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Research article:

Are symptoms of insomnia in primary care associated with subsequent onset of dementia? A matched retrospective case-control study

Reference:

Richard Hoile, Naji Tabet, Helen Smith, Stephen Bremner, Jackie Cassell, Elizabeth Ford(2019) Are symptoms of insomnia in primary care associated with subsequent onset of dementia? A matched retrospective case-control study. , doi:

Link to article
Abstract
Objective There is evidence from neuroimaging studies of an association between insomnia and early dementia biomarkers, but observational studies have so far failed to show a clear association between insomnia and the later development of dementia. We investigated the association between dementia diagnosis and recording of insomnia symptoms 5-10 years earlier in primary care. Method A case-control study using data from the Clinical Practice Research Datalink. 15,209 cases with dementia (either Alzheimer’s, vascular, mixed or non-specific subtypes) at least 65 years old at time of diagnosis, were matched with the same number of controls on year of birth and gender. We ascertained the presence of insomnia symptoms during a five-year period starting 10 years before the index date. Odds ratios for developing dementia were estimated using logistic regression after controlling for hypnotic exposure and physical and mental health comorbidities. Results The adjusted odds ratio for dementia in those with previous insomnia was 1.34 (95% CI = 1.20 to 1.50). Conclusion There is an association between dementia and previous insomnia. It may be possible to incorporate insomnia into predictive tools for dementia.
Author for correspondence
Richard Hoile
Email for correspondence
richard.hoile@sussexpartnership.nhs.uk

Code list: res78: Specific_Dementias_Not_Used_In_This_Study

14 codes in list

Code Coding system Description Entity type List name
E012.00 Read Other alcoholic dementia diagnostic res78: Specific_Dementias_Not_Used_In_This_Study
E012.11 Read Alcoholic dementia NOS diagnostic res78: Specific_Dementias_Not_Used_In_This_Study
E02y100 Read Drug-induced dementia diagnostic res78: Specific_Dementias_Not_Used_In_This_Study
Eu02.00 Read [X]Dementia in other diseases classified elsew... diagnostic res78: Specific_Dementias_Not_Used_In_This_Study
Eu02000 Read [X]Dementia in Pick's disease diagnostic res78: Specific_Dementias_Not_Used_In_This_Study
Eu02100 Read [X]Dementia in Creutzfeldt-Jakob disease diagnostic res78: Specific_Dementias_Not_Used_In_This_Study
Eu02200 Read [X]Dementia in Huntington's disease diagnostic res78: Specific_Dementias_Not_Used_In_This_Study
Eu02300 Read [X]Dementia in Parkinson's disease diagnostic res78: Specific_Dementias_Not_Used_In_This_Study
Eu02400 Read [X]Dementia in human immunodef virus [HIV] dis... diagnostic res78: Specific_Dementias_Not_Used_In_This_Study
Eu02500 Read [X]Lewy body dementia diagnostic res78: Specific_Dementias_Not_Used_In_This_Study
Eu10711 Read [X]Alcoholic dementia NOS diagnostic res78: Specific_Dementias_Not_Used_In_This_Study
F111.00 Read Pick's disease diagnostic res78: Specific_Dementias_Not_Used_In_This_Study
F116.00 Read Lewy body disease diagnostic res78: Specific_Dementias_Not_Used_In_This_Study
ZS7C500 Read Language disorder of dementia diagnostic res78: Specific_Dementias_Not_Used_In_This_Study

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