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Research article:

Are symptoms of insomnia in primary care associated with subsequent onset of dementia? A matched retrospective case-control study

Reference:

Richard Hoile, Naji Tabet, Helen Smith, Stephen Bremner, Jackie Cassell, Elizabeth Ford(2019) Are symptoms of insomnia in primary care associated with subsequent onset of dementia? A matched retrospective case-control study. , doi:

Link to article
Abstract
Objective There is evidence from neuroimaging studies of an association between insomnia and early dementia biomarkers, but observational studies have so far failed to show a clear association between insomnia and the later development of dementia. We investigated the association between dementia diagnosis and recording of insomnia symptoms 5-10 years earlier in primary care. Method A case-control study using data from the Clinical Practice Research Datalink. 15,209 cases with dementia (either Alzheimer’s, vascular, mixed or non-specific subtypes) at least 65 years old at time of diagnosis, were matched with the same number of controls on year of birth and gender. We ascertained the presence of insomnia symptoms during a five-year period starting 10 years before the index date. Odds ratios for developing dementia were estimated using logistic regression after controlling for hypnotic exposure and physical and mental health comorbidities. Results The adjusted odds ratio for dementia in those with previous insomnia was 1.34 (95% CI = 1.20 to 1.50). Conclusion There is an association between dementia and previous insomnia. It may be possible to incorporate insomnia into predictive tools for dementia.
Author for correspondence
Richard Hoile
Email for correspondence
richard.hoile@sussexpartnership.nhs.uk

Code list: res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific

55 codes in list

Code Coding system Description Entity type List name
1461.00 Read H/O: dementia diagnostic res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific
E000.00 Read Uncomplicated senile dementia diagnostic res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific
E001.00 Read Presenile dementia diagnostic res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific
E001000 Read Uncomplicated presenile dementia diagnostic res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific
E00..11 Read Senile dementia diagnostic res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific
E001100 Read Presenile dementia with delirium diagnostic res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific
E00..12 Read Senile/presenile dementia diagnostic res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific
E001200 Read Presenile dementia with paranoia diagnostic res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific
E001300 Read Presenile dementia with depression diagnostic res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific
E001z00 Read Presenile dementia NOS diagnostic res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific
E002.00 Read Senile dementia with depressive or paranoid fe... diagnostic res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific
E002000 Read Senile dementia with paranoia diagnostic res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific
E002100 Read Senile dementia with depression diagnostic res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific
E002z00 Read Senile dementia with depressive or paranoid fe... diagnostic res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific
E003.00 Read Senile dementia with delirium diagnostic res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific
E004.00 Read Arteriosclerotic dementia diagnostic res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific
E004000 Read Uncomplicated arteriosclerotic dementia diagnostic res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific
E004100 Read Arteriosclerotic dementia with delirium diagnostic res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific
E004.11 Read Multi infarct dementia diagnostic res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific
E004200 Read Arteriosclerotic dementia with paranoia diagnostic res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific
E004300 Read Arteriosclerotic dementia with depression diagnostic res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific
E004z00 Read Arteriosclerotic dementia NOS diagnostic res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific
Eu00.00 Read [X]Dementia in Alzheimer's disease diagnostic res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific
Eu00000 Read [X]Dementia in Alzheimer's disease with early ... diagnostic res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific
Eu00011 Read [X]Presenile dementiaAlzheimer's type diagnostic res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific
Eu00012 Read [X]Primary degen dementia Alzheimer's type p... diagnostic res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific
Eu00013 Read [X]Alzheimer's disease type 2 diagnostic res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific
Eu00100 Read [X]Dementia in Alzheimer's disease with late o... diagnostic res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific
Eu00111 Read [X]Alzheimer's disease type 1 diagnostic res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific
Eu00112 Read [X]Senile dementiaAlzheimer's type diagnostic res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific
Eu00113 Read [X]Primary degen dementia of Alzheimer's type... diagnostic res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific
Eu00200 Read [X]Dementia in Alzheimer's dis atypical or mi... diagnostic res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific
Eu00z00 Read [X]Dementia in Alzheimer's disease unspecified diagnostic res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific
Eu00z11 Read [X]Alzheimer's dementia unspec diagnostic res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific
Eu01.00 Read [X]Vascular dementia diagnostic res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific
Eu01000 Read [X]Vascular dementia of acute onset diagnostic res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific
Eu01100 Read [X]Multi-infarct dementia diagnostic res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific
Eu01.11 Read [X]Arteriosclerotic dementia diagnostic res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific
Eu01111 Read [X]Predominantly cortical dementia diagnostic res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific
Eu01200 Read [X]Subcortical vascular dementia diagnostic res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific
Eu01300 Read [X]Mixed cortical and subcortical vascular dem... diagnostic res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific
Eu01y00 Read [X]Other vascular dementia diagnostic res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific
Eu01z00 Read [X]Vascular dementia unspecified diagnostic res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific
Eu02y00 Read [X]Dementia in other specified diseases classi... diagnostic res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific
Eu02z00 Read [X] Unspecified dementia diagnostic res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific
Eu02z11 Read [X] Presenile dementia NOS diagnostic res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific
Eu02z13 Read [X] Primary degenerative dementia NOS diagnostic res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific
Eu02z14 Read [X] Senile dementia NOS diagnostic res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific
Eu02z16 Read [X] Senile dementia depressed or paranoid type diagnostic res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific
Eu04100 Read [X]Delirium superimposed on dementia diagnostic res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific
F110.00 Read Alzheimer's disease diagnostic res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific
F110000 Read Alzheimer's disease with early onset diagnostic res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific
F110100 Read Alzheimer's disease with late onset diagnostic res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific
F112.00 Read Senile degeneration of brain diagnostic res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific
Fyu3000 Read [X]Other Alzheimer's disease diagnostic res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific

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