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Research article:

Glucose, blood pressure and cholesterol levels and their relationships to clinical outcomes in type 2 diabetes: a retrospective cohort study

Reference:

Evangelos Kontopantelis, David A Springate, David Reeves, Darren M Ashcroft, Martin Rutter, Iain Buchan, Tim Doran(2015) Glucose, blood pressure and cholesterol levels and their relationships to clinical outcomes in type 2 diabetes: a retrospective cohort study. Diabetologia, doi: 10.1007/s00125-014-3473-8

Link to fulltext article
Abstract
Background: Observational data have been used to inform target levels for modifiable risk factors in type 2 diabetes but these data are limited by confounding. We aimed to describe the shape of observed relationships between risk factor levels and clinically important outcomes in type 2 diabetes after adjusting for multiple confounders. Methods: We used retrospective longitudinal data on 246,544 adults with type 2 diabetes from 600 practices contributing to the Clinical Practice Research Datalink between 2006 and 2012. Proportional hazards regression models quantified the risks of mortality, microvascular or macrovascular events associated with four modifiable risk factors: glycated haemoglobin (HbA1c), systolic and diastolic blood pressure and total cholesterol, while controlling for numerous patient and practice covariates. Findings: U-shaped relationships were observed between all-cause mortality and levels of the four risk factors. The lowest risks were associated with HbA1c 7.25-7.75%; total cholesterol 3.5-4.5 mmol/L; systolic blood pressure 135-145 mmHg; and diastolic blood pressure 82.5-87.5 mmHg. coronary and stroke mortality related to the four risk factors in a positive, curvilinear way, with the exception of blood pressure which related to coronary deaths in a U-shape. Macrovascular events showed a positive and curvilinear relationship with HbA1c but U-shaped for total cholesterol and systolic blood pressure. Microvascular related to the four risk factors in a curvilinear way: positive for HbA1c and systolic blood pressure but negative for cholesterol and diastolic blood pressure. Interpretation: We identified several relationships which, when considered in the light of relevant trial data, support a call for major changes to clinical practice. Most importantly, our results support trial data indicating that normalisation of glucose and blood pressure can lead to poorer outcomes, which makes a strong case for target ranges for these risk factors rather than target levels.
Author for correspondence
Evangelos Kontopantelis
Email for correspondence
E.Kontopantelis@manchester.ac.uk

Code list: res9: loop_diuretics

119 codes in list

Code Coding system Description Entity type List name multilexcode bnfcode bnfchapter
10066 CPRD_product_code TOREM tablets 5mg [MEDA] drug res9: loop_diuretics 7256002 2020200 Loop diuretics
10392 CPRD_product_code LASIX tablets 500mg [BORG] drug res9: loop_diuretics 3527001 2020200 Loop diuretics
10781 CPRD_product_code LASIX + K tablets [HOECHSTMAR] drug res9: loop_diuretics 1131001 2020800 Diuretic/potassium supplement combinations
11265 CPRD_product_code triamterene with furosemide tablets 50mg + 40mg drug res9: loop_diuretics 4874001 02020200/02020300/02020400 Loop diuretics/Potassium-sparing diuretics and aldosterone antagonists/Potassium-sparing diuretics w
11268 CPRD_product_code TOREM tablets 2.5mg [MEDA] drug res9: loop_diuretics 7256001 2020200 Loop diuretics
11487 CPRD_product_code torasemide tablets 2.5mg drug res9: loop_diuretics 7257001 2020200 Loop diuretics
12226 CPRD_product_code BURINEX oral liquid sugar-free 1mg/5ml [LEO] drug res9: loop_diuretics 1166001 2020200 Loop diuretics
12294 CPRD_product_code BURINEX tablets 5mg [LEO] drug res9: loop_diuretics 1165001 2020200 Loop diuretics
12354 CPRD_product_code etacrynic acid tablets 50mg drug res9: loop_diuretics 3225001 2020200 Loop diuretics
12367 CPRD_product_code piretanide capsules 6mg drug res9: loop_diuretics 4500001 2020200 Loop diuretics
1301 CPRD_product_code FRUMIL LS tablets 20mg + 2.5mg [HELIOS] drug res9: loop_diuretics 1257002 02020200/02020300/02020400 Loop diuretics/Potassium-sparing diuretics and aldosterone antagonists/Potassium-sparing diuretics w
13435 CPRD_product_code FRUMIL forte tablets 80mg + 10mg [HELIOS] drug res9: loop_diuretics 1257003 02020200/02020300/02020400 Loop diuretics/Potassium-sparing diuretics and aldosterone antagonists/Potassium-sparing diuretics w
1369 CPRD_product_code furosemide with amiloride tablets 40mg + 5mg drug res9: loop_diuretics 3524001 02020200/02020300/02020400 Loop diuretics/Potassium-sparing diuretics and aldosterone antagonists/Potassium-sparing diuretics w
14587 CPRD_product_code amiloride hydrochloride with bumetanide tablets 5mg + 1mg drug res9: loop_diuretics 6807001 02020200/02020300/02020400 Loop diuretics/Potassium-sparing diuretics and aldosterone antagonists/Potassium-sparing diuretics w
14761 CPRD_product_code FRUSID tablets 40mg [DDSA] drug res9: loop_diuretics 2907001 2020200 Loop diuretics
14837 CPRD_product_code FRUSOL oral solution sugar-free 50mg/5ml [ROSEMONT] drug res9: loop_diuretics 10605003 2020200 Loop diuretics
15874 CPRD_product_code amiloride hydrochloride with furosemide tablets 2.5mg + 20mg drug res9: loop_diuretics 5452001 02020200/02020300/02020400 Loop diuretics/Potassium-sparing diuretics and aldosterone antagonists/Potassium-sparing diuretics w
16206 CPRD_product_code FROOP 40 tablets 40mg [ASHBOURNE] drug res9: loop_diuretics 6921001 2020200 Loop diuretics
1776 CPRD_product_code BURINEX K tablets 500micrograms + 7.7mmol [LEO] drug res9: loop_diuretics 1058001 2020800 Diuretic/potassium supplement combinations
17960 CPRD_product_code furosemide with potassium tablets 20mg + 10mmol drug res9: loop_diuretics 3523002 2020800 Diuretic/potassium supplement combinations
18096 CPRD_product_code torasemide tablets 10mg drug res9: loop_diuretics 7257003 2020200 Loop diuretics
18332 CPRD_product_code ARIDIL tablets 20mg + 2.5mg [CP PHARM] drug res9: loop_diuretics 7202001 02020200/02020300/02020400 Loop diuretics/Potassium-sparing diuretics and aldosterone antagonists/Potassium-sparing diuretics w
18497 CPRD_product_code amiloride hydrochloride with furosemide tablets 10mg + 80mg drug res9: loop_diuretics 5452003 02020200/02020300/02020400 Loop diuretics/Potassium-sparing diuretics and aldosterone antagonists/Potassium-sparing diuretics w
18650 CPRD_product_code EDECRIN tablets 50mg [M S D] drug res9: loop_diuretics 297001 2020200 Loop diuretics
18983 CPRD_product_code BRINALDIX K effervescent tablet [BERK] drug res9: loop_diuretics 124001 2020800 Diuretic/potassium supplement combinations
19056 CPRD_product_code FUROSEMIDE solution sugar-free 50mg/5ml [ROSEMONT] drug res9: loop_diuretics 1902011 2020200 Loop diuretics
19192 CPRD_product_code FUROSEMIDE tablets 40mg [M&A PHARM] drug res9: loop_diuretics 3883009 2020200 Loop diuretics
19194 CPRD_product_code FUROSEMIDE tablets 20mg [TEVA] drug res9: loop_diuretics 1320011 2020200 Loop diuretics
193 CPRD_product_code co-amilofruse (amiloride and furosemide) tablets 2.5mg+20mg drug res9: loop_diuretics 6787002 02020200/02020300/02020400 Loop diuretics/Potassium-sparing diuretics and aldosterone antagonists/Potassium-sparing diuretics w
20538 CPRD_product_code FRUMAX tablets 40mg [ASHBOURNE] drug res9: loop_diuretics 60001 2020200 Loop diuretics
211 CPRD_product_code FRUMIL tablets 40mg + 5mg [HELIOS] drug res9: loop_diuretics 1257001 02020200/02020300/02020400 Loop diuretics/Potassium-sparing diuretics and aldosterone antagonists/Potassium-sparing diuretics w
21849 CPRD_product_code DRYPTAL tablets 40mg [BERK] drug res9: loop_diuretics 276001 2020200 Loop diuretics
21938 CPRD_product_code FROOP-CO tablets 5mg+40mg [ASHBOURNE] drug res9: loop_diuretics 11845001 02020200/02020300/02020400 Loop diuretics/Potassium-sparing diuretics and aldosterone antagonists/Potassium-sparing diuretics w
22658 CPRD_product_code TOREM tablets 10mg [MEDA] drug res9: loop_diuretics 7256003 2020200 Loop diuretics
22839 CPRD_product_code clopamide with potassium effervescent tablet drug res9: loop_diuretics 8448001 2020800 Diuretic/potassium supplement combinations
24832 CPRD_product_code LASIPRESSIN tablets [HOECHST] drug res9: loop_diuretics 1224001 02020200/02040000 Loop diuretics/Beta-blockers
2493 CPRD_product_code BURINEX A tablets [LEO] drug res9: loop_diuretics 6804001 02020200/02020300/02020400 Loop diuretics/Potassium-sparing diuretics and aldosterone antagonists/Potassium-sparing diuretics w
2495 CPRD_product_code bumetanide with amiloride tablets drug res9: loop_diuretics 6805001 02020200/02020300/02020400 Loop diuretics/Potassium-sparing diuretics and aldosterone antagonists/Potassium-sparing diuretics w
25334 CPRD_product_code FUROSEMIDE tablets 500mg [HILLCROSS] drug res9: loop_diuretics 415010 2020200 Loop diuretics
25717 CPRD_product_code FUROSEMIDE tablets 40mg [GEN (UK)] drug res9: loop_diuretics 2978009 2020200 Loop diuretics
25965 CPRD_product_code CO-AMILOFRUSE tablets 2.5mg+20mg [WOCKHARDT] drug res9: loop_diuretics 1990009 02020200/02020300/02020400 Loop diuretics/Potassium-sparing diuretics and aldosterone antagonists/Potassium-sparing diuretics w
26292 CPRD_product_code DIURESAL tablets 40mg [LAGAP] drug res9: loop_diuretics 2635001 2020200 Loop diuretics
26529 CPRD_product_code furosemide with penbutolol tablets drug res9: loop_diuretics 3526001 02020200/02040000 Loop diuretics/Beta-blockers
27447 CPRD_product_code FUROSEMIDE tablets 40mg [CP PHARM] drug res9: loop_diuretics 413010 2020200 Loop diuretics
27690 CPRD_product_code FUROSEMIDE tablets 40mg [HILLCROSS] drug res9: loop_diuretics 415009 2020200 Loop diuretics
27696 CPRD_product_code FUROSEMIDE tablets 40mg [KENT] drug res9: loop_diuretics 4397009 2020200 Loop diuretics
2772 CPRD_product_code LASORIDE tablets [BORG] drug res9: loop_diuretics 5082001 02020200/02020300/02020400 Loop diuretics/Potassium-sparing diuretics and aldosterone antagonists/Potassium-sparing diuretics w
2788 CPRD_product_code BURINEX tablets 1mg [LEO] drug res9: loop_diuretics 132001 2020200 Loop diuretics
27926 CPRD_product_code FUROSEMIDE tablets 20mg [GEN (UK)] drug res9: loop_diuretics 2978010 2020200 Loop diuretics
28129 CPRD_product_code CO-AMILOFRUSE tablets 5mg+40mg [TEVA] drug res9: loop_diuretics 3560009 02020200/02020300/02020400 Loop diuretics/Potassium-sparing diuretics and aldosterone antagonists/Potassium-sparing diuretics w
2961 CPRD_product_code FRUSENE tablets [ORION] drug res9: loop_diuretics 379001 02020200/02020300/02020400 Loop diuretics/Potassium-sparing diuretics and aldosterone antagonists/Potassium-sparing diuretics w
29780 CPRD_product_code FUROSEMIDE tablets 20mg [CP PHARM] drug res9: loop_diuretics 413009 2020200 Loop diuretics
3050 CPRD_product_code furosemide with triamterene tablets 40mg + 50mg drug res9: loop_diuretics 3525001 02020200/02020300/02020400 Loop diuretics/Potassium-sparing diuretics and aldosterone antagonists/Potassium-sparing diuretics w
30625 CPRD_product_code FUROSEMIDE tablets 20mg [HILLCROSS] drug res9: loop_diuretics 415011 2020200 Loop diuretics
30773 CPRD_product_code CO-AMILOFRUSE tablets 5mg+40mg [BERK] drug res9: loop_diuretics 1483009 02020200/02020300/02020400 Loop diuretics/Potassium-sparing diuretics and aldosterone antagonists/Potassium-sparing diuretics w
30913 CPRD_product_code BETINEX tablets 1mg [BERK] drug res9: loop_diuretics 11608001 2020200 Loop diuretics
31548 CPRD_product_code FUROSEMIDE tablets 20mg [ACTAVIS] drug res9: loop_diuretics 1449009 2020200 Loop diuretics
31773 CPRD_product_code CO-AMILOFRUSE tablets 5mg+40mg [WOCKHARDT] drug res9: loop_diuretics 1990010 02020200/02020300/02020400 Loop diuretics/Potassium-sparing diuretics and aldosterone antagonists/Potassium-sparing diuretics w
31932 CPRD_product_code BUMETANIDE tablets 1mg [CP PHARM] drug res9: loop_diuretics 2171009 2020200 Loop diuretics
32091 CPRD_product_code BUMETANIDE tablets 1mg [HILLCROSS] drug res9: loop_diuretics 2169009 2020200 Loop diuretics
3248 CPRD_product_code furosemide tablets 500mg drug res9: loop_diuretics 2886001 2020200 Loop diuretics
32896 CPRD_product_code FUROSEMIDE tablets 40mg [RANBAXY] drug res9: loop_diuretics 3058009 2020200 Loop diuretics
32918 CPRD_product_code FUROSEMIDE tablets 20mg [SANDOZ] drug res9: loop_diuretics 3657009 2020200 Loop diuretics
33527 CPRD_product_code CO-AMILOFRUSE tablets 5mg+40mg [GEN (UK)] drug res9: loop_diuretics 3100009 02020200/02020300/02020400 Loop diuretics/Potassium-sparing diuretics and aldosterone antagonists/Potassium-sparing diuretics w
33658 CPRD_product_code CO-AMILOFRUSE tablets 5mg+40mg [HILLCROSS] drug res9: loop_diuretics 3086009 02020200/02020300/02020400 Loop diuretics/Potassium-sparing diuretics and aldosterone antagonists/Potassium-sparing diuretics w
34006 CPRD_product_code FUROSEMIDE tablets 40mg [ACTAVIS] drug res9: loop_diuretics 1449010 2020200 Loop diuretics
34280 CPRD_product_code CO-AMILOFRUSE tablets 2.5mg+20mg [SANDOZ] drug res9: loop_diuretics 2122010 02020200/02020300/02020400 Loop diuretics/Potassium-sparing diuretics and aldosterone antagonists/Potassium-sparing diuretics w
34374 CPRD_product_code FUROSEMIDE tablets 40mg [TEVA] drug res9: loop_diuretics 1320009 2020200 Loop diuretics
34557 CPRD_product_code FUROSEMIDE tablets 40mg [IVAX] drug res9: loop_diuretics 1450009 2020200 Loop diuretics
34613 CPRD_product_code BUMETANIDE tablets 5mg [TEVA] drug res9: loop_diuretics 2933010 2020200 Loop diuretics
34622 CPRD_product_code CO-AMILOFRUSE tablets 10mg+80mg [WOCKHARDT] drug res9: loop_diuretics 1990011 02020200/02020300/02020400 Loop diuretics/Potassium-sparing diuretics and aldosterone antagonists/Potassium-sparing diuretics w
34934 CPRD_product_code BUMETANIDE tablets 1mg [GEN (UK)] drug res9: loop_diuretics 3682009 2020200 Loop diuretics
36190 CPRD_product_code furosemide oral solution sugar-free 5mg/5ml drug res9: loop_diuretics 15523001 2020200 Loop diuretics
36767 CPRD_product_code BUMETANIDE tablets 1mg [IVAX] drug res9: loop_diuretics 2827009 2020200 Loop diuretics
3793 CPRD_product_code co-amilofruse (amiloride and furosemide) tablets 10mg+80mg drug res9: loop_diuretics 6787003 02020200/02020300/02020400 Loop diuretics/Potassium-sparing diuretics and aldosterone antagonists/Potassium-sparing diuretics w
38901 CPRD_product_code FRUMIL LS tablets 20mg + 2.5mg [SANOFI/AVE] drug res9: loop_diuretics 16378001 02020200/02020300/02020400 Loop diuretics/Potassium-sparing diuretics and aldosterone antagonists/Potassium-sparing diuretics w
39602 CPRD_product_code BUMETANIDE tablets 1mg [ACTAVIS] drug res9: loop_diuretics 2922009 2020200 Loop diuretics
39807 CPRD_product_code FRUMIL tablets 40mg + 5mg [SANOFI/AVE] drug res9: loop_diuretics 16974001 02020200/02020300/02020400 Loop diuretics/Potassium-sparing diuretics and aldosterone antagonists/Potassium-sparing diuretics w
40898 CPRD_product_code TORASEMIDE tablets 5mg [HILLCROSS] drug res9: loop_diuretics 4904009 2020200 Loop diuretics
41292 CPRD_product_code FUROSEMIDE tablets 20mg [WOCKHARDT] drug res9: loop_diuretics 7697009 2020200 Loop diuretics
41405 CPRD_product_code FUROSEMIDE tablets 500mg [TEVA] drug res9: loop_diuretics 1320010 2020200 Loop diuretics
41533 CPRD_product_code CO-AMILOFRUSE tablets 2.5mg+20mg [TEVA] drug res9: loop_diuretics 3937009 02020200/02020300/02020400 Loop diuretics/Potassium-sparing diuretics and aldosterone antagonists/Potassium-sparing diuretics w
41719 CPRD_product_code CO-AMILOFRUSE tablets 5mg+40mg [ACTAVIS] drug res9: loop_diuretics 2127009 02020200/02020300/02020400 Loop diuretics/Potassium-sparing diuretics and aldosterone antagonists/Potassium-sparing diuretics w
41828 CPRD_product_code FUROSEMIDE tablets 500mg [ACTAVIS] drug res9: loop_diuretics 1449011 2020200 Loop diuretics
4211 CPRD_product_code furosemide with amiloride tablets 20mg + 2.5mg drug res9: loop_diuretics 3524002 02020200/02020300/02020400 Loop diuretics/Potassium-sparing diuretics and aldosterone antagonists/Potassium-sparing diuretics w
42388 CPRD_product_code FUROSEMIDE oral solution sugar-free 40mg/5ml [FOCUS] drug res9: loop_diuretics 6531009 2020200 Loop diuretics
42488 CPRD_product_code FUROSEMIDE oral solution 40mg/5ml [HILLCROSS] drug res9: loop_diuretics 6482009 2020200 Loop diuretics
43508 CPRD_product_code CO-AMILOFRUSE tablets 5mg+40mg [SANDOZ] drug res9: loop_diuretics 2122009 02020200/02020300/02020400 Loop diuretics/Potassium-sparing diuretics and aldosterone antagonists/Potassium-sparing diuretics w
45305 CPRD_product_code BUMETANIDE tablets 1mg [TEVA] drug res9: loop_diuretics 2933009 2020200 Loop diuretics
46525 CPRD_product_code TORASEMIDE tablets 5mg [TEVA] drug res9: loop_diuretics 4856009 2020200 Loop diuretics
4661 CPRD_product_code spironolactone with furosemide capsules 50mg + 20mg drug res9: loop_diuretics 4742001 02020200/02020300/02020400 Loop diuretics/Potassium-sparing diuretics and aldosterone antagonists/Potassium-sparing diuretics w
46699 CPRD_product_code FUROSEMIDE tablets 40mg [ALMUS] drug res9: loop_diuretics 6097009 2020200 Loop diuretics
46948 CPRD_product_code FUROSEMIDE tablets 40mg [ARROW] drug res9: loop_diuretics 4997009 2020200 Loop diuretics
47647 CPRD_product_code co-amilofruse oral liquid drug res9: loop_diuretics 14853001 02020200/02020300/02020400 Loop diuretics/Potassium-sparing diuretics and aldosterone antagonists/Potassium-sparing diuretics w
47815 CPRD_product_code FUROSEMIDE tablets 20mg [CELLTECH] drug res9: loop_diuretics 414010 2020200 Loop diuretics
4873 CPRD_product_code FRU-CO tablets 5mg + 40mg [IVAX] drug res9: loop_diuretics 2278001 02020200/02020300/02020400 Loop diuretics/Potassium-sparing diuretics and aldosterone antagonists/Potassium-sparing diuretics w
5218 CPRD_product_code bumetanide oral liquid sugar-free 1mg/5ml drug res9: loop_diuretics 4063003 2020200 Loop diuretics
5220 CPRD_product_code furosemide with amiloride tablets 80mg + 10mg drug res9: loop_diuretics 3524003 02020200/02020300/02020400 Loop diuretics/Potassium-sparing diuretics and aldosterone antagonists/Potassium-sparing diuretics w
5249 CPRD_product_code furosemide oral solution sugar-free 50mg/5ml drug res9: loop_diuretics 7170002 2020200 Loop diuretics
55 CPRD_product_code furosemide tablets 20mg drug res9: loop_diuretics 2885001 2020200 Loop diuretics
56 CPRD_product_code co-amilofruse (amiloride and furosemide) tablets 5mg+40mg drug res9: loop_diuretics 6787001 02020200/02020300/02020400 Loop diuretics/Potassium-sparing diuretics and aldosterone antagonists/Potassium-sparing diuretics w
5728 CPRD_product_code furosemide oral solution sugar-free 40mg/5ml drug res9: loop_diuretics 7170001 2020200 Loop diuretics
5868 CPRD_product_code FRUSOL oral solution sugar-free 20mg/5ml [ROSEMONT] drug res9: loop_diuretics 10605001 2020200 Loop diuretics
6 CPRD_product_code furosemide tablets 40mg drug res9: loop_diuretics 2885002 2020200 Loop diuretics
6118 CPRD_product_code furosemide oral solution sugar-free 20mg/5ml drug res9: loop_diuretics 2885003 2020200 Loop diuretics
6160 CPRD_product_code bumetanide with potassium tablets 500micrograms + 7.7mmol drug res9: loop_diuretics 4065001 2020800 Diuretic/potassium supplement combinations
7441 CPRD_product_code LASILACTONE capsules [SANOFI/AVE] drug res9: loop_diuretics 506001 02020200/02020300/02020400 Loop diuretics/Potassium-sparing diuretics and aldosterone antagonists/Potassium-sparing diuretics w
7582 CPRD_product_code LASIKAL tablets 20mg + 10mmol [BORG] drug res9: loop_diuretics 505001 2020800 Diuretic/potassium supplement combinations
7606 CPRD_product_code LASIX tablets 40mg [BORG] drug res9: loop_diuretics 508002 2020200 Loop diuretics
7709 CPRD_product_code ARELIX capsules 6mg [HOECHSTMAR] drug res9: loop_diuretics 1226001 2020200 Loop diuretics
7734 CPRD_product_code DIUMIDE-K CONTINUS tablets [TEOFARMA] drug res9: loop_diuretics 264001 2020800 Diuretic/potassium supplement combinations
7799 CPRD_product_code LASIX tablets 20mg [BORG] drug res9: loop_diuretics 508001 2020200 Loop diuretics
7806 CPRD_product_code bumetanide tablets 5mg drug res9: loop_diuretics 4063002 2020200 Loop diuretics
8052 CPRD_product_code torasemide tablets 5mg drug res9: loop_diuretics 7257002 2020200 Loop diuretics
8102 CPRD_product_code furosemide with potassium tablets 40mg + 8mmol drug res9: loop_diuretics 3523001 2020800 Diuretic/potassium supplement combinations
814 CPRD_product_code bumetanide tablets 1mg drug res9: loop_diuretics 4063001 2020200 Loop diuretics
9431 CPRD_product_code FRUSEMEK tablets 40mg + 5mg [APS] drug res9: loop_diuretics 10377001 02020200/02020300/02020400 Loop diuretics/Potassium-sparing diuretics and aldosterone antagonists/Potassium-sparing diuretics w
9456 CPRD_product_code amiloride hydrochloride with furosemide tablets 5mg + 40mg drug res9: loop_diuretics 5452002 02020200/02020300/02020400 Loop diuretics/Potassium-sparing diuretics and aldosterone antagonists/Potassium-sparing diuretics w
9680 CPRD_product_code FRUSOL oral solution sugar-free 40mg/5ml [ROSEMONT] drug res9: loop_diuretics 10605002 2020200 Loop diuretics

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