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Research article:
Glucose, blood pressure and cholesterol levels and their relationships to clinical outcomes in type 2 diabetes: a retrospective cohort study
Reference:
Evangelos Kontopantelis, David A Springate, David Reeves, Darren M Ashcroft, Martin Rutter, Iain Buchan, Tim Doran(2015) Glucose, blood pressure and cholesterol levels and their relationships to clinical outcomes in type 2 diabetes: a retrospective cohort study. Diabetologia, doi: 10.1007/s00125-014-3473-8
- Link to fulltext article
- Abstract
- Background: Observational data have been used to inform target levels for modifiable risk factors in type 2 diabetes but these data are limited by confounding. We aimed to describe the shape of observed relationships between risk factor levels and clinically important outcomes in type 2 diabetes after adjusting for multiple confounders. Methods: We used retrospective longitudinal data on 246,544 adults with type 2 diabetes from 600 practices contributing to the Clinical Practice Research Datalink between 2006 and 2012. Proportional hazards regression models quantified the risks of mortality, microvascular or macrovascular events associated with four modifiable risk factors: glycated haemoglobin (HbA1c), systolic and diastolic blood pressure and total cholesterol, while controlling for numerous patient and practice covariates. Findings: U-shaped relationships were observed between all-cause mortality and levels of the four risk factors. The lowest risks were associated with HbA1c 7.25-7.75%; total cholesterol 3.5-4.5 mmol/L; systolic blood pressure 135-145 mmHg; and diastolic blood pressure 82.5-87.5 mmHg. coronary and stroke mortality related to the four risk factors in a positive, curvilinear way, with the exception of blood pressure which related to coronary deaths in a U-shape. Macrovascular events showed a positive and curvilinear relationship with HbA1c but U-shaped for total cholesterol and systolic blood pressure. Microvascular related to the four risk factors in a curvilinear way: positive for HbA1c and systolic blood pressure but negative for cholesterol and diastolic blood pressure. Interpretation: We identified several relationships which, when considered in the light of relevant trial data, support a call for major changes to clinical practice. Most importantly, our results support trial data indicating that normalisation of glucose and blood pressure can lead to poorer outcomes, which makes a strong case for target ranges for these risk factors rather than target levels.
- Author for correspondence
- Evangelos Kontopantelis
- Email for correspondence
- E.Kontopantelis@manchester.ac.uk
Code list: hypertension
234 codes in list
| Code | Coding system | Description | Entity type | List name | resolve_code | ||
|---|---|---|---|---|---|---|---|
| 2126100 | Read | Hypertension resolved | diagnostic | hypertension | 1 | ||
| 2126100 | Read | Hypertension resolved | diagnostic | hypertension | -1 | Resolve | |
| 212K.00 | Read | Hypertension resolved | diagnostic | hypertension | -1 | Resolve | |
| 212K.00 | Read | Hypertension resolved | diagnostic | hypertension | 1 | ||
| 662..12 | Read | Hypertension monitoring | diagnostic | hypertension | 0 | Sensitivity | |
| 6627 | Read | Good hypertension control | diagnostic | hypertension | 0 | Sensitivity | |
| 6628 | Read | Poor hypertension control | diagnostic | hypertension | 0 | Sensitivity | |
| 6629 | Read | Hypertension:follow-up default | diagnostic | hypertension | 0 | Sensitivity | |
| 662b.00 | Read | Moderate hypertension control | diagnostic | hypertension | 0 | Sensitivity | |
| 662c.00 | Read | Hypertension six month review | diagnostic | hypertension | 0 | Sensitivity | |
| 662d.00 | Read | Hypertension annual review | diagnostic | hypertension | 0 | Sensitivity | |
| 662F.00 | Read | Hypertension treatm. started | diagnostic | hypertension | 0 | Sensitivity | |
| 662G.00 | Read | Hypertensive treatm.changed | diagnostic | hypertension | 0 | Sensitivity | |
| 662O.00 | Read | On treatment for hypertension | diagnostic | hypertension | 0 | Sensitivity | |
| 662P.00 | Read | Hypertension monitoring | diagnostic | hypertension | 0 | Sensitivity | |
| 8B26.00 | Read | Antihypertensive therapy | diagnostic | hypertension | 0 | Sensitivity | |
| 8BL0.00 | Read | Patient on maximal tolerated antihypertensive therapy | diagnostic | hypertension | 0 | Sensitivity | |
| 8CR4.00 | Read | Hypertension clinical management plan | diagnostic | hypertension | 0 | Sensitivity | |
| 8HT5.00 | Read | Referral to hypertension clinic | diagnostic | hypertension | 0 | Sensitivity | |
| 9N03.00 | Read | Seen in hypertension clinic | diagnostic | hypertension | 0 | Sensitivity | |
| 9N1y200 | Read | Seen in hypertension clinic | diagnostic | hypertension | 0 | Sensitivity | |
| 9OI1.00 | Read | Attends hypertension monitor. | diagnostic | hypertension | 0 | Sensitivity | |
| 9OIA.00 | Read | Hypertension monitor.chck done | diagnostic | hypertension | 0 | Sensitivity | |
| 9OIA.11 | Read | Hypertension monitored | diagnostic | hypertension | 0 | Sensitivity | |
| F404200 | Read | Blind hypertensive eye | diagnostic | hypertension | 0 | Sensitivity | |
| F421300 | Read | Hypertensive retinopathy | diagnostic | hypertension | 0 | Sensitivity | |
| G2...00 | Read | Hypertensive disease | diagnostic | hypertension | 0 | ||
| G2...00 | Read | Hypertensive disease | diagnostic | hypertension | 1 | Main | |
| G20..00 | Read | Essential hypertension | diagnostic | hypertension | 0 | ||
| G20..00 | Read | Essential hypertension | diagnostic | hypertension | 1 | Main | |
| G200.00 | Read | Malignant essential hypertension | diagnostic | hypertension | 1 | Main | |
| G200.00 | Read | Malignant essential hypertension | diagnostic | hypertension | 0 | ||
| G201.00 | Read | Benign essential hypertension | diagnostic | hypertension | 1 | Main | |
| G201.00 | Read | Benign essential hypertension | diagnostic | hypertension | 0 | ||
| G20..11 | Read | High blood pressure | diagnostic | hypertension | 1 | Sensitivity | |
| G202.00 | Read | Systolic hypertension | diagnostic | hypertension | 0 | ||
| G202.00 | Read | Systolic hypertension | diagnostic | hypertension | 1 | Main | |
| G20z.00 | Read | Essential hypertension NOS | diagnostic | hypertension | 0 | ||
| G20z.00 | Read | Essential hypertension NOS | diagnostic | hypertension | 1 | Main | |
| G20z.11 | Read | Hypertension NOS | diagnostic | hypertension | 1 | Main | |
| G20z.11 | Read | Hypertension NOS | diagnostic | hypertension | 0 | ||
| G21..00 | Read | Hypertensive heart disease | diagnostic | hypertension | 0 | ||
| G21..00 | Read | Hypertensive heart disease | diagnostic | hypertension | 0 | Main | |
| G210.00 | Read | Malignant hypertensive heart disease | diagnostic | hypertension | 0 | Main | |
| G210.00 | Read | Malignant hypertensive heart disease | diagnostic | hypertension | 0 | ||
| G210000 | Read | Malignant hypertensive heart disease without CCF | diagnostic | hypertension | 0 | ||
| G210000 | Read | Malignant hypertensive heart disease without CCF | diagnostic | hypertension | 0 | Main | |
| G210100 | Read | Malignant hypertensive heart disease with CCF | diagnostic | hypertension | 0 | ||
| G210100 | Read | Malignant hypertensive heart disease with CCF | diagnostic | hypertension | 0 | Main | |
| G210z00 | Read | Malignant hypertensive heart disease NOS | diagnostic | hypertension | 0 | Main | |
| G210z00 | Read | Malignant hypertensive heart disease NOS | diagnostic | hypertension | 0 | ||
| G2...11 | Read | BP - hypertensive disease | diagnostic | hypertension | 0 | ||
| G2...11 | Read | BP - hypertensive disease | diagnostic | hypertension | 1 | Main | |
| G211.00 | Read | Benign hypertensive heart disease | diagnostic | hypertension | 0 | Main | |
| G211.00 | Read | Benign hypertensive heart disease | diagnostic | hypertension | 0 | ||
| G211000 | Read | Benign hypertensive heart disease without CCF | diagnostic | hypertension | 0 | Main | |
| G211000 | Read | Benign hypertensive heart disease without CCF | diagnostic | hypertension | 0 | ||
| G211100 | Read | Benign hypertensive heart disease with CCF | diagnostic | hypertension | 0 | ||
| G211100 | Read | Benign hypertensive heart disease with CCF | diagnostic | hypertension | 0 | Main | |
| G211z00 | Read | Benign hypertensive heart disease NOS | diagnostic | hypertension | 0 | Main | |
| G21z.00 | Read | Hypertensive heart disease NOS | diagnostic | hypertension | 0 | Main | |
| G21z.00 | Read | Hypertensive heart disease NOS | diagnostic | hypertension | 0 | ||
| G21z000 | Read | Hypertensive heart disease NOS without CCF | diagnostic | hypertension | 0 | Main | |
| G21z000 | Read | Hypertensive heart disease NOS without CCF | diagnostic | hypertension | 0 | ||
| G21z011 | Read | Cardiomegaly - hypertensive | diagnostic | hypertension | 0 | ||
| G21z011 | Read | Cardiomegaly - hypertensive | diagnostic | hypertension | 0 | Main | |
| G21z100 | Read | Hypertensive heart disease NOS with CCF | diagnostic | hypertension | 0 | Main | |
| G21z100 | Read | Hypertensive heart disease NOS with CCF | diagnostic | hypertension | 0 | ||
| G21zz00 | Read | Hypertensive heart disease NOS | diagnostic | hypertension | 0 | Main | |
| G21zz00 | Read | Hypertensive heart disease NOS | diagnostic | hypertension | 0 | ||
| G22..00 | Read | Hypertensive renal disease | diagnostic | hypertension | 0 | ||
| G22..00 | Read | Hypertensive renal disease | diagnostic | hypertension | 0 | Main | |
| G220.00 | Read | Malignant hypertensive renal disease | diagnostic | hypertension | 0 | ||
| G220.00 | Read | Malignant hypertensive renal disease | diagnostic | hypertension | 0 | Main | |
| G221.00 | Read | Benign hypertensive renal disease | diagnostic | hypertension | 0 | Main | |
| G221.00 | Read | Benign hypertensive renal disease | diagnostic | hypertension | 0 | ||
| G222.00 | Read | Hypertensive renal disease with renal failure | diagnostic | hypertension | 0 | ||
| G222.00 | Read | Hypertensive renal disease with renal failure | diagnostic | hypertension | 0 | Main | |
| G22z.00 | Read | Hypertensive renal disease NOS | diagnostic | hypertension | 0 | ||
| G22z.00 | Read | Hypertensive renal disease NOS | diagnostic | hypertension | 0 | Main | |
| G22z.11 | Read | Renal hypertension | diagnostic | hypertension | 0 | Main | |
| G22z.11 | Read | Renal hypertension | diagnostic | hypertension | 0 | ||
| G23..00 | Read | Hypertensive heart and renal disease | diagnostic | hypertension | 0 | Main | |
| G23..00 | Read | Hypertensive heart and renal disease | diagnostic | hypertension | 0 | ||
| G230.00 | Read | Malignant hypertensive heart and renal disease | diagnostic | hypertension | 0 | ||
| G230.00 | Read | Malignant hypertensive heart and renal disease | diagnostic | hypertension | 0 | Main | |
| G231.00 | Read | Benign hypertensive heart and renal disease | diagnostic | hypertension | 0 | ||
| G231.00 | Read | Benign hypertensive heart and renal disease | diagnostic | hypertension | 0 | Main | |
| G232.00 | Read | Hypertensive heart&renal dis wth (congestive) heart failure | diagnostic | hypertension | 0 | ||
| G232.00 | Read | Hypertensive heart&renal dis wth (congestive) heart failure | diagnostic | hypertension | 0 | Main | |
| G233.00 | Read | Hypertensive heart and renal disease with renal failure | diagnostic | hypertension | 0 | Main | |
| G233.00 | Read | Hypertensive heart and renal disease with renal failure | diagnostic | hypertension | 0 | ||
| G234.00 | Read | Hyperten heart&renal dis+both(congestv)heart and renal fail | diagnostic | hypertension | 0 | ||
| G234.00 | Read | Hyperten heart&renal dis+both(congestv)heart and renal fail | diagnostic | hypertension | 0 | Main | |
| G23z.00 | Read | Hypertensive heart and renal disease NOS | diagnostic | hypertension | 0 | Main | |
| G23z.00 | Read | Hypertensive heart and renal disease NOS | diagnostic | hypertension | 0 | ||
| G24..00 | Read | Secondary hypertension | diagnostic | hypertension | 0 | ||
| G24..00 | Read | Secondary hypertension | diagnostic | hypertension | 1 | Main | |
| G240.00 | Read | Secondary malignant hypertension | diagnostic | hypertension | 1 | Main | |
| G240.00 | Read | Secondary malignant hypertension | diagnostic | hypertension | 0 | ||
| G240000 | Read | Secondary malignant renovascular hypertension | diagnostic | hypertension | 1 | Main | |
| G240000 | Read | Secondary malignant renovascular hypertension | diagnostic | hypertension | 0 | ||
| G240z00 | Read | Secondary malignant hypertension NOS | diagnostic | hypertension | 1 | Main | |
| G240z00 | Read | Secondary malignant hypertension NOS | diagnostic | hypertension | 0 | ||
| G241.00 | Read | Secondary benign hypertension | diagnostic | hypertension | 1 | Main | |
| G241.00 | Read | Secondary benign hypertension | diagnostic | hypertension | 0 | ||
| G241000 | Read | Secondary benign renovascular hypertension | diagnostic | hypertension | 1 | Main | |
| G241000 | Read | Secondary benign renovascular hypertension | diagnostic | hypertension | 0 | ||
| G241z00 | Read | Secondary benign hypertension NOS | diagnostic | hypertension | 1 | Main | |
| G241z00 | Read | Secondary benign hypertension NOS | diagnostic | hypertension | 0 | ||
| G244.00 | Read | Hypertension secondary to endocrine disorders | diagnostic | hypertension | 1 | Main | |
| G244.00 | Read | Hypertension secondary to endocrine disorders | diagnostic | hypertension | 0 | ||
| G24z.00 | Read | Secondary hypertension NOS | diagnostic | hypertension | 1 | Main | |
| G24z.00 | Read | Secondary hypertension NOS | diagnostic | hypertension | 0 | ||
| G24z000 | Read | Secondary renovascular hypertension NOS | diagnostic | hypertension | 1 | Main | |
| G24z000 | Read | Secondary renovascular hypertension NOS | diagnostic | hypertension | 0 | ||
| G24zz00 | Read | Secondary hypertension NOS | diagnostic | hypertension | 1 | Main | |
| G24zz00 | Read | Secondary hypertension NOS | diagnostic | hypertension | 0 | ||
| G2y..00 | Read | Other specified hypertensive disease | diagnostic | hypertension | 0 | ||
| G2y..00 | Read | Other specified hypertensive disease | diagnostic | hypertension | 1 | Main | |
| G2z..00 | Read | Hypertensive disease NOS | diagnostic | hypertension | 0 | ||
| G2z..00 | Read | Hypertensive disease NOS | diagnostic | hypertension | 1 | Main | |
| G672.00 | Read | Hypertensive encephalopathy | diagnostic | hypertension | 0 | Sensitivity | |
| G672.11 | Read | Hypertensive crisis | diagnostic | hypertension | 0 | Sensitivity | |
| Gyu2000 | Read | [X]Other secondary hypertension | diagnostic | hypertension | 0 | Main | |
| Gyu2000 | Read | [X]Other secondary hypertension | diagnostic | hypertension | 0 | ||
| Gyu2100 | Read | [X]Hypertension secondary to other renal disorders | diagnostic | hypertension | 0 | ||
| Gyu2100 | Read | [X]Hypertension secondary to other renal disorders | diagnostic | hypertension | 0 | Main | |
| L120.00 | Read | Benign essential hypertension in pregnancy/childbirth/puerp | diagnostic | hypertension | 0 | Main | |
| L120.00 | Read | Benign essential hypertension in pregnancy/childbirth/puerp | diagnostic | hypertension | 0 | ||
| L120000 | Read | Benign essential hypertension in preg/childb/puerp unspec | diagnostic | hypertension | 0 | ||
| L120000 | Read | Benign essential hypertension in preg/childb/puerp unspec | diagnostic | hypertension | 0 | Main | |
| L120100 | Read | Benign essential hypertension in preg/childb/puerp - deliv | diagnostic | hypertension | 0 | ||
| L120100 | Read | Benign essential hypertension in preg/childb/puerp - deliv | diagnostic | hypertension | 0 | Main | |
| L120300 | Read | Benign essential hypertension in preg/childb/puerp-not deliv | diagnostic | hypertension | 0 | Main | |
| L120300 | Read | Benign essential hypertension in preg/childb/puerp-not deliv | diagnostic | hypertension | 0 | ||
| L120400 | Read | Benign essential hypertension in preg/childb/puerp +p/n comp | diagnostic | hypertension | 0 | Main | |
| L120400 | Read | Benign essential hypertension in preg/childb/puerp +p/n comp | diagnostic | hypertension | 0 | ||
| L120z00 | Read | Benign essential hypertension in preg/childb/puerp NOS | diagnostic | hypertension | 0 | Main | |
| L120z00 | Read | Benign essential hypertension in preg/childb/puerp NOS | diagnostic | hypertension | 0 | ||
| L121.00 | Read | Renal hypertension in pregnancy/childbirth/puerperium | diagnostic | hypertension | 0 | ||
| L121.00 | Read | Renal hypertension in pregnancy/childbirth/puerperium | diagnostic | hypertension | 0 | Main | |
| L121000 | Read | Renal hypertension in pregnancy/childbirth/puerp unspecified | diagnostic | hypertension | 0 | Main | |
| L121000 | Read | Renal hypertension in pregnancy/childbirth/puerp unspecified | diagnostic | hypertension | 0 | ||
| L121100 | Read | Renal hypertension in pregnancy/childbirth/puerp - delivered | diagnostic | hypertension | 0 | Main | |
| L121100 | Read | Renal hypertension in pregnancy/childbirth/puerp - delivered | diagnostic | hypertension | 0 | ||
| L121200 | Read | Renal hypertension in preg/childb/puerp -deliv with p/n comp | diagnostic | hypertension | 0 | Main | |
| L121300 | Read | Renal hypertension in preg/childbirth/puerp - not delivered | diagnostic | hypertension | 0 | Main | |
| L121300 | Read | Renal hypertension in preg/childbirth/puerp - not delivered | diagnostic | hypertension | 0 | ||
| L121400 | Read | Renal hypertension in preg/childb/puerp + p/n complication | diagnostic | hypertension | 0 | Main | |
| L121z00 | Read | Renal hypertension in pregnancy/childbirth/puerperium NOS | diagnostic | hypertension | 0 | ||
| L121z00 | Read | Renal hypertension in pregnancy/childbirth/puerperium NOS | diagnostic | hypertension | 0 | Main | |
| L122.00 | Read | Other pre-existing hypertension in preg/childbirth/puerp | diagnostic | hypertension | 0 | ||
| L122.00 | Read | Other pre-existing hypertension in preg/childbirth/puerp | diagnostic | hypertension | 0 | Main | |
| L122000 | Read | Other pre-existing hypertension in preg/childb/puerp unspec | diagnostic | hypertension | 0 | Main | |
| L122000 | Read | Other pre-existing hypertension in preg/childb/puerp unspec | diagnostic | hypertension | 0 | ||
| L122100 | Read | Other pre-existing hypertension in preg/childb/puerp - deliv | diagnostic | hypertension | 0 | Main | |
| L122100 | Read | Other pre-existing hypertension in preg/childb/puerp - deliv | diagnostic | hypertension | 0 | ||
| L122300 | Read | Other pre-exist hypertension in preg/childb/puerp-not deliv | diagnostic | hypertension | 0 | Main | |
| L122300 | Read | Other pre-exist hypertension in preg/childb/puerp-not deliv | diagnostic | hypertension | 0 | ||
| L122400 | Read | Other pre-exist hypertension in preg/childb/puerp + p/n comp | diagnostic | hypertension | 0 | Main | |
| L122z00 | Read | Other pre-existing hypertension in preg/childb/puerp NOS | diagnostic | hypertension | 0 | ||
| L122z00 | Read | Other pre-existing hypertension in preg/childb/puerp NOS | diagnostic | hypertension | 0 | Main | |
| L128.00 | Read | Pre-exist hypertension compl preg childbirth and puerperium | diagnostic | hypertension | 0 | Main | |
| L128.00 | Read | Pre-exist hypertension compl preg childbirth and puerperium | diagnostic | hypertension | 0 | ||
| L128200 | Read | Pre-exist 2ndry hypertens comp preg childbth and puerperium | diagnostic | hypertension | 0 | ||
| L128200 | Read | Pre-exist 2ndry hypertens comp preg childbth and puerperium | diagnostic | hypertension | 0 | Main | |
| 3053HT | OXMIS | NEUROGENIC HYPERTENSION (SECONDARY) | diagnostic | hypertension | 0 | Main | |
| 4000 | OXMIS | MALIGNANT HYPERTENSION | diagnostic | hypertension | 0 | Main | |
| 4003 | OXMIS | HYPERTENSIVE NEPHROPATHY | diagnostic | hypertension | 0 | Main | |
| 4003AA | OXMIS | HYPERTENSIVE RENAL DISEASE | diagnostic | hypertension | 0 | Main | |
| 401 | OXMIS | BENIGN HYPERTENSION | diagnostic | hypertension | 0 | Main | |
| 401 A | OXMIS | HYPERTENSION | diagnostic | hypertension | 0 | Main | |
| 401 AC | OXMIS | HYPERTENSION ACCELERATED | diagnostic | hypertension | 0 | Main | |
| 401 AR | OXMIS | HYPERTENSION ARTERIOSCLEROTIC | diagnostic | hypertension | 0 | Main | |
| 401 AT | OXMIS | HYPERTENSION ATHEROSCLEROTIC | diagnostic | hypertension | 0 | Main | |
| 401 B | OXMIS | RETINOPATHY HYPERTENSIVE | diagnostic | hypertension | 0 | Sensitivity | |
| 401 BE | OXMIS | RETINOPATHY HYPERTENSIVE EXUDATES | diagnostic | hypertension | 0 | Sensitivity | |
| 401 BH | OXMIS | RETINOPATHY HYPERTENSIVE HAEMORRHAGE | diagnostic | hypertension | 0 | Sensitivity | |
| 401 BM | OXMIS | HYPERTENSION ON TREATMENT | diagnostic | hypertension | 0 | Main | |
| 401 BN | OXMIS | HYPERTENSION BENIGN | diagnostic | hypertension | 0 | Main | |
| 401 BP | OXMIS | RETINOPATHY HYPERTENSIVE PAPILLOEDEMA | diagnostic | hypertension | 0 | Sensitivity | |
| 401 BR | OXMIS | HYPERTENSION RESOLVED | diagnostic | hypertension | 0 | Resolve | |
| 401 C | OXMIS | HYPERTENSION ESSENTIAL | diagnostic | hypertension | 0 | Main | |
| 401 DC | OXMIS | HYPERTENSION DIASTOLIC | diagnostic | hypertension | 0 | Main | |
| 401 E | OXMIS | HYPERTENSION ARTERIAL | diagnostic | hypertension | 0 | Main | |
| 401 EL | OXMIS | HYPERTENSION ARTERIAL SYSTEMIC | diagnostic | hypertension | 0 | Main | |
| 401 LB | OXMIS | HYPERTENSION LABILE INTERMITTENT | diagnostic | hypertension | 0 | Main | |
| 401 NC | OXMIS | HYPERTENSION NECROTIZING STAGES | diagnostic | hypertension | 0 | Main | |
| 401 P | OXMIS | HYPERTENSION ARTERIAL PRIMARY | diagnostic | hypertension | 0 | Main | |
| 401 PA | OXMIS | HYPERTENSION PRIMARY | diagnostic | hypertension | 0 | Main | |
| 401 R | OXMIS | HYPERTENSION CRISIS | diagnostic | hypertension | 0 | Sensitivity | |
| 401 S | OXMIS | HYPERTENSION SYSTOLIC | diagnostic | hypertension | 0 | Main | |
| 401 T | OXMIS | THROMBOSIS HYPERTENSION | diagnostic | hypertension | 0 | Sensitivity | |
| 402 | OXMIS | HYPERTENSIVE HEART DISEASE | diagnostic | hypertension | 0 | Main | |
| 402 C | OXMIS | HYPERTENSION CONGESTIVE HEART FAILURE | diagnostic | hypertension | 0 | Main | |
| 402 MF | OXMIS | MYOCARDIAL FIBROSIS WITH HYPERTENSION | diagnostic | hypertension | 0 | Main | |
| 402 VH | OXMIS | VENTRICULAR HYPERTROPHY HYPERTENSIVE | diagnostic | hypertension | 0 | Main | |
| 403 | OXMIS | RENAL HYPERTENSION | diagnostic | hypertension | 0 | Main | |
| 403 AA | OXMIS | RENAL HYPERTENSIVE DISEASE | diagnostic | hypertension | 0 | Main | |
| 403 AH | OXMIS | RENOVASCULAR HYPERTENSION | diagnostic | hypertension | 0 | Main | |
| 403 M | OXMIS | NEPHROPATHY MALIGNANT HYPERTENSION | diagnostic | hypertension | 0 | Sensitivity | |
| 403 NC | OXMIS | HYPERTENSION IMPAIRED RENAL FUNCTION | diagnostic | hypertension | 0 | Main | |
| 403 NF | OXMIS | HYPERTENSION RENAL INSUFFICIENCY | diagnostic | hypertension | 0 | Main | |
| 403 NG | OXMIS | HYPERTENSIVE GLOMERULOSCLEROSIS | diagnostic | hypertension | 0 | Main | |
| 403 NH | OXMIS | NEPHROSCLEROSIS HYPERTENSIVE | diagnostic | hypertension | 0 | Sensitivity | |
| 4100N | OXMIS | MYOCARDIAL INFARCT WITH HYPERTENSION | diagnostic | hypertension | 0 | Main | |
| 4100NA | OXMIS | MYOCARDIAL INFARCT ACUTE WITH HYPERTENSI | diagnostic | hypertension | 0 | Main | |
| 4100T | OXMIS | THROMBOSIS CORONARY WITH HYPERTENSION | diagnostic | hypertension | 0 | Main | |
| 4120 | OXMIS | INSUFFICIENCY CORONARY HYPERTENSIVE | diagnostic | hypertension | 0 | Main | |
| 4120A | OXMIS | ISCHAEMIC HEART DISEASE HYPERTENSIVE | diagnostic | hypertension | 0 | Main | |
| 4120BD | OXMIS | SYNDROME DRESSLER'S WITH HYPERTENSION | diagnostic | hypertension | 0 | Main | |
| 4120CA | OXMIS | CORONARY ARTERY DISEASE WITH HYPERTENSIO | diagnostic | hypertension | 0 | Main | |
| 4120M | OXMIS | MYOCARDIAL ISCHAEMIA WITH HYPERTENSION | diagnostic | hypertension | 0 | Main | |
| 4130 | OXMIS | ANGINA PECTORIS WITH HYPERTENSION | diagnostic | hypertension | 0 | Main | |
| 4130E | OXMIS | ANGINA EFFORT WITH HYPERTENSION | diagnostic | hypertension | 0 | Main | |
| 4140 | OXMIS | ASYMPTOMATIC HYPERTENSIVE ISCHAEMIC HEAR | diagnostic | hypertension | 0 | Main | |
| 4300 | OXMIS | SUBARACHNOID HAEMORRHAGE WITH HYPERTENSI | diagnostic | hypertension | 0 | Main | |
| 4310 | OXMIS | HAEMORRHAGE INTRACEREBRAL WITH HYPERTENS | diagnostic | hypertension | 0 | Main | |
| 4330 | OXMIS | CEREBRAL THROMBOSIS WITH HYPERTENSION | diagnostic | hypertension | 0 | Main | |
| 4340 | OXMIS | EMBOLISM CEREBRAL WITH HYPERTENSION | diagnostic | hypertension | 0 | Main | |
| 4340CR | OXMIS | EMBOLISM INTRACRANIAL WITH HYPERTENSION | diagnostic | hypertension | 0 | Main | |
| 4360A | OXMIS | CEREBROVASCULAR ACCIDENT WITH HYPERTENSI | diagnostic | hypertension | 0 | Main | |
| 4360B | OXMIS | STROKE WITH HYPERTENSION | diagnostic | hypertension | 0 | Main | |
| 4360D | OXMIS | HYPERTENSIVE ENCEPHALOPATHY | diagnostic | hypertension | 0 | Main | |
| 4370 | OXMIS | CEREBRAL ISCHAEMIA HYPERTENSIVE | diagnostic | hypertension | 0 | Main | |
| 4380 | OXMIS | CEREBROVASCULAR DISEASE WITH HYPERTENSIO | diagnostic | hypertension | 0 | Main | |
| 4380HP | OXMIS | HEMIPLEGIA WITH HYPERTENSION | diagnostic | hypertension | 0 | Main | |
| 4419H | OXMIS | HYPERTENSION ANEURYSM AORTA | diagnostic | hypertension | 0 | Main | |
| 791 HP | OXMIS | HYPERTENSIVE HEADACHE | diagnostic | hypertension | 0 | Sensitivity | |
| L0010AM | OXMIS | SEEN IN HYPERTENSION CLINIC | diagnostic | hypertension | 0 | Sensitivity | |
| L0010EM | OXMIS | REFERRED TO HYPERTENSION CLINIC | diagnostic | hypertension | 0 | Sensitivity | |
| Y0601JA | OXMIS | HYPERTENSION CLINIC ATTENDANCE | diagnostic | hypertension | 0 | Sensitivity | |
| Y060 JA | OXMIS | HYPERTENSION CLINIC | diagnostic | hypertension | 0 | Sensitivity |
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