder
Eu31500 Read [X]Bipolar affect dis cur epi severe depres with psyc symp diagnostic res38: Bipolar disorder
Eu31600 Read [X]Bipolar affective disorder, current episode mixed diagnostic res38: Bipolar disorder
Eu31700 Read [X]Bipolar affective disorder, currently in remission diagnostic res38: Bipolar disorder
Eu31y00 Read [X]Other bipolar affective disorders diagnostic res38: Bipolar disorder
Eu31y11 Read [X]Bipolar II disorder diagnostic res38: Bipolar disorder
Eu31y12 Read [X]Recurrent manic episodes diagnostic res38: Bipolar disorder
Eu31z00 Read [X]Bipolar affective disorder, unspecified diagnostic res38: Bipolar disorder
Eu33213 Read [X]Manic-depress psychosis,depressd,no psychotic symptoms diagnostic res38: Bipolar disorder
Eu33312 Read [X]Manic-depress psychosis,depressed type+psychotic symptoms diagnostic res38: Bipolar disorder
Eu34.00 Read [X]Persistent mood affective disorders diagnostic res38: Bipolar disorder
Eu34000 Read [X]Cyclothymia diagnostic res38: Bipolar disorder
Eu34y00 Read [X]Other persistent mood affective disorders diagnostic res38: Bipolar disorder
Eu34z00 Read [X]Persistent mood affective disorder, unspecified diagnostic res38: Bipolar disorder
Eu3y.00 Read [X]Other mood affective disorders diagnostic res38: Bipolar disorder
Eu3y000 Read [X]Other single mood affective disorders diagnostic res38: Bipolar disorder
Eu3y011 Read [X]Mixed affective episode diagnostic res38: Bipolar disorder
Eu3y100 Read [X]Other recurrent mood affective disorders diagnostic res38: Bipolar disorder
Eu3yy00 Read [X]Other specified mood affective disorders diagnostic res38: Bipolar disorder
Eu3z.00 Read [X]Unspecified mood affective disorder diagnostic res38: Bipolar disorder
Eu3z.11 Read [X]Affective psychosis NOS diagnostic res38: Bipolar disorder
ZV11111 Read [V]Personal history of manic-depressive psychosis diagnostic res38: Bipolar disorder
ZV11112 Read [V]Personal history of manic-depressive psychosis diagnostic res38: Bipolar disorder

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