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Research article:

Are symptoms of insomnia in primary care associated with subsequent onset of dementia? A matched retrospective case-control study

Reference:

Richard Hoile, Naji Tabet, Helen Smith, Stephen Bremner, Jackie Cassell, Elizabeth Ford(2019) Are symptoms of insomnia in primary care associated with subsequent onset of dementia? A matched retrospective case-control study. , doi:

Link to article
Abstract
Objective There is evidence from neuroimaging studies of an association between insomnia and early dementia biomarkers, but observational studies have so far failed to show a clear association between insomnia and the later development of dementia. We investigated the association between dementia diagnosis and recording of insomnia symptoms 5-10 years earlier in primary care. Method A case-control study using data from the Clinical Practice Research Datalink. 15,209 cases with dementia (either Alzheimer’s, vascular, mixed or non-specific subtypes) at least 65 years old at time of diagnosis, were matched with the same number of controls on year of birth and gender. We ascertained the presence of insomnia symptoms during a five-year period starting 10 years before the index date. Odds ratios for developing dementia were estimated using logistic regression after controlling for hypnotic exposure and physical and mental health comorbidities. Results The adjusted odds ratio for dementia in those with previous insomnia was 1.34 (95% CI = 1.20 to 1.50). Conclusion There is an association between dementia and previous insomnia. It may be possible to incorporate insomnia into predictive tools for dementia.
Author for correspondence
Richard Hoile
Email for correspondence
richard.hoile@sussexpartnership.nhs.uk

Code list: res38: Eating disorder

38 codes in list

Code Coding system Description Entity type List name
1612.00 Read Appetite loss - anorexia diagnostic res38: Eating disorder
1612.11 Read Anorexia symptom diagnostic res38: Eating disorder
1614.00 Read Excessive eating - polyphagia diagnostic res38: Eating disorder
1614.11 Read Hyperalimentation - symptom diagnostic res38: Eating disorder
1614.12 Read Polyphagia symptom diagnostic res38: Eating disorder
8HTN.00 Read Referral to eating disorders clinic diagnostic res38: Eating disorder
9Nk9.00 Read Seen in eating disorder clinic diagnostic res38: Eating disorder
E271.00 Read Anorexia nervosa diagnostic res38: Eating disorder
E275.00 Read Other and unspecified non-organic eating disorders diagnostic res38: Eating disorder
E275000 Read Unspecified non-organic eating disorder diagnostic res38: Eating disorder
E275100 Read Bulimia (non-organic overeating) diagnostic res38: Eating disorder
E275111 Read Compulsive eating disorder diagnostic res38: Eating disorder
E275y00 Read Other specified non-organic eating disorder diagnostic res38: Eating disorder
E275z00 Read Non-organic eating disorder NOS diagnostic res38: Eating disorder
Eu50.00 Read [X]Eating disorders diagnostic res38: Eating disorder
Eu50000 Read [X]Anorexia nervosa diagnostic res38: Eating disorder
Eu50100 Read [X]Atypical anorexia nervosa diagnostic res38: Eating disorder
Eu50200 Read [X]Bulimia nervosa diagnostic res38: Eating disorder
Eu50211 Read [X]Bulimia NOS diagnostic res38: Eating disorder
Eu50212 Read [X]Hyperorexia nervosa diagnostic res38: Eating disorder
Eu50300 Read [X]Atypical bulimia nervosa diagnostic res38: Eating disorder
Eu50400 Read [X]Overeating associated with other psychological disturbncs diagnostic res38: Eating disorder
Eu50411 Read [X]Psychogenic overeating diagnostic res38: Eating disorder
Eu50y00 Read [X]Other eating disorders diagnostic res38: Eating disorder
Eu50y11 Read [X]Pica in adults diagnostic res38: Eating disorder
Eu50z00 Read [X]Eating disorder, unspecified diagnostic res38: Eating disorder
Fy05.00 Read Nocturnal sleep-related eating disorder diagnostic res38: Eating disorder
R030.00 Read [D]Anorexia diagnostic res38: Eating disorder
R030z00 Read [D]Anorexia NOS diagnostic res38: Eating disorder
R036.00 Read [D]Polyphagia diagnostic res38: Eating disorder
R036000 Read [D]Excessive eating diagnostic res38: Eating disorder
R036011 Read [D]Bulimia NOS diagnostic res38: Eating disorder
R036100 Read [D]Hyperalimentation diagnostic res38: Eating disorder
R036z00 Read [D]Polyphagia NOS diagnostic res38: Eating disorder
SN42100 Read Starvation diagnostic res38: Eating disorder
U1B3.11 Read [X]Starvation diagnostic res38: Eating disorder
Z4B5.00 Read Eating disorder counselling diagnostic res38: Eating disorder
ZC2CD00 Read Dietary advice for eating disorder diagnostic res38: Eating disorder

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