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Research article:

Are symptoms of insomnia in primary care associated with subsequent onset of dementia? A matched retrospective case-control study

Reference:

Richard Hoile, Naji Tabet, Helen Smith, Stephen Bremner, Jackie Cassell, Elizabeth Ford(2019) Are symptoms of insomnia in primary care associated with subsequent onset of dementia? A matched retrospective case-control study. , doi:

Link to article
Abstract
Objective There is evidence from neuroimaging studies of an association between insomnia and early dementia biomarkers, but observational studies have so far failed to show a clear association between insomnia and the later development of dementia. We investigated the association between dementia diagnosis and recording of insomnia symptoms 5-10 years earlier in primary care. Method A case-control study using data from the Clinical Practice Research Datalink. 15,209 cases with dementia (either Alzheimer’s, vascular, mixed or non-specific subtypes) at least 65 years old at time of diagnosis, were matched with the same number of controls on year of birth and gender. We ascertained the presence of insomnia symptoms during a five-year period starting 10 years before the index date. Odds ratios for developing dementia were estimated using logistic regression after controlling for hypnotic exposure and physical and mental health comorbidities. Results The adjusted odds ratio for dementia in those with previous insomnia was 1.34 (95% CI = 1.20 to 1.50). Conclusion There is an association between dementia and previous insomnia. It may be possible to incorporate insomnia into predictive tools for dementia.
Author for correspondence
Richard Hoile
Email for correspondence
richard.hoile@sussexpartnership.nhs.uk

Code list: res38: Personality disorder

78 codes in list

Code Coding system Description Entity type List name
E21..00 Read Personality disorders diagnostic res38: Personality disorder
E210.00 Read Paranoid personality disorder diagnostic res38: Personality disorder
E211.00 Read Affective personality disorder diagnostic res38: Personality disorder
E211000 Read Unspecified affective personality disorder diagnostic res38: Personality disorder
E21..11 Read Neurotic personality disorder diagnostic res38: Personality disorder
E211100 Read Hypomanic personality disorder diagnostic res38: Personality disorder
E211200 Read Depressive personality disorder diagnostic res38: Personality disorder
E211300 Read Cyclothymic personality disorder diagnostic res38: Personality disorder
E211z00 Read Affective personality disorder NOS diagnostic res38: Personality disorder
E212.00 Read Schizoid personality disorder diagnostic res38: Personality disorder
E212000 Read Unspecified schizoid personality disorder diagnostic res38: Personality disorder
E212z00 Read Schizoid personality disorder NOS diagnostic res38: Personality disorder
E213.00 Read Explosive personality disorder diagnostic res38: Personality disorder
E214.00 Read Compulsive personality disorders diagnostic res38: Personality disorder
E214000 Read Anankastic personality diagnostic res38: Personality disorder
E214.11 Read Anancastic personality diagnostic res38: Personality disorder
E214z00 Read Compulsive personality disorder NOS diagnostic res38: Personality disorder
E215.00 Read Histrionic personality disorders diagnostic res38: Personality disorder
E215000 Read Unspecified histrionic personality disorder diagnostic res38: Personality disorder
E215.11 Read Hysterical personality disorders diagnostic res38: Personality disorder
E215z00 Read Histrionic personality disorder NOS diagnostic res38: Personality disorder
E216.00 Read Inadequate personality disorder diagnostic res38: Personality disorder
E217.00 Read Antisocial or sociopathic personality disorder diagnostic res38: Personality disorder
E21y.00 Read Other personality disorders diagnostic res38: Personality disorder
E21y000 Read Narcissistic personality disorder diagnostic res38: Personality disorder
E21y100 Read Avoidant personality disorder diagnostic res38: Personality disorder
E21y200 Read Borderline personality disorder diagnostic res38: Personality disorder
E21y300 Read Passive-aggressive personality disorder diagnostic res38: Personality disorder
E21y400 Read Eccentric personality disorder diagnostic res38: Personality disorder
E21y500 Read Immature personality disorder diagnostic res38: Personality disorder
E21y600 Read Masochistic personality disorder diagnostic res38: Personality disorder
E21y700 Read Psychoneurotic personality disorder diagnostic res38: Personality disorder
E21yz00 Read Other personality disorder NOS diagnostic res38: Personality disorder
E21z.00 Read Personality disorder NOS diagnostic res38: Personality disorder
E21z.11 Read Psychopathic personality diagnostic res38: Personality disorder
Eu06000 Read [X]Organic personality disorder diagnostic res38: Personality disorder
Eu06011 Read [X]Organic pseudopsychopathic personality diagnostic res38: Personality disorder
Eu21.17 Read [X]Pseudopsychopathic schizophrenia diagnostic res38: Personality disorder
Eu21.18 Read [X]Schizotypal personality disorder diagnostic res38: Personality disorder
Eu34011 Read [X]Affective personality disorder diagnostic res38: Personality disorder
Eu34112 Read [X]Depressive personality disorder diagnostic res38: Personality disorder
Eu60.00 Read [X]Specific personality disorders diagnostic res38: Personality disorder
Eu60000 Read [X]Paranoid personality disorder diagnostic res38: Personality disorder
Eu60013 Read [X]Querulant personality disorder diagnostic res38: Personality disorder
Eu60014 Read [X]Sensitive paranoid personality disorder diagnostic res38: Personality disorder
Eu60100 Read [X]Schizoid personality disorder diagnostic res38: Personality disorder
Eu60200 Read [X]Dissocial personality disorder diagnostic res38: Personality disorder
Eu60212 Read [X]Antisocial personality disorder diagnostic res38: Personality disorder
Eu60213 Read [X]Asocial personality disorder diagnostic res38: Personality disorder
Eu60214 Read [X]Psychopathic personality disorder diagnostic res38: Personality disorder
Eu60215 Read [X]Sociopathic personality disorder diagnostic res38: Personality disorder
Eu60300 Read [X]Emotionally unstable personality disorder diagnostic res38: Personality disorder
Eu60311 Read [X]Aggressive personality disorder diagnostic res38: Personality disorder
Eu60312 Read [X]Borderline personality disorder diagnostic res38: Personality disorder
Eu60313 Read [X]Explosive personality disorder diagnostic res38: Personality disorder
Eu60400 Read [X]Histrionic personality disorder diagnostic res38: Personality disorder
Eu60411 Read [X]Hysterical personality disorder diagnostic res38: Personality disorder
Eu60412 Read [X]Psychoinfantile personality disorder diagnostic res38: Personality disorder
Eu60500 Read [X]Anankastic personality disorder diagnostic res38: Personality disorder
Eu60511 Read [X]Compulsive personality disorder diagnostic res38: Personality disorder
Eu60512 Read [X]Obsessional personality disorder diagnostic res38: Personality disorder
Eu60513 Read [X]Obsessive-compulsive personality disorder diagnostic res38: Personality disorder
Eu60600 Read [X]Anxious [avoidant] personality disorder diagnostic res38: Personality disorder
Eu60700 Read [X]Dependent personality disorder diagnostic res38: Personality disorder
Eu60711 Read [X]Asthenic personality disorder diagnostic res38: Personality disorder
Eu60712 Read [X]Inadequate personality disorder diagnostic res38: Personality disorder
Eu60713 Read [X]Passive personality disorder diagnostic res38: Personality disorder
Eu60714 Read [X]Self defeating personality disorder diagnostic res38: Personality disorder
Eu60y00 Read [X]Other specific personality disorders diagnostic res38: Personality disorder
Eu60y11 Read [X]Eccentric personality disorder diagnostic res38: Personality disorder
Eu60y12 Read [X]Haltlose type personality disorder diagnostic res38: Personality disorder
Eu60y13 Read [X]Immature personality disorder diagnostic res38: Personality disorder
Eu60y14 Read [X]Narcissistic personality disorder diagnostic res38: Personality disorder
Eu60y16 Read [X]Psychoneurotic personality disorder diagnostic res38: Personality disorder
Eu60z00 Read [X]Personality disorder, unspecified diagnostic res38: Personality disorder
Eu61.00 Read [X]Mixed and other personality disorders diagnostic res38: Personality disorder
Eu84511 Read [X]Autistic psychopathy diagnostic res38: Personality disorder
Eu94211 Read [X]Affectionless psychopathy diagnostic res38: Personality disorder

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